Progress in mimicking brain microenvironments to understand and treat neurological disorders

Rapid 3D Bioprinting of Glioblastoma Model Mimicking Native Biophysical Heterogeneity

(2021) Min Tang et al.   Small

Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics

(2021) Yong Huang et al.   Communications Biology

Photolabile Linkers: Exploiting Labile Bond Chemistry to Control Mode and Rate of Hydrogel Degradation and Protein Release

(2020) Paige J. LeValley et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Long‐Living Bioengineered Neural Tissue Platform to Study Neurodegeneration

(2020) Nicolas Rouleau et al.   MACROMOLECULAR BIOSCIENCE

Angiomotin links ROCK and YAP signaling in mechanosensitive differentiation of neural stem cells

(2020) Phillip H. Kang et al.   MOLECULAR BIOLOGY OF THE CELL

Control of Astrocyte Quiescence and Activation in a Synthetic Brain Hydrogel

(2020) Sualyneth Galarza et al.   Advanced Healthcare Materials

Modeling Nanocarrier Transport across a 3D In Vitro Human Blood‐Brain–Barrier Microvasculature

(2020) Sharon Wei Ling Lee et al.   Advanced Healthcare Materials

Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips

(2020) Anna Herland et al.   Nature Biomedical Engineering

Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient

(2020) Pedro Rifes et al.   NATURE BIOTECHNOLOGY

Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions

(2020) Min Tang et al.   CELL RESEARCH

Thermofluidic heat exchangers for actuation of transcription in artificial tissues

(2020) Daniel C. Corbett et al.   Science Advances

Local Delivery of BDNF Enables Behavioural Recovery and Tissue Repair in Stroke-Injured Rats

(2019) Jaclyn M. Obermeyer et al.   TISSUE ENGINEERING PART A

Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesis

(2019) Michael R. Blatchley et al.   Science Advances

Hyaluronic Acid: Incorporating the Bio into the Material

(2019) Kayla J. Wolf et al.   ACS Biomaterials-Science & Engineering

Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

(2019) Hong-pyo Lee et al.   Nature Communications

Multifunctionalized hydrogels foster hNSC maturation in 3D cultures and neural regeneration in spinal cord injuries

(2019) Amanda Marchini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Catherine Owens Johnson et al.   LANCET NEUROLOGY

A bioprinted human-glioblastoma-on-a-chip for the identification of patient-specific responses to chemoradiotherapy

(2019) Hee-Gyeong Yi et al.   Nature Biomedical Engineering

Mimicking brain tumor-vasculature microanatomical architecture via co-culture of brain tumor and endothelial cells in 3D hydrogels

(2019) Christine Wang et al.   BIOMATERIALS

Varying PEG density to control stress relaxation in alginate-PEG hydrogels for 3D cell culture studies

(2019) Sungmin Nam et al.   BIOMATERIALS

Global, regional, and national burden of brain and other CNS cancer, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Anoop P Patel et al.   LANCET NEUROLOGY

Bioengineered scaffolds for 3D culture demonstrate extracellular matrix-mediated mechanisms of chemotherapy resistance in glioblastoma

(2019) Weikun Xiao et al.   MATRIX BIOLOGY

Bioactive site-specifically modified proteins for 4D patterning of gel biomaterials

(2019) Jared A. Shadish et al.   NATURE MATERIALS

Beyond Linear Elastic Modulus: Viscoelastic Models for Brain and Brain Mimetic Hydrogels

(2019) Mark A. Calhoun et al.   ACS Biomaterials-Science & Engineering

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex

(2019) Silvia Velasco et al.   NATURE

Engineered signaling centers for the spatially controlled patterning of human pluripotent stem cells

(2019) Andrea Manfrin et al.   NATURE METHODS

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

(2019) Tae-Eun Park et al.   Nature Communications

An on-chip model of protein paracellular and transcellular permeability in the microcirculation

(2019) Giovanni S. Offeddu et al.   BIOMATERIALS

Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease

(2019) Yoojin Shin et al.   Advanced Science

Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimens

(2019) Sara Pedron et al.   BIOMATERIALS

3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors

(2019) Disha Sood et al.   Nature Communications

Fate of nanoparticles in the central nervous system after intrathecal injection in healthy mice

(2019) K. T. Householder et al.   Scientific Reports

Functional maturation of human neural stem cells in a 3D bioengineered brain model enriched with fetal brain-derived matrix

(2019) Disha Sood et al.   Scientific Reports

Methods to measure, model and manipulate fluid flow in brain

(2019) Krishnashis Chatterjee et al.   JOURNAL OF NEUROSCIENCE METHODS

Response of neuroglia to hypoxia-induced oxidative stress using enzymatically crosslinked hydrogels

(2019) Samantha G. Zambuto et al.   MRS Communications

Perivascular signals alter global gene expression profile of glioblastoma and response to temozolomide in a gelatin hydrogel

(2018) Mai T. Ngo et al.   BIOMATERIALS

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis

(2018) Erin L Stephenson et al.   BRAIN

3D Culture Method for Alzheimer's Disease Modeling Reveals Interleukin-4 Rescues Aβ42-Induced Loss of Human Neural Stem Cell Plasticity

(2018) Christos Papadimitriou et al.   DEVELOPMENTAL CELL

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Estimating the global incidence of traumatic brain injury

(2018) Michael C. Dewan et al.   JOURNAL OF NEUROSURGERY

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke

(2018) Lina R. Nih et al.   NATURE MATERIALS

A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer’s disease

(2018) Joseph Park et al.   NATURE NEUROSCIENCE

Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models

(2018) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Generation of human vascularized brain organoids

(2018) Missy T. Pham et al.   NEUROREPORT

Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition

(2018) R. Marisol Herrera-Perez et al.   PLoS One

The mode and dynamics of glioblastoma cell invasion into a decellularized tissue-derived extracellular matrix-based three-dimensional tumor model

(2018) IlKyoo Koh et al.   Scientific Reports

Hypoxia activates enhanced invasive potential and endogenous hyaluronic acid production by glioblastoma cells

(2018) Jee-Wei Emily Chen et al.   Biomaterials Science

hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model

(2018) Maroof M. Adil et al.   Stem Cell Reports

A Reversible and Repeatable Thiol–Ene Bioconjugation for Dynamic Patterning of Signaling Proteins in Hydrogels

(2018) Joseph C. Grim et al.   ACS Central Science

Influence of Hyaluronic Acid Transitions in Tumor Microenvironment on Glioblastoma Malignancy and Invasive Behavior

(2018) Jee-Wei E. Chen et al.   Frontiers in Materials

Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons

(2018) Yoonhee Jin et al.   Nature Biomedical Engineering

Biodegradation of ECM hydrogel promotes endogenous brain tissue restoration in a rat model of stroke

(2018) Harmanvir Ghuman et al.   Acta Biomaterialia

A molecular atlas of cell types and zonation in the brain vasculature

(2018) Michael Vanlandewijck et al.   NATURE

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression

(2018) Xin Chen et al.   NEURON

Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons

(2018) Tatsuya Osaki et al.   Science Advances

An engineering design approach to systems biology

(2017) Kevin A. Janes et al.   Integrative Biology

Enhanced neuroprotection with decellularized brain extracellular matrix containing bFGF after intracerebral transplantation in Parkinson’s disease rat model

(2017) Qian Lin et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tau Pathology Promotes the Reorganization of the Extracellular Matrix and Inhibits the Formation of Perineuronal Nets by Regulating the Expression and the Distribution of Hyaluronic Acid Synthases

(2017) Yin Li et al.   JOURNAL OF ALZHEIMERS DISEASE

Tissue mechanics regulate brain development, homeostasis and disease

(2017) J. Matthew Barnes et al.   JOURNAL OF CELL SCIENCE

The Combined Influence of Hydrogel Stiffness and Matrix-Bound Hyaluronic Acid Content on Glioblastoma Invasion

(2017) Jee-Wei Emily Chen et al.   MACROMOLECULAR BIOSCIENCE

Hyaluronic acid-laminin hydrogels increase neural stem cell transplant retention and migratory response to SDF-1α

