Therapy-induced lipid uptake and remodeling underpin ferroptosis hypersensitivity in prostate cancer

Extracellular Fatty Acids are the Major Contributor to Lipid Synthesis in Prostate Cancer

(2019) Seher Balaban et al.   MOLECULAR CANCER RESEARCH

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

(2019) Kim Vriens et al.   NATURE

NPC intracellular cholesterol transporter 1 (NPC1)-mediated cholesterol export from lysosomes

(2019) Suzanne R. Pfeffer   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of MAPK Signaling by CXCR7 Leads to Enzalutamide Resistance in Prostate Cancer

(2019) Shangze Li et al.   CANCER RESEARCH

Targeting the metabolic response to statin-mediated oxidative stress produces a synergistic anti-tumor response

(2019) Grace H McGregor et al.   CANCER RESEARCH

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

(2018) Alexia Karen Cotte et al.   Nature Communications

PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells

(2018) Seong M. Kim et al.   Cancer Discovery

Association of tamoxifen resistance and lipid reprogramming in breast cancer

(2018) Susanne Hultsch et al.   BMC CANCER

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipid Droplets in Cancer: Guardians of Fat in a Stressful World

(2018) Toni Petan et al.   MOLECULES

Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses

(2018) Qiuhui Li et al.   Nature Communications

Dormant, quiescent, tolerant and persister cells: Four synonyms for the same target in cancer

(2018) François M. Vallette et al.   BIOCHEMICAL PHARMACOLOGY

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade

(2017) Hui-wen Lue et al.   GENES & DEVELOPMENT

Androgen-independent LNCaP cells are a subline of LNCaP cells with a more aggressive phenotype and androgen suppresses their growth by inducing cell cycle arrest at the G1 phase

(2017) Pan Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

ω-3 Long Chain Polyunsaturated Fatty Acids as Sensitizing Agents and Multidrug Resistance Revertants in Cancer Therapy

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The Diagnosis and Treatment of Prostate Cancer

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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Proteomics analyses of prostate cancer cells reveal cellular pathways associated with androgen resistance

(2017) Naseruddin Höti et al.   PROTEOMICS

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

The Proteome of Primary Prostate Cancer

(2016) Diego Iglesias-Gato et al.   EUROPEAN UROLOGY

Lipids, lysosomes, and autophagy

(2016) Bharat Jaishy et al.   JOURNAL OF LIPID RESEARCH

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Diverse drug-resistance mechanisms can emerge from drug-tolerant cancer persister cells

(2016) Michael Ramirez et al.   Nature Communications

Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer

(2016) Steven Kregel et al.   Oncotarget

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells

(2016) Snider Desir et al.   Oncotarget

Antioxidant Role for Lipid Droplets in a Stem Cell Niche of Drosophila

(2015) Andrew P. Bailey et al.   CELL

The role of albumin receptors in regulation of albumin homeostasis: Implications for drug delivery

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Simplified assays of lipolysis enzymes for drug discovery and specificity assessment of known inhibitors

(2015) Jose Iglesias et al.   JOURNAL OF LIPID RESEARCH

Denhaminols A–H, Dihydro-β-agarofurans from the Endemic Australian Rainforest Plant Denhamia celastroides

(2015) Claire Levrier et al.   JOURNAL OF NATURAL PRODUCTS

Oral simvastatin administration delays castration-resistant progression and reduces intratumoral steroidogenesis of LNCaP prostate cancer xenografts

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Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells

(2015) Ksenia Astanina et al.   Scientific Reports

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Fatostatin Displays High Antitumor Activity in Prostate Cancer by Blocking SREBP-Regulated Metabolic Pathways and Androgen Receptor Signaling

(2014) X. Li et al.   MOLECULAR CANCER THERAPEUTICS

GSVA: gene set variation analysis for microarray and RNA-Seq data

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Next-generation Sequencing of Advanced Prostate Cancer Treated with Androgen-deprivation Therapy

(2013) Prabhakar Rajan et al.   EUROPEAN UROLOGY

SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids

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(2011) Minja Pfeiffer et al.   MOLECULAR MEDICINE

Characterization of the Small RNA Transcriptomes of Androgen Dependent and Independent Prostate Cancer Cell Line by Deep Sequencing

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GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists

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Novel Lipogenic Enzyme ELOVL7 Is Involved in Prostate Cancer Growth through Saturated Long-Chain Fatty Acid Metabolism

(2009) K. Tamura et al.   CANCER RESEARCH

Molecular mechanisms of castration-resistant prostate cancer progression

(2009) Smitha S Dutt et al.   Future Oncology

Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts

(2009) Jennifer A. Locke et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Androgen Levels Increase by Intratumoral De novo Steroidogenesis during Progression of Castration-Resistant Prostate Cancer

(2008) J. A. Locke et al.   CANCER RESEARCH

Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol

(2008) Paulette R. Dillard et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of Stargardt-3 macular dystrophy protein (ELOVL4) in the biosynthesis of very long chain fatty acids

(2008) M.-P. Agbaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA