Review
Obstetrics & Gynecology
Alexander Katalinic, Lee P. Shulman, Jerome F. Strauss, Juan A. Garcia-Velasco, John N. van den Anker
Summary: No evidence supports the suggestion that using dydrogesterone in the first trimester increases the risk of fetal abnormalities. Previous studies suggesting a link have been retracted. A scoping review and meta-analysis found no plausible mechanism for this potential causality.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Pharmacology & Pharmacy
Kai Chen, Xiaoxia Liu, Xianhua Meng, Hui Li, Chenchen Yang, Xiaohong Wang
Summary: This meta-analysis evaluated the effectiveness and safety of combining Gushen Antai Pills with dydrogesterone in treating threatened miscarriage. The results showed that the combination therapy significantly reduced the incidence of early pregnancy loss, alleviated clinical symptoms, and improved hormone levels compared to dydrogesterone alone. However, further randomized controlled trials with rigorous design are needed to confirm these findings due to limitations and bias in the included studies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Ka Ying Bonnie Ng, George Cherian, Alexandra J. Kermack, Sarah Bailey, Nick Macklon, Sesh K. Sunkara, Ying Cheong
Summary: Lifestyle factors like being underweight and having BMI>25 significantly contribute to increased risk of RPL in the general population, and BMI>30 and BMI>25 also increase the odds of further miscarriages in women with RPL. However, the quality of evidence for these findings is low. Larger studies focusing on alcohol, cigarette smoking, and caffeine intake effects on RPL risk with BMI optimization are now needed.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Asher Bashiri, Gabi Galperin, Atif Zeadna, Yael Baumfeld, Tamar Wainstock
Summary: This retrospective cohort study compared the live birth rates of women with and without progesterone treatment for recurrent pregnancy loss (RPL). The results showed that progesterone treatment was independently associated with a higher rate of live births in RPL patients. Further studies with larger sample sizes are recommended to confirm these findings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Clara Q. Wu, Kelly Nichols, Matthew Carwana, Nicholas Cormier, Christina Maratta
Summary: This study conducted a systematic review and meta-analysis to evaluate the impact of recurrent pregnancy loss (RPL) on the risk of preterm birth (PTB) in subsequent pregnancies. The results showed that women with a history of RPL had significantly higher odds of delivering preterm infants in subsequent pregnancies, and the risk of PTB increased with the number of pregnancy losses.
FERTILITY AND STERILITY
(2022)
Review
Obstetrics & Gynecology
Jennifer A. Tamblyn, Nicole S. P. Pilarski, Alexandra D. Markland, Ella J. Marson, Adam Devall, Martin Hewison, Rachel K. Morris, Arri Coomarasamy
Summary: This systematic review and meta-analysis found an association between vitamin D deficiency or insufficiency and increased risk of miscarriage. However, it remains unclear whether preconception treatment of vitamin D deficiency can protect women at risk of miscarriage from pregnancy loss.
FERTILITY AND STERILITY
(2022)
Review
Biochemistry & Molecular Biology
Xiuhua Yang, Yingying Tian, Linlin Zheng, Thanh Luu, Joanne Kwak-Kim
Summary: Recurrent pregnancy losses (RPL) is a common reproductive disorder with various underlying etiologies. Recent research has shown that the immune response, particularly the imbalance of cytokines in the maternal-fetal interface, plays a crucial role in RPL. The increased NK1/NK2 ratio in decidual NK (dNK) cells of RPL patients contributes to a pro-inflammatory cytokine milieu and increased NK cell cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Yanpeng Dai, Junjie Liu, Enwu Yuan, Yushan Li, Ying Shi, Linlin Zhang
Summary: This meta-analysis explores the relationship among traditional semen parameters, SDF, and unexplained RM. The results show that couples with unexplained RM have significantly increased levels of SDF and significantly decreased levels of total motility and progressive motility. Therefore, SDF assay may be important in the evaluation of couples with unexplained RM.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Genetics & Heredity
Amin Jalilvand, Kheirollah Yari, Fatemeh Heydarpour
Summary: This study evaluated the effect of unstudied polymorphisms on recurrent miscarriage. A systematic review identified 143 studies worldwide, and 13 genes were assessed in case-control studies. Quantitative analysis included 92 studies and 22 SNPs. Certain variations showed significant association with recurrent miscarriage risk, but further research is needed for confirmation.
Article
Obstetrics & Gynecology
Marie Carbonnel, Paul Pirtea, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Both congenital and acquired uterine anomalies are associated with recurrent pregnancy loss. Initial evaluation of uterine anatomy is crucial for women with RPL. Surgical management of certain uterine anomalies, such as uterine septa, endometrial polyps, intrauterine adhesions, and submucosal myomas, may improve subsequent pregnancy outcomes in specific circumstances.
FERTILITY AND STERILITY
(2021)
Article
Genetics & Heredity
Feiyang Wang, Wentong Jia, Mengjie Fan, Xuan Shao, Zhilang Li, Yongjie Liu, Yeling Ma, Yu-Xia Li, Rong Li, Qiang Tu, Yan-Ling Wang
Summary: This study compared the cellular and molecular characteristics of decidual and peripheral leukocytes in normal and unexplained recurrent miscarriage (RM) pregnancies using single-cell RNA sequencing (scRNA-seq). The results revealed significant differences in immune cell subsets and molecular properties in RM cases, providing insights into the immune pathogenesis of early pregnancy loss.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2021)
Review
Medicine, General & Internal
Akbayan Turesheva, Gulzhanat Aimagambetova, Talshyn Ukybassova, Aizada Marat, Perizat Kanabekova, Lyazzat Kaldygulova, Ainur Amanzholkyzy, Svetlana Ryzhkova, Anastassiya Nogay, Zaituna Khamidullina, Aktoty Ilmaliyeva, Wassim Y. Almawi, Kuralay Atageldiyeva
Summary: Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. The true incidence is difficult to estimate due to inconsistency in definitions and criteria applied by international guidelines. The exact etiology remains questionable and up to 75% of cases are unexplained. This review aimed to summarize accumulated knowledge on etiology, risk factors, diagnostic options, and management approach to recurrent pregnancy loss.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Abey Eapen, Emily T. Hayes, Dana B. McQueen, Molly Beestrum, Patrick Ten Eyck, Christina Boots
Summary: The study found an association between maternal body mass index (BMI) and recurrent pregnancy loss (RPL), with women with a history of RPL having significantly higher BMI compared to controls.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Haley G. Genovese, Dana B. Mcqueen
Summary: This manuscript reports on the prevalence of early pregnancy loss and discusses the impact of improved pregnancy diagnosis, as well as the influence of increased age and body mass index at first birth.
FERTILITY AND STERILITY
(2023)
Review
Andrology
Annalisa Inversetti, Arianna Bossi, Martina Cristodoro, Alessandro Larcher, Andrea Busnelli, Giuseppe Grande, Andrea Salonia, Nicoletta Di Simone
Summary: The study found a correlation between sperm DNA fragmentation, semen parameters, and recurrent pregnancy loss in multiple ethnic groups.
