Journal
MRS COMMUNICATIONS
Volume 10, Issue 1, Pages 83-90Publisher
SPRINGER HEIDELBERG
DOI: 10.1557/mrc.2019.159
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Funding
- Scott H. Fisher IGB Graduate Student Research Fund
- National Cancer Institute of the National Institutes of Health (NIH) [R01 CA197488]
- National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health [R01 DK099528]
- Chemical Transformations Initiative at Pacific Northwest National Laboratory (PNNL) under the Laboratory Directed Research and Development Program at PNNL, a multiprogram national laboratory
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Three-dimensional cultures have exciting potential to mimic aspects of healthy and diseased brain tissue to examine the role of physiological conditions on neural biomarkers, as well as disease onset and progression. Hypoxia is associated with oxidative stress, mitochondrial damage, and inflammation, key processes potentially involved in Alzheimer's and multiple sclerosis. We describe the use of an enzymatically-crosslinkable gelatin hydrogel system within a microfluidic device to explore the effects of hypoxia-induced oxidative stress on rat neuroglia, human astrocyte reactivity, and myelin production. This versatile platform offers new possibilities for drug discovery and modeling disease progression.
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