Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development

Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis

(2016) Nijiro Nohata et al.   DEVELOPMENTAL BIOLOGY

The Rho GTPase Rif signals through IRTKS, Eps8 and WAVE2 to generate dorsal membrane ruffles and filopodia

(2016) Thankiah Sudhaharan et al.   JOURNAL OF CELL SCIENCE

IRSp53/BAIAP2 in dendritic spine development, NMDA receptor regulation, and psychiatric disorders

(2016) Jaeseung Kang et al.   NEUROPHARMACOLOGY

Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice

(2015) D. M. Barry et al.   DEVELOPMENT

MIM-Induced Membrane Bending Promotes Dendritic Spine Initiation

(2015) Juha Saarikangas et al.   DEVELOPMENTAL CELL

Severe learning deficits of IRSp53 mutant mice are caused by altered NMDA receptor-dependent signal transduction

(2015) Kristin Bobsin et al.   JOURNAL OF NEUROCHEMISTRY

Social deficits in IRSp53 mutant mice improved by NMDAR and mGluR5 suppression

(2015) Woosuk Chung et al.   NATURE NEUROSCIENCE

Dynamin1 Is a Novel Target for IRSp53 Protein and Works with Mammalian Enabled (Mena) Protein and Eps8 to Regulate Filopodial Dynamics

(2014) Ai Mei Chou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors

(2014) David J Kast et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deficiency of IRTKS as an adaptor of insulin receptor leads to insulin resistance

(2013) Li-Yu Huang et al.   CELL RESEARCH

CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP

(2013) Andrea Disanza et al.   EMBO JOURNAL

Deletion of Cdc42 Enhances ADAM17-Mediated Vascular Endothelial Growth Factor Receptor 2 Shedding and Impairs Vascular Endothelial Cell Survival and Vasculogenesis

(2013) Y. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY

Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease

(2012) Alexander von Gise et al.   CIRCULATION RESEARCH

Partitioning the heart: mechanisms of cardiac septation and valve development

(2012) C.-J. Lin et al.   DEVELOPMENT

Insulin Receptor Substrate protein 53kDa (IRSp53) is a negative regulator of myogenic differentiation

(2012) Ashish Misra et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development

(2012) Ryo Aizawa et al.   MECHANISMS OF DEVELOPMENT

Enterohaemorrhagic Escherichia Coli Exploits a Tryptophan Switch to Hijack Host F-Actin Assembly

(2012) Olli Aitio et al.   STRUCTURE

mDia1 and WAVE2 Proteins Interact Directly with IRSp53 in Filopodia and Are Involved in Filopodium Formation

(2011) Wah Ing Goh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia

(2011) J. Saarikangas et al.   JOURNAL OF CELL SCIENCE

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures

(2011) Anette Pykäläinen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mice deficient in MIM expression are predisposed to lymphomagenesis

(2011) D Yu et al.   ONCOGENE

I-BAR domain proteins: linking actin and plasma membrane dynamics

(2010) Hongxia Zhao et al.   CURRENT OPINION IN CELL BIOLOGY

The embryonic epicardium: an essential element of cardiac development

(2010) R. Carmona et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly

(2010) O. Aitio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of lymphatic-blood vessel separation by endothelial Rac1

(2009) G. D'Amico et al.   DEVELOPMENT

Cdc42- and IRSp53-dependent contractile filopodia tether presumptive lens and retina to coordinate epithelial invagination

(2009) B. K. Chauhan et al.   DEVELOPMENT

Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development

(2009) Dai Suzuki et al.   DEVELOPMENTAL BIOLOGY

The Insulin Receptor Substrate of 53 kDa (IRSp53) Limits Hippocampal Synaptic Plasticity

(2009) Corinna Sawallisch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced NMDA Receptor-Mediated Synaptic Transmission, Enhanced Long-Term Potentiation, and Impaired Learning and Memory in Mice Lacking IRSp53

(2009) M.-H. Kim et al.   JOURNAL OF NEUROSCIENCE

I-BAR domains, IRSp53 and filopodium formation

(2009) Sohail Ahmed et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

An essential role for Rac1 in endothelial cell function and vascular development

(2008) Wenfu Tan et al.   FASEB JOURNAL

Transforming Growth Factor-β-stimulated Endocardial Cell Transformation Is Dependent on Par6c Regulation of RhoA

(2008) Todd A. Townsend et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cdc42 Effector IRSp53 Generates Filopodia by Coupling Membrane Protrusion with Actin Dynamics

(2008) Kim Buay Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IRSp53: crossing the road of membrane and actin dynamics in the formation of membrane protrusions

(2008) Giorgio Scita et al.   TRENDS IN CELL BIOLOGY