Elevated immunoexpression of interferon-gamma in placenta tissue samples from pregnancies complicated with preeclampsia compared to the placenta previa

Aim: The present study aimed to compare the immunohistochemical expression of interferon-gamma (IFN-gamma) in placentas from pregnancies complicated with preeclampsia (PE) and placenta previa (PP) and normal healthy placentas. Methods: Placentas were collected from cases of PE, PP and normal pregnancies as a control group (10 placentas in each group). All the deliveries were at full-term (37-42 weeks) by cesarean section and newborns were without any complications or diseases. Expression of IFN-gamma in the placenta was determined using immunohistochemical methods and findings were compared. Statistical analysis was performed by Mann-Whitney and Kruskal-Wallis tests for comparing the mean values of IFN-gamma expression in the placentas from PE, PP and control groups. Our results showed that the immunoexpression of IFN-gamma in syncytiotrophoblast cells, extravillous trophoblast cells, vascular endothelium and basal plate of the placenta from PE group were more than control and PP groups (P < 0.05) and in PP group were more than the control group (P < 0.05). Conclusion: We concluded that the immunoexpression of IFN-gamma was increased significantly in placenta tissue samples of the PE group compared to the PP group and normal pregnancies. It is proposed that IFN-gamma has an important role in the different mechanisms of PE and PP progression.