Journal
CURRENT OPINION IN SOLID STATE & MATERIALS SCIENCE
Volume 20, Issue 4, Pages 202-211Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cossms.2016.02.002
Keywords
Stem cells; Differentiation; Biomaterials; High throughput screening; 3D
Funding
- Engineering and Physical Sciences Research Council (EPSRC) [EP/I017801/1, EP/H045384/1]
- National Institutes of Health (NIH) through a Ruth L. Kirschstein National Research Service Award [F32HL122009]
- European Commission under FP7 IOF project Stem Cell Hydrogels [629320]
- Wellcome Trust
- Royal Society
- NIH [R01 DE016516]
- Biotechnology and Biological Sciences Research Council [BBS/B/06164, BB/G021821/1, BB/E006159/1] Funding Source: researchfish
- British Heart Foundation [PG/09/027/27141] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/N006615/1, EP/H045384/1, EP/I017801/1] Funding Source: researchfish
- Heart Research UK [RG2616] Funding Source: researchfish
- Medical Research Council [G113/30, G0801098, MR/M017354/1] Funding Source: researchfish
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [NC/K000225/1, NC/C013202/1, NC/C013105/1] Funding Source: researchfish
- BBSRC [BB/E006159/1, BB/G021821/1] Funding Source: UKRI
- EPSRC [EP/H045384/1, EP/N006615/1, EP/I017801/1] Funding Source: UKRI
- MRC [MR/M017354/1, G0801098, G113/30] Funding Source: UKRI
Ask authors/readers for more resources
Insights into the complex stem cell niche have identified the cell material interface to be a potent regulator of stem cell fate via material properties such as chemistry, topography and stiffness. In light of this, materials scientists have the opportunity to develop bioactive materials for stem cell culture that elicit specific cellular responses. To accelerate materials discovery, high throughput screening platforms have been designed which can rapidly evaluate combinatorial material libraries in two and three-dimensional environments. In this review, we present screening platforms for the discovery of material properties that influence stem cell behavior. (C) 2016 The Authors. Published by Elsevier Ltd.
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