Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis

Mitochondrial dysfunction, perturbations of mitochondrial dynamics and biogenesis involved in endothelial injury induced by silica nanoparticles

(2018) Caixia Guo et al.   ENVIRONMENTAL POLLUTION

The NLPR3 inflammasome and obesity-related kidney disease

(2017) Ben Ke et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tethering Interleukin-22 to Apolipoprotein A-I Ameliorates Mice from Acetaminophen-induced Liver Injury

(2017) Wei Chen et al.   Theranostics

Targeting CD47 and Autophagy Elicited Enhanced Antitumor Effects in Non–Small Cell Lung Cancer

(2017) Xuyao Zhang et al.   Cancer Immunology Research

Targeting TNFα Ameliorated Cationic PAMAM Dendrimer-Induced Hepatotoxicity via Regulating NLRP3 Inflammasomes Pathway

(2017) Yubin Li et al.   ACS Biomaterials-Science & Engineering

Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific

(2017) Nobuo Nishijima et al.   Frontiers in Immunology

Targeting TNFα Ameliorated Cationic PAMAM Dendrimer-Induced Hepatotoxicity via Regulating NLRP3 Inflammasomes Pathway

(2017) Yubin Li et al.   ACS Biomaterials Science & Engineering

CdSe/ZnS quantum dots induce hepatocyte pyroptosis and liver inflammation via NLRP3 inflammasome activation

(2016) Yonghui Lu et al.   BIOMATERIALS

Inhibition of autophagy overcomes the nanotoxicity elicited by cadmium-based quantum dots

(2016) Jiajun Fan et al.   BIOMATERIALS

Mesoporous silica nanoparticles with organo-bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery

(2016) Xin Du et al.   BIOMATERIALS

A Hyaluronidase-Responsive Nanoparticle-Based Drug Delivery System for Targeting Colon Cancer Cells

(2016) Mingzhen Zhang et al.   CANCER RESEARCH

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

(2016) Si Ming Man et al.   CELL

Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

(2016) Yuanhui Song et al.   International Journal of Nanomedicine

Ultrasmall nanoparticles induce ferroptosis in nutrient-deprived cancer cells and suppress tumour growth

(2016) Sung Eun Kim et al.   Nature Nanotechnology

Comparative in vivo toxicity assessment places multiwalled carbon nanotubes at a higher level than mesoporous silica nanoparticles

(2016) Nidhi Rawat et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Programmed packaging of mesoporous silica nanocarriers for matrix metalloprotease 2-triggered tumor targeting and release

(2015) Zhen Zou et al.   BIOMATERIALS

Caspase-1 but Not Caspase-11 Is Required for NLRC4-Mediated Pyroptosis and Restriction of Infection by FlagellatedLegionellaSpecies in Mouse Macrophages and In Vivo

(2015) Daiane M. Cerqueira et al.   JOURNAL OF IMMUNOLOGY

ROS-Mediated NLRP3 Inflammasome Activity Is Essential for Burn-Induced Acute Lung Injury

(2015) Shichao Han et al.   MEDIATORS OF INFLAMMATION

NADPH Oxidase-Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes

(2015) Bingbing Sun et al.   Small

Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells

(2015) Luisana Di Cristo et al.   TOXICOLOGICAL SCIENCES

Biodegradable and Renal Clearable Inorganic Nanoparticles

(2015) Emily B. Ehlerding et al.   Advanced Science

Large-Pore Ultrasmall Mesoporous Organosilica Nanoparticles: Micelle/Precursor Co-templating Assembly and Nuclear-Targeted Gene Delivery

(2014) Meiying Wu et al.   ADVANCED MATERIALS

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Biphase Stratification Approach to Three-Dimensional Dendritic Biodegradable Mesoporous Silica Nanospheres

(2014) Dengke Shen et al.   NANO LETTERS

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes

(2013) Changhui Fu et al.   BIOMATERIALS

Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock

(2013) Kairui Mao et al.   CELL RESEARCH

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

(2012) Alexandre Albanese et al.   Annual Review of Biomedical Engineering

Combinatorial Nanoparticles for Cancer Diagnosis and Therapy

(2012) A. Mukerjee et al.   CURRENT MEDICINAL CHEMISTRY

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Pathological mechanisms of liver injury caused by continuous intraperitoneal injection of silica nanoparticles

(2011) Tianlong Liu et al.   BIOMATERIALS

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers

(2011) Carlee E. Ashley et al.   NATURE MATERIALS

Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice

(2010) Tianlong Liu et al.   BIOMATERIALS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function

(2009) Xinglu Huang et al.   BIOMATERIALS

Cytotoxicity study of ordered mesoporous silica MCM-41 and SBA-15 microparticles on Caco-2 cells

(2009) Teemu Heikkilä et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A Mutation in the Nlrp3 Gene Causing Inflammasome Hyperactivation Potentiates Th17 Cell-Dominant Immune Responses

(2009) Guangxun Meng et al.   IMMUNITY

Changing the dose metric for inhalation toxicity studies: Short-term study in rats with engineered aerosolized amorphous silica nanoparticles

(2009) Christie M. Sayes et al.   INHALATION TOXICOLOGY

Biodegradable luminescent porous silicon nanoparticles for in vivo applications

(2009) Ji-Ho Park et al.   NATURE MATERIALS

Silica binding and toxicity in alveolar macrophages

(2007) Raymond F. Hamilton et al.   FREE RADICAL BIOLOGY AND MEDICINE