Article
Medicine, Research & Experimental
Ewa Kowalczyk, Monika Kniotek, Grazyna Korczak-Kowalska, Jan Borysowski
Summary: Recurrent pregnancy loss (RPL) affects around 1-3% of child-bearing couples and the etiology of many cases remains unknown. This study proposes the use of recombinant PIBF or IL-4 as a potential treatment for immune system-mediated RPL, as both proteins have immunomodulatory effects that may be beneficial for patients.
MEDICAL HYPOTHESES
(2022)
Review
Obstetrics & Gynecology
Vincenzo Berghella, Moti Gulersen, Amanda Roman, Rupsa C. Boelig
Summary: After the withdrawal of 17-alpha hydroxyprogesterone caproate by the FDA, recommendations for the management of patients with singleton pregnancy and previous spontaneous preterm birth have varied among national societies. This article highlights the use of vaginal progesterone for preventing recurrent spontaneous preterm birth in singleton pregnancies, based on randomized trial data and translational evidence. It suggests offering prophylactic vaginal progesterone starting at 16 weeks and 0 days every night to patients with singletons and previous singleton spontaneous preterm birth, irrespective of cervical length. If a transvaginal ultrasound detects a cervical length = 25 mm at <24 weeks, the progesterone should be continued along with cerclage placement.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Immunology
Alla Arefieva, Marina Nikolaeva, Elena Stepanova, Lubov Krechetova, Elena Golubeva, Nana Tetruashvili, Gennady Sukhikh
Summary: The study found that the intensity of CD200 expression and the Th1/Th2 cytokine ratios after LIT were significant predictors of pregnancy establishment. Elevated CD200 expression on allogeneic lymphocytes is likely to suppress the pro-inflammatory Th1-type immunity needed for successful embryo implantation.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Immunology
Yonglian Lan, Ying Li, Xiaokui Yang, Lingling Lei, Yu Liang, Shuyu Wang
Summary: The study found that PIBF-mediated Th1/Th2 balance plays an important role in IVF-ET outcomes, with lower PIBF and IL-4 levels but higher TNF-alpha levels and Th1/Th2 ratios in the fetal arrest group compared to the live birth group. Increased TNF-alpha/IL-4 ratio may serve as a predictive marker for fetal arrest.
CLINICAL IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Khondoker M. Akram, Lucy I. Frost, Dilly OC. Anumba
Summary: Our research suggests that imbalanced autophagy and enhanced apoptosis in a Th1/Th2 imbalanced placental micro-environment may be associated with the pathogenesis of spontaneous PTB.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Endocrinology & Metabolism
Xiaoqing Li, Xiaomin Xu, Wenhuan Wang, Congcong Sun, Hai Wang, Jiayong Zheng
Summary: This study aimed to investigate the mechanism of lymphocyte immunotherapy (LIT) in the treatment of unexplained recurrent spontaneous abortion (URSA). The results showed that the proportion of Th1 cells increased significantly after LIT and the Th1/Th2 balance decreased significantly. Additionally, the proportion of Th1 and Th2 cells was significantly higher in patients with successful pregnancies, while the Th17/Treg balance decreased in successful pregnancy after LIT.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Kamaludin Dingle, Osama M. Kassem, Fawaz Azizieh, Ghadeer AbdulHussain, Raj Raghupathy
Summary: This study examined the effects of estrogen, progesterone, and dydrogesterone on cytokine profiles in women with recurrent spontaneous miscarriages. The results showed that estrogen had the fewest effects on cytokines, while progesterone and dydrogesterone affected seven out of eight cytokines. The new statistical method identified IFN-gamma, IL-10, and IL-23 as particularly significant for progesterone and dydrogesterone treatments.
Article
Immunology
Ying Qian, Yue Pei, Wei Jiang, Caihong Zheng
Summary: This study found that astilbin has a therapeutic effect on rats with RSA by regulating the balance of Th1/Th2 in maternal circulation and likely in decidual tissue.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Acoustics
T. Wikstrom, P. Kuusela, B. Jacobsson, H. Hagberg, P. Lindgren, M. Svensson, U-B. Wennerholm, L. Valentin
Summary: This study aimed to evaluate the cost-effectiveness of strategies to prevent spontaneous preterm delivery in asymptomatic singleton pregnancies in the Swedish healthcare context. The research found that screening and treatment of high-risk populations may be the most cost-effective strategy, but cost-effectiveness is still strongly influenced by the effectiveness of progesterone and productivity loss.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Integrative & Complementary Medicine
Qimeng Wang, Jian Zhang, Fang Wang
Summary: This study investigated the influence of Th1/Th2 cytokines and Treg cells on the pregnancy outcome of patients with recurrent pregnancy loss (RPL) and revealed their predictive value. Treg and Th1/Th2 cytokines showed a predictive ability for the pregnancy outcome of RPL patients, and their combined use had higher predictive efficacy.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Review
Immunology
Weihang Luo, Jindong Hu, Weifang Xu, Jingcheng Dong
Summary: The immune response in the asthmatic respiratory tract is driven by CD4(+) T helper cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, with different stages of the disease course showing different immune responses. The complex immune networks in the inflammatory airway make it challenging to find a universal treatment for all asthmatics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiao-Hui Wang, Sha Xu, Xiang-Yu Zhou, Rui Zhao, Yan Lin, Jing Cao, Wei-Dong Zang, Hui Tao, Wei Xu, Ming-Qing Li, Shi-Min Zhao, Li-Ping Jin, Jian-Yuan Zhao
Summary: Abnormal metabolite levels in the villous tissues inhibit extravillous trophoblast function, leading to an increased risk of recurrent spontaneous abortion (RSA). Modulating succinate levels may serve as a potential intervention strategy for RSA.
