Inhibition of SERPINA3N‐dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride–induced neurotoxicity

In vitro models to study insulin and glucocorticoids modulation of trimethyltin (TMT)-induced neuroinflammation and neurodegeneration, and in vivo validation in db/db mice

(2019) Jenny Sandström et al.   ARCHIVES OF TOXICOLOGY

Melatonin stabilizes rupture‐prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORα‐dependent manner

(2019) Song Ding et al.   JOURNAL OF PINEAL RESEARCH

Porphyromonas gingivalis lipopolysaccharide induces cognitive dysfunction, mediated by neuronal inflammation via activation of the TLR4 signaling pathway in C57BL/6 mice

(2018) Jing Zhang et al.   Journal of Neuroinflammation

Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases

(2018) Mithilesh Kumar Jha et al.   PROGRESS IN NEUROBIOLOGY

Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy

(2018) Marine Gueugneau et al.   Journal of Cachexia Sarcopenia and Muscle

Melatonin and inflammation - story of a double-edged blade

(2018) Rüdiger Hardeland   JOURNAL OF PINEAL RESEARCH

The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: In vivo assessment and a randomized controlled trial

(2018) Zhewei Zhao et al.   JOURNAL OF PINEAL RESEARCH

Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N

(2018) Matthew J. Dalby et al.   Scientific Reports

Trimethyltin chloride induces reactive oxygen species-mediated apoptosis in retinal cells during zebrafish eye development

(2018) Jin Kim et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Melatonin successfully rescues hippocampal bioenergetics and improves cognitive function following drug intoxication by promoting Nrf2-ARE signaling activity

(2017) Li-You Chen et al.   JOURNAL OF PINEAL RESEARCH

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

The far-reaching scope of neuroinflammation after traumatic brain injury

(2017) Dennis W. Simon et al.   Nature Reviews Neurology

Differential overexpression of SERPINA3 in human prion diseases

(2017) S. Vanni et al.   Scientific Reports

Enhancing lysosomal biogenesis and autophagic flux by activating the transcription factor EB protects against cadmium-induced neurotoxicity

(2017) Huifeng Pi et al.   Scientific Reports

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Involvement of BDNF/ERK signaling in spontaneous recovery from trimethyltin-induced hippocampal neurotoxicity in mice

(2016) Sueun Lee et al.   BRAIN RESEARCH BULLETIN

Trimethyltin-induced hippocampal neurodegeneration: A mechanism-based review

(2016) Sueun Lee et al.   BRAIN RESEARCH BULLETIN

Neuronal seipin knockout facilitates Aβ-induced neuroinflammation and neurotoxicity via reduction of PPARγ in hippocampus of mouse

(2016) Yun Qian et al.   Journal of Neuroinflammation

Melatonin attenuates traumatic brain injury-induced inflammation: a possible role for mitophagy

(2016) Chao Lin et al.   JOURNAL OF PINEAL RESEARCH

Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy-lysosome machinery in mouse neuroblastoma cells

(2016) Min Li et al.   JOURNAL OF PINEAL RESEARCH

Melatonin attenuates postmyocardial infarction injury via increasing Tom70 expression

(2016) Hai-Feng Pei et al.   JOURNAL OF PINEAL RESEARCH

SIRT1 Overexpression in Mouse Hippocampus Induces Cognitive Enhancement Through Proteostatic and Neurotrophic Mechanisms

(2016) Rubén Corpas et al.   MOLECULAR NEUROBIOLOGY

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer’s disease

(2015) Maike Hartlage-Rübsamen et al.   ACTA NEUROPATHOLOGICA

Protein kinase Cδ mediates trimethyltin-induced neurotoxicity in mice in vivo via inhibition of glutathione defense mechanism

(2015) Eun-Joo Shin et al.   ARCHIVES OF TOXICOLOGY

An overview on the advanced oxidation processes applied for the treatment of water pollutants defined in the recently launched Directive 2013/39/EU

(2015) Ana R. Ribeiro et al.   ENVIRONMENT INTERNATIONAL

Unc93b1-Dependent Endosomal Toll-Like Receptor Signaling Regulates Inflammation and Mortality during Coxsackievirus B3 Infection

(2015) Erin I. Lafferty et al.   Journal of Innate Immunity

A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD

(2015) Pawel M. Switonski et al.   NEUROBIOLOGY OF DISEASE

Characterization of binge-dosed methamphetamine-induced neurotoxicity and neuroinflammation

(2015) Sarah E.A. McConnell et al.   NEUROTOXICOLOGY

Neuroprotective effects of fermented soybean products (Cheonggukjang) manufactured by mixed culture ofBacillus subtilisMC31 andLactobacillus sakei383 on trimethyltin-induced cognitive defects mice

(2015) Jun Go et al.   NUTRITIONAL NEUROSCIENCE

Melatonin and brain inflammaging

(2015) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer’s disease model

(2014) Marius Krauthausen et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin attenuates D-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE/NF-KB/JNK signaling pathway in aging mouse model

(2014) Tahir Ali et al.   JOURNAL OF PINEAL RESEARCH

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Melatonin: Exceeding Expectations

(2014) Russel J. Reiter et al.   PHYSIOLOGY

Exposure to As-, Cd-, and Pb-Mixture Induces Aβ, Amyloidogenic APP Processing and Cognitive Impairments via Oxidative Stress-Dependent Neuroinflammation in Young Rats

(2014) Anushruti Ashok et al.   TOXICOLOGICAL SCIENCES

Circadian Melatonin Rhythm and Excessive Daytime Sleepiness in Parkinson Disease

(2014) Aleksandar Videnovic et al.   JAMA Neurology

Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy

(2013) Hitoshi Ando et al.   BRAIN

Toxicity of Trimethyltin and Dimethyltin in Rats and Mice

(2013) Xiaojiang Tang et al.   BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Minocycline prevents retinal inflammation and vascular permeability following ischemia-reperfusion injury

(2013) Steven F Abcouwer et al.   Journal of Neuroinflammation

Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: possible involvement of TLR4-mediated inflammatory pathway

(2013) Zhong Wang et al.   JOURNAL OF PINEAL RESEARCH

Chronic low level trimethyltin exposure and the risk of developing nephrolithiasis

(2013) Xiaojiang Tang et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Serine protease inhibitor A3 in atherosclerosis and aneurysm disease

(2012) DICK WÅGSÄTER et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Shifting of Immune Responsiveness to House Dust Mite by Influenza A Infection: Genomic Insights

(2011) A. Al-Garawi et al.   JOURNAL OF IMMUNOLOGY

Vitamin B6 suppresses serine protease inhibitor 3 expression in the colon of rats and in TNF-α-stimulated HT-29 cells

(2011) Noriyuki Yanaka et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Trimethyltin-induced hippocampal degeneration as a tool to investigate neurodegenerative processes

(2011) Maria Concetta Geloso et al.   NEUROCHEMISTRY INTERNATIONAL

The dual role of the neuroinflammatory response after ischemic stroke: modulatory effects of hypothermia

(2010) An-Gaëlle Ceulemans et al.   Journal of Neuroinflammation

Melatonin modulates neuroinflammation and oxidative stress in experimental diabetic neuropathy: effects on NF-κB and Nrf2 cascades

(2010) Geeta Negi et al.   JOURNAL OF PINEAL RESEARCH

Melatonin protects against Nickel-induced neurotoxicity in vitro by reducing oxidative stress and maintaining mitochondrial function

(2010) Shang-Cheng Xu et al.   JOURNAL OF PINEAL RESEARCH

Estradiol inhibits ongoing autoimmune neuroinflammation and NF B-dependent CCL2 expression in reactive astrocytes

(2010) S. N. Giraud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA