Journal
GYNECOLOGICAL ENDOCRINOLOGY
Volume 37, Issue 8, Pages 683-688Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/09513590.2021.1908252
Keywords
Dydrogesterone; dysmenorrhea; premenstrual syndrome; luteal phase support; miscarriage
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Dydrogesterone is an orally active synthetic progestogen with no inhibitory effect on ovulation, making it suitable for use throughout a woman's lifetime. Apart from being part of menopausal hormone therapy, dydrogesterone is also effective in treating gynecological issues in younger women and providing luteal phase support in assisted reproduction techniques.
Dydrogesterone is an orally active synthetic progestogen, with a molecular structure similar to that of natural progesterone. As dydrogesterone does not inhibit ovulation at standard doses, is devoid of estrogenic or androgenic properties, and does not induce metabolic side effects, it is suitable for use throughout a woman's lifetime, from adolescence to older age, for conditions associated with altered levels of endogenous progesterone. Aside from its well established role as a component of menopausal hormone therapy, dydrogesterone is indicated in younger women for treatment of dysmenorrhea, irregular menstrual cycles, premenstrual syndrome, and threatened or recurrent miscarriage; and is effective as luteal phase support during assisted reproduction techniques. In this narrative review, evidence is examined for use of dydrogesterone across a range of disorders affecting menses and pregnancy. A case study woven into the review illustrates the clinical uses of dydrogesterone during a young woman's journey to become a mother.
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