Progesterone: A Unique Hormone with Immunomodulatory Roles in Pregnancy

Progesterone induced blocking factor improves blood pressure, inflammation and pup weight in response to reduced uterine perfusion pressure (RUPP)

(2021) Jesse N Cottrell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Dydrogesterone indications beyond menopausal hormone therapy: an evidence review and woman’s journey

(2021) Petra Stute   GYNECOLOGICAL ENDOCRINOLOGY

Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction

(2021) Marie-Pierre Piccinni et al.   Frontiers in Immunology

Efficacy of dydrogesterone on treating recurrent miscarriage and its influence on immune factors: a systematic review and meta-analysis

(2021) Hongyu Guo et al.   Annals of Palliative Medicine

Micronized vaginal progesterone to prevent miscarriage: a critical evaluation of randomized evidence

(2020) Arri Coomarasamy et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Characterisation of serum progesterone and progesterone-induced blocking factor (PIBF) levels across trimesters in healthy pregnant women

(2020) Mark Kit Lim et al.   Scientific Reports

Autophagy suppression of trophoblast cells induces pregnancy loss by activating decidual NK cytotoxicity and inhibiting trophoblast invasion

(2020) Hai-Xia Tan et al.   Cell Communication and Signaling

Altered Immune Response and Implantation Failure in Progesterone-Induced Blocking Factor-Deficient Mice

(2020) Timea Csabai et al.   Frontiers in Immunology

The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications†

(2020) Ozlem Equils et al.   BIOLOGY OF REPRODUCTION

Effects of Progesterone, Dydrogesterone and Estrogen on the Production of Th1/Th2/Th17 Cytokines by Lymphocytes from Women with Recurrent Spontaneous Miscarriage

(2020) Ghadeer AbdulHussain et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Preterm birth prevention

(2020) Eduardo B. da Fonseca et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Correlations of the expression of γδ T cells and their costimulatory molecules TIGIT, PD‐1, ICOS, and BTLA with PR and PIBF in the peripheral blood and decidual tissues of women with URSA

(2020) Qianqian Liang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Cytokine profiling: variation in immune modulation with preterm birth vs. uncomplicated term birth identifies pivotal signals in pathogenesis of preterm birth

(2020) Jeffrey M. Denney et al.   JOURNAL OF PERINATAL MEDICINE

Elevated immunoexpression of interferon-gamma in placenta tissue samples from pregnancies complicated with preeclampsia compared to the placenta previa

(2020) Nadia Sheibak et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Administration of Exogenous Progesterone Protects Against Brucella abortus Infection–Induced Inflammation in Pregnant Mice

(2020) Jingjing Ren et al.   JOURNAL OF INFECTIOUS DISEASES

Association of pro- and anti-inflammatory cytokines in preeclampsia

(2019) Ruby Aggarwal et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Progesterone-Related Immune Modulation of Pregnancy and Labor

(2019) Nishel M. Shah et al.   Frontiers in Endocrinology

Impaired Progesterone-Responsiveness of CD11c+ Dendritic Cells Affects the Generation of CD4+ Regulatory T Cells and Is Associated With Intrauterine Growth Restriction in Mice

(2019) Kristin Thiele et al.   Frontiers in Endocrinology

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

(2019) Elizabeth A. Phipps et al.   Nature Reviews Nephrology

Primary and secondary prevention of preterm birth: a review of systematic reviews and ongoing randomized controlled trials

(2019) Anca Matei et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

The Cytokines of Asthma

(2019) Bart N. Lambrecht et al.   IMMUNITY

Immunotherapy for Recurrent Pregnancy Loss

(2019) Howard Carp   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Premature ovarian insufficiency (POI) and autoimmunity-an update appraisal

(2019) Michal Kirshenbaum et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Role of Antisperm Antibodies in Infertility, Pregnancy, and Potential forContraceptive and Antifertility Vaccine Designs: Research Progress and Pioneering Vision

(2019) A. S. et al.   Vaccines

Cytokines in Inflammatory Disease

(2019) Shinwan Kany et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of progestogen supplementation (dydrogesterone) in the prevention of preeclampsia

(2019) V. Tskhay et al.   GYNECOLOGICAL ENDOCRINOLOGY

Progestogens and pregnancy loss

(2018) H. J. A. Carp   CLIMACTERIC

New data about preeclampsia: some possibilities of prevention

(2018) Adolf E. Schindler   GYNECOLOGICAL ENDOCRINOLOGY

Distinct pattern of Th17/Treg cells in pregnant women with a history of unexplained recurrent spontaneous abortion

(2018) Jinfeng Qian et al.   BioScience Trends

Plasma inflammatory and immune proteins as predictors of intra-amniotic infection and spontaneous preterm delivery in women with preterm labor: a retrospective study

(2018) Hyunsoo Park et al.   BMC Pregnancy and Childbirth

Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development

(2018) Laura J. Yockey et al.   IMMUNITY

Altered crosstalk of estradiol and progesterone with Myeloid derived suppressor cells and Th1/Th2 cytokines in early miscarriage is associated with early breakdown of maternal-fetal tolerance