(2017) C.P. Addington et al.   MATRIX BIOLOGY

Chondroitin Sulfate Impairs Neural Stem Cell Migration Through ROCK Activation

(2017) Layla T. Galindo et al.   MOLECULAR NEUROBIOLOGY

Synthetic hydrogels for human intestinal organoid generation and colonic wound repair

(2017) Ricardo Cruz-Acuña et al.   NATURE CELL BIOLOGY

Maintenance of neural progenitor cell stemness in 3D hydrogels requires matrix remodelling

(2017) Christopher M. Madl et al.   NATURE MATERIALS

Mechanical confinement regulates cartilage matrix formation by chondrocytes

(2017) Hong-pyo Lee et al.   NATURE MATERIALS

The role of peripheral immune cells in the CNS in steady state and disease

(2017) Marco Prinz et al.   NATURE NEUROSCIENCE

O2-controllable hydrogels for studying cellular responses to hypoxic gradients in three dimensions in vitro and in vivo

(2017) Daniel M Lewis et al.   Nature Protocols

The use of brain organoids to investigate neural development and disease

(2017) Elizabeth Di Lullo et al.   NATURE REVIEWS NEUROSCIENCE

MR elastography of the brain and its application in neurological diseases

(2017) Matthew C. Murphy et al.   NEUROIMAGE

Extracellular Hyaluronic Acid Influences the Efficacy of EGFR Tyrosine Kinase Inhibitors in a Biomaterial Model of Glioblastoma

(2017) Sara Pedron et al.   Advanced Healthcare Materials

The Influence of Hyaluronic Acid and Glioblastoma Cell Coculture on the Formation of Endothelial Cell Networks in Gelatin Hydrogels

(2017) Mai T. Ngo et al.   Advanced Healthcare Materials

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

(2017) Spyros Darmanis et al.   Cell Reports

A 3-Dimensional Hydrogel Model of Multiple Sclerosis Brain Lesions Reveals Insights into Re-Myelination

(2017) Shivani Baisiwala et al.   Journal of Biomaterials and Tissue Engineering

Reducing Astrocytic Scarring after Traumatic Brain Injury with a Multifaceted Anti-Inflammatory Hydrogel System

(2017) Francesca L. Maclean et al.   ACS Biomaterials-Science & Engineering

Reducing Astrocytic Scarring after Traumatic Brain Injury with a Multifaceted Anti-Inflammatory Hydrogel System

(2017) Francesca L. Maclean et al.   ACS Biomaterials Science & Engineering

Biomimetic Strategies for the Glioblastoma Microenvironment

(2017) Junghwa Cha et al.   Frontiers in Materials

3D-printed vascular networks direct therapeutic angiogenesis in ischaemia

(2017) T. Mirabella et al.   Nature Biomedical Engineering

Encapsulation of primary dopaminergic neurons in a GDNF-loaded collagen hydrogel increases their survival, re-innervation and function after intra-striatal transplantation

(2017) Niamh Moriarty et al.   Scientific Reports

Brain stiffness increases with myelin content

(2016) J. Weickenmeier et al.   Acta Biomaterialia

Systematic optimization of an engineered hydrogel allows for selective control of human neural stem cell survival and differentiation after transplantation in the stroke brain

(2016) Pouria Moshayedi et al.   BIOMATERIALS

Functionalized composite scaffolds improve the engraftment of transplanted dopaminergic progenitors in a mouse model of Parkinson's disease

(2016) Ting-Yi Wang et al.   BIOMATERIALS

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

High throughput screening for discovery of materials that control stem cell fate

(2016) Asha K. Patel et al.   CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE

Dishing out mini-brains: Current progress and future prospects in brain organoid research

(2016) Iva Kelava et al.   DEVELOPMENTAL BIOLOGY

Gradually softening hydrogels for modeling hepatic stellate cell behavior during fibrosis regression

(2016) Steven R. Caliari et al.   Integrative Biology

Interstitial flow differentially increases patient-derived glioblastoma stem cell invasion via CXCR4, CXCL12, and CD44-mediated mechanisms

(2016) Kathryn M. Kingsmore et al.   Integrative Biology

Integrin-mediated mechanotransduction

(2016) Zhiqi Sun et al.   JOURNAL OF CELL BIOLOGY

Hydrogel-delivered brain-derived neurotrophic factor promotes tissue repair and recovery after stroke

