Journal
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
Volume 42, Issue 2, Pages 158-165Publisher
WILEY
DOI: 10.1111/jog.12882
Keywords
cervical length; cervicovaginal fluid; impending preterm delivery; interleukin; preterm labor
Categories
Funding
- Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea [HI 14C1798]
- Seoul National University Bundang Hospital Research Fund [02-2012-020]
Ask authors/readers for more resources
AimsThe aim of this study was to determine whether cervicovaginal interleukin (IL)-1, IL-6 and IL-8 levels, and cervical length, alone or in combination, could predict impending preterm delivery in women with preterm labor and intact membranes. Material and MethodsCervicovaginal swab samples for IL-1, IL-6, and IL-8 assays were taken from 136 consecutive women with preterm labor (23-34 weeks) before the transvaginal ultrasonography examination to measure cervical length. The primary outcome measurement was spontaneous preterm delivery within 7 days of sampling. ResultsSpontaneous preterm delivery within 7 days occurred in 28.6% (39/136) of patients. Receiver-operator characteristic (ROC) curves indicated that cervical length (P < 0.001), cervicovaginal IL-6 (P < 0.001) and IL-8 (P = 0.014), but not IL-1, could predict delivery within 7 days. According to the logistic regression analysis, high cervicovaginal IL-8 (P = 0.008) and IL-6 (P = 0.038) levels and short cervical length (P < 0.001) were significantly associated with delivery within 7 days, even after controlling for baseline variables. A combination of cervix length and cervicovaginal IL-8 increased the specificity of detecting delivery within 7 days to 92.8%, which was superior to either test alone (P < 0.001), but the sensitivity was only 56.4%. ConclusionIn women with preterm labor, among the parameters assessed, cervicovaginal IL-6 and IL-8 and cervical length are the most important parameters in predicting impending preterm delivery. A combination of cervix length and cervicovaginal IL-8 appeared to be the best for predicting impending preterm delivery, but the relatively low sensitivity of this test may limit its clinical usefulness.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available