Purinergic Receptor Antagonist A438079 Protects Against Acetaminophen-Induced Liver Injury by Inhibiting P450 Isoenzymes, Not by Inflammasome Activation
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Title
Purinergic Receptor Antagonist A438079 Protects Against Acetaminophen-Induced Liver Injury by Inhibiting P450 Isoenzymes, Not by Inflammasome Activation
Authors
Keywords
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Journal
TOXICOLOGICAL SCIENCES
Volume 131, Issue 1, Pages 325-335
Publisher
Oxford University Press (OUP)
Online
2012-09-18
DOI
10.1093/toxsci/kfs283
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Note: Only part of the references are listed.- P2X7 receptor-mediated purinergic signaling promotes liver injury in acetaminophen hepatotoxicity in mice
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- The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
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- (2010) Mitchell R. McGill et al. HEPATOLOGY
- Acetaminophen-induced hepatic neutrophil accumulation and inflammatory liver injury in CD18-deficient mice
- (2010) Clarence David Williams et al. LIVER INTERNATIONAL
- Role of caspase-1 and interleukin-1β in acetaminophen-induced hepatic inflammation and liver injury
- (2010) C. David Williams et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity
- (2010) Chieko Saito et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice
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- Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury
- (2008) Naoko Hanawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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