(2016) Douglas J Cook et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

Mechanosensing is critical for axon growth in the developing brain

(2016) David E Koser et al.   NATURE NEUROSCIENCE

Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects caused by MeCP2 dysfunction

(2016) Zhen-Ning Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural tube morphogenesis in synthetic 3D microenvironments

(2016) Adrian Ranga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional bioprinting of thick vascularized tissues

(2016) David B. Kolesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors

(2016) Zeinab Chitforoushzadeh et al.   Science Signaling

Mechanotransduction of Neural Cells Through Cell–Substrate Interactions

(2016) Jessica M. Stukel et al.   TISSUE ENGINEERING PART B-REVIEWS

Glioma cell invasion is significantly enhanced in composite hydrogel matrices composed of chondroitin 4- and 4,6-sulfated glycosaminoglycans

(2016) Meghan T. Logun et al.   Journal of Materials Chemistry B

Three dimensional conjugation of recombinant N-cadherin to a hydrogel for in vitro anisotropic neural growth

(2016) Johana C. M. Vega L. et al.   Journal of Materials Chemistry B

Oxygen delivering biomaterials for tissue engineering

(2016) Ashley L. Farris et al.   Journal of Materials Chemistry B

TNF-insulin crosstalk at the transcription factor GATA6 is revealed by a model that links signaling and transcriptomic data tensors

(2016) Zeinab Chitforoushzadeh et al.   Science Signaling

Regional brain stiffness changes across the Alzheimer's disease spectrum

(2016) Matthew C. Murphy et al.   NeuroImage-Clinical

Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

(2016) Anna Herland et al.   PLoS One

Enhancing neural stem cell response to SDF-1α gradients through hyaluronic acid-laminin hydrogels

(2015) C.P. Addington et al.   BIOMATERIALS

3D culture of murine neural stem cells on decellularized mouse brain sections

(2015) Jorrit De Waele et al.   BIOMATERIALS

Human astrocytes develop physiological morphology and remain quiescent in a novel 3D matrix

(2015) Amanda L. Placone et al.   BIOMATERIALS

The use of covalently immobilized stem cell factor to selectively affect hematopoietic stem cell activity within a gelatin hydrogel

(2015) Bhushan P. Mahadik et al.   BIOMATERIALS

Self healing hydrogels composed of amyloid nano fibrils for cell culture and stem cell differentiation

(2015) Reeba S. Jacob et al.   BIOMATERIALS

Cell-to-Cell Transcript Variability: Seeing Signal in the Noise

(2015) Kevin A. Janes   CELL

Adult Neural Stem Cells from the Subventricular Zone Give Rise to Reactive Astrocytes in the Cortex after Stroke

(2015) Maryam Faiz et al.   Cell Stem Cell

Involvement of platelet-derived growth factor receptor β in fibrosis through extracellular matrix protein production after ischemic stroke

(2015) Noriko Makihara et al.   EXPERIMENTAL NEUROLOGY

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Mechanical properties of gray and white matter brain tissue by indentation

(2015) Silvia Budday et al.   Journal of the Mechanical Behavior of Biomedical Materials

Designing Cell-Type-Specific Genome-wide Experiments

(2015) Ava Handley et al.   MOLECULAR CELL

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Measuring the effects of aging and sex on regional brain stiffness with MR elastography in healthy older adults

(2015) Arvin Arani et al.   NEUROIMAGE

Traumatic Brain Injury and the Neuronal Microenvironment: A Potential Role for Neuropathological Mechanotransduction

(2015) Matthew A. Hemphill et al.   NEURON

A survey of human brain transcriptome diversity at the single cell level

(2015) Spyros Darmanis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human pluripotent stem cell-derived neural constructs for predicting neural toxicity

(2015) Michael P. Schwartz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner

(2015) Janahan Arulmoli et al.   Scientific Reports

The Powerful Functions of Peptide-Based Bioactive Matrices for Regenerative Medicine

(2014) Charles M. Rubert Pérez et al.   ANNALS OF BIOMEDICAL ENGINEERING

Bioengineered Scaffolds for 3D Analysis of Glioblastoma Proliferation and Invasion

