Article
Chemistry, Analytical
Qian Bi, Feng Qiu, Ruo Yuan, Yun Xiang
Summary: This study introduces a highly sensitive and non-label electrochemical biosensor for detecting ACP by inhibiting the coordination of metal ion/PPi and amplifying the signal with G-quadruplex/hemin nanowires. This method allows for the selective and sensitive detection of low levels of ACP in diluted serum samples, without the need for enzymes or nanomaterials.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yang-Yang Hou, Wan-Zhen Xie, Ke-Jing Huang, Jing Xu
Summary: This article introduces a novel self-powered biosensor, which integrates DNAzyme walker and AuNPs/graphdiyne biosensing interface to achieve sensitive detection of target microRNA. The self-powered biosensor has excellent signal transduction ability and can obtain an amplified signal response. The electron transport speed of the biosensing interface is significantly improved by AuNPs/graphdiyne, thereby enhancing the sensitivity of the biosensor. The self-powered biosensor has a dynamic linear range of 0.05 fM-10 pM and a low detection limit of 0.015 fM (S/N = 3). It is capable of assaying miRNA-21 in human serum samples with satisfactory recoveries. This strategy provides an effective method for sensitive microRNA detection and shows great potential in point-of-care detection of tumor biomarkers.
ANALYTICA CHIMICA ACTA
(2023)
Article
Electrochemistry
Amina Rhouati, Jean-Louis Marty, Alina Vasilescu
Summary: The review discusses the powerful tool of combining aptamers' specific recognition abilities and enzymes' catalytic power for highly selective and sensitive detection in bioanalysis. The use of enzymes and DNAzymes as amplification methods, along with the integration of nucleic acid catalysts into aptazymes, are highlighted as preferred approaches in electrochemical aptasensors.
ELECTROCHIMICA ACTA
(2021)
Review
Chemistry, Analytical
Yongxin Li, Zewei Luo, Chuyan Zhang, Rui Sun, Chen Zhou, Chengjun Sun
Summary: Nucleic acids serve as genetic information carriers and powerful building blocks for signal amplification. Entropy-driven circuit (EDC) is considered a milestone in DNA circuits, featuring advantages of rapidness, simplicity, robustness, and modularity.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Environmental Sciences
Liuyin Hu, Jiahua Cui, Yalin Wang, Jinping Jia
Summary: A novel synergistic signal-amplifying electrochemical biosensor was developed for the sensitive and rapid quantification of Bisphenol A (BPA). The biosensor utilized a recognition probe (RP) constructed by BPA aptamer modified gold nanoparticles-loaded magnetic reduced graphene oxide (Aptamer-MrGO@AuNPs), and a signal probe (SP) constructed by BPA aptamer-complementary single-stranded DNA (ssDNA) functionalized methylene blue (MB)-loaded gold nanoparticle (ssDNA-AuNP@MBs). The biosensor achieved a low detection limit of 0.141 pg/mL and successfully detected BPA in real environmental water samples.
Article
Engineering, Electrical & Electronic
Junyuan Zhao, Lihao Wang, Dengyuan Fu, Dongyan Zhao, Yubo Wang, Quan Yuan, Yinfang Zhu, Jinling Yang, Fuhua Yang
Summary: The study proposed a microcantilever biosensor based on AuNPs amplification for sensitive detection of the protein biomarker AFP. The signal amplification immunoassay dramatically enhanced sensitivity and achieved good detection reproducibility, showing linear dependence on the AFP concentration.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)
Article
Biochemistry & Molecular Biology
Mengtian Deng, Jialu Feng, Dan Tao, Hanhui Yan, Jingjing Ding, Nicole Jaffrezic-Renault, Zhenzhong Guo
Summary: A sensitive biosensor for the detection of miRNA-21, a common biomarker in breast tumors, was developed using a TH/rGO/CMK-3/AuNPs nanocomposite. The biosensor exhibited a wide concentration range and a low detection limit, and showed effective detection of human serum samples.
BIOELECTROCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
M. Faisal, Jahir Ahmed, Jari S. Algethami, Mohammed Jalalah, Saeed A. Alsareii, Mabkhoot Alsaiari, Farid A. Harraz
Summary: Highly precise, determined and mind provoking steps are necessary for the design of efficient visible light photocatalysts. In this study, a new photocatalyst comprising of SnO2, polypyrrole doped carbon black (PPy-C) and gold nanoparticles (Au NPs) was successfully designed and characterized. The photocatalytic performance of the newly created Au@PPy-C/SnO2 trio combination was found to be the most efficient, with 93.18% removal of imidacloprid in just 20 min and complete destruction of MB dye in 10 min. The study also investigated the effects of different parameters on imidacloprid photodegradation.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2023)
Article
Chemistry, Analytical
Chenxin Fang, Yuxing Yang, Shuhao Zou, Ping Ouyang, Yang Qing, Jialun Han, Haiyu Li, Zhencui Wang, Jie Du
Summary: This study aims to develop a label-free sensing strategy for highly sensitive detection of miRNA-21. The co-action of DNAzymes and double-hairpin molecular beacons is utilized to enhance the fluorescence signal and detect miRNA-21.
Article
Optics
Yanqun Tong, Jiangyi Lu, Chao Wang, Bin Jiang, Liuxin Ding, Xudong Ren
Summary: Laser cavitation degradation has low efficiency without medium gain, but can be enhanced using Au nanoparticles (AuNPs) for degrading organic dye wastewater. The strong absorption characteristics of AuNPs and the mechanism underlying the enhancement were analyzed. The local field enhancement effect and shock wave signal were obtained, and the relationships among AuNPs, laser energy, irradiations number and degradation effect were investigated. Compared with other methods, AuNPs-enhanced laser cavitation approach exhibits remarkable controllability and higher degradation efficiency.
