The Yin and Yang of Type I IFNs in Cancer Promotion and Immune Activation

Loss of type I IFN responsiveness impairs natural killer cell antitumor activity in breast cancer

(2021) Damien J. Zanker et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

(2021) Gwenola Manic et al.   CELL DEATH AND DIFFERENTIATION

Type I interferon activating type I dendritic cells for anti-tumor immunity

(2021) Yong Liang et al.   CLINICAL CANCER RESEARCH

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

(2021) Adele De Ninno et al.   Jove-Journal of Visualized Experiments

Clinical and Immunological Outcomes in High-Risk Resected Melanoma Patients Receiving Peptide-Based Vaccination and Interferon Alpha, With or Without Dacarbazine Preconditioning: A Phase II Study

(2020) Francesca Urbani et al.   Frontiers in Oncology

Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation

(2020) Xiaoyan Zhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

(2020) Lorenzo Galluzzi et al.   Journal for ImmunoTherapy of Cancer

Type I Interferons in the Pathogenesis and Treatment of Autoimmune Diseases

(2020) Jiao Jiang et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The pros and cons of interferons for oncolytic virotherapy

(2020) Karen Geoffroy et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Tuning Cancer Fate: Tumor Microenvironment's Role in Cancer Stem Cell Quiescence and Reawakening

(2020) Antonella Sistigu et al.   Frontiers in Immunology

Opposing Roles of Type I Interferons in Cancer Immunity

(2020) Giselle M. Boukhaled et al.   Annual Review of Pathology-Mechanisms of Disease

Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling Pathways

(2020) Candice Mazewski et al.   Frontiers in Immunology

Cancer Stem Cells: The Architects of the Tumor Ecosystem

(2019) Briana C. Prager et al.   Cell Stem Cell

Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

(2019) Imran Siddiqui et al.   IMMUNITY

Interferons α and β in cancer: therapeutic opportunities from new insights

(2019) Ernest C. Borden   NATURE REVIEWS DRUG DISCOVERY

Cell cycle arrest in mitosis promotes interferon-induced necroptosis

(2019) Tanja Frank et al.   CELL DEATH AND DIFFERENTIATION

Type I interferon signaling, regulation and gene stimulation in chronic virus infection

(2019) Sabelo Lukhele et al.   SEMINARS IN IMMUNOLOGY

Inhibiting of Proliferation, Migration, and Invasion in Lung Cancer Induced by Silencing Interferon-Induced Transmembrane Protein 1 (IFITM1)

(2019) Jun Yan et al.   Biomed Research International

A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription

(2019) Ekaterini Platanitis et al.   Nature Communications

Interferon Signaling is Diminished with Age and is Associated with Immune Checkpoint Blockade Efficacy in Triple-Negative Breast Cancer

(2019) Jaclyn Sceneay et al.   Cancer Discovery

Interferon-Stimulated Genes: What Do They All Do?

(2019) John W. Schoggins   Annual Review of Virology

Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

(2019) Chunwan Lu et al.   Journal for ImmunoTherapy of Cancer

Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

(2019) Joseph L. Benci et al.   CELL

Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade

(2019) Nicolas Jacquelot et al.   CELL RESEARCH

STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade

(2019) Hannah Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Damage-associated molecular patterns in trauma

(2019) Borna Relja et al.   European Journal of Trauma and Emergency Surgery

Interferon target-gene expression and epigenomic signatures in health and disease

(2019) Franck J. Barrat et al.   NATURE IMMUNOLOGY

Regulation of interferon stimulated gene expression levels at homeostasis

(2019) Sivan Leviyang et al.   CYTOKINE

Type I Interferons and Cancer: An Evolving Story Demanding Novel Clinical Applications

(2019) Eleonora Aricò et al.   Cancers

Mechanisms of resistance to immune checkpoint inhibitors

(2018) Russell W Jenkins et al.   BRITISH JOURNAL OF CANCER

Cytosolic DNA Sensing in Organismal Tumor Control

(2018) Claire Vanpouille-Box et al.   CANCER CELL

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Disruption of IFN-I Signaling Promotes HER2/Neu Tumor Progression and Breast Cancer Stem Cells

(2018) Luciano Castiello et al.   Cancer Immunology Research

Detection of Microbial Infections Through Innate Immune Sensing of Nucleic Acids

(2018) Xiaojun Tan et al.   Annual Review of Microbiology

Human Lymph Nodes Maintain TCF-1hiMemory T Cells with High Functional Potential and Clonal Diversity throughout Life