(2014) John M. Heffernan et al.   ANNALS OF BIOMEDICAL ENGINEERING

Proliferation and enrichment of CD133+ glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds

(2014) Forrest M. Kievit et al.   BIOMATERIALS

ECM stiffness regulates glial migration in Drosophila and mammalian glioma models

(2014) S. N. Kim et al.   DEVELOPMENT

Generation of 3D functional microvascular networks with human mesenchymal stem cells in microfluidic systems

(2014) Jessie S. Jeon et al.   Integrative Biology

Cell-specific Labeling Enzymes for Analysis of Cell–Cell Communication in Continuous Co-culture

(2014) Christopher J. Tape et al.   MOLECULAR & CELLULAR PROTEOMICS

CD44-Mediated Adhesion to Hyaluronic Acid Contributes to Mechanosensing and Invasive Motility

(2014) Yushan Kim et al.   MOLECULAR CANCER RESEARCH

Bioengineered 3D Brain Tumor Model To Elucidate the Effects of Matrix Stiffness on Glioblastoma Cell Behavior Using PEG-Based Hydrogels

(2014) Christine Wang et al.   MOLECULAR PHARMACEUTICS

Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres

(2014) Anjana Jain et al.   NATURE MATERIALS

Reactive Gliosis and the Multicellular Response to CNS Damage and Disease

(2014) Joshua E. Burda et al.   NEURON

Single-cell RNA-seq: advances and future challenges

(2014) Antoine-Emmanuel Saliba et al.   NUCLEIC ACIDS RESEARCH

Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

(2014) Jessie S. Jeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Perlecan is required for FGF-2 signaling in the neural stem cell niche

(2014) Aurelien Kerever et al.   Stem Cell Research

Towards efficient cancer immunotherapy: advances in developing artificial antigen-presenting cells

(2014) Loek J. Eggermont et al.   TRENDS IN BIOTECHNOLOGY

Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress

(2014) A Suttkus et al.   Cell Death & Disease

3D niche microarrays for systems-level analyses of cell fate

(2014) A. Ranga et al.   Nature Communications

Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity

(2014) Yao Yao et al.   Nature Communications

Effects of GDNF-Loaded Injectable Gelatin-Based Hydrogels on Endogenous Neural Progenitor Cell Migration

(2014) Deniece Fon et al.   Advanced Healthcare Materials

Tenascin-C Causes Neuronal Apoptosis After Subarachnoid Hemorrhage in Rats

(2014) Masato Shiba et al.   Translational Stroke Research

Glioblastoma Behaviors in Three-Dimensional Collagen-Hyaluronan Composite Hydrogels

(2013) Shreyas S. Rao et al.   ACS Applied Materials & Interfaces

Self-assembly of short peptides to form hydrogels: Design of building blocks, physical properties and technological applications

(2013) Galit Fichman et al.   Acta Biomaterialia

Mimicking white matter tract topography using core–shell electrospun nanofibers to examine migration of malignant brain tumors

(2013) Shreyas S. Rao et al.   BIOMATERIALS

Regulation of glioma cell phenotype in 3D matrices by hyaluronic acid

(2013) Sara Pedron et al.   BIOMATERIALS

A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons

(2013) Dawei Zhang et al.   BIOMATERIALS

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

(2013) Joel C. Sunshine et al.   BIOMATERIALS

Fibronectin aggregation in multiple sclerosis lesions impairs remyelination

(2013) Josephine M. J. Stoffels et al.   BRAIN

Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination

(2013) Su Wang et al.   Cell Stem Cell

Cadherin mechanotransduction in tissue remodeling

(2013) Floor Twiss et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cancer cell glycocalyx mediates mechanotransduction and flow-regulated invasion

(2013) Henry Qazi et al.   Integrative Biology

Impact of the biophysical features of a 3D gelatin microenvironment on glioblastoma malignancy

(2013) S. Pedron et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Tenascin-C deficiency ameliorates Alzheimer's disease-related pathology in mice

(2013) Kan Xie et al.   NEUROBIOLOGY OF AGING

MR elastography in a murine stroke model reveals correlation of macroscopic viscoelastic properties of the brain with neuronal density

