Tunneling Nanotubes and Tumor Microtubes in Cancer

Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy

(2019) Judith Reindl et al.   CELL STRESS & CHAPERONES

Tunneling nanotubes, a novel mode of tumor cell-macrophage communication in tumor cell invasion

(2019) Samer J. Hanna et al.   JOURNAL OF CELL SCIENCE

The Role of SVZ Stem Cells in Glioblastoma

(2019) Christine Altmann et al.   Cancers

Glutamate signaling at cytoneme synapses

(2019) Hai Huang et al.   SCIENCE

The cytoneme connection: direct long-distance signal transfer during development

(2019) Laura González-Méndez et al.   DEVELOPMENT

Visualization of spatiotemporal dynamics of human glioma stem cell invasion

(2019) Ryota Tamura et al.   Molecular Brain

Stress-induced tunneling nanotubes support treatment adaptation in prostate cancer

(2019) Alexander Kretschmer et al.   Scientific Reports

Intercellular Transfer of Oncogenic KRAS via Tunneling Nanotubes Introduces Intracellular Mutational Heterogeneity in Colon Cancer Cells

(2019) Desir et al.   Cancers

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress

(2019) Richard Burt et al.   BLOOD

Perspectives of cellular communication through tunneling nanotubes in cancer cells and the connection to radiation effects

(2019) Nicole Matejka et al.   Radiation Oncology

RalGPS2 is involved in tunneling nanotubes formation in 5637 bladder cancer cells

(2018) A. D’Aloia et al.   EXPERIMENTAL CELL RESEARCH

Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells

(2018) Jiancheng Wang et al.   Journal of Hematology & Oncology

Chemotherapy-Induced Tunneling Nanotubes Mediate Intercellular Drug Efflux in Pancreatic Cancer

(2018) Snider Desir et al.   Scientific Reports

The role of metabolism and tunneling nanotube-mediated intercellular mitochondria exchange in cancer drug resistance

(2018) Yalda Hekmatshoar et al.   BIOCHEMICAL JOURNAL

Cell communication by tunneling nanotubes: Implications in disease and therapeutic applications

(2018) Rahul Mittal et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Macrophage conditioned medium induced cellular network formation in MCF-7 cells through enhanced tunneling nanotube formation and tunneling nanotube mediated release of viable cytoplasmic fragments

(2017) Pooja Patheja et al.   EXPERIMENTAL CELL RESEARCH

Tweety-Homolog 1 Drives Brain Colonization of Gliomas

(2017) Erik Jung et al.   JOURNAL OF NEUROSCIENCE

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

(2017) Sophie Weil et al.   NEURO-ONCOLOGY

Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells

(2017) Jinjin Lu et al.   Oncotarget

Control of long-distance cell-to-cell communication and autophagosome transfer in squamous cell carcinoma via tunneling nanotubes

(2017) Inés Sáenz-de-Santa-María et al.   Oncotarget

The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis

(2017) Samer J. Hanna et al.   Scientific Reports

Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells

(2017) Lan-Feng Dong et al.   eLife

Tunneling Nanotubes and Gap Junctions–Their Role in Long-Range Intercellular Communication during Development, Health, and Disease Conditions

(2017) Jennifer Ariazi et al.   Frontiers in Molecular Neuroscience

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

(2017) Brice Nzigou Mombo et al.   Jove-Journal of Visualized Experiments

Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy

(2016) R. Moschoi et al.   BLOOD

The role of neural connexins in HeLa cell mobility and intercellular communication through tunneling tubes

(2016) Lina Rimkutė et al.   BMC CELL BIOLOGY

A malignant cellular network in gliomas: potential clinical implications

(2016) Matthias Osswald et al.   NEURO-ONCOLOGY

Intercellular Transport of Nanomaterials is Mediated by Membrane Nanotubes In Vivo

(2016) Markus Rehberg et al.   Small

Association between tumor-stroma ratio and prognosis in solid tumor patients: a systematic review and meta-analysis

(2016) Jiayuan Wu et al.   Oncotarget

Tunneling nanotube formation is stimulated by hypoxia in ovarian cancer cells

(2016) Snider Desir et al.   Oncotarget

The missing link: does tunnelling nanotube-based supercellularity provide a new understanding of chronic and lifestyle diseases?

