Development of the DNA-based biosensors for high performance in detection of molecular biomarkers: More rapid, sensitive, and universal

A complementary-DNA-enhanced fiber-optic sensor based on microfiber-assisted Mach-Zehnder interferometry for biocompatible pH sensing

(2021) Yujia Wang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Rapid One-Step Detection of Viral Particles Using an Aptamer-Based Thermophoretic Assay

(2021) Jinqi Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Self-paired dumbbell DNA -assisted simple preparation of stable circular DNAzyme and its application in Pb2+ sensor

(2021) Hongxin Jiang et al.   ANALYTICA CHIMICA ACTA

Discovery and Characterization of Spike N‐Terminal Domain‐Binding Aptamers for Rapid SARS‐CoV‐2 Detection

(2021) Nataly Kacherovsky et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Remember Beta? New data reveal variant’s deadly powers

(2021) Ewen Callaway   NATURE

A zero-background fluorescent aptasensor for ultrasensitive detection of pesticides based on magnetic three-dimensional DNA walker and poly(T) -templated copper nanoparticles

(2021) Yunwei Zhao et al.   SENSORS AND ACTUATORS B-CHEMICAL

Rapid and Efficient Detection of the SARS-CoV-2 Spike Protein Using an Electrochemical Aptamer-Based Sensor

(2021) Andrea Idili et al.   ACS Sensors

Sensitive Detection of SARS-CoV-2 Using a SERS-Based Aptasensor

(2021) Hao Chen et al.   ACS Sensors

A photo-electrochemical aptasensor for the determination of severe acute respiratory syndrome coronavirus 2 receptor-binding domain by using graphitic carbon nitride-cadmium sulfide quantum dots nanocomposite

(2021) Mahmoud Amouzadeh Tabrizi et al.   SENSORS AND ACTUATORS B-CHEMICAL

CRISPR-Cas9 Triggered Two-Step Isothermal Amplification Method for E. coli O157:H7 Detection Based on a Metal–Organic Framework Platform

(2020) Xuan Sun et al.   ANALYTICAL CHEMISTRY

DNA Nanofirecrackers Assembled through Hybridization Chain Reaction for Ultrasensitive SERS Immunoassay of Prostate Specific Antigen

(2020) Jia Ru Wang et al.   ANALYTICAL CHEMISTRY

Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system

(2020) Susanne Pfefferle et al.   Eurosurveillance

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(2020) Victor M Corman et al.   Eurosurveillance

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Combination of RT‐qPCR Testing and Clinical Features For Diagnosis of COVID‐19 facilitates management of SARS‐CoV‐2 Outbreak

(2020) Yishan Wang et al.   JOURNAL OF MEDICAL VIROLOGY

Splitting aptamers and nucleic acid enzymes for the development of advanced biosensors

(2020) Mégane Debiais et al.   NUCLEIC ACIDS RESEARCH

Reliable FRET-ON imaging of telomerase in living cells by a tetrahedral DNA nanoprobe integrated with structure-switchable molecular beacon

(2020) Xinmin Yue et al.   SENSORS AND ACTUATORS B-CHEMICAL

Direct Quantification of Damaged Nucleotides in Oligonucleotides Using an Aerolysin Single Molecule Interface

(2020) Jiajun Wang et al.   ACS Central Science

Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review

(2020) Junxiong Pang et al.   Journal of Clinical Medicine

Dual-Functional Plasmonic Photothermal Biosensors for Highly Accurate Severe Acute Respiratory Syndrome Coronavirus 2 Detection

(2020) Guangyu Qiu et al.   ACS Nano

Photodriven Regeneration of G-Quadruplex Aptasensor for Sensitively Detecting Thrombin

(2020) Liangliang Zhang et al.   ANALYTICAL CHEMISTRY

Versatile Sensing Platform for Cd2+ Detection in Rice Samples and Its Applications in Logic Gate Computation

(2020) Junhua Chen et al.   ANALYTICAL CHEMISTRY

A Multi‐component All‐DNA Biosensing System Controlled by a DNAzyme

(2020) Zhixue Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selection of a metal ligand modified DNAzyme for detecting Ni2+

(2020) Wei Ren et al.   BIOSENSORS & BIOELECTRONICS

RT-qPCR Testing of SARS-CoV-2: A Primer

(2020) Stephen A. Bustin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ultrafast DNA Sensors with DNA Framework-Bridged Hybridization Reactions

