Plasma Hemopexin ameliorates murine spinal cord injury by switching microglia from the M1 state to the M2 state

A distinct entorhinal cortex to hippocampal CA1 direct circuit for olfactory associative learning

(2017) Yiding Li et al.   NATURE NEUROSCIENCE

Apolipoprotein E−/−Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage FunctionHighlights

(2016) Niyati U. Mehta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red CellsClinical Perspective

(2016) Jan A. Graw et al.   CIRCULATION

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

(2015) Nevenka Dudvarski Stankovic et al.   ACTA NEUROPATHOLOGICA

Hemopexin therapy reverts heme-induced proinflammatory phenotypic switching of macrophages in a mouse model of sickle cell disease

(2015) F. Vinchi et al.   BLOOD

Neuroprotective effects of nitidine against traumatic CNS injury via inhibiting microglia activation

(2015) Yimin Yuan et al.   BRAIN BEHAVIOR AND IMMUNITY

MSX3 Switches Microglia Polarization and Protects from Inflammation-Induced Demyelination

(2015) Z. Yu et al.   JOURNAL OF NEUROSCIENCE

Macrophages in spinal cord injury: Phenotypic and functional change from exposure to myelin debris

(2014) Xi Wang et al.   GLIA

Lack of Plasma Protein Hemopexin Dampens Mercury-Induced Autoimmune Response in Mice

(2014) S. Fagoonee et al.   JOURNAL OF IMMUNOLOGY

Large-Scale Chondroitin Sulfate Proteoglycan Digestion with Chondroitinase Gene Therapy Leads to Reduced Pathology and Modulates Macrophage Phenotype following Spinal Cord Contusion Injury

(2014) K. Bartus et al.   JOURNAL OF NEUROSCIENCE

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2014) Antje Kroner et al.   NEURON

Heme on innate immunity and inflammation

(2014) Fabianno F. Dutra et al.   Frontiers in Pharmacology

A Small Molecule Inhibitor to Plasminogen Activator Inhibitor 1 Inhibits Macrophage Migration

(2013) Atsuhiko Ichimura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hemopexin induces neuroprotection in the rat subjected to focal cerebral ischemia

(2013) Beibei Dong et al.   BMC NEUROSCIENCE

Low density receptor-related protein 1 (LRP1) promotes anti-inflammatory phenotype in murine macrophages

(2013) Petra May et al.   CELL AND TISSUE RESEARCH

A LewisX Glycoprotein Screen Identifies the Low Density Lipoprotein Receptor-related Protein 1 (LRP1) as a Modulator of Oligodendrogenesis in Mice

(2013) Eva Hennen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute-Phase Protein Hemopexin Is a Negative Regulator of Th17 Response and Experimental Autoimmune Encephalomyelitis Development

(2013) S. Rolla et al.   JOURNAL OF IMMUNOLOGY

Characterization of Vascular Disruption and Blood–Spinal Cord Barrier Permeability following Traumatic Spinal Cord Injury

(2013) Sarah A. Figley et al.   JOURNAL OF NEUROTRAUMA

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Identification of Hemopexin as an Anti-Inflammatory Factor That Inhibits Synergy of Hemoglobin with HMGB1 in Sterile and Infectious Inflammation

(2012) T. Lin et al.   JOURNAL OF IMMUNOLOGY

Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity

(2012) Hyejin Jeon et al.   Journal of Neuroinflammation

Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages

(2011) D. J. Donnelly et al.   JOURNAL OF NEUROSCIENCE

RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis

(2011) Rieko Muramatsu et al.   NATURE MEDICINE

Repertoire of microglial and macrophage responses after spinal cord injury

(2011) Samuel David et al.   NATURE REVIEWS NEUROSCIENCE

A Role for Hemopexin in Oligodendrocyte Differentiation and Myelin Formation

(2011) Noemi Morello et al.   PLoS One

MAG and OMgp Synergize with Nogo-A to Restrict Axonal Growth and Neurological Recovery after Spinal Cord Trauma

(2010) W. B. J. Cafferty et al.   JOURNAL OF NEUROSCIENCE

Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice

(2010) Lifen Chen et al.   JOURNAL OF NEUROSURGERY

Assessing Spinal Axon Regeneration and Sprouting in Nogo-, MAG-, and OMgp-Deficient Mice

(2010) Jae K. Lee et al.   NEURON

Heme Scavenging and the Other Facets of Hemopexin

(2009) Emanuela Tolosano et al.   ANTIOXIDANTS & REDOX SIGNALING

Heme–Hemopexin Complex Attenuates Neuronal Cell Death and Stroke Damage

(2009) Rung-chi Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages

(2009) Xueya Liang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice

(2009) Ravid Shechter et al.   PLOS MEDICINE

A Graded Forceps Crush Spinal Cord Injury Model in Mice

(2008) Jason R. Plemel et al.   JOURNAL OF NEUROTRAUMA

Can the immune system be harnessed to repair the CNS?

(2008) Phillip G. Popovich et al.   NATURE REVIEWS NEUROSCIENCE