(2016) Amin Rustom   Open Biology

Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection

(2016) Justin Ady et al.   Molecular Therapy-Oncolytics

B-cell precursor acute lymphoblastic leukemia cells use tunneling nanotubes to orchestrate their microenvironment

(2015) R. Polak et al.   BLOOD

The Biology of Brain Metastasis

(2015) Isaiah J. Fidler   CANCER JOURNAL

Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells

(2015) X Wang et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes

(2015) Anne Burtey et al.   FASEB JOURNAL

Characterization of tweety gene (ttyh1-3) expression in Xenopus laevis during embryonic development

(2015) Andrew D. Halleran et al.   GENE EXPRESSION PATTERNS

Glioma cells escaped from cytotoxicity of temozolomide and vincristine by communicating with human astrocytes

(2015) Weiliang Chen et al.   MEDICAL ONCOLOGY

Astrocytes protect glioma cells from chemotherapy and upregulate survival genes via gap junctional communication

(2015) QINGTANG LIN et al.   Molecular Medicine Reports

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

Nanotubes mediate niche–stem-cell signalling in the Drosophila testis

(2015) Mayu Inaba et al.   NATURE

Toward understanding and exploiting tumor heterogeneity

(2015) Ash A Alizadeh et al.   NATURE MEDICINE

Pan-cancer analysis of the extent and consequences of intratumor heterogeneity

(2015) Noemi Andor et al.   NATURE MEDICINE

Physical nanoscale conduit-mediated communication between tumour cells and the endothelium modulates endothelial phenotype

(2015) Yamicia Connor et al.   Nature Communications

Tunneling nanotubes between rat primary astrocytes and C6 glioma cells alter proliferation potential of glioma cells

(2015) Lei Zhang et al.   Neuroscience Bulletin

Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure

(2015) Xuebing Ding et al.   Oncotarget

Lipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells

(2015) Ksenia Astanina et al.   Scientific Reports

MitoCeption as a new tool to assess the effects of mesenchymal stem/stromal cell mitochondria on cancer cell metabolism and function

(2015) Andrés Caicedo et al.   Scientific Reports

Wild-Type H- and N-Ras Promote Mutant K-Ras-Driven Tumorigenesis by Modulating the DNA Damage Response

(2014) Elda Grabocka et al.   CANCER CELL

Tumor exosomes induce tunneling nanotubes in lipid raft-enriched regions of human mesothelioma cells

(2014) Venugopal Thayanithy et al.   EXPERIMENTAL CELL RESEARCH

Benefit From Procarbazine, Lomustine, and Vincristine in Oligodendroglial Tumors Is Associated With Mutation ofIDH

(2014) J. Gregory Cairncross et al.   JOURNAL OF CLINICAL ONCOLOGY

Cutting Edge: Membrane Nanotubes In Vivo: A Feature of MHC Class II + Cells in the Mouse Cornea

(2014) Holly R. Chinnery et al.   JOURNAL OF IMMUNOLOGY

In Vitro Effects of Cocaine on Tunneling Nanotube Formation and Extracellular Vesicle Release in Glioblastoma Cell Cultures

(2014) Chiara Carone et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A neurocentric perspective on glioma invasion

(2014) Vishnu Anand Cuddapah et al.   NATURE REVIEWS NEUROSCIENCE

Long-Distance Communication between Laryngeal Carcinoma Cells

(2014) Ieva Antanavičiūtė et al.   PLoS One

Tumor-stromal cross talk: direct cell-to-cell transfer of oncogenic microRNAs via tunneling nanotubes

(2014) Venugopal Thayanithy et al.   Translational Research

Intercellular communication in malignant pleural mesothelioma: properties of tunneling nanotubes

(2014) Justin W. Ady et al.   Frontiers in Physiology

Prognostic significance of the tumor-stroma ratio: validation study in node-negative premenopausal breast cancer patients from the EORTC perioperative chemotherapy (POP) trial (10854)

(2013) T. J. A. Dekker et al.   BREAST CANCER RESEARCH AND TREATMENT

Tunneling nanotube (TNT) formation is independent of p53 expression

(2013) V Andresen et al.   CELL DEATH AND DIFFERENTIATION

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

(2013) Jonathan Welti et al.   JOURNAL OF CLINICAL INVESTIGATION

Preferential transfer of mitochondria from endothelial to cancer cells through tunneling nanotubes modulates chemoresistance

(2013) Jennifer Pasquier et al.   Journal of Translational Medicine

Cytonemes are required for the establishment of a normal Hedgehog morphogen gradient in Drosophila epithelia

(2013) Marcus Bischoff et al.   NATURE CELL BIOLOGY

Membrane nanotubes in myeloid cells in the adult mouse cornea represent a novel mode of immune cell interaction

(2012) Yashar Seyed-Razavi et al.   IMMUNOLOGY AND CELL BIOLOGY

Standards of care for treatment of recurrent glioblastoma—are we there yet?