(2018) Michelle Miron et al.   JOURNAL OF IMMUNOLOGY

Interferon stimulation creates chromatin marks and establishes transcriptional memory

(2018) Rui Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance

(2018) Megha Budhwani et al.   Frontiers in Oncology

Intratumoral IFN-α gene delivery reduces tumor-infiltrating regulatory T cells through the downregulation of tumor CCL17 expression

(2018) Aya Hirata et al.   CANCER GENE THERAPY

CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

(2018) Laura M. Snell et al.   IMMUNITY

Sirtuin 2–mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses

(2018) Ewa M. Kosciuczuk et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer

(2018) Qiang Lan et al.   ONCOGENE

Both Type I and Type II Interferons Can Activate Antitumor M1 Macrophages When Combined With TLR Stimulation

(2018) Elisabeth Müller et al.   Frontiers in Immunology

Regulatory Networks Involving STATs, IRFs, and NFκB in Inflammation

(2018) Ekaterini Platanitis et al.   Frontiers in Immunology

Innate immunosensing of DNA in cellular senescence

(2018) Selene Glück et al.   CURRENT OPINION IN IMMUNOLOGY

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

(2017) Abhishek D. Garg et al.   IMMUNOLOGICAL REVIEWS

The molecular basis for differential type I interferon signaling

(2017) Gideon Schreiber   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

(2017) Kei-ichiro Arimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma

(2017) A D Arslan et al.   ONCOGENE

Overexpression of Interferon Regulatory Factor 7 (IRF7) Reduces Bone Metastasis of Prostate Cancer Cells in Mice

(2017) Yang Zhao et al.   ONCOLOGY RESEARCH

Interferon-beta represses cancer stem cell properties in triple-negative breast cancer

(2017) Mary R. Doherty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Retinoic Acid Inducible Gene 1 Protein (RIG1)-Like Receptor Pathway Is Required for Efficient Nuclear Reprogramming

(2017) Nazish Sayed et al.   STEM CELLS

The anticancer functions of RIG-I–like receptors, RIG-I and MDA5, and their applications in cancer therapy

(2017) Yuanbing Wu et al.   Translational Research

NOD1 and NOD2: Beyond Peptidoglycan Sensing

(2017) A. Marijke Keestra-Gounder et al.   TRENDS IN IMMUNOLOGY

Responses to Cytokines and Interferons that Depend upon JAKs and STATs

(2017) George R. Stark et al.   Cold Spring Harbor Perspectives in Biology

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP

(2017) K. L. Jønsson et al.   Nature Communications

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling

(2017) Kei-ichiro Arimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy

(2017) Ruan F.V. Medrano et al.   Oncotarget

CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response

(2017) Abdul S. Qadir et al.   Cell Reports

RIG-I: a multifunctional protein beyond a pattern recognition receptor

(2017) Xiao-xiao Xu et al.   Protein & Cell

Interferon-α Promotes the Expression of Cancer Stem Cell Markers in Oral Squamous Cell Carcinoma

(2017) Hailong Ma et al.   Journal of Cancer

Deciphering of the Human Interferon-Regulated Proteome by Mass Spectrometry-Based Quantitative Analysis Reveals Extent and Dynamics of Protein Induction and Repression

(2017) Dominik A. Megger et al.   Frontiers in Immunology

Role of Type I and II Interferons in Colorectal Cancer and Melanoma

(2017) Simone Di Franco et al.   Frontiers in Immunology

Interferon-Lambda: A Potent Regulator of Intestinal Viral Infections

(2017) Sanghyun Lee et al.   Frontiers in Immunology

Type-I-interferons in infection and cancer: Unanticipated dynamics with therapeutic implications

(2017) Martina Musella et al.   OncoImmunology

Cancer Stem Cells: Basic Concepts and Therapeutic Implications

(2016) Dany Nassar et al.   Annual Review of Pathology-Mechanisms of Disease

The anti-proliferative effects of type I IFN involve STAT6-mediated regulation of SP1 and BCL6

(2016) Yu-An Hsu et al.   CANCER LETTERS

Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy

(2016) Xiaohong Wang et al.   CANCER RESEARCH

Parsing the Interferon Transcriptional Network and Its Disease Associations

(2016) Sara Mostafavi et al.   CELL

Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade

(2016) Joseph L. Benci et al.   CELL

Interferon alpha antagonizes STAT3 and SOCS3 signaling triggered by hepatitis C virus

