Activation of Innate Immunity by Therapeutic Nucleic Acids

Regulation of RIG-I-like receptor-mediated signaling: interaction between host and viral factors

(2021) Koji Onomoto et al.   Cellular & Molecular Immunology

mRNA vaccine for cancer immunotherapy

(2021) Lei Miao et al.   Molecular Cancer

Emerging concepts in the science of vaccine adjuvants

(2021) Bali Pulendran et al.   NATURE REVIEWS DRUG DISCOVERY

FDA approves 100th monoclonal antibody product

(2021) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Delivery Systems for Nucleic Acids and Proteins: Barriers, Cell Capture Pathways and Nanocarriers

(2021) Julian D. Torres-Vanegas et al.   Pharmaceutics

A Guide to Nucleic Acid Vaccines in the Prevention and Treatment of Infectious Diseases and Cancers: From Basic Principles to Current Applications

(2021) Furong Qin et al.   Frontiers in Cell and Developmental Biology

Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways

(2021) Lukas Kraehenbuehl et al.   Nature Reviews Clinical Oncology

CpG Oligodeoxynucleotides Induces Apoptosis of Human Bladder Cancer Cells via Caspase-3-Bax/Bcl-2-p53 Axis

(2020) Yang Luo et al.   ARCHIVES OF MEDICAL RESEARCH

Construction of Monomeric and Dimeric G-Quadruplex-Structured Cytosine-Phosphate-Guanine Oligodeoxynucleotides for Enhanced Uptake and Activation in Toll-Like Receptor 9-Positive Macrophages

(2020) Wenqing Liao et al.   Nucleic Acid Therapeutics

TREX1 – Apex predator of cytosolic DNA metabolism

(2020) Sean R. Simpson et al.   DNA REPAIR

Nucleic Acid-Based Approaches for Tumor Therapy

(2020) Simone Hager et al.   Cells

Immunostimulating RNA Delivered by P1500 PEGylated Cationic Liposomes Limits Influenza Infection in C57Bl/6 Mice

(2020) Elena P. Goncharova et al.   Pharmaceutics

Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

(2020) Sreya Bagchi et al.   Annual Review of Pathology-Mechanisms of Disease

Targeting immunogenic cell death in cancer

(2020) Asma Ahmed et al.   Molecular Oncology

RIG-I Selectively Discriminates against 5′-Monophosphate RNA

(2019) Xiaoming Ren et al.   Cell Reports

G-Quadruplex Structure Improves the Immunostimulatory Effects of Cytosine-Phosphate-Guanine Oligonucleotides

(2019) Kazuaki Hoshi et al.   Nucleic Acid Therapeutics

Mechanisms of resistance to CAR T cell therapy

(2019) Nirali N. Shah et al.   Nature Reviews Clinical Oncology

Damage-Associated Molecular Pattern-Triggered Immunity in Plants

(2019) Shuguo Hou et al.   Frontiers in Plant Science

Development of a Nanostructured RNA/DNA Assembly as an Adjuvant Targeting Toll-Like Receptor 7/8

(2019) Fusae Komura et al.   Nucleic Acid Therapeutics

Comparative Structure and Function Analysis of the RIG-I-Like Receptors: RIG-I and MDA5

(2019) Morgan Brisse et al.   Frontiers in Immunology

Polymeric Carriers for Nucleic Acid Delivery: Current Designs and Future Directions

(2019) Lun Peng et al.   BIOMACROMOLECULES

LGP2 binds to PACT to regulate RIG-I– and MDA5-mediated antiviral responses

(2019) Raul Y. Sanchez David et al.   Science Signaling

Current Perspectives in Cancer Immunotherapy

(2019) Theodoulakis Christofi et al.   Cancers

N6-Methyladenosine Modification Controls Circular RNA Immunity

(2019) Y. Grace Chen et al.   MOLECULAR CELL

Molecular Mechanism of the Antiproliferative Activity of Short Immunostimulating dsRNA

(2019) Mikhail I. Zharkov et al.   Frontiers in Oncology

TLR8 activation and inhibition by guanosine analogs in RNA: Importance of functional groups and chain length

(2018) Tiannan Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells

(2018) Jeonghyun Ahn et al.   CANCER CELL

Cytosolic sensing of immuno-stimulatory DNA, the enemy within

(2018) Rekha Dhanwani et al.   CURRENT OPINION IN IMMUNOLOGY

Toll-like Receptor 9 Contains Two DNA Binding Sites that Function Cooperatively to Promote Receptor Dimerization and Activation