NATURE COMMUNICATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yiwen Deng, Yilin Yao, Guanhuan Du, Wei Liu
Summary: This study found that systemic prednisone treatment significantly reduced the levels of cytokine expression in the saliva of minor RAS patients and promoted a Th1/Th2 balance.
CLINICAL ORAL INVESTIGATIONS
(2022)
Review
Immunology
Marie-Pierre Piccinni, Raj Raghupathy, Shigeru Saito, Julia Szekeres-Bartho
Summary: During pregnancy, the semi-allogeneic nature of the conceptus makes it vulnerable to attacks from the maternal immune system. Protective mechanisms, such as the effects of progesterone and PIBF on immune functions, work to support a healthy pregnancy outcome. The modulation of cytokine production by progesterone and dydrogesterone, as well as the induction of Treg cells, play crucial roles in maintaining a normal materno-foetal interaction and preventing pregnancy pathologies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Na Yu, Yiming Weng, Wei Liu, Lixia Chen, Furhan Iqbal, Zhe Yin, Yinyan He, Yanqiu Wang
Summary: The study demonstrates that Toll-like receptor (TLRs) agonists enhance CCL2 production, affecting cytokine secretion by immune cells and potentially promoting Th1/Th2 immune bias.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Obstetrics & Gynecology
Fawaz Azizieh, Raj Raghupathy, Diaa Shehab, Khaled Al-Jarallah, Renu Gupta
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2017)
Article
Endocrinology & Metabolism
H. Johansson, F. Azizieh, N. al Ali, T. Alessa, N. C. Harvey, E. McCloskey, J. A. Kanis
OSTEOPOROSIS INTERNATIONAL
(2017)
Article
Rheumatology
Fawaz Y. Azizieh, Khaled Al Jarallah, Diaa Shehab, Renu Gupta, Kamaludin Dingle, Raj Raghupathy
RHEUMATOLOGY INTERNATIONAL
(2017)
Article
Immunology
Fawaz Azizieh, Kannaludin Dingle, Raj Raghupathy, Kjell Johnson, Jacob VanderPlas, Ali Ansari
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
K. Dingle, A. Zimek, F. Azizieh, A. R. Ansari
SCIENTIFIC REPORTS
(2019)
Article
Medicine, General & Internal
Kamaludin Dingle, Fawaz Azizieh
Article
Multidisciplinary Sciences
M. John Albert, Raj Raghupathy, Islam Khan, Fawaz Y. Azizieh
SCIENTIFIC REPORTS
(2019)
Article
Immunology
Ghadeer AbdulHussain, Fawaz Azizieh, Ma'asoumah Makhseed, Raj Raghupathy
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2020)
Article
Immunology
Osama Kassem, Abdulwahab Al-Saleh, Fawaz Azizieh, Kamaludin Dingle
JOURNAL OF INFLAMMATION RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Kamaludin Dingle, Osama M. Kassem, Fawaz Azizieh, Ghadeer AbdulHussain, Raj Raghupathy
Summary: This study examined the effects of estrogen, progesterone, and dydrogesterone on cytokine profiles in women with recurrent spontaneous miscarriages. The results showed that estrogen had the fewest effects on cytokines, while progesterone and dydrogesterone affected seven out of eight cytokines. The new statistical method identified IFN-gamma, IL-10, and IL-23 as particularly significant for progesterone and dydrogesterone treatments.
Article
Medicine, Research & Experimental
Fawaz Y. Azizieh, Diaa Shehab, Khaled Al Jarallah, Renu Gupta, Raj Raghupathy
BIOMARKER INSIGHTS
(2019)
Article
Immunology
Fawaz Y. Azizieh, Diaa Shehab, Khaled Al Jarallah, Olusegun Mojiminiyi, Renu Gupta, Raj Raghupathy
JOURNAL OF INFLAMMATION RESEARCH
(2019)
Meeting Abstract
Rheumatology
Khaled Aljarallah, Fawaz Azizieh, Diaa Shehab, Raj Raghupathy, Renu Gupta, Kamaludin Dingle
Meeting Abstract
Endocrinology & Metabolism
H. Johansson, F. Azizieh, N. Al Ali, A. Thamer, N. Harvey, E. Mccloskey, J. Kanis
OSTEOPOROSIS INTERNATIONAL
(2018)
Meeting Abstract
Endocrinology & Metabolism
F. Azizieh, K. Alyahya, K. Dingle
OSTEOPOROSIS INTERNATIONAL
(2017)