Tunneling nanotubes and related structures: molecular mechanisms of formation and function

Tunneling nanotubes: Reshaping connectivity

(2021) Chiara Zurzolo   CURRENT OPINION IN CELL BIOLOGY

Centrosome, the Newly Identified Passenger through Tunneling Nanotubes, Increases Binucleation and Proliferation Marker in Receiving Cells

(2021) Fatéméh Dubois et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of Tunneling Nanotubes in Viral Infection, Neurodegenerative Disease, and Cancer

(2021) Vaibhav Tiwari et al.   Frontiers in Immunology

Bridging the gap: virus long distance spread via tunneling nanotubes

(2020) Robert J.J. Jansens et al.   JOURNAL OF VIROLOGY

The tubulin code and its role in controlling microtubule properties and functions

(2020) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rhes Tunnels: A Radical New Way of Communication in the Brain's Striatum?

(2020) Srinivasa Subramaniam   BIOESSAYS

Tunneling Nanotubes and the Eye: Intercellular Communication and Implications for Ocular Health and Disease

(2020) Holly R. Chinnery et al.   Biomed Research International

Investigating Tunneling Nanotubes in Cancer Cells: Guidelines for Structural and Functional Studies through Cell Imaging

(2020) Fatéméh Dubois et al.   Biomed Research International

Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

(2020) Maeva Dupont et al.   eLife

Tunneling Nanotubes and Tumor Microtubes in Cancer

(2020) Cora Roehlecke et al.   Cancers

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

(2020) Mehdi Bouhaddou et al.   CELL

M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms

(2020) Sameh Lotfi et al.   Retrovirology

Classical and Nonclassical Intercellular Communication in Senescence and Ageing

(2020) Juan Antonio Fafián-Labora et al.   TRENDS IN CELL BIOLOGY

Bacterial nanotubes as a manifestation of cell death

(2020) Jiří Pospíšil et al.   Nature Communications

Ultrastructural analysis of SARS-CoV-2 interactions with the host cell via high resolution scanning electron microscopy

(2020) Lucio Ayres Caldas et al.   Scientific Reports

Rab35 and its effectors promote formation of tunneling nanotubes in neuronal cells

(2020) Shaarvari Bhat et al.   Scientific Reports

Nucleolin regulates 14‐3‐3ζ mRNA and promotes cofilin phosphorylation to induce tunneling nanotube formation

(2020) Sunayana Dagar et al.   FASEB JOURNAL

A Ticket to Ride: The Implications of Direct Intercellular Communication via Tunneling Nanotubes in Peritoneal and Other Invasive Malignancies

(2020) Emil Lou   Frontiers in Oncology

The Ways of Actin: Why Tunneling Nanotubes Are Unique Cell Protrusions

(2020) Nina Ljubojevic et al.   TRENDS IN CELL BIOLOGY

Tunneling nanotubes, a novel mode of tumor cell-macrophage communication in tumor cell invasion

(2019) Samer J. Hanna et al.   JOURNAL OF CELL SCIENCE

Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control

(2019) Sylvia Varland et al.   TRENDS IN BIOCHEMICAL SCIENCES

Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells

(2019) Anna Sartori-Rupp et al.   Nature Communications

IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration

(2019) David J. Kast et al.   MOLECULAR BIOLOGY OF THE CELL

The chaperone ERp29 is required for tunneling nanotube formation by stabilizing MSec.

(2019) Rajaiah Pergu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion

(2019) Manish Sharma et al.   JOURNAL OF CELL BIOLOGY

Effect of tolytoxin on tunneling nanotube formation and function

(2019) Aysegul Dilsizoglu Senol et al.   Scientific Reports

Inception Mechanisms of Tunneling Nanotubes

(2019) Mitja Drab et al.   Cells

Triple labelling of actin filaments, intermediate filaments and microtubules for broad application in cell biology: uncovering the cytoskeletal composition in tunneling nanotubes

(2019) Nataša Resnik et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Myoferlin, a multifunctional protein in normal cells, has novel and key roles in various cancers

(2019) Wei Zhu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The Wnt/Ca 2+ pathway is involved in interneuronal communication mediated by tunneling nanotubes

(2019) Jessica Y Vargas et al.   EMBO JOURNAL

Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided imatinib resistance in chronic myeloid leukemia cells

(2019) Marta D. Kolba et al.   Cell Death & Disease

Tunneling Nanotubes Mediated microRNA-155 Intercellular Transportation Promotes Bladder Cancer Cells’ Invasive and Proliferative Capacity

(2019) Jin Jin Lu et al.   International Journal of Nanomedicine

Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects

(2019) Nicole Matejka et al.   Radiation Oncology

Cell Fusion: Merging Membranes and Making Muscle

(2019) Michael J. Petrany et al.   TRENDS IN CELL BIOLOGY

Tunneling Nanotubes: A Versatile Target for Cancer Therapy

(2018) Pragyaparamita Sahu et al.   CURRENT CANCER DRUG TARGETS

RalGPS2 is involved in tunneling nanotubes formation in 5637 bladder cancer cells

(2018) A. D’Aloia et al.   EXPERIMENTAL CELL RESEARCH

Tunneling Nanotubes as a Novel Route of Cell-to-Cell Spread of Herpesviruses

(2018) Mirosława Panasiuk et al.   JOURNAL OF VIROLOGY

Two subunits of the exocyst, Sec3p and Exo70p, can function exclusively on the plasma membrane

(2018) Dongmei Liu et al.   MOLECULAR BIOLOGY OF THE CELL

Tunneling Nanotubes: Intimate Communication between Myeloid Cells

(2018) Maeva Dupont et al.   Frontiers in Immunology

Myoblast fusion confusion: the resolution begins

(2018) Srihari C. Sampath et al.   Skeletal Muscle

Specialized Intercellular Communications via Cytonemes and Nanotubes

(2018) Yukiko M. Yamashita et al.   Annual Review of Cell and Developmental Biology

Rab11a-Rab8a cascade regulate the formation of tunneling nanotubes through vesicle recycling

(2018) Seng Zhu et al.   JOURNAL OF CELL SCIENCE

A role for RASSF1A in tunneling nanotube formation between cells through GEFH1/Rab11 pathway control

(2018) Fatéméh Dubois et al.   Cell Communication and Signaling

Concise Review: Intercellular Communication Via Organelle Transfer in the Biology and Therapeutic Applications of Stem Cells

(2018) Lisa M.A. Murray et al.   STEM CELLS

Helical organization of microtubules occurs in a minority of tunneling membrane nanotubes in normal and cancer urothelial cells

(2018) Nataša Resnik et al.   Scientific Reports

Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes

(2018) Jaime Uhl et al.   Journal of Cell Communication and Signaling

Emerging roles of MICAL family proteins – from actin oxidation to membrane trafficking during cytokinesis

(2017) Stéphane Frémont et al.   JOURNAL OF CELL SCIENCE

Pseudorabies Virus US3-Induced Tunneling Nanotubes Contain Stabilized Microtubules, Interact with Neighboring Cells via Cadherins, and Allow Intercellular Molecular Communication

(2017) Robert J. J. Jansens et al.   JOURNAL OF VIROLOGY

Rab GTPases: master regulators that establish the secretory and endocytic pathways

(2017) Suzanne R. Pfeffer   MOLECULAR BIOLOGY OF THE CELL

Alpha-synuclein fibrils propagate through tunneling nanotubes

(2017) Shinya Okuda et al.   MOVEMENT DISORDERS

Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells

(2017) Gal Haimovich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis

(2017) Samer J. Hanna et al.   Scientific Reports

Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development

(2017) Ai Mei Chou et al.   Scientific Reports

Influenza virus exploits tunneling nanotubes for cell-to-cell spread

(2017) Amrita Kumar et al.   Scientific Reports

The Multifaceted Role of SNARE Proteins in Membrane Fusion

(2017) Jing Han et al.   Frontiers in Physiology

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients

(2017) Birger Victor Dieriks et al.   Scientific Reports

RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

(2016) Fatéméh Dubois et al.   CANCER RESEARCH

The growth determinants and transport properties of tunneling nanotube networks between B lymphocytes

(2016) Anikó Osteikoetxea-Molnár et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes

(2016) Saïda Abounit et al.   EMBO JOURNAL

Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages

(2016) Michihiro Hashimoto et al.   JOURNAL OF IMMUNOLOGY

Porcine Reproductive and Respiratory Syndrome Virus Utilizes Nanotubes for Intercellular Spread

(2016) Rui Guo et al.   JOURNAL OF VIROLOGY

Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases

(2016) Stephanie Hamill et al.   MOLECULAR CELL

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

(2016) Saida Abounit et al.   Prion

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS

(2016) Megan V. Jackson et al.   STEM CELLS

Rab35 GTPase: A Central Regulator of Phosphoinositides and F-actin in Endocytic Recycling and Beyond

(2016) Kerstin Klinkert et al.   TRAFFIC

Rab8a/Rab11a regulate intercellular communications between neural cells via tunneling nanotubes

(2016) Hui Zhu et al.   Cell Death & Disease

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells

(2016) Snider Desir et al.   Oncotarget

Intercellular Extensions Are Induced by the Alphavirus Structural Proteins and Mediate Virus Transmission

(2016) Maria Guadalupe Martinez et al.   PLoS Pathogens

Human metapneumovirus Induces Reorganization of the Actin Cytoskeleton for Direct Cell-to-Cell Spread

(2016) Farah El Najjar et al.   PLoS Pathogens

Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation

(2016) Shunsuke Kimura et al.   Scientific Reports

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

(2016) Elise Delage et al.   Scientific Reports

Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes

(2015) Anne Burtey et al.   FASEB JOURNAL

Ral GTPases: crucial mediators of exocytosis and tumourigenesis

(2015) R. Shirakawa et al.   JOURNAL OF BIOCHEMISTRY

Cytoskeletal dynamics: A view from the membrane

(2015) Magdalena Bezanilla et al.   JOURNAL OF CELL BIOLOGY

The Exocyst at a Glance

(2015) B. Wu et al.   JOURNAL OF CELL SCIENCE

Bone marrow-derived mesenchymal stem cells rescue injured H9c2 cells via transferring intact mitochondria through tunneling nanotubes in an in vitro simulated ischemia/reperfusion model

(2015) HUI HAN et al.   Molecular Medicine Reports

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2

(2015) L Jia et al.   ONCOGENE

Prion aggregates transfer through tunneling nanotubes in endocytic vesicles

(2015) Seng Zhu et al.   Prion

Chew on this: amoebic trogocytosis and host cell killing by Entamoeba histolytica

(2015) Katherine S. Ralston   TRENDS IN PARASITOLOGY

Metabolic cross-feeding via intercellular nanotubes among bacteria

(2015) Samay Pande et al.   Nature Communications

Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells

(2015) Ksenia Astanina et al.   Scientific Reports

Tuberculosis and HIV Coinfection: Table 1.

(2015) Judith Bruchfeld et al.   Cold Spring Harbor Perspectives in Medicine

Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II + Cells in the Mouse Cornea

(2014) Holly R. Chinnery et al.   JOURNAL OF IMMUNOLOGY

Influenza A Virus Uses Intercellular Connections To Spread to Neighboring Cells

(2014) Kari L. Roberts et al.   JOURNAL OF VIROLOGY

Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia–reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer

(2014) Kaiming Liu et al.   MICROVASCULAR RESEARCH

Trogocytosis by Entamoeba histolytica contributes to cell killing and tissue invasion

(2014) Katherine S. Ralston et al.   NATURE

Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors

(2014) David J Kast et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes

(2014) Venugopal Thayanithy et al.   Translational Research

The exocyst at the interface between cytoskeleton and membranes in eukaryotic cells

(2014) Lukáš Synek et al.   Frontiers in Plant Science

Tunneling nanotube (TNT) formation is independent of p53 expression

(2013) V Andresen et al.   CELL DEATH AND DIFFERENTIATION

Exo70 Generates Membrane Curvature for Morphogenesis and Cell Migration

(2013) Yuting Zhao et al.   DEVELOPMENTAL CELL

Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth

(2013) H. Kobayashi et al.   JOURNAL OF CELL SCIENCE

Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes

(2013) M. Costanzo et al.   JOURNAL OF CELL SCIENCE

Myo10 is a key regulator of TNT formation in neuronal cells

(2013) K. Gousset et al.   JOURNAL OF CELL SCIENCE

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning

(2013) Timothy A. Sanders et al.   NATURE

H-Ras transfers from B to T cells via tunneling nanotubes

(2013) N Rainy et al.   Cell Death & Disease

Myosin-Driven Intercellular Transportation of Wheat Germ Agglutinin Mediated by Membrane Nanotubes between Human Lung Cancer Cells

(2012) Zhi-Gang Wang et al.   ACS Nano

The molecular basis of induction and formation of tunneling nanotubes

(2012) Shunsuke Kimura et al.   CELL AND TISSUE RESEARCH

Exo70 Stimulates the Arp2/3 Complex for Lamellipodia Formation and Directional Cell Migration

(2012) Jianglan Liu et al.   CURRENT BIOLOGY

The Microtubule-Associated Rho Activating Factor GEF-H1 Interacts with Exocyst Complex to Regulate Vesicle Traffic

(2012) Ritu Pathak et al.   DEVELOPMENTAL CELL

Microvesicle and tunneling nanotube mediated intercellular transfer of g-protein coupled receptors in cell cultures

(2012) M. Guescini et al.   EXPERIMENTAL CELL RESEARCH

Tunneling nanotubes enable intercellular transfer of MHC class I molecules

(2012) Christian Schiller et al.   HUMAN IMMUNOLOGY

The role of cholesterol-sphingomyelin membrane nanodomains in the stability of intercellular membrane nanotubes

(2012) Doron Kabaso   International Journal of Nanomedicine

LST1 promotes the assembly of a molecular machinery responsible for tunneling nanotube formation

(2012) C. Schiller et al.   JOURNAL OF CELL SCIENCE

Wiring through tunneling nanotubes - from electrical signals to organelle transfer

(2012) S. Abounit et al.   JOURNAL OF CELL SCIENCE

Tunneling nanotubes, an emerging intercellular communication route in development

(2012) Hans-Hermann Gerdes et al.   MECHANISMS OF DEVELOPMENT

Intercellular communication: diverse structures for exchange of genetic information

(2012) Maria Mittelbrunn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes

(2012) Dierk Wittig et al.   PLoS One

Tunneling Nanotubes Provide a Unique Conduit for Intercellular Transfer of Cellular Contents in Human Malignant Pleural Mesothelioma

(2012) Emil Lou et al.   PLoS One

Developing Neurons Form Transient Nanotubes Facilitating Electrical Coupling and Calcium Signaling with Distant Astrocytes

(2012) Xiang Wang et al.   PLoS One

Tunneling-nanotube direction determination in neurons and astrocytes

(2012) X Sun et al.   Cell Death & Disease

Active Generation and Propagation of Ca2+ Signals within Tunneling Membrane Nanotubes

(2011) Ian F. Smith et al.   BIOPHYSICAL JOURNAL

Intercellular Nanotubes Mediate Bacterial Communication

(2011) Gyanendra P. Dubey et al.   CELL

Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions

(2011) Carsten Janke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intercellular Bridges in Vertebrate Gastrulation

(2011) Luca Caneparo et al.   PLoS One

Intercellular Communication by Exchange of Cytoplasmic Material via Tunneling Nano-Tube Like Structures in Primary Human Renal Epithelial Cells

(2011) Sophie Domhan et al.   PLoS One

Dynamics of the Rho-family small GTPases in actin regulation and motility

(2011) Désirée Spiering et al.   Cell Adhesion & Migration

The Eps8/IRSp53/VASP Network Differentially Controls Actin Capping and Bundling in Filopodia Formation

(2011) Federico Vaggi et al.   PLoS Computational Biology

Intercellular Transportation of Quantum Dots Mediated by Membrane Nanotubes

(2010) Kangmin He et al.   ACS Nano

Tunneling-nanotube development in astrocytes depends on p53 activation

(2010) Y Wang et al.   CELL DEATH AND DIFFERENTIATION

Malaria parasites form filamentous cell-to-cell connections during reproduction in the mosquito midgut

(2010) Ingrid Rupp et al.   CELL RESEARCH

Dynamic imaging of mammalian neural tube closure

(2010) Christina Pyrgaki et al.   DEVELOPMENTAL BIOLOGY

The Direction of Plasma Membrane Exchange between Lymphocytes and Accessory Cells by Trogocytosis Is Influenced by the Nature of the Accessory Cell

(2010) Sandrine Daubeuf et al.   JOURNAL OF IMMUNOLOGY

Sec5 and Exo84 Foster Oncogenic Ras-Mediated Tumorigenesis

(2010) S. H. Issaq et al.   MOLECULAR CANCER RESEARCH

Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels

(2010) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human T-cell leukemia virus type 1 p8 protein increases cellular conduits and virus transmission

(2010) N. Van Prooyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protruding membrane nanotubes: attachment of tubular protrusions to adjacent cells by several anchoring junctions

(2010) Maruša Lokar et al.   PROTOPLASMA

EHD proteins: key conductors of endocytic transport

(2010) Naava Naslavsky et al.   TRENDS IN CELL BIOLOGY

The HTLV-1 Virological Synapse

(2010) Mohamed Nejmeddine et al.   Viruses-Basel

The Exo70 Subunit of the Exocyst Is an Effector for Both Cdc42 and Rho3 Function in Polarized Exocytosis

(2009) Hao Wu et al.   MOLECULAR BIOLOGY OF THE CELL

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

(2009) Koji Hase et al.   NATURE CELL BIOLOGY

Coordination of Membrane and Actin Cytoskeleton Dynamics during Filopodia Protrusion

(2009) Changsong Yang et al.   PLoS One

Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived Neurotrophic Factor (BDNF)

(2009) Elisabetta Menna et al.   PLOS BIOLOGY

Tunneling nanotube (TNT)-like structures facilitate a constitutive, actomyosin-dependent exchange of endocytic organelles between normal rat kidney cells☆

(2008) Steffen Gurke et al.   EXPERIMENTAL CELL RESEARCH

The art of cellular communication: tunneling nanotubes bridge the divide

(2008) Steffen Gurke et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Sec6p Anchors the Assembled Exocyst Complex at Sites of Secretion

(2008) Jennifer A. Songer et al.   MOLECULAR BIOLOGY OF THE CELL

IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions

(2008) Giorgio Scita et al.   TRENDS IN CELL BIOLOGY

Cytonemes and tunneling nanotubules in cell–cell communication and viral pathogenesis

(2008) Nathan M. Sherer et al.   TRENDS IN CELL BIOLOGY