(2018) Umeharu Ohto et al.   IMMUNITY

Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review)

(2018) Masaru Katoh   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Gene therapy clinical trials worldwide to 2017: An update

(2018) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

The revival of CpG oligonucleotide-based cancer immunotherapies

(2018) Tomasz Adamus et al.   Wspolczesna Onkologia-Contemporary Oncology

TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles

(2018) Mojca Frank-Bertoncelj et al.   Frontiers in Immunology

A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation

(2018) Antonio Gregorio Dias Junior et al.   TRENDS IN MICROBIOLOGY

Nuclear-resident RIG-I senses viral replication inducing antiviral immunity

(2018) GuanQun Liu et al.   Nature Communications

Short Double-Stranded RNA with Immunostimulatory Activity: Sequence Dependence

(2018) Tatyana O. Kabilova et al.   Nucleic Acid Therapeutics

Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers

(2018) Mikhail Durymanov et al.   Frontiers in Pharmacology

Damage-Associated Molecular Patterns in Inflammatory Diseases

(2018) Jong Seong Roh et al.   Immune Network

Cytokines in clinical cancer immunotherapy

(2018) Pedro Berraondo et al.   BRITISH JOURNAL OF CANCER

Novel PEGylated Liposomes Enhance Immunostimulating Activity of isRNA

(2018) Tatyana Kabilova et al.   MOLECULES

RNA-Based Immunostimulatory Liposomal Spherical Nucleic Acids as Potent TLR7/8 Modulators

(2018) Chenxia Guan et al.   Small

Trial Watch: Toll-like receptor agonists in cancer immunotherapy

(2018) Melody Smith et al.   OncoImmunology

Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways

(2017) Kai Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of TLR9 in Oncogenic Virus-Produced Cancer

(2017) Cecilia Martínez-Campos et al.   VIRAL IMMUNOLOGY

RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?

(2017) Zhongji Meng et al.   Frontiers in Immunology

Design Considerations for RNA Spherical Nucleic Acids (SNAs)

(2016) Stacey N. Barnaby et al.   BIOCONJUGATE CHEMISTRY

Molecular mechanisms of regulation of Toll-like receptor signaling

(2016) Cynthia A. Leifer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Innate recognition of microbial-derived signals in immunity and inflammation

(2016) Yue Zhang et al.   Science China-Life Sciences

Comparative analysis of viral RNA signatures on different RIG-I-like receptors

(2016) Raul Y Sanchez David et al.   eLife

Efficacy of rintatolimod in the treatment of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)

(2016) William M Mitchell   Expert Review of Clinical Pharmacology

Antitumor and Antimetastatic Effect of Small Immunostimulatory RNA against B16 Melanoma in Mice

(2016) Tatyana O. Kabilova et al.   PLoS One

LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling

(2015) Annie M. Bruns et al.   CYTOKINE

Glycans in the immune system and The Altered Glycan Theory of Autoimmunity: A critical review

(2015) Emanual Maverakis et al.   JOURNAL OF AUTOIMMUNITY

An Overview of Pathogen Recognition Receptors for Innate Immunity in Dental Pulp

(2015) Ji-Hyun Jang et al.   MEDIATORS OF INFLAMMATION

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

(2015) Umeharu Ohto et al.   NATURE

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Immunomodulatory spherical nucleic acids

(2015) Aleksandar F. Radovic-Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR4 activation by lipopolysaccharide confers survival advantage to growth factor deprived prostate cancer cells

(2015) Sumeet Jain et al.   PROSTATE

RIG-I ATPase Activity and Discrimination of Self-RNA versus Non-Self-RNA

(2015) Stéphanie Anchisi et al.   mBio

Toll-like receptor 8 senses degradation products of single-stranded RNA

(2015) Hiromi Tanji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanisms of immune system activation in mammalians by small interfering RNA (siRNA)