(2020) Fengqin Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Controlling the DNA Hybridization Chain Reaction

(2020) C. Adrian Figg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Allosteric Regulation of DNAzyme Activities through Intrastrand Transformation Induced by Cu(II)-Mediated Artificial Base Pairing

(2020) Takahiro Nakama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

Amplified electrochemical determination of UO22+ based on the cleavage of the DNAzyme and DNA-modified gold nanoparticle network structure

(2020) Chen Cao et al.   MICROCHIMICA ACTA

CRISPR–Cas12-based detection of SARS-CoV-2

(2020) James P. Broughton et al.   NATURE BIOTECHNOLOGY

Design of hidden thermodynamic driving for non-equilibrium systems via mismatch elimination during DNA strand displacement

(2020) Natalie E. C. Haley et al.   Nature Communications

Nucleic Acid Detection Using CRISPR/Cas Biosensing Technologies

(2020) Rashid Aman et al.   ACS Synthetic Biology

COVID-19 pandemic – An African perspective

(2020) Shabir Ahmad Lone et al.   Emerging Microbes & Infections

Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020

(2020) Rui Liu et al.   CLINICA CHIMICA ACTA

Rapid and visual detection of 2019 novel coronavirus (SARS-CoV-2) by a reverse transcription loop-mediated isothermal amplification assay

(2020) C. Yan et al.   CLINICAL MICROBIOLOGY AND INFECTION

Considerations for diagnostic COVID-19 tests

(2020) Olivier Vandenberg et al.   NATURE REVIEWS MICROBIOLOGY

Terminal deoxynucleotidyl transferase combined CRISPR-Cas12a amplification strategy for ultrasensitive detection of uracil-DNA glycosylase with zero background

(2020) Yi-Chen Du et al.   BIOSENSORS & BIOELECTRONICS

Ultrasensitive ratiometric detection of Pb2+ using DNA tetrahedron-mediated hyperbranched hybridization chain reaction

(2020) Pingping Ji et al.   ANALYTICA CHIMICA ACTA

CRISPR-Cas12a coupled with terminal deoxynucleotidyl transferase mediated isothermal amplification for sensitive detection of polynucleotide kinase activity

(2020) Xiaolong Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

CRISPR/Cas Systems towards Next-Generation Biosensing

(2019) Yi Li et al.   TRENDS IN BIOTECHNOLOGY

DNA nanodevices map enzymatic activity in organelles

(2019) Krishna Dan et al.   Nature Nanotechnology

Programmable DNA Ring/Hairpin-Constrained Structure Enables Ligation-Free Rolling Circle Amplification for Imaging mRNAs in Single Cells

(2019) Wenjiao Zhou et al.   ANALYTICAL CHEMISTRY

Detection of unamplified target genes via CRISPR–Cas9 immobilized on a graphene field-effect transistor

(2019) Reza Hajian et al.   Nature Biomedical Engineering

Nonviolent Self-Catabolic DNAzyme Nanosponges for Smart Anticancer Drug Delivery

(2019) Jing Wang et al.   ACS Nano

Biomineralized Metal–Organic Framework Nanoparticles Enable Enzymatic Rolling Circle Amplification in Living Cells for Ultrasensitive MicroRNA Imaging

(2019) Juan Zhang et al.   ANALYTICAL CHEMISTRY

DNA Cascade Reaction with High-Efficiency Target Conversion for Ultrasensitive Electrochemiluminescence microRNA Detection

(2019) Xinya Jiang et al.   ANALYTICAL CHEMISTRY

Nanolantern-Based DNA Probe and Signal Amplifier for Tumor-Related Biomarker Detection in Living Cells

(2019) Dong-Xia Wang et al.   ANALYTICAL CHEMISTRY

Single-Molecule Topochemical Analyses for Large-Scale Multiplexing Tasks

(2019) Shankar Mandal et al.   ANALYTICAL CHEMISTRY

Analysis of the Isolated and the Clustered DNA Damages by Single-Molecule Counting

(2019) Yan Zhang et al.   ANALYTICAL CHEMISTRY

Cas12aVDet: A CRISPR/Cas12a-Based Platform for Rapid and Visual Nucleic Acid Detection

