CRISPR-Cas12a coupled with terminal deoxynucleotidyl transferase mediated isothermal amplification for sensitive detection of polynucleotide kinase activity

Zirconium–Metalloporphyrin Frameworks–Luminol Competitive Electrochemiluminescence for Ratiometric Detection of Polynucleotide Kinase Activity

(2020) Guangyao Zhang et al.   ANALYTICAL CHEMISTRY

Single-Step, Salt-Aging-Free, and Thiol-Free Freezing Construction of AuNP-Based Bioprobes for Advancing CRISPR-Based Diagnostics

(2020) Menglu Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

CRISPR-Cas12a based aptasensor for sensitive and selective ATP detection

(2020) Lei Peng et al.   SENSORS AND ACTUATORS B-CHEMICAL

Nucleic Acid Detection Using CRISPR/Cas Biosensing Technologies

(2020) Rashid Aman et al.   ACS Synthetic Biology

Applying CRISPR-Cas12a as a Signal Amplifier to Construct Biosensors for Non-DNA Targets in Ultralow Concentrations

(2020) Junjie Li et al.   ACS Sensors

Terminal deoxynucleotidyl transferase induced activators to unlock the trans-cleavage of CRISPR/Cpf 1 (TdT-IU- CRISPR/Cpf 1): An ultrasensitive biosensor for Dam MTase activity detection

(2020) Xiaolong Chen et al.   BIOSENSORS & BIOELECTRONICS

CRISPR–Cas: a tool for cancer research and therapeutics

(2019) Hao Yin et al.   Nature Reviews Clinical Oncology

CRISPR/Cas Systems towards Next-Generation Biosensing

(2019) Yi Li et al.   TRENDS IN BIOTECHNOLOGY

An RNA-Guided Cas9 Nickase-Based Method for Universal Isothermal DNA Amplification

(2019) Ting Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploring the Trans-Cleavage Activity of CRISPR-Cas12a (cpf1) for the Development of a Universal Electrochemical Biosensor

(2019) Yifan Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules

(2019) Mindong Liang et al.   Nature Communications

Adaption of an autonomously cascade DNA circuit for amplified detection and intracellular imaging of polynucleotide kinase with ultralow background

(2019) Jinhua Shang et al.   BIOSENSORS & BIOELECTRONICS

Functional DNA Regulated CRISPR-Cas12a Sensors for Point-of-Care Diagnostics of Non-Nucleic-Acid Targets

(2019) Ying Xiong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Designed zwitterionic peptide combined with sacrificial Fe-MOF for low fouling and highly sensitive electrochemical detection of T4 polynucleotide kinase

(2019) Zhen Song et al.   SENSORS AND ACTUATORS B-CHEMICAL

A Dual-Enzyme-Assisted Three-Dimensional DNA Walking Machine Using T4 Polynucleotide Kinase as Activators and Application in Polynucleotide Kinase Assays

(2018) Chang Feng et al.   ANALYTICAL CHEMISTRY

The Biology of CRISPR-Cas: Backward and Forward

(2018) Frank Hille et al.   CELL

CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA

(2018) Shi-Yuan Li et al.   CELL RESEARCH

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

(2018) Janice S. Chen et al.   SCIENCE

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

(2018) Jonathan S. Gootenberg et al.   SCIENCE

Ultrasensitive, label-free detection of T4 ligase and T4 polynucleotide kinase based on target-triggered hyper-branched rolling circle amplification

(2018) Hongxin Jiang et al.   SENSORS AND ACTUATORS B-CHEMICAL

CRISPR-Cas12a-assisted nucleic acid detection

(2018) Shi-Yuan Li et al.   Cell Discovery

TiO2/g-C3N4/CdS Nanocomposite-Based Photoelectrochemical Biosensor for Ultrasensitive Evaluation of T4 Polynucleotide Kinase Activity

(2018) Pan-Pan Li et al.   ANALYTICAL CHEMISTRY

Determination of the activity of T4 polynucleotide kinase phosphatase by exploiting the sequence-dependent fluorescence of DNA-templated copper nanoclusters

(2018) Xingxing Zhang et al.   MICROCHIMICA ACTA

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

(2018) Lucas B. Harrington et al.   SCIENCE

Polynucleotide kinase-phosphatase (PNKP) mutations and neurologic disease

(2017) Lavinia C. Dumitrache et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3’-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

(2015) Arpita Chatterjee et al.   PLoS Genetics

A WS2 nanosheet based sensing platform for highly sensitive detection of T4 polynucleotide kinase and its inhibitors

(2014) Jia Ge et al.   Nanoscale

Amplified Detection of T4 Polynucleotide Kinase Activity by the Coupled λ Exonuclease Cleavage Reaction and Catalytic Assembly of Bimolecular Beacons

(2013) Ting Hou et al.   ANALYTICAL CHEMISTRY

Synthetic Lethal Targeting of PTEN-Deficient Cancer Cells Using Selective Disruption of Polynucleotide Kinase/Phosphatase

(2013) T. R. Mereniuk et al.   MOLECULAR CANCER THERAPEUTICS

Genetic Screening for Synthetic Lethal Partners of Polynucleotide Kinase/Phosphatase: Potential for Targeting SHP-1-Depleted Cancers

(2012) T. R. Mereniuk et al.   CANCER RESEARCH

Sensitive and Rapid Screening of T4 Polynucleotide Kinase Activity and Inhibition Based on Coupled Exonuclease Reaction and Graphene Oxide Platform

(2011) Lei Lin et al.   ANALYTICAL CHEMISTRY

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair

(2011) Michael Weinfeld et al.   TRENDS IN BIOCHEMICAL SCIENCES