(2012) Michael Weller et al.   NEURO-ONCOLOGY

Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes

(2012) Dierk Wittig et al.   PLoS One

Tunneling Nanotubes Provide a Unique Conduit for Intercellular Transfer of Cellular Contents in Human Malignant Pleural Mesothelioma

(2012) Emil Lou et al.   PLoS One

Feedback within the Inter-Cellular Communication and Tumorigenesis in Carcinomas

(2012) Felix Rückert et al.   PLoS One

Nos2 Inactivation Promotes the Development of Medulloblastoma in Ptch1+/− Mice by Deregulation of Gap43–Dependent Granule Cell Precursor Migration

(2012) Daniel Haag et al.   PLoS Genetics

Molecular Genetics of Colorectal Cancer

(2011) Eric R. Fearon   Annual Review of Pathology-Mechanisms of Disease

Long-distance electrical coupling via tunneling nanotubes

(2011) Xiang Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Long-distance intercellular connectivity between cardiomyocytes and cardiofibroblasts mediated by membrane nanotubes

(2011) Kangmin He et al.   CARDIOVASCULAR RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Neural crest cell communication involves an exchange of cytoplasmic material through cellular bridges revealed by photoconversion of KikGR

(2011) Mary Cathleen McKinney et al.   DEVELOPMENTAL DYNAMICS

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

(2011) Mina J Bissell et al.   NATURE MEDICINE

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Intercellular Communication by Exchange of Cytoplasmic Material via Tunneling Nano-Tube Like Structures in Primary Human Renal Epithelial Cells

(2011) Sophie Domhan et al.   PLoS One

Nanotube Action between Human Mesothelial Cells Reveals Novel Aspects of Inflammatory Responses

(2011) Julia Ranzinger et al.   PLoS One

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

Cancer invasion and resistance: interconnected processes of disease progression and therapy failure

(2011) Stephanie Alexander et al.   TRENDS IN MOLECULAR MEDICINE

Adriamycin Nephropathy

(2010) Kaoru Yasuda et al.   AMERICAN JOURNAL OF PATHOLOGY

Mesenchymal stem cells rescue cardiomyoblasts from cell death in an in vitro ischemia model via direct cell-to-cell connections

(2010) Attila Cselenyák et al.   BMC CELL BIOLOGY

Tunneling-nanotube development in astrocytes depends on p53 activation

(2010) Y Wang et al.   CELL DEATH AND DIFFERENTIATION

The role of membrane vesicles in tumorigenesis

(2010) Erna Pap et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Cytoplasm and organelle transfer between mesenchymal multipotent stromal cells and renal tubular cells in co-culture

(2010) Egor Y. Plotnikov et al.   EXPERIMENTAL CELL RESEARCH

Expression of Ttyh1, a member of the Tweety family in neurons in vitro and in vivo and its potential role in brain pathology

(2010) Marzena Stefaniuk et al.   JOURNAL OF NEUROCHEMISTRY

KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer

(2010) Wendy De Roock et al.   LANCET ONCOLOGY

Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy

(2010) Sylvine Cottin et al.   Molecular Cancer

Animal cells connected by nanotubes can be electrically coupled through interposed gap-junction channels

(2010) X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial alkaloid staurosporine induces formation of nanometer-wide membrane tubular extensions (cytonemes, membrane tethers) in human neutrophils

(2010) Svetlana I. Galkina et al.   Cell Adhesion & Migration

Selective block of tunneling nanotube (TNT) formation inhibits intercellular organelle transfer between PC12 cells

(2009) Nickolay V. Bukoreshtliev et al.   FEBS LETTERS

Simultaneous Cell-to-Cell Transmission of Human Immunodeficiency Virus to Multiple Targets through Polysynapses

(2009) D. Rudnicka et al.   JOURNAL OF VIROLOGY

Prions hijack tunnelling nanotubes for intercellular spread

(2009) Karine Gousset et al.   NATURE CELL BIOLOGY

M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex

(2009) Koji Hase et al.   NATURE CELL BIOLOGY

HIV-1 evades virus-specific IgG2 and IgA responses by targeting systemic and intestinal B cells via long-range intercellular conduits

(2009) Weifeng Xu et al.   NATURE IMMUNOLOGY

The trip of the tip: understanding the growth cone machinery

(2009) Laura Anne Lowery et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Different Types of Cell-to-Cell Connections Mediated by Nanotubular Structures

(2008) Peter Veranič et al.   BIOPHYSICAL JOURNAL

Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: A potential mechanism for intercellular HIV trafficking

(2008) E.A. Eugenin et al.   CELLULAR IMMUNOLOGY

Tunneling nanotube (TNT)-like structures facilitate a constitutive, actomyosin-dependent exchange of endocytic organelles between normal rat kidney cells☆

(2008) Steffen Gurke et al.   EXPERIMENTAL CELL RESEARCH

Membrane nanotubes physically connect T cells over long distances presenting a novel route for HIV-1 transmission

(2008) Stefanie Sowinski et al.   NATURE CELL BIOLOGY

Membrane nanotubes: dynamic long-distance connections between animal cells

(2008) Daniel M. Davis et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cytonemes and tunneling nanotubules in cell–cell communication and viral pathogenesis

(2008) Nathan M. Sherer et al.   TRENDS IN CELL BIOLOGY

Micromanagers of malignancy: role of microRNAs in regulating metastasis

(2008) Li Ma et al.   TRENDS IN GENETICS