Trial Watch: Toll-like receptor agonists in cancer immunotherapy

Combined immunotherapy encompassing intratumoral poly-ICLC, dendritic-cell vaccination and radiotherapy in advanced cancer patients

(2018) M E Rodríguez-Ruiz et al.   ANNALS OF ONCOLOGY

Highly enhanced cancer immunotherapy by combining nanovaccine with hyaluronidase

(2018) Xiuwen Guan et al.   BIOMATERIALS

Polymeric nanoparticles encapsulating novel TLR7/8 agonists as immunostimulatory adjuvants for enhanced cancer immunotherapy

(2018) Hyunjoon Kim et al.   BIOMATERIALS

Personalized neoantigen vaccines: A new approach to cancer immunotherapy

(2018) Amanda R. Aldous et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Downregulation of Membrane Trafficking Proteins and Lactate Conditioning Determine Loss of Dendritic Cell Function in Lung Cancer

(2018) Nicoletta Caronni et al.   CANCER RESEARCH

Vaccine immunotherapy with ARNAX induces tumor-specific memory T cells and durable anti-tumor immunity in mouse models

(2018) Yohei Takeda et al.   CANCER SCIENCE

SnapShot: CGAS-STING Signaling

(2018) Lorenzo Galluzzi et al.   CELL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Intravesical Immunomodulatory Imiquimod Enhances Bacillus Calmette-Guérin Downregulation of Nonmuscle-invasive Bladder Cancer

(2018) Juliana A. Camargo et al.   Clinical Genitourinary Cancer

Lenalidomide as immune adjuvant to a dendritic cell vaccine in chronic lymphocytic leukemia patients

(2018) Marzia Palma et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Treatment Strategy for Newly Diagnosed T1 High-grade Bladder Urothelial Carcinoma: New Insights and Updated Recommendations

(2018) Zachary Klaassen et al.   EUROPEAN UROLOGY

Importance of immune monitoring approaches and the use of immune checkpoints for the treatment of diffuse intrinsic pontine glioma: From bench to clinic and vice versa (Review)

(2018) Jorge Scutti   INTERNATIONAL JOURNAL OF ONCOLOGY

The autophagic network and cancer

(2018) Marissa D. Rybstein et al.   NATURE CELL BIOLOGY

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

The revival of CpG oligonucleotide-based cancer immunotherapies

(2018) Tomasz Adamus et al.   Wspolczesna Onkologia-Contemporary Oncology

Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma

(2018) Tomas Garzon-Muvdi et al.   Oncotarget

Prognostic value of ki67 in BCG-treated non-muscle invasive bladder cancer: a meta-analysis and systematic review

(2018) Yuhui He et al.   BMJ Open

Functional Analysis of the Chaperone-Usher Fimbrial Gene Clusters of Salmonella enterica serovar Typhi

(2018) Karine Dufresne et al.   Frontiers in Cellular and Infection Microbiology

Combination Immunotherapy: Taking Cancer Vaccines to the Next Level

(2018) Jeremy M. Grenier et al.   Frontiers in Immunology

Computational Pipeline for the PGV-001 Neoantigen Vaccine Trial

(2018) Alex Rubinsteyn et al.   Frontiers in Immunology

Complimentary mechanisms of dual checkpoint blockade expand unique T-cell repertoires and activate adaptive anti-tumor immunity in triple-negative breast tumors

(2018) Erika J. Crosby et al.   OncoImmunology

Vaccination-induced skin-resident memory CD8+ T cells mediate strong protection against cutaneous melanoma

(2018) Felipe Gálvez-Cancino et al.   OncoImmunology

Anti-CTLA-4 based therapy elicits humoral immunity to galectin-3 in patients with metastatic melanoma

(2018) Xinqi Wu et al.   OncoImmunology

A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer

(2018) Friedrich H. Schmitz-Winnenthal et al.   OncoImmunology

Immunocompetence and mechanism of the DRibble-DCs vaccine for oral squamous cell carcinoma

(2018) Heng Dong et al.   Cancer Management and Research

Long-term survival follow-up of atezolizumab in combination with platinum-based doublet chemotherapy in patients with advanced non–small-cell lung cancer

(2018) Stephen V. Liu et al.   EUROPEAN JOURNAL OF CANCER

Safety and clinical activity of atezolizumab monotherapy in metastatic non-small-cell lung cancer: final results from a phase I study