(2013) Florian Baptist Freimann et al.   NMR IN BIOMEDICINE

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Microfluidic Generation of Gradient Hydrogels to Modulate Hematopoietic Stem Cell Culture Environment

(2013) Bhushan P. Mahadik et al.   Advanced Healthcare Materials

Long-term three-dimensional neural tissue cultures in functionalized self-assembling peptide hydrogels, Matrigel and Collagen I

(2012) Sotirios Koutsopoulos et al.   Acta Biomaterialia

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior

(2012) Brooke N. Mason et al.   Acta Biomaterialia

Chondroitin sulfate proteoglycans in demyelinated lesions impair remyelination

(2012) Lorraine W. Lau et al.   ANNALS OF NEUROLOGY

Fibronectin supports neurite outgrowth and axonal regeneration of adult brain neurons in vitro

(2012) David A. Tonge et al.   BRAIN RESEARCH

Microenvironment changes in mild traumatic brain injury

(2012) Enci Mary Kan et al.   BRAIN RESEARCH BULLETIN

Interstitial Flow in a 3D Microenvironment Increases Glioma Invasion by a CXCR4-Dependent Mechanism

(2012) J. M. Munson et al.   CANCER RESEARCH

Light-controlled synthetic gene circuits

(2012) Laura Gardner et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Engineering an in situ crosslinkable hydrogel for enhanced remyelination

(2012) Xiaowei Li et al.   FASEB JOURNAL

Chemotactic recruitment of adult neural progenitor cells into multifunctional hydrogels providing sustained SDF-1α release and compatible structural support

(2012) Teck Chuan Lim et al.   FASEB JOURNAL

Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease

(2012) Azeb Tadesse Argaw et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

(2012) Jordan S. Miller et al.   NATURE MATERIALS

The mechanobiology of brain function

(2012) William J. Tyler   NATURE REVIEWS NEUROSCIENCE

Brain Viscoelasticity Alteration in Chronic-Progressive Multiple Sclerosis

(2012) Kaspar-Josche Streitberger et al.   PLoS One

Demyelination reduces brain parenchymal stiffness quantified in vivo by magnetic resonance elastography

(2012) K. Schregel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stiffening hydrogels to probe short- and long-term cellular responses to dynamic mechanics

(2012) Murat Guvendiren et al.   Nature Communications

Enhanced proliferation of neural stem cells in a collagen hydrogel incorporating engineered epidermal growth factor

(2011) Edgar Y. Egawa et al.   BIOMATERIALS

Elucidating the mechanobiology of malignant brain tumors using a brain matrix-mimetic hyaluronic acid hydrogel platform

(2011) Badriprasad Ananthanarayanan et al.   BIOMATERIALS

Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

(2011) Janel E. Le Belle et al.   Cell Stem Cell

Self-assembling peptide scaffolds for regenerative medicine

(2011) John B. Matson et al.   CHEMICAL COMMUNICATIONS

Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke

(2011) Kim M. Baeten et al.   Developmental Neurobiology

Extracellular matrix and perineuronal nets in CNS repair

(2011) Jessica C.F. Kwok et al.   Developmental Neurobiology

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

(2011) P. P. Provenzano et al.   JOURNAL OF CELL SCIENCE

Decreased brain stiffness in Alzheimer's disease determined by magnetic resonance elastography

(2011) Matthew C. Murphy et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Microscopic magnetic resonance elastography of traumatic brain injury model

(2011) Thomas Boulet et al.   JOURNAL OF NEUROSCIENCE METHODS

Defining and designing polymers and hydrogels for neural tissue engineering

(2011) Emily R. Aurand et al.   NEUROSCIENCE RESEARCH

Specific Glycosaminoglycans Modulate Neural Specification of Mouse Embryonic Stem Cells

(2011) Claire E. Pickford et al.   STEM CELLS

Rho GTPases Mediate the Mechanosensitive Lineage Commitment of Neural Stem Cells

(2011) Albert J. Keung et al.   STEM CELLS

Decellularized Porcine Brain Matrix for Cell Culture and Tissue Engineering Scaffolds

