Imatinib-induced hepatotoxicity via oxidative stress and activation of NLRP3 inflammasome: an in vitro and in vivo study

Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

(2020) Kun Wang et al.   CELL

Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation

(2020) Liang Shi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Imatinib and Dasatinib Provoke Mitochondrial Dysfunction Leading to Oxidative Stress in C2C12 Myotubes and Human RD Cells

(2020) Jamal Bouitbir et al.   Frontiers in Pharmacology

Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells

(2020) Xuting Liu et al.   JOURNAL OF HAZARDOUS MATERIALS

Belinostat, at Its Clinically Relevant Concentrations, Inhibits Rifampicin Induced CYP3A4 and MDR1 Gene Expression

(2019) Kodye L Abbott et al.   MOLECULAR PHARMACOLOGY

Factors Influencing Imatinib-Induced Hepatotoxicity

(2019) Ji Min Han et al.   Cancer Research and Treatment

Inter-Individual Variation in CYP3A Activity Influences Lapatinib Bioactivation

(2019) Jennifer E. Bissada et al.   DRUG METABOLISM AND DISPOSITION

Carbamazepine promotes specific stimuli-induced NLRP3 inflammasome activation and causes idiosyncratic liver injury in mice

(2019) Zhilei Wang et al.   ARCHIVES OF TOXICOLOGY

Multitargeted kinase inhibitors imatinib, sorafenib and sunitinib perturb energy metabolism and cause cytotoxicity to cultured C2C12 skeletal muscle derived myotubes

(2018) Vijaya L. Damaraju et al.   BIOCHEMICAL PHARMACOLOGY

Critical role of NLRP3-caspase-1 pathway in age-dependent isoflurane-induced microglial inflammatory response and cognitive impairment

(2018) Zhi Wang et al.   Journal of Neuroinflammation

Dissecting the molecular pathophysiology of drug-induced liver injury

(2018) Hui Ye et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis

(2018) Xuyao Zhang et al.   Nanoscale

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Novel sulphur-containing imatinib metabolites found by untargeted LC-HRMS analysis

(2017) Ivo Vrobel et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure

(2017) Benjamin L. Woolbright et al.   JOURNAL OF HEPATOLOGY

Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia

(2017) Andreas Hochhaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hepatocellular Toxicity Associated with Tyrosine Kinase Inhibitors: Mitochondrial Damage and Inhibition of Glycolysis

(2017) Franziska Paech et al.   Frontiers in Pharmacology

How Reactive Metabolites Induce an Immune Response That Sometimes Leads to an Idiosyncratic Drug Reaction

(2016) Tiffany Cho et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Adjuvant Imatinib for High-Risk GI Stromal Tumor: Analysis of a Randomized Trial

(2016) Heikki Joensuu et al.   JOURNAL OF CLINICAL ONCOLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Clinical Relevance of Biomarkers of Oxidative Stress

(2015) Jeroen Frijhoff et al.   ANTIOXIDANTS & REDOX SIGNALING

Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways

(2015) Jack Rivers-Auty et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

Formation of reactive metabolites and management of tyrosine kinase inhibitor-induced hepatotoxicity: a literature review

(2014) Yi Ling Teo et al.   Expert Opinion on Drug Metabolism & Toxicology

NADPH oxidase- and mitochondria-derived reactive oxygen species in proinflammatory microglial activation: a bipartisan affair?

(2014) Evan A. Bordt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatotoxicity of Tyrosine Kinase Inhibitors: Clinical and Regulatory Perspectives

(2013) Rashmi R. Shah et al.   DRUG SAFETY

Mitochondria-targeted drugs enhance Nlrp3 inflammasome-dependent IL-1β secretion in association with alterations in cellular redox and energy status

(2013) Joshua Jabaut et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calpains, mitochondria, and apoptosis

(2012) M. A. Smith et al.   CARDIOVASCULAR RESEARCH

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Purinergic Receptor Antagonist A438079 Protects Against Acetaminophen-Induced Liver Injury by Inhibiting P450 Isoenzymes, Not by Inflammasome Activation

(2012) Yuchao Xie et al.   TOXICOLOGICAL SCIENCES

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Clinical pharmacokinetics of tyrosine kinase inhibitors

(2009) Nielka P. van Erp et al.   CANCER TREATMENT REVIEWS

Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome

(2009) Avlin B. Imaeda et al.   JOURNAL OF CLINICAL INVESTIGATION