(2018) Leora Horn et al.   EUROPEAN JOURNAL OF CANCER

Pembrolizumab effective in PD-L1-positive disease

(2018) Louise Stone   Nature Reviews Urology

The rationale of indoleamine 2,3-dioxygenase inhibition for cancer therapy

(2017) Lieve Brochez et al.   EUROPEAN JOURNAL OF CANCER

Systematic Review of Immune Checkpoint Inhibition in Urological Cancers

(2017) Maud Rijnders et al.   EUROPEAN UROLOGY

Nivolumab for the treatment of bladder cancer

(2017) Oliver W. Hakenberg   EXPERT OPINION ON BIOLOGICAL THERAPY

Lenalidomide in the treatment of chronic lymphocytic leukemia

(2017) Gilad Itchaki et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Programmed death-1 pathway blockade produces a synergistic antitumor effect: combined application in ovarian cancer

(2017) Xinxin Zhu et al.   Journal of Gynecologic Oncology

Immunotherapy in genitourinary malignancies

(2017) Kathan Mehta et al.   Journal of Hematology & Oncology

Vaccination with poly(IC:LC) and peptide-pulsed autologous dendritic cells in patients with pancreatic cancer

(2017) Shikhar Mehrotra et al.   Journal of Hematology & Oncology

Checkpoint inhibitors in hematological malignancies

(2017) Chi Young Ok et al.   Journal of Hematology & Oncology

Efficacy of bacillus Calmette-Guérin Strains for Treatment of Nonmuscle Invasive Bladder Cancer: A Systematic Review and Network Meta-Analysis

(2017) Brock E. Boehm et al.   JOURNAL OF UROLOGY

Immunotherapy for the Treatment of Urothelial Carcinoma

(2017) Nicholas M. Donin et al.   JOURNAL OF UROLOGY

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

(2017) Martina Molgora et al.   NATURE

Therapeutic T cell engineering

(2017) Michel Sadelain et al.   NATURE

Immunotherapy in metastatic urothelial carcinoma: focus on immune checkpoint inhibition

(2017) Arlene Siefker-Radtke et al.   Nature Reviews Urology

BAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells

(2017) Alexis Combes et al.   Nature Communications

SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages

(2017) Lin Luo et al.   Nature Communications

Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth

(2017) Johanna C. Klein et al.   Nature Communications

The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma

(2017) Jeong Hyun Cho et al.   Oncotarget

A TLR3-Specific Adjuvant Relieves Innate Resistance to PD-L1 Blockade without Cytokine Toxicity in Tumor Vaccine Immunotherapy

(2017) Yohei Takeda et al.   Cell Reports

CD4 + T Cell and NK Cell Interplay Key to Regression of MHC Class I low Tumors upon TLR7/8 Agonist Therapy

(2017) Elien M. Doorduijn et al.   Cancer Immunology Research

Toll-Like Receptor 3 Signal in Dendritic Cells Benefits Cancer Immunotherapy

(2017) Misako Matsumoto et al.   Frontiers in Immunology

Toll-Like Receptor Ligands and Interferon-γ Synergize for Induction of Antitumor M1 Macrophages

(2017) Elisabeth Müller et al.   Frontiers in Immunology

Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity

(2017) Xenia Geeraerts et al.   Frontiers in Immunology

NK cell activation and recovery of NK cell subsets in lymphoma patients after obinutuzumab and lenalidomide treatment

(2017) Dang-Nghiem Vo et al.   OncoImmunology

Soluble NKG2D ligands limit the efficacy of immune checkpoint blockade

(2017) Alejandro López-Soto et al.   OncoImmunology

Trial Watch: Adoptively transferred cells for anticancer immunotherapy

(2017) Carole Fournier et al.   OncoImmunology

Antigenic expression and spontaneous immune responses support the use of a selected peptide set from the IMA950 glioblastoma vaccine for immunotherapy of grade II and III glioma

(2017) Valérie Dutoit et al.   OncoImmunology

Trial watch: DNA-based vaccines for oncological indications

(2017) Stefano Pierini et al.   OncoImmunology

PD-L1 blockade for urothelial carcinoma

(2017) Josephine Kang et al.   OncoImmunology

Trial watch: Dendritic cell-based anticancer immunotherapy

(2017) Abhishek D. Garg et al.   OncoImmunology

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

(2017) Abhishek D. Garg et al.   OncoImmunology

Trial watch: Immune checkpoint blockers for cancer therapy

(2017) Claire Vanpouille-Box et al.   OncoImmunology

A pilot study of an autologous tumor-derived autophagosome vaccine with docetaxel in patients with stage IV non-small cell lung cancer

(2017) Rachel E. Sanborn et al.   Journal for ImmunoTherapy of Cancer

Topical treatment of melanoma metastases with imiquimod, plus administration of a cancer vaccine, promotes immune signatures in the metastases

(2016) Ileana S. Mauldin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TLR Adaptor Protein MYD88 Mediates Sensitivity to HDAC Inhibitors via a Cytokine-Dependent Mechanism

(2016) Maria New et al.   CANCER RESEARCH

A Cancer Research UK First Time in Human Phase I Trial of IMA950 (Novel Multipeptide Therapeutic Vaccine) in Patients with Newly Diagnosed Glioblastoma

(2016) R. Rampling et al.   CLINICAL CANCER RESEARCH

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

(2016) Lorenzo Galluzzi et al.   IMMUNITY

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA

(2016) Zhikuan Zhang et al.   IMMUNITY

Imiquimod in dermatology: an overview

(2016) Edith Hanna et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations

(2016) Axel Hoos   NATURE REVIEWS DRUG DISCOVERY

Immune responses and outcome after vaccination with glioma-associated antigen peptides and poly-ICLC in a pilot study for pediatric recurrent low-grade gliomas

(2016) Ian F. Pollack et al.   NEURO-ONCOLOGY

Intratumoral injection of a CpG oligonucleotide reverts resistance to PD-1 blockade by expanding multifunctional CD8+T cells

(2016) Shu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TLR3 or TLR4 Activation Enhances Mesenchymal Stromal Cell-Mediated Treg Induction via Notch Signaling

(2016) Iran Rashedi et al.   STEM CELLS

Microbial HSP70 peptide epitope 407–426 as adjuvant in tumor-derived autophagosome vaccine therapy of mouse lung cancer

(2016) Jian Li et al.   TUMOR BIOLOGY

αv Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells

(2016) Mridu Acharya et al.   Nature Communications

Stimulation of the toll-like receptor 3 promotes metabolic reprogramming in head and neck carcinoma cells

(2016) Mathieu Veyrat et al.   Oncotarget

Combinational Immunotherapy with Allo-DRibble Vaccines and Anti-OX40 Co-Stimulation Leads to Generation of Cross-Reactive Effector T Cells and Tumor Regression

(2016) Guangjie Yu et al.   Scientific Reports

Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1

(2016) Erika Vacchelli et al.   OncoImmunology

Trial Watch: Immunotherapy plus radiation therapy for oncological indications

(2016) Erika Vacchelli et al.   OncoImmunology

Notching tumor: Signaling through Notch receptors improves antitumor T cell immunity

(2016) Roman Uzhachenko et al.   OncoImmunology

Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy

(2016) Masahiro Azuma et al.   OncoImmunology

A novel TLR7 agonist reverses NK cell anergy and cures RMA-S lymphoma-bearing mice

(2016) Gabriela Maria Wiedemann et al.   OncoImmunology

Reprogramming the lung microenvironment by inhaled immunotherapy fosters immune destruction of tumor

(2016) Valentino Le Noci et al.   OncoImmunology

Nucleic acid-sensing toll-like receptors 3, 7 and 8 in esophageal epithelium, barrett’s esophagus, dysplasia and adenocarcinoma

(2016) Olli Helminen et al.   OncoImmunology

Immunosuppressive γδ T cells foster pancreatic carcinogenesis

(2016) Laura Mondragón et al.   OncoImmunology

Reprogramming of TLR7 signaling enhances antitumor NK and cytotoxic T cell responses

(2016) Christian Hotz et al.   OncoImmunology

Intra-cheek immunization as a novel vaccination route for therapeutic vaccines of head and neck squamous cell carcinomas using plasmo virus-like particles

(2016) Rodney Macedo et al.   OncoImmunology

Trial Watch—Small molecules targeting the immunological tumor microenvironment for cancer therapy

(2016) Aitziber Buqué et al.   OncoImmunology

Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100

(2016) Matthew P Morrow et al.   Molecular Therapy-Oncolytics

Adjuvants for peptide-based cancer vaccines

(2016) Hiep Khong et al.   Journal for ImmunoTherapy of Cancer

Glimpse into the future: harnessing autophagy to promote anti-tumor immunity with the DRibbles vaccine

(2016) David B. Page et al.   Journal for ImmunoTherapy of Cancer

Hormesis, cell death and aging

(2016) Isabelle Martins et al.   Aging-US

Ibrutinib enhances the antitumor immune response induced by intratumoral injection of a TLR9 ligand in mouse lymphoma

(2015) I. Sagiv-Barfi et al.   BLOOD

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells

(2015) Carolina Iraporda et al.   IMMUNOBIOLOGY

Inhibition of indoleamine 2,3-dioxygenase activity enhances the anti-tumour effects of a Toll-like receptor 7 agonist in an established cancer model

(2015) Hiroyasu Ito et al.   IMMUNOLOGY

Correlation of serum toll like receptor 9 and trace elements with lipid peroxidation in the patients of breast diseases

(2015) Kanchan Karki et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial

(2015) Cornelia L Trimble et al.   LANCET

Organelle-Specific Initiation of Autophagy

(2015) Valentina Sica et al.   MOLECULAR CELL

In situ vaccination: Cancer immunotherapy both personalized and off-the-shelf

(2015) Linda Hammerich et al.   Molecular Oncology

Big opportunities for small molecules in immuno-oncology

(2015) Jerry L. Adams et al.   NATURE REVIEWS DRUG DISCOVERY

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pembrolizumab versus Ipilimumab in Advanced Melanoma

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Poly(I:C) as cancer vaccine adjuvant: Knocking on the door of medical breakthroughs

(2015) Rachid Ammi et al.   PHARMACOLOGY & THERAPEUTICS

Current Clinical Trials Testing Combinations of Immunotherapy and Radiation

(2015) Marka Crittenden et al.   SEMINARS IN RADIATION ONCOLOGY

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

Prognostic and Predictive Value of DAMPs and DAMP-Associated Processes in Cancer

(2015) Jitka Fucikova et al.   Frontiers in Immunology

SA-4-1BBL/MPL as a novel immune adjuvant platform to combat cancer

(2015) Abhishek K. Srivastava et al.   OncoImmunology

Trial Watch: Immunostimulation with Toll-like receptor agonists in cancer therapy

(2015) Kristina Iribarren et al.   OncoImmunology

First oncolytic virus approved for melanoma immunotherapy

(2015) Jonathan Pol et al.   OncoImmunology

OX40 Agonists and Combination Immunotherapy: Putting the Pedal to the Metal

(2015) Stefanie N. Linch et al.   Frontiers in Oncology

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Combination Immunotherapy after ASCT for Multiple Myeloma Using MAGE-A3/Poly-ICLC Immunizations Followed by Adoptive Transfer of Vaccine-Primed and Costimulated Autologous T Cells

(2014) Aaron P. Rapoport et al.   CLINICAL CANCER RESEARCH

Pembrolizumab: First Global Approval

(2014) Raewyn M. Poole   DRUGS

TLR8 signaling enhances tumor immunity by preventing tumor-induced T-cell senescence

(2014) J. Ye et al.   EMBO Molecular Medicine

Bacillus Calmette-Guérin Strain Differences Have an Impact on Clinical Outcome in Bladder Cancer Immunotherapy

(2014) Cyrill A. Rentsch et al.   EUROPEAN UROLOGY

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

(2014) Rafaz Hoque et al.   GASTROENTEROLOGY

Therapeutic Antitumor Efficacy of B Cells Loaded With Tumor-derived Autophagasomes Vaccine (DRibbles)

(2014) Hongyan Ren et al.   JOURNAL OF IMMUNOTHERAPY

A novel TLR-9 agonist C792 inhibits plasmacytoid dendritic cell-induced myeloma cell growth and enhance cytotoxicity of bortezomib

(2014) A Ray et al.   LEUKEMIA

A cell-intrinsic role for TLR2–MYD88 in intestinal and breast epithelia and oncogenesis

(2014) Ferenc A. Scheeren et al.   NATURE CELL BIOLOGY

The mechanism of action of BCG therapy for bladder cancer—a current perspective

(2014) Gil Redelman-Sidi et al.   Nature Reviews Urology

Intravesical ALT-803 and BCG Treatment Reduces Tumor Burden in a Carcinogen Induced Bladder Cancer Rat Model; a Role for Cytokine Production and NK Cell Expansion

(2014) Evan Gomes-Giacoia et al.   PLoS One

HLA ligandome analysis identifies the underlying specificities of spontaneous antileukemia immune responses in chronic lymphocytic leukemia (CLL)

(2014) Daniel J. Kowalewski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Antigen-Specific Immunity with a Vaccine Targeting NY-ESO-1 to the Dendritic Cell Receptor DEC-205

(2014) M. V. Dhodapkar et al.   Science Translational Medicine

Efficacy of imiquimod 5% cream for persistent human papillomavirus in genital intraepithelial neoplasm

(2014) Fang-Ping Chen   Taiwanese Journal of Obstetrics & Gynecology

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

(2014) Austin Pantel et al.   PLOS BIOLOGY

Metabolic Influences That Regulate Dendritic Cell Function in Tumors

(2014) Han Dong et al.   Frontiers in Immunology

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation

(2013) F Wolff et al.   ONCOGENE

Cancer Immunotherapy

(2013) J. Couzin-Frankel   SCIENCE

Trial Watch

(2013) Erika Vacchelli et al.   OncoImmunology

Trial watch

(2013) Erika Vacchelli et al.   OncoImmunology

Dual character of Toll-like receptor signaling: Pro-tumorigenic effects and anti-tumor functions

(2012) Li Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Exploiting the glioblastoma peptidome to discover novel tumour-associated antigens for immunotherapy

(2012) Valérie Dutoit et al.   BRAIN

Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1

(2012) Joseph E. Qualls et al.   Cell Host & Microbe

Molecular Pathways: Toll-like Receptors in the Tumor Microenvironment--Poor Prognosis or New Therapeutic Opportunity

(2012) L. A. Ridnour et al.   CLINICAL CANCER RESEARCH

Adaptors in Toll-Like Receptor Signaling and their Potential as Therapeutic Targets

(2012) Thomas Ve et al.   CURRENT DRUG TARGETS

Cervarix®: a bivalent vaccine against HPV types 16 and 18, with cross-protection against other high-risk HPV types

(2012) Anne Szarewski   Expert Review of Vaccines

Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure

(2012) Pedro E. Marques et al.   HEPATOLOGY

Toll-like Receptor 11 (TLR11) PreventsSalmonellaPenetration into the Murine Peyer Patches

(2012) Zhongcheng Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-Gr-1 antibody depletion fails to eliminate hepatic myeloid-derived suppressor cells in tumor-bearing mice

(2012) Chi Ma et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Azacytidine and erlotinib exert synergistic effects against acute myeloid leukemia

(2012) E Lainey et al.   ONCOGENE

TLR13 Recognizes Bacterial 23S rRNA Devoid of Erythromycin Resistance-Forming Modification

(2012) M. Oldenburg et al.   SCIENCE

Structural Basis of TLR5-Flagellin Recognition and Signaling

(2012) S.-i. Yoon et al.   SCIENCE

The Structure of the TLR5-Flagellin Complex: A New Mode of Pathogen Detection, Conserved Receptor Dimerization for Signaling

(2012) J. Lu et al.   Science Signaling

News

(2012) Eva M. Riedmann   Human Vaccines & Immunotherapeutics

Trial watch: FDA-approved Toll-like receptor agonists for cancer therapy

(2012) Erika Vacchelli et al.   OncoImmunology

In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study

(2011) Y. H. Kim et al.   BLOOD

Tumor-Derived Autophagosome Vaccine: Mechanism of Cross-Presentation and Therapeutic Efficacy

(2011) Y. Li et al.   CLINICAL CANCER RESEARCH

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

gp100 Peptide Vaccine and Interleukin-2 in Patients with Advanced Melanoma

(2011) Douglas J. Schwartzentruber et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mesenchymal stem cell effects on T-cell effector pathways

(2011) Michelle M Duffy et al.   Stem Cell Research & Therapy

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Toll-Like Receptor Agonists

(2010) Sacha Gnjatic et al.   CANCER JOURNAL

In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study

(2010) Joshua D. Brody et al.   JOURNAL OF CLINICAL ONCOLOGY

Mesenchymal Stem Cells Inhibit Human Th17 Cell Differentiation and Function and Induce a T Regulatory Cell Phenotype

(2010) S. Ghannam et al.   JOURNAL OF IMMUNOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

(2010) Karin Loser et al.   NATURE MEDICINE

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

Tumor Microenvironments Direct the Recruitment and Expansion of Human Th17 Cells

(2009) X. Su et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Toll-like receptors TLR4 and 7 signaling pathways by SIGIRR: A computational approach

(2009) Jing Gong et al.   JOURNAL OF STRUCTURAL BIOLOGY

Efficacy of human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine against cervical infection and precancer caused by oncogenic HPV types (PATRICIA): final analysis of a double-blind, randomised study in young women

(2009) J Paavonen et al.   LANCET

TLR signaling by tumor and immune cells: a double-edged sword

(2008) B Huang et al.   ONCOGENE

The Use of TLR7 and TLR8 Ligands for the Enhancement of Cancer Immunotherapy

(2008) E. L. J. M. Smits et al.   ONCOLOGIST

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE