Rhes Tunnels: A Radical New Way of Communication in the Brain's Striatum?

Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells

(2019) Anna Sartori-Rupp et al.   Nature Communications

A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

(2019) Israel Hernandez et al.   Science Translational Medicine

Glutamate signaling at cytoneme synapses

(2019) Hai Huang et al.   SCIENCE

De novo single-nucleotide and copy number variation in discordant monozygotic twins reveals disease-related genes

(2019) Nirmal Vadgama et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The cytoneme connection: direct long-distance signal transfer during development

(2019) Laura González-Méndez et al.   DEVELOPMENT

Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion

(2019) Manish Sharma et al.   JOURNAL OF CELL BIOLOGY

Keratinocytes Share Gene Expression Fingerprint with Epidermal Langerhans Cells via mRNA Transfer

(2019) Qingtai Su et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Are cell membrane nanotubes the ancestors of the nervous system?

(2019) H. Moysés Nussenzveig   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

RNAi screen reveals a role for PACSIN2 and caveolins during bacterial cell-to-cell spread

(2019) Allen G. Sanderlin et al.   MOLECULAR BIOLOGY OF THE CELL

Langerhans Cells Spy on Keratinocytes

(2019) Jacinto S. De La Cruz Diaz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Rhes, a striatal-enriched protein, promotes mitophagy via Nix

(2019) Manish Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided imatinib resistance in chronic myeloid leukemia cells

(2019) Marta D. Kolba et al.   Cell Death & Disease

Tunneling Nanotubes as a Novel Route of Cell-to-Cell Spread of Herpesviruses

(2018) Mirosława Panasiuk et al.   JOURNAL OF VIROLOGY

Intercellular transfer of mitochondria rescues virus-induced cell death but facilitates cell-to-cell spreading of porcine reproductive and respiratory syndrome virus

(2018) Rui Guo et al.   VIROLOGY

Chemotherapy-Induced Tunneling Nanotubes Mediate Intercellular Drug Efflux in Pancreatic Cancer

(2018) Snider Desir et al.   Scientific Reports

Specialized Intercellular Communications via Cytonemes and Nanotubes

(2018) Yukiko M. Yamashita et al.   Annual Review of Cell and Developmental Biology

Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates

(2018) Benjamin Mattes et al.   eLife

Feedback regulation of cytoneme-mediated transport shapes a tissue-specific FGF morphogen gradient

(2018) Lijuan Du et al.   eLife

Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes

(2017) Jinar Rostami et al.   JOURNAL OF NEUROSCIENCE

Tweety-Homolog 1 Drives Brain Colonization of Gliomas

(2017) Erik Jung et al.   JOURNAL OF NEUROSCIENCE

Pseudorabies Virus US3-Induced Tunneling Nanotubes Contain Stabilized Microtubules, Interact with Neighboring Cells via Cadherins, and Allow Intercellular Molecular Communication

(2017) Robert J. J. Jansens et al.   JOURNAL OF VIROLOGY

Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells

(2017) Jinjin Lu et al.   Oncotarget

Influenza virus exploits tunneling nanotubes for cell-to-cell spread

(2017) Amrita Kumar et al.   Scientific Reports

Cytoneme-mediated cell-cell contacts for Hedgehog reception

(2017) Laura González-Méndez et al.   eLife

The Striosome and Matrix Compartments of the Striatum: A Path through the Labyrinth from Neurochemistry toward Function

(2016) Katherine R. Brimblecombe et al.   ACS Chemical Neuroscience

Human-to-mouse prion-like propagation of mutant huntingtin protein

(2016) Iksoo Jeon et al.   ACTA NEUROPATHOLOGICA

The growth determinants and transport properties of tunneling nanotube networks between B lymphocytes

(2016) Anikó Osteikoetxea-Molnár et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tunneling nanotubes spread fibrillar α‐synuclein by intercellular trafficking of lysosomes

(2016) Saïda Abounit et al.   EMBO JOURNAL

Tunneling nanotubes mediate the transfer of stem cell marker CD133 between hematopoietic progenitor cells

(2016) Doreen Reichert et al.   EXPERIMENTAL HEMATOLOGY

DrosophilaKette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion

(2016) Julia Hamp et al.   JOURNAL OF CELL SCIENCE

Potential Role of the Formation of Tunneling Nanotubes in HIV-1 Spread in Macrophages

(2016) Michihiro Hashimoto et al.   JOURNAL OF IMMUNOLOGY

Neural Activity-Dependent Regulation of Radial Glial Filopodial Motility Is Mediated by Glial cGMP-Dependent Protein Kinase 1 and Contributes to Synapse Maturation in the Developing Visual System

(2016) Mari Sild et al.   JOURNAL OF NEUROSCIENCE

In vivo imaging of axonal transport in murine motor and sensory neurons

(2016) Katherine L. Gibbs et al.   JOURNAL OF NEUROSCIENCE METHODS

Tunneling nanotubes: A possible highway in the spreading of tau and other prion-like proteins in neurodegenerative diseases

(2016) Saida Abounit et al.   Prion

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum

(2016) N. Shahani et al.   Science Signaling

The Role of Extracellular Vesicle and Tunneling Nanotube-Mediated Intercellular Cross-Talk Between Mesenchymal Stem Cells and Human Peripheral T Cells

(2016) Zsolt Matula et al.   STEM CELLS AND DEVELOPMENT

Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage

(2016) Dan Jiang et al.   Cell Death & Disease

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells

(2016) Snider Desir et al.   Oncotarget

RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum

(2016) N. Shahani et al.   Science Signaling

Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies

(2016) Meryem Tardivel et al.   Acta Neuropathologica Communications

Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

(2016) Elise Delage et al.   Scientific Reports

B-cell precursor acute lymphoblastic leukemia cells use tunneling nanotubes to orchestrate their microenvironment

(2015) R. Polak et al.   BLOOD

Communication between distant epithelial cells by filopodia-like protrusions during embryonic development

(2015) Sagar et al.   DEVELOPMENT

Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions

(2015) J. C. Snyder et al.   JOURNAL OF CELL SCIENCE

Rhes regulates dopamine D2 receptor transmission in striatal cholinergic interneurons

(2015) Giuseppe Sciamanna et al.   NEUROBIOLOGY OF DISEASE

Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease

(2015) Supriya Swarnkar et al.   NEUROBIOLOGY OF DISEASE

Prion aggregates transfer through tunneling nanotubes in endocytic vesicles

(2015) Seng Zhu et al.   Prion

Transcellular spreading of huntingtin aggregates in theDrosophilabrain

(2015) Daniel T. Babcock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells

(2015) Ksenia Astanina et al.   Scientific Reports

Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion

(2015) Veronica Ghiglieri et al.   Scientific Reports

Myoblast cytonemes mediate Wg signaling from the wing imaginal disc and Delta-Notch signaling to the air sac primordium

(2015) Hai Huang et al.   eLife

Mutant huntingtin is present in neuronal grafts in huntington disease patients

(2014) Francesca Cicchetti et al.   ANNALS OF NEUROLOGY

Listeria monocytogenesantagonizes the human GTPase Cdc42 to promote bacterial spread

(2014) Luciano A. Rigano et al.   CELLULAR MICROBIOLOGY

Membrane Dynamics at the Nuclear Exchange Junction during Early Mating (One to Four Hours) in the Ciliate Tetrahymena thermophila

(2014) Eric S. Cole et al.   EUKARYOTIC CELL

Tumor exosomes induce tunneling nanotubes in lipid raft-enriched regions of human mesothelioma cells

(2014) Venugopal Thayanithy et al.   EXPERIMENTAL CELL RESEARCH

Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II + Cells in the Mouse Cornea

(2014) Holly R. Chinnery et al.   JOURNAL OF IMMUNOLOGY

In Vitro Effects of Cocaine on Tunneling Nanotube Formation and Extracellular Vesicle Release in Glioblastoma Cell Cultures

(2014) Chiara Carone et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons

(2014) Eline Pecho-Vrieseling et al.   NATURE NEUROSCIENCE

Long-Distance Communication between Laryngeal Carcinoma Cells

(2014) Ieva Antanavičiūtė et al.   PLoS One

Cytoneme-Mediated Contact-Dependent Transport of the Drosophila Decapentaplegic Signaling Protein

(2014) S. Roy et al.   SCIENCE

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

(2014) W. M. Pryor et al.   Science Signaling

Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes

(2014) Venugopal Thayanithy et al.   Translational Research

Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion

(2014) Ana-Citlali Gradilla et al.   Nature Communications

Interleukin-1β Induces Hyaluronan and CD44-Dependent Cell Protrusions That Facilitate Fibroblast-Monocyte Binding

(2013) Soma Meran et al.   AMERICAN JOURNAL OF PATHOLOGY

Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes

(2013) Ross Corriden et al.   EMBO REPORTS

Cajal, Golgi, Nansen, Schäfer and the Neuron Doctrine

(2013) Ortwin Bock   ENDEAVOUR

A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration

(2013) Boxun Lu et al.   FASEB JOURNAL

Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy

(2013) Robert G. Mealer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia

(2013) Marcus Bischoff et al.   NATURE CELL BIOLOGY

Attenuation of Rhes Activity Significantly Delays the Appearance of Behavioral Symptoms in a Mouse Model of Huntington's Disease

(2013) Brandon A. Baiamonte et al.   PLoS One

H-Ras transfers from B to T cells via tunneling nanotubes

(2013) N Rainy et al.   Cell Death & Disease

Golgi Protein ACBD3 Mediates Neurotoxicity Associated with Huntington’s Disease

(2013) Juan I. Sbodio et al.   Cell Reports

Rhes: A GTP-Binding Protein Integral to Striatal Physiology and Pathology

(2012) Laura M. Harrison   CELLULAR AND MOLECULAR NEUROBIOLOGY

Balancing Hedgehog, a retention and release equilibrium given by Dally, Ihog, Boi and shifted/DmWif

(2012) Aphrodite Bilioni et al.   DEVELOPMENTAL BIOLOGY

Different Modalities of Intercellular Membrane Exchanges Mediate Cell-to-cell P-glycoprotein Transfers in MCF-7 Breast Cancer Cells

(2012) Jennifer Pasquier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tunneling nanotube formation is essential for the regulation of osteoclastogenesis

(2012) Akira Takahashi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Directed glia-assisted angiogenesis in a mature neurosensory structure: Pericytes mediate an adaptive response in human dental pulp that maintains blood-barrier function

(2012) Ramin M. Farahani et al.   JOURNAL OF COMPARATIVE NEUROLOGY

RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C

(2012) Kazuhisa Koizumi et al.   MOLECULAR BIOLOGY OF THE CELL

Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes

(2012) Dierk Wittig et al.   PLoS One

Tunneling Nanotubes Provide a Unique Conduit for Intercellular Transfer of Cellular Contents in Human Malignant Pleural Mesothelioma

(2012) Emil Lou et al.   PLoS One

Vascular Smooth Muscle Cells Initiate Proliferation of Mesenchymal Stem Cells by Mitochondrial Transfer via Tunneling Nanotubes

(2012) Krishna C. Vallabhaneni et al.   STEM CELLS AND DEVELOPMENT

Cytoneme-Mediated Delivery of Hedgehog Regulates the Expression of Bone Morphogenetic Proteins to Maintain Germline Stem Cells in Drosophila

(2012) Patricia Rojas-Ríos et al.   PLOS BIOLOGY

Tubular Structure Induced by a Plant Virus Facilitates Viral Spread in Its Vector Insect

(2012) Qian Chen et al.   PLoS Pathogens

The induction of stromule formation by a plant DNA-virus in epidermal leaf tissues suggests a novel intra- and intercellular macromolecular trafficking route

(2012) Björn Krenz et al.   Frontiers in Plant Science

Active Generation and Propagation of Ca2+ Signals within Tunneling Membrane Nanotubes

(2011) Ian F. Smith et al.   BIOPHYSICAL JOURNAL

Rhes and AGS1/Dexras1 affect signaling by dopamine D1 receptors through adenylyl cyclase

(2011) Laura M. Harrison et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Coxsackievirus B3-Induced Cellular Protrusions: Structural Characteristics and Functional Competence

(2011) O. Paloheimo et al.   JOURNAL OF VIROLOGY

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia

(2011) Srinivasa Subramaniam et al.   NATURE NEUROSCIENCE

Intercellular Bridges in Vertebrate Gastrulation

(2011) Luca Caneparo et al.   PLoS One

Intercellular Communication by Exchange of Cytoplasmic Material via Tunneling Nano-Tube Like Structures in Primary Human Renal Epithelial Cells

(2011) Sophie Domhan et al.   PLoS One

Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation

(2011) Tamara Seredenina et al.   PLoS One

Related pituitary cell lineages develop into interdigitated 3D cell networks

(2011) L. Budry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic imaging of mammalian neural tube closure

(2010) Christina Pyrgaki et al.   DEVELOPMENTAL BIOLOGY

Cytoplasm and organelle transfer between mesenchymal multipotent stromal cells and renal tubular cells in co-culture

(2010) Egor Y. Plotnikov et al.   EXPERIMENTAL CELL RESEARCH

Membrane tubules attach Salmonella  Typhimurium to eukaryotic cells and bacteria

(2010) Svetlana I. Galkina et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Interaction between activated chemokine receptor 1 and FcεRI at membrane rafts promotes communication and F-actin-rich cytoneme extensions between mast cells

(2010) Nimita H. Fifadara et al.   INTERNATIONAL IMMUNOLOGY

Rhes, a Physiologic Regulator of Sumoylation, Enhances Cross-sumoylation between the Basic Sumoylation Enzymes E1 and Ubc9

(2010) Srinivasa Subramaniam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variola and Monkeypox Viruses Utilize Conserved Mechanisms of Virion Motility and Release That Depend on Abl and Src Family Tyrosine Kinases

(2010) P. M. Reeves et al.   JOURNAL OF VIROLOGY

Huntington’s Disease is a disorder of the corpus striatum: Focus on Rhes (Ras homologue enriched in the striatum)

(2010) Srinivasa Subramaniam et al.   NEUROPHARMACOLOGY

Tunnelling nanotubes

(2010) Karine Gousset et al.   Prion

Hen or Egg?

(2009) Amin Rustom   Annals of the New York Academy of Sciences

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Ontogeny and dopaminergic regulation in brain of Ras homolog enriched in striatum (Rhes)

(2008) Laura M. Harrison et al.   BRAIN RESEARCH

Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: A potential mechanism for intercellular HIV trafficking

(2008) E.A. Eugenin et al.   CELLULAR IMMUNOLOGY

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

(2008) Stefanie Sowinski et al.   NATURE CELL BIOLOGY

Cytonemes and tunneling nanotubules in cell–cell communication and viral pathogenesis

(2008) Nathan M. Sherer et al.   TRENDS IN CELL BIOLOGY

The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons

(2007) Francesco Errico et al.   MOLECULAR AND CELLULAR NEUROSCIENCE