Article
Obstetrics & Gynecology
Elinor Chelsom Vogt, Eirik Bratland, Siren Berland, Ragnhild Berentsen, Agnethe Lund, Sigridur Bjornsdottir, Eystein Husebye, Marianne Oksnes
Summary: Extensive screening and the use of next generation sequencing techniques can significantly increase the determination of potential etiological diagnosis of primary ovarian insufficiency, providing new insights into cases with unknown causes.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Xudong Zhang, Yimeng Lu, Shanshan Wu, Xinyang Zhao, Shuyu Li, Siwen Zhang, Jichun Tan
Summary: This study conducted a bibliometric analysis of primary ovarian insufficiency (POI) related literature, and found that significant progress has been made in POI research over the past 20 years, but unevenly developed globally. The United States may lead in POI research influence. Research hotspots mainly focus on pathogenesis and treatment, including genetic mutation, hormone therapy, fertility preservation, and stem cell transplantation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Rachel K. Vanderschelden, Marta Rodriguez-Escriba, Serena H. Chan, Andrea J. Berman, Aleksandar Rajkovic, Svetlana A. Yatsenko
Summary: The purpose of this study was to identify the genetic causes of non-syndromic primary ovarian insufficiency (POI) in female patients. Whole exome sequencing was performed in females with isolated POI and their family members. Two pathogenic TP63 heterozygous deleterious single nucleotide variants and a novel TP63 intragenic copy number alteration were detected in three unrelated women with isolated POI. These genetic variants are predicted to affect the transactivation inhibitory domain of p63 and the first exon of the ΔNp63 isoforms.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Mengchi Chen, Haotian Jiang, Chunping Zhang
Summary: Primary ovarian insufficiency (POI) is a heterogeneous disease characterized by non-functional ovaries in women under 40. Genetic factors play a crucial role in POI cases, accounting for around 20% to 25%. This paper reviews various genetic causes of POI, including chromosomal abnormalities, single gene mutations, defects in mitochondrial functions, and non-coding RNA abnormalities, providing valuable insights for diagnosing and predicting POI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Junyan Sun, Yihui Fan, Ying Guo, Huiying Pan, Chen Zhang, Guoping Mao, Yating Huang, Boning Li, Tingting Gu, Lulu Wang, Qiuwan Zhang, Qian Wang, Qian Zhou, Bai Li, Dongmei Lai
Summary: Background and Purpose: This study aimed to explore high-frequency adverse life events among women with primary ovarian insufficiency (POI) and found that workplace stress, family stress, and sleep problems were important factors influencing the development of POI. The study highlights the influence of social environmental factors on POI disease risks and proposes tailored interventions for high-risk populations to prevent new POI cases and improve the conditions of women with POI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Xiaodi Pu, Leisheng Zhang, Peiyu Zhang, Yaqiong Xu, Jun Wang, Xiaomei Zhao, Zhihua Dai, Hua Zhou, Shuyun Zhao, Anran Fan
Summary: Premature ovarian insufficiency (POI) induced by chemotherapy is a difficult-to-treat disorder that affects female fertility. The use of human umbilical cord mesenchymal stem cells (hUCMSCs) and exosomes derived from them shows potential in improving ovarian function and protecting fertility in POI patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
K. Beitl, J. Ott, K. Rosta, I. Holzer, P. Foessleitner, J. Steininger, N. Panay
Summary: Compared to a healthy young collective, a high prevalence of autoimmunity was demonstrated in women with POI. Thyroid antibodies, specifically TGAb and TPOAb, were significantly increased in POI women. Our findings highlight the increased risk of autoimmune diseases, especially thyroid disorders, in women with POI.
Review
Medicine, General & Internal
Junyu Chen, Shan Wu, Mengqi Wang, Haoxian Zhang, Manhua Cui
Summary: This review focuses on the role of autoimmunity in primary ovarian insufficiency (POI) and potential therapies for autoimmunity-related POI. Various markers of ovarian reserve, specifically anti-Mullerian hormone, can be negatively affected by autoimmune diseases. Lymphocytic oophoritis, anti-ovarian autoantibodies, and concurrent autoimmune diseases are the main characteristics of autoimmune POI. T lymphocytes play a crucial role in the immune pathogenesis of POI.
Review
Endocrinology & Metabolism
Bunpei Ishizuka
Summary: POI affects at least 1% of women and can have lifelong health problems and psychological stress. Hormone replacement therapy is recommended to alleviate symptoms and prevent complications. Further research is needed to understand the genetic background and improve infertility treatment for POI patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Yi-Ting Hsieh, Jason Y. P. Ho
Summary: The study revealed that thyroid autoimmunity significantly increases the risk of POI in women, especially for patients with Hashimoto's disease. It suggests that more efficient methods of infertility treatment may be needed for patients with autoimmune thyroid disease, and close monitoring of ovarian reserve is recommended.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Xue Jiao, Tingting Meng, Yiwei Zhai, Lijuan Zhao, Wei Luo, Peihao Liu, Yingying Qin
Summary: Ovarian reserve indicators deteriorate with the progression of ovarian insufficiency, with an increase in FSH and LH but a decrease in AMH, inhibin B, AFC, E-2 and T. AMH has the highest predictive value for POI, and the combination of AMH and AFC is promising for early prediction. Significant differences exist in hormone status among women with different etiologies of POI, with genetic POI showing the worst hormone status.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Jin-Sung Yuk, Myounghwan Kim
Summary: The study found that the incidence of primary ovarian insufficiency in South Korea is 9.2 per 100,000 (0.0092%), which is considerably lower than reported in previous studies. Cancer, diabetes mellitus without complications, and renal disease were associated with an increased incidence of POI.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2021)
Article
Medicine, General & Internal
Fernanda Velluzzi, Silvia Pisanu, Maura Galletta, Michele Fosci, Gianni Secci, Andrea Deledda, Francesco Boi, Rossella Rodia, Giuseppe Fanciulli, Alessandro Palmerio Delitala, Gianmarco Sainas, Andrea Loviselli
Summary: There is a positive correlation between Thyroid-Stimulating Hormone (TSH) and Body Mass Index (BMI), but the data is controversial when TSH values are within the normal range. This study investigated the role of thyroid autoimmunity in the interconnection between TSH, BMI, and waist circumference (WC) in euthyroid patients with overweight or obesity. The study found a significant correlation between TSH and BMI only in obese women with positive anti-thyroid autoantibodies (ATAs).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Fengping He, Yanhui Liu, Tang Li, Qiulin Ma, Zhang Yongmei, Peiqing He, Chuanyin Xiong
Summary: The up-regulation of miRNA-146 expression protects against LPS-induced ovarian dysfunction by inhibiting the TLR4/NF-κB signaling pathway and reducing the expression of inflammatory cytokines TNF-a and IL-6.
Article
Endocrinology & Metabolism
Kris Gustave Poppe, Laura Frommer, Burak Hatun, Candice Autin, Fleur Wolff, George Jean Kahaly
Summary: Women with thyroid autoimmunity (TAI) undergoing assisted reproductive technology (ART) treatment are at higher risk of miscarriage, possibly due to the presence of thyrotropin receptor antibodies (TSH-R-Ab) that hinder corpus luteum development. This pilot study measured both binding and functional TSH-R-Ab using five different assays in women with TAI and one without TAI before and after ovarian stimulation (OS) during ART. Results showed that TSH-R-Ab levels were below the cut-off for all assays and four bioassays.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)