Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells

Chemical multi-fingerprinting of exogenous ultrafine particles in human serum and pleural effusion

(2020) Dawei Lu et al.   Nature Communications

Nanoparticles promote in vivo breast cancer cell intravasation and extravasation by inducing endothelial leakiness

(2019) Fei Peng et al.   Nature Nanotechnology

Regulation of TLR4 in silica-induced inflammation: An underlying mechanism of silicosis

(2018) Judy Yuet Wa Chan et al.   International Journal of Medical Sciences

Age-Dependent Rat Lung Deposition Patterns of Inhaled 20 Nanometer Gold Nanoparticles and their Quantitative Biokinetics in Adult Rats

(2018) Wolfgang G. Kreyling et al.   ACS Nano

Lung inflammation caused by inhaled toxicants: a review

(2016) John Wong et al.   International Journal of Chronic Obstructive Pulmonary Disease

Reduction of Acute Inflammatory Effects of Fumed Silica Nanoparticles in the Lung by Adjusting Silanol Display through Calcination and Metal Doping

(2015) Bingbing Sun et al.   ACS Nano

Industrial applications of nanoparticles

(2015) W. J. Stark et al.   CHEMICAL SOCIETY REVIEWS

Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

(2015) Andreas Wicki et al.   JOURNAL OF CONTROLLED RELEASE

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

(2015) Marina E Vance et al.   Beilstein Journal of Nanotechnology

Cigarette Smoke-Induced Pulmonary Inflammation Is TLR4/MyD88 and IL-1R1/MyD88 Signaling Dependent

(2014) E. Doz et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs

(2014) Paul M Peeters et al.   Particle and Fibre Toxicology

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-activated peroxisome proliferator-activated receptor-δ and -γ inhibit lipopolysaccharide-primed release of high mobility group box 1 through upregulation of SIRT1

(2014) J S Hwang et al.   Cell Death & Disease

Effect of zinc oxide nanomaterials-induced oxidative stress on the p53 pathway

(2013) Magdiel I. Setyawati et al.   BIOMATERIALS

Cardiovascular toxicity evaluation of silica nanoparticles in endothelial cells and zebrafish model

(2013) Junchao Duan et al.   BIOMATERIALS

Interlaboratory Evaluation of in Vitro Cytotoxicity and Inflammatory Responses to Engineered Nanomaterials: The NIEHS Nano GO Consortium

(2013) Tian Xia et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Silica induces NLRP3 inflammasome activation in human lung epithelial cells

(2013) Paul M Peeters et al.   Particle and Fibre Toxicology

Mesoporous silica nanoparticles in medicine—Recent advances

(2012) Veronika Mamaeva et al.   ADVANCED DRUG DELIVERY REVIEWS

Processing Pathway Dependence of Amorphous Silica Nanoparticle Toxicity: Colloidal vs Pyrolytic

(2012) Haiyuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

Aspect Ratio Determines the Quantity of Mesoporous Silica Nanoparticle Uptake by a Small GTPase-Dependent Macropinocytosis Mechanism

(2011) Huan Meng et al.   ACS Nano

The effect of particle size on the cytotoxicity, inflammation, developmental toxicity and genotoxicity of silver nanoparticles

(2011) Margriet V.D.Z. Park et al.   BIOMATERIALS

Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 and NF-κB pathways

(2010) Xin Liu et al.   BIOMATERIALS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Activation of the inflammasome by amorphous silica and TiO2nanoparticles in murine dendritic cells

(2010) Meike Winter et al.   Nanotoxicology

The nanosilica hazard: another variable entity

(2010) Dorota Napierska et al.   Particle and Fibre Toxicology

Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1  and IL-1 

(2010) A. S. Yazdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling

(2009) Patrick L Apopa et al.   Particle and Fibre Toxicology

Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)

(2008) Judy R. van Beijnum et al.   ANGIOGENESIS

Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro

(2008) Eun-Jung Park et al.   TOXICOLOGY LETTERS