(2015) Behzad Mansoori et al.   Artificial Cells Nanomedicine and Biotechnology

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

(2014) Jiazhen Zhang et al.   BIOCHEMICAL JOURNAL

Immunotherapy of hepatocellular carcinoma with small double-stranded RNA

(2014) Tatyana O Kabilova et al.   BMC CANCER

Role of the Microbiota in Immunity and Inflammation

(2014) Yasmine Belkaid et al.   CELL

Side Effects of Cytokines Approved for Therapy

(2014) Brian A. Baldo   DRUG SAFETY

Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING

(2014) Jeonghyun Ahn et al.   JOURNAL OF IMMUNOLOGY

Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

(2014) Delphine Goubau et al.   NATURE

The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

(2014) Xu Zhang et al.   Cell Reports

TLR9 Activation Is Triggered by the Excess of Stimulatory versus Inhibitory Motifs Present in Trypanosomatidae DNA

(2014) Mélissa Erin Khan et al.   PLoS Neglected Tropical Diseases

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

5′-Triphosphate-siRNA activates RIG-I-dependent type I interferon production and enhances inhibition of hepatitis B virus replication in HepG2.2.15 cells

(2013) Xiaojuan Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

DNA-dependent Activator of Interferon-regulatory Factors (DAI) Promotes Lupus Nephritis by Activating the Calcium Pathway

(2013) Weijuan Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Length of dsRNA (poly I:C) drives distinct innate immune responses, depending on the cell type

(2013) M. Firoz Mian et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CpG oligodeoxynucleotide induces apoptosis and cell cycle arrest in A20 lymphoma cells via TLR9-mediated pathways

(2013) Xu-Feng Qi et al.   MOLECULAR IMMUNOLOGY

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates

(2013) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING-dependent cytosolic DNA sensing pathways

(2013) Glen N. Barber   TRENDS IN IMMUNOLOGY

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

Extraordinary GU-rich single-strand RNA identified from SARS coronavirus contributes an excessive innate immune response

(2012) Yan Li et al.   MICROBES AND INFECTION

STING and the innate immune response to nucleic acids in the cytosol

(2012) Dara L Burdette et al.   NATURE IMMUNOLOGY

Mechanisms of fibrosis: therapeutic translation for fibrotic disease

(2012) Thomas A Wynn et al.   NATURE MEDICINE

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

(2012) Y. Tanaka et al.   Science Signaling

DNA-PK is a DNA sensor for IRF-3-dependent innate immunity

(2012) Brian J Ferguson et al.   eLife

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo

(2011) Norliana Khairuddin et al.   IMMUNOLOGY AND CELL BIOLOGY

Immunostimulatory Motifs Enhance Antiviral siRNAs Targeting Highly Pathogenic Avian Influenza H5N1

(2011) Cameron R. Stewart et al.   PLoS One

RIG-I, MDA5 and TLR3 Synergistically Play an Important Role in Restriction of Dengue Virus Infection

(2011) A. M. A. Nasirudeen et al.   PLoS Neglected Tropical Diseases

Inflammation: A driving force speeds cancer metastasis

(2010) Yadi Wu et al.   CELL CYCLE

Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant

(2010) Bo Jin et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

CpG oligonucleotides as immunotherapeutic adjuvants: innovative applications and delivery strategies

(2009) Aliasger K. Salem et al.   ADVANCED DRUG DELIVERY REVIEWS

Synthetic and Natural Immunomodulators Acting as Interferon Inducers

(2009) Dmytro Silin et al.   CURRENT PHARMACEUTICAL DESIGN

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY

Immunostimulatory RNA Blocks Suppression by Regulatory T Cells

(2009) D. Anz et al.   JOURNAL OF IMMUNOLOGY

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

(2009) Benjamin Weide et al.   JOURNAL OF IMMUNOTHERAPY

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

(2009) Marcin Kortylewski et al.   NATURE BIOTECHNOLOGY

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA

(2009) Diana A. Pippig et al.   NUCLEIC ACIDS RESEARCH

Inhibition of Human Cancer-Cell Proliferation by Long Double-Stranded RNAs

(2009) Ivan A. Akimov et al.   OLIGONUCLEOTIDES

siRNA and Innate Immunity

(2009) Marjorie Robbins et al.   OLIGONUCLEOTIDES

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Differential recognition of double-stranded RNA by RIG-I–like receptors in antiviral immunity: Figure 1.

(2008) Takeshi Saito et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

(2008) Hendrik Poeck et al.   NATURE MEDICINE

The TLR3 signaling complex forms by cooperative receptor dimerization

(2008) J. N. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA