RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant?

Short Double-Stranded RNA with Immunostimulatory Activity: Sequence Dependence

(2018) Tatyana O. Kabilova et al.   Nucleic Acid Therapeutics

Recent advances in RNAi-based strategies for therapy and prevention of HIV-1/AIDS

(2016) Manjunath N. Swamy et al.   ADVANCED DRUG DELIVERY REVIEWS

Imaging-guided delivery of RNAi for anticancer treatment

(2016) Junqing Wang et al.   ADVANCED DRUG DELIVERY REVIEWS

Differential Reductions in Viral Antigens Expressed from CCCDNAVS Integrated DNA in Treatment Naïve HBEAG Positive and Negative Patients with Chronic HBV after RNA Interference Therapy with ARC-520

(2016) M.-F. Yuen et al.   JOURNAL OF HEPATOLOGY

Bifunctional siRNA Containing Immunostimulatory Motif Enhances Protection Against Pandemic H1N1 Virus Infection

(2015) Gaurav Joshi et al.   CURRENT GENE THERAPY

Progress in RNAi-mediated Molecular Therapy of Acute and Chronic Myeloid Leukemia

(2015) Breanne Landry et al.   Molecular Therapy-Nucleic Acids

TLR7 Is Involved in Sequence-Specific Sensing of Single-Stranded RNAs in Human Macrophages

(2014) M. P. Gantier et al.   JOURNAL OF IMMUNOLOGY

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

(2014) A. Forsbach et al.   JOURNAL OF IMMUNOLOGY

5′-Triphosphate-siRNA activates RIG-I-dependent type I interferon production and enhances inhibition of hepatitis B virus replication in HepG2.2.15 cells

(2013) Xiaojuan Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chemical modifications on siRNAs avoid Toll-like-receptor-mediated activation of the hepatic immune system in vivo and in vitro

(2013) R. Broering et al.   INTERNATIONAL IMMUNOLOGY

Silencing of indoleamine 2,3-dioxygenase enhances dendritic cell immunogenicity and antitumour immunity in cancer patients

(2013) MOULDY SIOUD et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

5′-Triphosphate-siRNA Against Survivin Gene Induces Interferon Production and Inhibits Proliferation of Lung Cancer Cells In Vitro

(2013) Kai Wang et al.   JOURNAL OF IMMUNOTHERAPY

RNAi Induces Innate Immunity through Multiple Cellular Signaling Pathways

(2013) Zhongji Meng et al.   PLoS One

RNAimmuno: A database of the nonspecific immunological effects of RNA interference and microRNA reagents

(2012) M. Olejniczak et al.   RNA

RNA interference and its potential applications to chronic HBV treatment: results of a Phase I safety and tolerability study

(2011) Robert G Gish et al.   ANTIVIRAL THERAPY

Recent Advances in Understanding of the Immunological Off-Target Effects of siRNA

(2011) Marta Olejniczak et al.   CURRENT GENE THERAPY

5′ Triphosphorylated Small Interfering RNAs Control Replication of Hepatitis B Virus and Induce an Interferon Response in Human Liver Cells and Mice

(2011) Gregor Ebert et al.   GASTROENTEROLOGY

Reversal of hepatitis B virus-induced immune tolerance by an immunostimulatory 3p-HBx-siRNAs in a retinoic acid inducible gene I-dependent manner

(2011) Qiuju Han et al.   HEPATOLOGY

Rational Design of Immunostimulatory siRNAs

(2010) Michael P Gantier et al.   MOLECULAR THERAPY

A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus

(2010) J. DeVincenzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase

(2009) Gro F. Flatekval et al.   IMMUNOLOGY

Misinterpreting the Therapeutic Effects of Small Interfering RNA Caused by Immune Stimulation

(2008) Marjorie Robbins et al.   HUMAN GENE THERAPY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

(2008) Hendrik Poeck et al.   NATURE MEDICINE

Inhibition of woodchuck hepatitis virus gene expression in primary hepatocytes by siRNA enhances the cellular gene expression

(2008) Zhongji Meng et al.   VIROLOGY