Carbamazepine promotes specific stimuli-induced NLRP3 inflammasome activation and causes idiosyncratic liver injury in mice

Cardamonin from a medicinal herb protects against LPS-induced septic shock by suppressing NLRP3 inflammasome

(2019) Zhilei Wang et al.   Acta Pharmaceutica Sinica B

The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes; Implications for Carbamazepine-induced Hypersensitivity Reactions

(2019) Ryuji Kato et al.   DRUG METABOLISM AND DISPOSITION

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

934 Carbamazepine-10,11-epoxide drives CD8+ T-cell skin trafficking through NLRP3 inflammasome upregulation and contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions

(2018) C. Zhang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

Drug-induced liver injury: a safety review

(2018) Miren García-Cortés et al.   Expert Opinion On Drug Safety

Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis

(2018) Xuyao Zhang et al.   Nanoscale

Drug-Induced Liver Injury: Highlights of the Recent Literature

(2018) Mark Real et al.   DRUG SAFETY

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study

(2017) Paola Nicoletti et al.   GASTROENTEROLOGY

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Neutrophils: a cornerstone of liver ischemia and reperfusion injury

(2017) Thiago Henrique Caldeira de Oliveira et al.   LABORATORY INVESTIGATION

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

(2017) Nan Song et al.   MOLECULAR CELL

Efficacy and safety of eslicarbazepine-acetate in elderly patients with focal epilepsy: Case series

(2017) A. Gómez-Ibáñez et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

How Reactive Metabolites Induce an Immune Response That Sometimes Leads to an Idiosyncratic Drug Reaction

(2016) Tiffany Cho et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2016) Herbert Tilg et al.   HEPATOLOGY

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

(2016) Letteria Minutoli et al.   Oxidative Medicine and Cellular Longevity

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

Drug-induced liver injury: an overview over the most critical compounds

(2015) Einar S. Björnsson   ARCHIVES OF TOXICOLOGY

The Combination of Anti-CTLA-4 and PD1–/– Mice Unmasks the Potential of Isoniazid and Nevirapine To Cause Liver Injury

(2015) Alastair Mak et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study

(2015) Naga Chalasani et al.   GASTROENTEROLOGY

Treatment of PD-1−/−mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients

(2015) Imir G. Metushi et al.   HEPATOLOGY

Heatstroke induces liver injury via IL-1β and HMGB1-induced pyroptosis

(2015) Yan Geng et al.   JOURNAL OF HEPATOLOGY

ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury

(2014) Naga P Chalasani et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Activation of Inflammasomes by Agents Causing Idiosyncratic Skin Reactions: A Possible Biomarker

(2014) J. Kyle Weston et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pathogenesis of Idiosyncratic Drug-Induced Liver Injury and Clinical Perspectives

(2014) Robert J. Fontana   GASTROENTEROLOGY

The role of oxidative stress during inflammatory processes

(2013) Jérôme Lugrin et al.   BIOLOGICAL CHEMISTRY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

Roles of the Hemostatic System and Neutrophils in Liver Injury From Co-exposure to Amiodarone and Lipopolysaccharide

(2013) Jingtao Lu et al.   TOXICOLOGICAL SCIENCES

Intravital Imaging of Neutrophil Recruitment in Hepatic Ischemia-Reperfusion Injury in Mice

(2013) Masaki Honda et al.   TRANSPLANTATION

Relationship Between theHLA-B*1502Allele and Carbamazepine-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

(2013) Wimonchat Tangamornsuksan et al.   JAMA Dermatology

Role of immune reactions in drug-induced liver injury (DILI)

(2012) Cynthia Ju et al.   DRUG METABOLISM REVIEWS

Sterile Inflammation in the Liver

(2012) Paul Kubes et al.   GASTROENTEROLOGY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxidized low-density lipoprotein and tissue factor are involved in monocrotaline/lipopolysaccharide-induced hepatotoxicity

(2011) Mohamed A. Hammad et al.   ARCHIVES OF TOXICOLOGY

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

(2011) Hartmut Jaeschke   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Risk Factors for Idiosyncratic Drug-Induced Liver Injury

(2010) Naga Chalasani et al.   GASTROENTEROLOGY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Mechanisms of Immune-Mediated Liver Injury

(2010) David H. Adams et al.   TOXICOLOGICAL SCIENCES

Coexposure of Mice to Trovafloxacin and Lipopolysaccharide, a Model of Idiosyncratic Hepatotoxicity, Results in a Unique Gene Expression Profile and Interferon Gamma–Dependent Liver Injury

(2008) Patrick J. Shaw et al.   TOXICOLOGICAL SCIENCES