Modeling Nanocarrier Transport across a 3D In Vitro Human Blood‐Brain–Barrier Microvasculature

An on-chip model of protein paracellular and transcellular permeability in the microcirculation

(2019) Giovanni S. Offeddu et al.   BIOMATERIALS

The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model

(2018) A. Boussommier-Calleja et al.   BIOMATERIALS

3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes

(2018) Marco Campisi et al.   BIOMATERIALS

In vitro models of molecular and nano-particle transport across the blood-brain barrier

(2018) Cynthia Hajal et al.   Biomicrofluidics

Blood–brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders

(2018) Melanie D. Sweeney et al.   Nature Reviews Neurology

Brain Metastases

(2018) Ayal A. Aizer et al.   NEUROLOGIC CLINICS

Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation

(2018) Michelle B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel human induced pluripotent stem cell blood-brain barrier model: Applicability to study antibody-triggered receptor-mediated transcytosis

(2018) Maria Ribecco-Lutkiewicz et al.   Scientific Reports

Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends

(2018) Hira Choudhury et al.   Drug Delivery and Translational Research

Characterizing the Role of Monocytes in T Cell Cancer Immunotherapy Using a 3D Microfluidic Model

(2018) Sharon Wei Ling Lee et al.   Frontiers in Immunology

Alternating block copolymer-based nanoparticles as tools to modulate the loading of multiple chemotherapeutics and imaging probes

(2018) C. Mattu et al.   Acta Biomaterialia

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

(2018) Amir R. Aref et al.   LAB ON A CHIP

Genetic and transcriptional evolution alters cancer cell line drug response

(2018) Uri Ben-David et al.   NATURE

A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells

(2018) Ben M Maoz et al.   NATURE BIOTECHNOLOGY

Analysis of the trafficking system in blood-brain barrier models by high content screening microscopy

(2018) MortenS Nielsen et al.   Neural Regeneration Research

Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System

(2017) Francesco Barbero et al.   SEMINARS IN IMMUNOLOGY

In Vitro Microfluidic Models for Neurodegenerative Disorders

(2017) Tatsuya Osaki et al.   Advanced Healthcare Materials

Ror2 signaling regulates Golgi structure and transport through IFT20 for tumor invasiveness

(2017) Michiru Nishita et al.   Scientific Reports

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

(2017) Kasper Bendix Johnsen et al.   Scientific Reports

CSF, blood-brain barrier, and brain drug delivery

(2016) William M. Pardridge   Expert Opinion on Drug Delivery

Regulation of podocalyxin trafficking by Rab small GTPases in 2D and 3D epithelial cell cultures

(2016) Paulina S. Mrozowska et al.   JOURNAL OF CELL BIOLOGY

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

(2016) Cláudia Saraiva et al.   JOURNAL OF CONTROLLED RELEASE

Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery

(2016) S. Aday et al.   TRENDS IN BIOTECHNOLOGY

Progress and perspectives on targeting nanoparticles for brain drug delivery

(2016) Huile Gao   Acta Pharmaceutica Sinica B

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Increased brain uptake of targeted nanoparticles by adding an acid-cleavable linkage between transferrin and the nanoparticle core

(2015) Andrew J. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of nanoparticle size on the probability to cross the blood-brain barrier: an in-vitro endothelial cell model

(2015) Malka Shilo et al.   JOURNAL OF NANOBIOTECHNOLOGY

A Multifunctional Polymeric Nanotheranostic System Delivers Doxorubicin and Imaging Agents across the Blood–Brain Barrier Targeting Brain Metastases of Breast Cancer

(2014) Jason Li et al.   ACS Nano

Increased Brain Penetration and Potency of a Therapeutic Antibody Using a Monovalent Molecular Shuttle

(2014) Jens Niewoehner et al.   NEURON

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Design of pH-responsive nanoparticles of terpolymer of poly(methacrylic acid), polysorbate 80 and starch for delivery of doxorubicin

(2012) Alireza Shalviri et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Screening therapeutic EMT blocking agents in a three-dimensional microenvironment

(2012) Amir R. Aref et al.   Integrative Biology

Nanoparticles for imaging and treating brain cancer

(2012) Joseph D Meyers et al.   Nanomedicine

Transferrin Coated Nanoparticles: Study of the Bionano Interface in Human Plasma

(2012) Andrzej S. Pitek et al.   PLoS One

Modern methods for delivery of drugs across the blood–brain barrier

(2011) Yan Chen et al.   ADVANCED DRUG DELIVERY REVIEWS

The role of shear stress in Blood-Brain Barrier endothelial physiology

(2011) Luca Cucullo et al.   BMC NEUROSCIENCE

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

(2011) Yasuo Uchida et al.   JOURNAL OF NEUROCHEMISTRY

Soft Interactions at Nanoparticles Alter Protein Function and Conformation in a Size Dependent Manner

(2011) Jing Wang et al.   NANO LETTERS

Distinct Polymer Architecture Mediates Switching of Complement Activation Pathways at the Nanosphere−Serum Interface: Implications for Stealth Nanoparticle Engineering

(2010) Islam Hamad et al.   ACS Nano

Transferrin-conjugated nanoparticles of Poly(lactide)-d-α-Tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood–brain barrier

(2010) Chee Wee Gan et al.   BIOMATERIALS

Lactoferrin-modified procationic liposomes as a novel drug carrier for brain delivery

(2010) Huali Chen et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1

(2010) M. Tabuchi et al.   JOURNAL OF CELL SCIENCE

Angiopep-2 modified PE-PEG based polymeric micelles for amphotericin B delivery targeted to the brain

(2010) Kun Shao et al.   JOURNAL OF CONTROLLED RELEASE

Pericytes regulate the blood–brain barrier

(2010) Annika Armulik et al.   NATURE

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Intravaginal gene silencing using biodegradable polymer nanoparticles densely loaded with small-interfering RNA

(2009) Kim A. Woodrow et al.   NATURE MATERIALS

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE