Article
Pharmacology & Pharmacy
Doron Kabiri, Yael Hamou, Gali Gordon, Yosef Ezra, Ilan Matok
Summary: A study on 1,048 pregnant women found that vaginal micronized progesterone significantly reduces the risk of preterm birth in women with a shortened cervix in the second trimester; there was no significant difference in the effectiveness of vaginal gel and vaginal capsules containing micronized progesterone for preventing preterm birth.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Obstetrics & Gynecology
Aude Figarella, Cecile Chau, Anderson Loundou, Claude d'Ercole, Florence Bretelle
Summary: This study found that women with short cervix detected during midtrimester ultrasound had a higher rate of preterm birth. The study aimed to evaluate the impact of implementing universal transvaginal cervical length screening on preterm birth rate. The results showed a significant decrease in preterm birth rate after the implementation of universal cervical length screening.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Matthew K. Hoffman, Rebecca G. Clifton, Joseph R. Biggio, George R. Saade, Lynda G. Ugwu, Monica Longo, Sabine Z. Bousleiman, Kelly Clark, William A. Grobman, Heather A. Frey, Suneet P. Chauhan, Lorraine Dugoff, Tracy A. Manuck, Edward K. Chien, Dwight J. Rouse, Hyagriv N. Simhan, M. Sean Esplin, George A. Macones
Summary: A short cervix is a known risk factor for preterm birth, but the use of cervical pessary to prevent preterm delivery in singleton pregnancies with a short cervix has conflicting results. This study aimed to determine if cervical pessary placement reduces the risk of preterm birth in individuals with a short cervix. The findings showed that the use of cervical pessary did not decrease the risk of preterm birth in singleton pregnancies with a short cervix and was associated with a higher rate of fetal or neonatal/infant mortality.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Medicine, General & Internal
Francesco D'Antonio, Nashwa Eltaweel, Smriti C. Prasad, Maria Elena C. Flacco, Lamberto C. Manzoli, Asma C. Khalil
Summary: This systematic review and meta-analysis aimed to evaluate the role of cervical cerclage in preventing preterm birth and adverse outcomes in twin pregnancies. The findings suggest that cervical cerclage in twin pregnancies with short cervical length or cervical dilatation is associated with a reduced risk of preterm birth and improved neonatal outcomes. However, confirmation of these findings in large and well-designed randomized controlled trials is needed for stronger evidence.
Article
Obstetrics & Gynecology
Heather R. Masters, Carri Warshak, Samantha Sinclair, Sara Rountree, Emily DeFranco
Summary: This study aims to quantify the time requirement for transvaginal cervical length (TVCL) screening with the implementation of universal TVCL screening. The results show that the average duration of TVCL screening is 9.8 minutes, and the majority of ultrasounds require less than 15 minutes to complete. Ultrasounds performed in private practice sites require less time compared to those at teaching sites. Implementation of a universal TVCL program adds an average of 10 minutes to each ultrasound exam, but this additional time diminishes with increasing experience.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Acoustics
C. J. J. Cuijpers, J. van't Hooft, C. Schneeberger, J. H. Van der Lee, N. E. Simons, M. A. Van Os, J. Van der Ven, C. J. M. De Groot, B. W. J. Mol, A. G. Van Wassenaer-Leemhuis
Summary: This study found no significant differences in neurodevelopmental, behavioral, health, and physical outcomes between children born to low-risk women with a short cervix who were exposed to vaginal progesterone and those exposed to a placebo.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Rupsa C. Boelig, Varsha Kripalu, Sarah L. Chen, Yuri Cruz, Amanda Roman, Vincenzo Berghella
Summary: This study evaluated the utility of follow-up cervical length screening in low-risk women with singleton pregnancies and an initial cervical length measurement of 26 to 29 mm. Approximately 15% of women in this group experienced cervical shortening to <= 25 mm before 24 weeks' gestation, significantly increasing the risk of spontaneous preterm birth.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Shimrit Shor, Ariel Zimerman, Ron Maymon, Michal Kovo, Maya Wolf, Ifat Wiener, Jacob Bar, Yaakov Melcer
Summary: The study compared the outcomes of pregnant women with short cervical length managed with different treatment protocols. The combination therapy involving vaginal progesterone, cervical cerclage, and Arabin cervical pessary emerged as a promising management strategy for pregnant women at high risk for preterm delivery. Additional studies are required to confirm these findings.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
P. Kuusela, B. Jacobsson, H. Hagberg, H. Fadl, P. Lindgren, J. Wesstrom, U-B Wennerholm, L. Valentin
Summary: The study indicates that second-trimester sonographic cervical length can identify women at high risk of spontaneous preterm birth. However, in a population of mainly white women with a low prevalence of preterm birth, its diagnostic performance is at best moderate.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Medicine, General & Internal
Lee Reicher, Yuval Fouks, Yariv Yogev
Summary: Preterm birth is considered a major cause of neonatal death and short- and long-term disabilities globally. Various pathophysiological processes leading to cervical modifications are the key factors in preterm birth. Cervical assessment is commonly used for prediction and risk stratification in women at high risk for preterm birth.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Putora Katharina, Hornung Rene, Kinkel Janis, Fischer Tina, Putora Paul Martin
Summary: This study aimed to investigate guidelines on preterm birth, analyze decision-criteria, and identify consensus and discrepancies among these guidelines. The results showed that a shortened cervix and a history of preterm birth are relevant in singleton pregnancies. Most guidelines recommend progesterone treatment for cases with no history of preterm birth and with a shortened cervix.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Rasha E. Khamees, Basma M. Khattab, Amal M. Elshahat, Omima T. Taha, Ahmed A. Aboelroose
Summary: The study evaluated the predictive role of the uterocervical angle and cervical length in preterm birth, finding that a uterocervical angle greater than 105 degrees poses a higher risk for preterm deliveries and provides better diagnostic performance in high-risk patients.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Multidisciplinary Sciences
Xavier P. Burgos-Artizzu, Nuria Banos, David Coronado-Gutierrez, Julia Ponce, Brenda Valenzuela-Alcaraz, Ana L. Moreno-Espinosa, Laia Grau, Alvaro Perez-Moreno, Eduard Gratacos, Montse Palacio
Summary: This study evaluated a novel automated test based on ultrasound cervical texture analysis for predicting spontaneous Preterm Birth (sPTB) and found that combining texture analysis with Cervical Length (CL) significantly improved prediction performance compared to using CL alone.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Kiarna Brown, Chor Kiu (Maree) Lam, Michael Binks
Summary: This study retrospectively assessed the uptake of mid-trimester cervical length measurement in the Northern Territory of Australia and investigated the impact of treating a short cervix on preterm birth rates. The results showed an increase in the adoption of cervical length measurement, but no reduction in preterm birth rates.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Acoustics
K. N. Rennert, S. H. Breuking, E. Schuit, M. N. Bekker, M. Woiski, M. A. De Boer, M. Sueters, H. C. J. Scheepers, M. T. M. Franssen, E. Pajkrt, B. W. J. Mol, M. Kok, F. J. R. Hermans
Summary: The study suggests that women whose cervical length increases after arrested preterm labor have a lower risk of preterm birth before 34 weeks compared to women whose cervical length does not change or decreases.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