(2011) Jessica A. DeQuach et al.   TISSUE ENGINEERING PART A

The effects of hyaluronic acid hydrogels with tunable mechanical properties on neural progenitor cell differentiation

(2010) Stephanie K. Seidlits et al.   BIOMATERIALS

Differentiation of neural stem cells in three-dimensional growth factor-immobilized chitosan hydrogel scaffolds

(2010) Nic D. Leipzig et al.   BIOMATERIALS

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

(2010) Malgorzata Zawadzka et al.   Cell Stem Cell

Cortical Neural Precursors Inhibit Their Own Differentiation via N-Cadherin Maintenance of β-Catenin Signaling

(2010) Jianing Zhang et al.   DEVELOPMENTAL CELL

CSPG Is a Secreted Factor that Stimulates Neural Stem Cell Survival Possibly by Enhanced EGFR Signaling

(2010) Muly Tham et al.   PLoS One

Matrigel: A complex protein mixture required for optimal growth of cell culture

(2010) Chris S. Hughes et al.   PROTEOMICS

Impact of Degradable Macromer Content in a Poly(Ethylene Glycol) Hydrogel on Neural Cell Metabolic Activity, Redox State, Proliferation, and Differentiation

(2010) Kyle J. Lampe et al.   TISSUE ENGINEERING PART A

Modulating the Gelation Properties of Self-Assembling Peptide Amphiphiles

(2009) Joel M. Anderson et al.   ACS Nano

Hypoxia and Neurodegeneration

(2009) Chris Peers et al.   Annals of the New York Academy of Sciences

Self-Assembly of Multidomain Peptides: Sequence Variation Allows Control over Cross-Linking and Viscoelasticity

(2009) Lorenzo Aulisa et al.   BIOMACROMOLECULES

The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells

(2009) Akhilesh Banerjee et al.   BIOMATERIALS

The role and regulation of hypoxia-inducible factor-1α expression in brain development and neonatal hypoxic–ischemic brain injury

(2009) Xiyong Fan et al.   BRAIN RESEARCH REVIEWS

The Mechanical Rigidity of the Extracellular Matrix Regulates the Structure, Motility, and Proliferation of Glioma Cells

(2009) T. A. Ulrich et al.   CANCER RESEARCH

Imaging glioma cell invasionin vivoreveals mechanisms of dissemination and peritumoral angiogenesis

(2009) Frank Winkler et al.   GLIA

Age-Dependent Regional Mechanical Properties of the Rat Hippocampus and Cortex

(2009) Benjamin S. Elkin   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

The role of oxygen in regulating neural stem cells in development and disease

(2009) David M. Panchision   JOURNAL OF CELLULAR PHYSIOLOGY

E-Cadherin Regulates Neural Stem Cell Self-Renewal

(2009) P. Karpowicz et al.   JOURNAL OF NEUROSCIENCE

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

Biomaterials for promoting brain protection, repair and regeneration

(2009) Gorka Orive et al.   NATURE REVIEWS NEUROSCIENCE

The impact of aging and gender on brain viscoelasticity

(2009) Ingolf Sack et al.   NEUROIMAGE

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

Laminin enhances the growth of human neural stem cells in defined culture media

(2008) Peter E Hall et al.   BMC NEUROSCIENCE

Brain Extracellular Matrix in Neurodegeneration

(2008) Dafna Bonneh-Barkay et al.   BRAIN PATHOLOGY

A Specialized Vascular Niche for Adult Neural Stem Cells

(2008) Masoud Tavazoie et al.   Cell Stem Cell

β 1 Integrin-mediated Effects of Tenascin-R Domains EGFL and FN6-8 on Neural Stem/Progenitor Cell Proliferation and Differentiationin Vitro

(2008) Hong Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Proteoglycan Brevican Binds to Fibronectin after Proteolytic Cleavage and Promotes Glioma Cell Motility

(2008) Bin Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chondroitin-4-sulfation negatively regulates axonal guidance and growth

(2008) H. Wang et al.   JOURNAL OF CELL SCIENCE

Non-invasive measurement of brain viscoelasticity using magnetic resonance elastography

(2007) Ingolf Sack et al.   NMR IN BIOMEDICINE