(2018) Priyanka Verma et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Supplementation with progestogens in the first trimester of pregnancy to prevent miscarriage in women with unexplained recurrent miscarriage: a systematic review and meta-analysis of randomized, controlled trials

(2017) Gabriele Saccone et al.   FERTILITY AND STERILITY

Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia

(2017) Ingrid C.Weel et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Progesterone and VIP cross-talk enhances phagocytosis and anti-inflammatory profile in trophoblast-derived cells

(2017) Daiana Vota et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dydrogesterone use in early pregnancy

(2016) Fadi Ghazi Mirza et al.   GYNECOLOGICAL ENDOCRINOLOGY

PROMISE: first-trimester progesterone therapy in women with a history of unexplained recurrent miscarriages – a randomised, double-blind, placebo-controlled, international multicentre trial and economic evaluation

(2016) Arri Coomarasamy et al.   HEALTH TECHNOLOGY ASSESSMENT

Pre-eclampsia

(2016) Ben W J Mol et al.   LANCET

Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance

(2015) Chong Jai Kim et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

IL-17 Induces Fetal Loss in a CBA/J×BALB/c Mouse Model, and an Anti-IL-17 Antibody Prevents Fetal Loss in a CBA/J ×DBA/2 Mouse Model

(2015) Wang-Ming Xu et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Modulation of Cytokine Production by the Dydrogesterone Metabolite Dihydrodydrogesterone

(2015) Raj Raghupathy et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

A systematic review of dydrogesterone for the treatment of recurrent miscarriage

(2015) Howard Carp   GYNECOLOGICAL ENDOCRINOLOGY

Prediction of impending preterm delivery based on sonographic cervical length and different cytokine levels in cervicovaginal fluid in preterm labor

(2015) Eun Young Jung et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Immunological Modes of Pregnancy Loss: Inflammation, Immune Effectors, and Stress

(2014) Joanne Kwak-Kim et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Oral dydrogesterone treatment during early pregnancy to prevent recurrent pregnancy loss and its role in modulation of cytokine production: a double-blind, randomized, parallel, placebo-controlled trial

(2014) Ashok Kumar et al.   FERTILITY AND STERILITY

Role of uterine stromal-epithelial crosstalk in embryo implantation

(2014) Alison M. Hantak et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

NK Cells Expressing a Progesterone Receptor Are Susceptible to Progesterone-Induced Apoptosis

(2014) L. Arruvito et al.   JOURNAL OF IMMUNOLOGY

Preterm labor: One syndrome, many causes

(2014) R. Romero et al.   SCIENCE

Endocrine Factors Modulating Immune Responses in Pregnancy

(2014) Anne Schumacher et al.   Frontiers in Immunology

The Rebirth of Progesterone in the Prevention of Preterm Labor

(2013) Vanessa M Schmouder et al.   ANNALS OF PHARMACOTHERAPY

Cytokines as Key Players in the Pathophysiology of Preeclampsia

(2013) Raj Raghupathy   MEDICAL PRINCIPLES AND PRACTICE

Identification of Key Contributory Factors Responsible for Vascular Dysfunction in Idiopathic Recurrent Spontaneous Miscarriage

(2013) Priyanka Banerjee et al.   PLoS One

Biomarkers of Coagulation, Inflammation, and Angiogenesis are Independently Associated with Preeclampsia

(2012) Roland Boij et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Glucocorticoid Receptor Mediates the Effect of Progesterone on Uterine Natural Killer Cells

(2012) Wei Guo et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Selective inhibition and augmentation of alternative macrophage activation by progesterone

(2011) Fiona M. Menzies et al.   IMMUNOLOGY

Cytokines in Autoimmunity: Role in Induction, Regulation, and Treatment

(2011) Kamal D. Moudgil et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array

(2010) Andras Szarka et al.   BMC IMMUNOLOGY

Differential Modulation of TLR3- and TLR4-Mediated Dendritic Cell Maturation and Function by Progesterone

(2010) L. A. Jones et al.   JOURNAL OF IMMUNOLOGY

Increased prevalence of T helper 17 (Th17) cells in peripheral blood and decidua in unexplained recurrent spontaneous abortion patients

(2010) Wen-Juan Wang et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

T helper cytokine patterns: defined subsets, random expression, and external modulation

(2009) Tim R. Mosmann et al.   IMMUNOLOGIC RESEARCH

Progesterone inhibits Toll-like receptor 4-mediated innate immune response in macrophages by suppressing NF-κB activation and enhancing SOCS1 expression

(2009) Li Su et al.   IMMUNOLOGY LETTERS

Progesterone-induced blocking factor (PIBF) modulates cytokine production by lymphocytes from women with recurrent miscarriage or preterm delivery

(2009) R. Raghupathy et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Dydrogesterone in threatened miscarriage: A Malaysian experience

(2009) Ramachandhiran Udayar Pandian   MATURITAS

Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy

(2009) G.J. Burton et al.   PLACENTA

Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors

(2008) Leigh A. Jones et al.   IMMUNOLOGY

Inflammatory processes in preterm and term parturition

(2008) Inge Christiaens et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY