SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation

Microglial/Macrophage polarization and function in brain injury and repair after stroke

(2021) Junxuan Lyu et al.   CNS Neuroscience & Therapeutics

Disrupting nNOS–PSD95 Interaction Improves Neurological and Cognitive Recoveries after Traumatic Brain Injury

(2020) Wenrui Qu et al.   CEREBRAL CORTEX

Potential microglia‐based interventions for stroke

(2020) Ling‐Zhi Li et al.   CNS Neuroscience & Therapeutics

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Regional, cellular and species difference of two key neuroinflammatory genes implicated in schizophrenia

(2020) Caitlin E. Murphy et al.   BRAIN BEHAVIOR AND IMMUNITY

Sodium butyrate attenuated neuronal apoptosis via GPR41/Gβγ/PI3K/Akt pathway after MCAO in rats

(2020) Zhenhua Zhou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

(2020) Nathalie Percie du Sert et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transcriptomic characterization of microglia activation in a rat model of ischemic stroke

(2020) Wenjun Deng et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Clusterin suppresses spermatogenic cell apoptosis to alleviate diabetes‐induced testicular damage by inhibiting autophagy via the PI3K/AKT/mTOR axis

(2020) Yuan Tian et al.   BIOLOGY OF THE CELL

Microglia/macrophage polarization: Fantasy or evidence of functional diversity?

(2020) Xiaoming Hu   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Secretory clusterin promotes oral cancer cell survival via inhibiting apoptosis by activation of autophagy in AMPK/mTOR/ULK1 dependent pathway

(2020) Prajna Paramita Naik et al.   LIFE SCIENCES

Early treatment with minocycline following stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes

(2019) Wai Ping Yew et al.   Journal of Neuroinflammation

Excitatory pathway engaging glutamate, calcineurin, and NFAT upregulates IL-4 in ischemic neurons to polarize microglia

(2019) Shun-Ming Ting et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Dual Functions of Microglia in Ischemic Stroke

(2019) Chuan Qin et al.   Neuroscience Bulletin

Absence of BBSome function leads to astrocyte reactivity in the brain

(2019) Minati Singh et al.   Molecular Brain

Granzyme B as a therapeutic target for wound healing

(2019) Christopher T. Turner et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inhibition of SERPINA3N‐dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride–induced neurotoxicity

(2019) Yu Xi et al.   JOURNAL OF PINEAL RESEARCH

Faecal neutrophil elastase-antiprotease balance reflects colitis severity

(2019) Rachael Barry et al.   Mucosal Immunology

Expression of P2X receptors in the rat anterior pituitary

(2019) Wenqi Zhao et al.   Purinergic Signalling

PI3K/Akt/GSK3β induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: Neuroprotective role of curcumin

(2018) Pranay Srivastava et al.   NEUROTOXICOLOGY

Plasma Hemopexin ameliorates murine spinal cord injury by switching microglia from the M1 state to the M2 state

(2018) Dunxin Han et al.   Cell Death & Disease

Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy

(2018) Marine Gueugneau et al.   Journal of Cachexia Sarcopenia and Muscle

SerpinA3N is a novel hypothalamic gene upregulated by a high-fat diet and leptin in mice

(2018) Domenico Sergi et al.   Genes and Nutrition

Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response

(2017) Irina Grechowa et al.   FASEB JOURNAL

The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia

(2017) Dong-Jie Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Functional Roles of the Interaction of APP and Lipoprotein Receptors

(2017) Theresa Pohlkamp et al.   Frontiers in Molecular Neuroscience

Protective effect of clusterin on rod photoreceptor in rat model of retinitis pigmentosa

(2017) Andrew Vargas et al.   PLoS One

Astrocytes Grown in Alvetex® Three Dimensional Scaffolds Retain a Non-reactive Phenotype

(2016) Christopher I. Ugbode et al.   NEUROCHEMICAL RESEARCH

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Co-localization of Pirt protein and P2X2 receptors in the mouse enteric nervous system

(2016) Wei Guo et al.   Purinergic Signalling

Sexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy

(2015) Mehwish A Mirza et al.   Journal of Neuroinflammation

Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo

(2015) Yohannes Haile et al.   Journal of Neuroinflammation

Novel Insights into NeuN: from Neuronal Marker to Splicing Regulator

(2015) Wei Duan et al.   MOLECULAR NEUROBIOLOGY

The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell–derived leukocyte elastase

(2015) Lucas Vicuña et al.   NATURE MEDICINE

Cardiac and skeletal muscles show molecularly distinct responses to cancer cachexia

(2015) Angie M. Y. Shum et al.   PHYSIOLOGICAL GENOMICS

Secretory clusterin is upregulated in rats with pulmonary arterial hypertension induced by systemic-to-pulmonary shunts and exerts important roles in pulmonary artery smooth muscle cells

(2014) X. Liu et al.   Acta Physiologica

Innate Inflammatory Responses in Stroke: Mechanisms and Potential Therapeutic Targets

(2014) J.Y. Kim et al.   CURRENT MEDICINAL CHEMISTRY

Glutamate triggers neurosecretion and apoptosis in bovine chromaffin cells through a mechanism involving NO production by neuronal NO synthase activation

(2014) R. Pérez-Rodríguez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain

(2014) I. L. Campbell et al.   JOURNAL OF NEUROSCIENCE

Low Density Lipoprotein Receptor-related Protein 1 (LRP1) ModulatesN-Methyl-d-aspartate (NMDA) Receptor-dependent Intracellular Signaling and NMDA-induced Regulation of Postsynaptic Protein Complexes

(2013) Chikako Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype

(2013) Wladislaw Maier et al.   Molecular Neurodegeneration

PI3 k/akt inhibition induces apoptosis through p38 activation in neurons

(2013) Aurelio Vázquez de la Torre et al.   PHARMACOLOGICAL RESEARCH

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Testosterone and interleukin-1β increase cardiac remodeling during coxsackievirus B3 myocarditis via serpin A 3n

(2012) Michael J. Coronado et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Serine protease inhibitor A3 in atherosclerosis and aneurysm disease

(2012) DICK WÅGSÄTER et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Serpin structure, function and dysfunction

(2011) J. A. HUNTINGTON   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Nogo-A inhibits necdin-accelerated neurite outgrowth by retaining necdin in the cytoplasm

(2009) Xiujie Liu et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Clusterin increases post-ischemic damages in organotypic hippocampal slice cultures

(2008) David Hakkoum et al.   JOURNAL OF NEUROCHEMISTRY