(2019) Bei Wang et al.   ANALYTICAL CHEMISTRY

Exploring the Trans-Cleavage Activity of CRISPR-Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor

(2019) Yifan Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Engineering Aptamer with Enhanced Affinity by Triple Helix-Based Terminal Fixation

(2019) Lianhui Zhao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An amplification-free detection method of nucleic acids by a molecular beacon probe based on endonuclease activity

(2019) Zhen Yang et al.   SENSORS AND ACTUATORS B-CHEMICAL

A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules

(2019) Mindong Liang et al.   Nature Communications

Nanomechanics and co-transcriptional folding of Spinach and Mango

(2019) Jaba Mitra et al.   Nature Communications

Rolling Circular Amplification (RCA)-Assisted CRISPR/Cas9 Cleavage (RACE) for Highly Specific Detection of Multiple Extracellular Vesicle MicroRNAs

(2019) Ruixuan Wang et al.   ANALYTICAL CHEMISTRY

Efficient and Exponential Rolling Circle Amplification Molecular Network Leads to Ultrasensitive and Label-Free Detection of MicroRNA

(2019) Daxiu Li et al.   ANALYTICAL CHEMISTRY

Target Self-Enhanced Selectivity in Metal-Specific DNAzymes

(2019) Po-Jung Jimmy Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Adaption of an autonomously cascade DNA circuit for amplified detection and intracellular imaging of polynucleotide kinase with ultralow background

(2019) Jinhua Shang et al.   BIOSENSORS & BIOELECTRONICS

Detection of microRNAs using toehold-initiated rolling circle amplification and fluorescence resonance energy transfer

(2019) Kaili Liang et al.   TALANTA

Localized DNA Hybridization Chain Reactions on DNA Origami

(2018) Hieu Bui et al.   ACS Nano

Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 Triggered Isothermal Amplification for Site-Specific Nucleic Acid Detection

(2018) Mengqi Huang et al.   ANALYTICAL CHEMISTRY

Single-Molecule Mechanochemical pH Sensing Revealing the Proximity Effect of Hydroniums Generated by an Alkaline Phosphatase

(2018) Prakash Shrestha et al.   ANALYTICAL CHEMISTRY

Exponential isothermal amplification of nucleic acids and amplified assays for proteins, cells, and enzyme activities

(2018) Michael S Reid et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

(2018) Shi-Yuan Li et al.   CELL RESEARCH

Label-free and high-throughput bioluminescence detection of uracil-DNA glycosylase in cancer cells through tricyclic cascade signal amplification

(2018) Yan Zhang et al.   CHEMICAL COMMUNICATIONS

Accelerating DNA-based computing on a supramolecular polymer

(2018) Wouter Engelen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

(2018) Janice S. Chen et al.   SCIENCE

Protein scaffolded DNA tetrads enable efficient delivery and ultrasensitive imaging of miRNA through crosslinking hybridization chain reaction

(2018) Du-Juan Huang et al.   Chemical Science

A highly integrated DNA nanomachine operating in living cells powered by an endogenous stimulus

(2018) Pei-Qiang Ma et al.   Chemical Science

A novel restriction endonuclease GlaI for rapid and highly sensitive detection of DNA methylation coupled with isothermal exponential amplification reaction

(2018) Yueying Sun et al.   Chemical Science

Single-ribonucleotide repair-mediated ligation-dependent cycling signal amplification for sensitive and specific detection of DNA methyltransferase

(2018) Li-juan Wang et al.   Chemical Science

Direct Visualization of Single-Nucleotide Variation in mtDNA Using a CRISPR/Cas9-Mediated Proximity Ligation Assay

(2018) Kaixiang Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A DNA nanowire based localized catalytic hairpin assembly reaction for microRNA imaging in live cells

(2018) Qiaomei Wei et al.   Chemical Science

Advanced microRNA-based cancer diagnostics using amplified time-gated FRET

(2018) Xue Qiu et al.   Chemical Science

Multiplex microRNA imaging in living cells using DNA-capped-Au assembled hydrogels

(2018) Xiangdan Meng et al.   Chemical Science

A DNA-based fluorescent reporter maps HOCl production in the maturing phagosome

(2018) Shareefa Thekkan et al.   Nature Chemical Biology

Controlling the Catalytic Functions of DNAzymes within Constitutional Dynamic Networks of DNA Nanostructures

(2017) Shan Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A DNA Walker as a Fluorescence Signal Amplifier

(2017) Dongfang Wang et al.   NANO LETTERS

A spatially localized architecture for fast and modular DNA computing

(2017) Gourab Chatterjee et al.   Nature Nanotechnology

Sensing telomerase: From in vitro detection to in vivo imaging

(2017) Li-juan Wang et al.   Chemical Science

A microRNA-initiated DNAzyme motor operating in living cells

(2017) Hanyong Peng et al.   Nature Communications

Antibody-powered nucleic acid release using a DNA-based nanomachine

(2017) Simona Ranallo et al.   Nature Communications

DNAzyme Based Nanomachine for in Situ Detection of MicroRNA in Living Cells

(2017) Jing Liu et al.   ACS Sensors

Enzyme-Powered Three-Dimensional DNA Nanomachine for DNA Walking, Payload Release, and Biosensing

(2016) Xiaolong Yang et al.   ACS Nano

Mechanochemical Sensing of Single and Few Hg(II) Ions Using Polyvalent Principles

(2016) Shankar Mandal et al.   ANALYTICAL CHEMISTRY

One-Step Modification of Electrode Surface for Ultrasensitive and Highly Selective Detection of Nucleic Acids with Practical Applications

(2016) Chao Li et al.   ANALYTICAL CHEMISTRY

An electrochemical peptide cleavage-based biosensor for matrix metalloproteinase-2 detection with exonuclease III-assisted cycling signal amplification

(2016) Ding Wang et al.   CHEMICAL COMMUNICATIONS

Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy

(2016) Hong-Min Meng et al.   CHEMICAL SOCIETY REVIEWS

Role of DNA methylation in cardiovascular diseases

(2016) Ye Zhang et al.   CLINICAL AND EXPERIMENTAL HYPERTENSION

Binding-Induced DNA Nanomachines Triggered by Proteins and Nucleic Acids

(2015) Hongquan Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isothermal Amplification of Nucleic Acids

(2015) Yongxi Zhao et al.   CHEMICAL REVIEWS

A stochastic DNA walker that traverses a microparticle surface

(2015) C. Jung et al.   Nature Nanotechnology

Toehold-initiated Rolling Circle Amplification for Visualizing Individual MicroRNAs In Situ in Single Cells

(2014) Ruijie Deng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Liquid Biopsies: Genotyping Circulating Tumor DNA

(2014) Luis A. Diaz et al.   JOURNAL OF CLINICAL ONCOLOGY

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Optimizing the specificity of nucleic acid hybridization

(2012) David Yu Zhang et al.   Nature Chemistry

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Aptamer in Bioanalytical Applications

(2011) Anton B. Iliuk et al.   ANALYTICAL CHEMISTRY

A Multicenter Study of [-2]Pro-Prostate Specific Antigen Combined With Prostate Specific Antigen and Free Prostate Specific Antigen for Prostate Cancer Detection in the 2.0 to 10.0 ng/ml Prostate Specific Antigen Range

(2011) William J. Catalona et al.   JOURNAL OF UROLOGY

Scaling Up Digital Circuit Computation with DNA Strand Displacement Cascades

(2011) L. Qian et al.   SCIENCE

Pyrene-Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids in Complex Biological Fluids

(2010) Jin Huang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programmable in situ amplification for multiplexed imaging of mRNA expression

(2010) Harry M T Choi et al.   NATURE BIOTECHNOLOGY

microRNA involvement in developmental and functional aspects of the nervous system and in neurological diseases

(2009) Mette Christensen et al.   NEUROSCIENCE LETTERS

A Bipedal DNA Brownian Motor with Coordinated Legs

(2009) Tosan Omabegho et al.   SCIENCE

Sensitive optical biosensors for unlabeled targets: A review

(2008) Xudong Fan et al.   ANALYTICA CHIMICA ACTA

The cancer biomarker problem

(2008) Charles L. Sawyers   NATURE

Programming biomolecular self-assembly pathways

(2008) Peng Yin et al.   NATURE

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Electrochemical Glucose Biosensors

(2007) Joseph Wang   CHEMICAL REVIEWS