OPTICS AND LASER TECHNOLOGY
(2023)
Review
Chemistry, Analytical
Qing Wang, Zeyue Wang, Yuqiu He, Bin Xiong, Yingfu Li, Fuan Wang
Summary: DNAzyme is a single-stranded catalytic DNA with various physical and chemical features. Efforts have been made to incorporate RNA-cleaving DNAzyme (RCD) into biosensors and biomedical research, but its in vivo application is limited by off-target activation. Therefore, there is a need to develop spatiotemporally controlled DNAzyme. This paper provides an overview of various methods for specific stimulation/regulation of RCD activities and reviews examples of stimuli-responsive biosensing and biomedical research using chemically and/or structurally caged RCD within the past five years.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jinchen Dong, Tangchun Wang, Enze Xu, Feng Bai, Jun Liu, Zhiliang Zhang
Summary: In this study, hydrophobic SERS substrates were developed by synthesizing gold nanoparticles on cellulose filter paper. The substrates exhibited excellent sensitivity, reproducibility, and stability, and were capable of detecting methylene blue residues in lake water with high sensitivity.
Article
Chemistry, Analytical
Rui Zhang, Mingrui Zhang, Qiao Ding, Ruo Yuan, Yali Yuan
Summary: In this study, a novel label-free and signal-off electrochemical biosensor based on efficient target-trigger T-structure recycling with dual strand displacement amplification (T-DSDA) was constructed for the sensitive detection of miRNA-155 related to cardiovascular diseases. The sensor demonstrated rapid and sensitive detection capability with a low detection limit, and showed strong anti-interference ability in bovine whole blood. This research provides a foundation for clinical diagnosis.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemical Research Methods
Huali Jin, Ruike Liu, Tian Bai, Min Wei, Baoshan He, Zhiguang Suo
Summary: A low-noise ratiometric fluorescence biosensor based on Pb2+-dependent DNAzyme and exonuclease III (Exo III)-assisted cascade signal amplification was developed for the detection of lead ions. The biosensor exhibited a lower limit of detection and a wider detection range compared to other methods, and showed satisfactory results in the detection of lead ions in tap water, tea, and rice flour samples. This ratiometric fluorescence biosensor has great potential in various target monitoring.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Almudena Marti, Jurriaan Huskens
Summary: Affinity sensing of nucleic acids is a highly investigated area in biosensing, and in this study, a simple electrochemical DNA detection layer is developed using poly-l-lysine and gold nanoparticles as a signal amplifier. The method shows high contrast and sensitivity, making it potentially useful in DNA diagnostics.
Article
Chemistry, Analytical
Fubing Xiao, Hui Tan, Yan Wu, Shuzhen Liao, Zhaoyang Wu, Guoli Shen, Ruqin Yu
Article
Chemistry, Analytical
Fubing Xiao, Guoguo Li, Yan Wu, Qianshan Chen, Zhaoyang Wu, Ruqin Yu
ANALYTICAL CHEMISTRY
(2016)
Article
Chemistry, Analytical
Yan Wu, Yongfang Sun, Fubing Xiao, Zhaoyang Wu, Ruqin Yu
Article
Chemistry, Analytical
Guoguo Li, Fubing Xiao, Shuzhen Liao, Qianshan Chen, Jun Zhou, Zhaoyang Wu, Ruqin Yu
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Chemistry, Analytical
Xi Lin, Fubing Xiao, Xuejiao Li, Feifei Li, Can Liu, Xilin Xiao, Nan Hu, Shengyuan Yang
Article
Chemistry, Analytical
Feifei Li, Yajie Yu, Fubing Xiao, Hao Liang, Can Liu, Pengfei Fan, Shengyuan Yang
Article
Chemistry, Multidisciplinary
Xi Lin, Shunzhen He, Dongliang Xuan, Hao Liang, Fubing Xiao, Feifei Li, Can Liu, Pengfei Fan, Congcong Hu, Shengyuan Yang
Article
Environmental Sciences
Xi Lin, Dongliang Xuan, Hao Liang, Fubing Xiao, Feifei Li, Can Liu, Pengfei Fan, Congcong Hu, Shengyuan Yang, Yong Liu
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
(2020)
Article
Chemistry, Multidisciplinary
Fubing Xiao, Jie Liu, Qinghui Guo, Zhibo Du, Hong Li, Chunlong Sun, Wenfang Du
Article
Chemistry, Analytical
Shunzhen He, Xi Lin, Hao Liang, Fubing Xiao, Feifei Li, Can Liu, Pengfei Fan, Shengyuan Yang, Yong Liu
ANALYTICAL METHODS
(2019)
Article
Chemistry, Analytical
Wenfang Du, Junjie Li, Fubing Xiao, Ruqin Yu, Jianhui Jiang
ANALYTICA CHIMICA ACTA
(2017)
Article
Chemistry, Multidisciplinary
Fubing Xiao, Yongfang Sun, Wenfang Du, Wenhui Shi, Yan Wu, Shuzhen Liao, Zhaoyang Wu, Ruqin Yu
ADVANCED FUNCTIONAL MATERIALS
(2017)
Article
Chemistry, Analytical
Yan Wu, Fubing Xiao, Zhaoyang Wu, Ruqin Yu
ANALYTICAL CHEMISTRY
(2017)
Article
Chemistry, Analytical
Ma Zhen-Zhen, Yu Hui-Cheng, Wu Zhao-Yang, Wu Yan, Xiao Fu-Bing
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
(2016)