(2016) Lan-Juan Zhao et al.   CYTOKINE

The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses

(2016) Katarzyna Blaszczyk et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function

(2016) Duojiao Wu et al.   IMMUNITY

Recognition of Endogenous Nucleic Acids by the Innate Immune System

(2016) Axel Roers et al.   IMMUNITY

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

(2016) Se Jin Im et al.   NATURE

Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma

(2016) Jesse M. Zaretsky et al.   NEW ENGLAND JOURNAL OF MEDICINE

AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity

(2016) Antonia Di Micco et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

Role of interleukin-6 in cancer progression and therapeutic resistance

(2016) Neeraj Kumari et al.   TUMOR BIOLOGY

ISG15 deficiency and increased viral resistance in humans but not mice

(2016) Scott D. Speer et al.   Nature Communications

Primary Resistance to PD-1 Blockade Mediated by JAK1/2 Mutations

(2016) Daniel Sanghoon Shin et al.   Cancer Discovery

ISG15 predicts poor prognosis and promotes cancer stem cell phenotype in nasopharyngeal carcinoma

(2016) Ren-Hui Chen et al.   Oncotarget

Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents

(2016) Julie Gaston et al.   Oncotarget

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression

(2016) Yuliya V. Katlinskaya et al.   Cell Reports

Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence

(2016) Cameron R. Cunningham et al.   PLoS Pathogens

NF-κB and IRF pathways: cross-regulation on target genes promoter level

(2015) Marta Iwanaszko et al.   BMC GENOMICS

Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling

(2015) Autumn G. York et al.   CELL

Viral RNA detection by RIG-I-like receptors

(2015) Mitsutoshi Yoneyama et al.   CURRENT OPINION IN IMMUNOLOGY

Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs)

(2015) Darren J. Perkins et al.   CYTOKINE

Cut, copy, move, delete: The study of human interferon genes reveal multiple mechanisms underlying their evolution in amniotes

(2015) Christopher D. Krause et al.   CYTOKINE

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

(2015) T. Goldmann et al.   EMBO JOURNAL

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

(2015) Anetta Härtlova et al.   IMMUNITY

Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins

(2015) Edmond M. Linossi et al.   IMMUNOLOGICAL REVIEWS

Type IIFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human

(2015) Lisa Andzinski et al.   INTERNATIONAL JOURNAL OF CANCER

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

(2015) Stephan Wilmes et al.   JOURNAL OF CELL BIOLOGY

Interferon alpha-inducible protein 27 promotes epithelial–mesenchymal transition and induces ovarian tumorigenicity and stemness

(2015) Shuqin Li et al.   JOURNAL OF SURGICAL RESEARCH

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

(2015) Juan Fu et al.   Science Translational Medicine

Targeting of type I interferon in systemic autoimmune diseases

(2015) Mary K. Crow et al.   Translational Research

Interferons and the Immunogenic Effects of Cancer Therapy

(2015) Andy J. Minn   TRENDS IN IMMUNOLOGY

Central Role of ULK1 in Type I Interferon Signaling

(2015) Diana Saleiro et al.   Cell Reports

The innate immune sensor IFI16 recognizes foreign DNA in the nucleus by scanning along the duplex

(2015) Sarah A Stratmann et al.   eLife

Loss of Host Type-I IFN Signaling Accelerates Metastasis and Impairs NK-cell Antitumor Function in Multiple Models of Breast Cancer

(2015) J. Rautela et al.   Cancer Immunology Research

MicroRNA as Type I Interferon-Regulated Transcripts and Modulators of the Innate Immune Response

(2015) Samuel C. Forster et al.   Frontiers in Immunology

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Chromatin Contributions to the Regulation of Innate Immunity

(2014) Stephen T. Smale et al.   Annual Review of Immunology

Targeting the Tumor Microenvironment with Interferon-β Bridges Innate and Adaptive Immune Responses

(2014) Xuanming Yang et al.   CANCER CELL

Type I IFN gene delivery suppresses regulatory T cells within tumors

(2014) H Hashimoto et al.   CANCER GENE THERAPY

Strict Requirement for Vector-Induced Type I Interferon in Efficacious Antitumor Responses to Virally Encoded IL12

(2014) I. Melero et al.   CANCER RESEARCH

ISG15 Is a Critical Microenvironmental Factor for Pancreatic Cancer Stem Cells

(2014) B. Sainz et al.   CANCER RESEARCH

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer

(2014) D Jia et al.   CELL DEATH AND DIFFERENTIATION

A new cytosolic DNA-recognition pathway for DNA-induced inflammatory responses

(2014) Jun Meng et al.   Cellular & Molecular Immunology

Expansion of circulating CD56brightnatural killer cells in patients with JAK2-positive chronic myeloproliferative neoplasms during treatment with interferon-α

(2014) Caroline H. Riley et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Influence of interferon-α on the expression of the cancer stem cell markers in pancreatic carcinoma cells

(2014) Yifan Zhu et al.   EXPERIMENTAL CELL RESEARCH

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Functions of invariant NK T cells are modulated by TLR ligands and IFN-α

(2014) A Ian Villanueva et al.   Innate Immunity

Dual Regulatory Roles of Phosphatidylinositol 3-Kinase in IFN Signaling

(2014) S. Kaur et al.   JOURNAL OF IMMUNOLOGY

The Indoleamine 2,3-Dioxygenase Pathway Is Essential for Human Plasmacytoid Dendritic Cell-Induced Adaptive T Regulatory Cell Generation

(2014) W. Chen et al.   JOURNAL OF IMMUNOLOGY

Post-Transcriptional Regulation of Interferons and Their Signaling Pathways

(2014) Ram Savan   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

(2014) Heidi J A Wallweber et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Copy Number Loss of the Interferon Gene Cluster in Melanomas Is Linked to Reduced T Cell Infiltrate and Poor Patient Prognosis

(2014) Peter S. Linsley et al.   PLoS One

Annotation of long non-coding RNAs expressed in Collaborative Cross founder mice in response to respiratory virus infection reveals a new class of interferon-stimulated transcripts

(2014) Laurence Josset et al.   RNA Biology

Interferons and Their Stimulated Genes in the Tumor Microenvironment

(2014) HyeonJoo Cheon et al.   SEMINARS IN ONCOLOGY

Immune Cell-Poor Melanomas Benefit from PD-1 Blockade after Targeted Type I IFN Activation

(2014) T. Bald et al.   Cancer Discovery

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

(2014) Austin Pantel et al.   PLOS BIOLOGY

Type I interferons induced by radiation therapy mediate recruitment and effector function of CD8+ T cells

(2013) Joanne Y. H. Lim et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Latent Enhancers Activated by Stimulation in Differentiated Cells

(2013) Renato Ostuni et al.   CELL

Fine tuning type I interferon responses

(2013) Paul J. Hertzog et al.   CYTOKINE & GROWTH FACTOR REVIEWS

IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage

(2013) HyeonJoo Cheon et al.   EMBO JOURNAL

Endothelial TNF Receptor 2 Induces IRF1 Transcription Factor-Dependent Interferon-β Autocrine Signaling to Promote Monocyte Recruitment

(2013) Deepak Venkatesh et al.   IMMUNITY

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

The Schlafen Family of Proteins and Their Regulation by Interferons

(2013) Evangelos Mavrommatis et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Short-term memory of danger signals and environmental stimuli in immune cells

(2013) Silvia Monticelli et al.   NATURE IMMUNOLOGY

Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors

(2013) James N. Kochenderfer et al.   Nature Reviews Clinical Oncology

Deciphering the modulation of gene expression by type I and II interferons combining 4sU-tagging, translational arrest and in silico promoter analysis

(2013) Mirko Trilling et al.   NUCLEIC ACIDS RESEARCH

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

(2013) T. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells

(2013) A R Bernardo et al.   Cell Death & Disease

USP18 establishes the transcriptional and anti-proliferative interferon α/β differential

(2012) Véronique Francois-Newton et al.   BIOCHEMICAL JOURNAL

Activation of Innate Immunity Is Required for Efficient Nuclear Reprogramming

(2012) Jieun Lee et al.   CELL

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

(2012) Daniel J. Gough et al.   IMMUNITY

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

Pathogen-Specific Inflammatory Milieux Tune the Antigen Sensitivity of CD8+ T Cells by Enhancing T Cell Receptor Signaling

(2012) Martin J. Richer et al.   IMMUNITY

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Modulation of T-cell function by type I interferon

(2012) David F Tough   IMMUNOLOGY AND CELL BIOLOGY

Identification of STAT2 Serine 287 as a Novel Regulatory Phosphorylation Site in Type I Interferon-induced Cellular Responses

(2012) Håkan C. Steen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-Term Results of the Randomized Phase III Trial EORTC 18991 of Adjuvant Therapy With Pegylated Interferon Alfa-2b Versus Observation in Resected Stage III Melanoma

(2012) Alexander M.M. Eggermont et al.   JOURNAL OF CLINICAL ONCOLOGY

Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

(2012) Bradley N Bidwell et al.   NATURE MEDICINE

Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses

(2012) S Bhattacharya et al.   ONCOGENE

Expression Signature of IFN/STAT1 Signaling Genes Predicts Poor Survival Outcome in Glioblastoma Multiforme in a Subtype-Specific Manner

(2012) Christine W. Duarte et al.   PLoS One

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Type I interferon response and innate immune sensing of cancer

(2012) Mercedes B. Fuertes et al.   TRENDS IN IMMUNOLOGY

Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance

(2012) Tatsuaki Mizutani et al.   OncoImmunology

Type I interferonopathies: a novel set of inborn errors of immunity

(2011) Yanick J. Crow   Annals of the New York Academy of Sciences

Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis

(2011) H. Zheng et al.   BLOOD

Combination of pegylated IFN- 2b with imatinib increases molecular response rates in patients with low- or intermediate-risk chronic myeloid leukemia

(2011) B. Simonsson et al.   BLOOD

Type I-IFNs control GVHD and GVL responses after transplantation

(2011) R. J. Robb et al.   BLOOD

A signature of immune function genes associated with recurrence-free survival in breast cancer patients

(2011) Maria Libera Ascierto et al.   BREAST CANCER RESEARCH AND TREATMENT

The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon-Dependent Innate and Adaptive Immunity

(2011) B. C. Burnette et al.   CANCER RESEARCH

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

(2011) Christoph Thomas et al.   CELL

CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice

(2011) C. Zoglmeier et al.   CLINICAL CANCER RESEARCH

Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy

(2011) S. A. Rosenberg et al.   CLINICAL CANCER RESEARCH

Binding and activity of all human alpha interferon subtypes

(2011) Thomas B. Lavoie et al.   CYTOKINE

Regulation of effector and memory T-cell functions by type I interferon

(2011) Jonathan P. Huber et al.   IMMUNOLOGY

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon α Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2

(2011) Rebecca A. R. Piganis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety and Efficacy of Combination Immunotherapy With Interferon Alfa-2b and Tremelimumab in Patients With Stage IV Melanoma

(2011) Ahmad A. Tarhini et al.   JOURNAL OF CLINICAL ONCOLOGY

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I IFNs Control Antigen Retention and Survival of CD8 + Dendritic Cells after Uptake of Tumor Apoptotic Cells Leading to Cross-Priming

(2011) S. Lorenzi et al.   JOURNAL OF IMMUNOLOGY

STAT3 Negatively Regulates Type I IFN-Mediated Antiviral Response

(2011) W.-B. Wang et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptors as Interferon-Regulated Genes and Their Role in Disease

(2011) Jing Jing Khoo et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The Role of Nuclear Factor κB in the Interferon Response

(2011) Lawrence M. Pfeffer   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

G1P3, an interferon- and estrogen-induced survival protein contributes to hyperplasia, tamoxifen resistance and poor outcomes in breast cancer

(2011) V Cheriyath et al.   ONCOGENE

Inflammatory signaling compromises cell responses to interferon alpha

(2011) W-C HuangFu et al.   ONCOGENE

USP18-Based Negative Feedback Control Is Induced by Type I and Type III Interferons and Specifically Inactivates Interferon α Response

(2011) Véronique François-Newton et al.   PLoS One

Anti-ErbB-2 mAb therapy requires type I and II interferons and synergizes with anti-PD-1 or anti-CD137 mAb therapy

(2011) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Type I interferons: diversity of sources, production pathways and effects on immune responses

(2011) Melissa Swiecki et al.   Current Opinion in Virology

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Interferon-α as angiogenesis inhibitor: Learning from tumor models

(2010) Stefano Indraccolo   AUTOIMMUNITY

Cyclophosphamide Synergizes with Type I Interferons through Systemic Dendritic Cell Reactivation and Induction of Immunogenic Tumor Apoptosis

(2010) G. Schiavoni et al.   CANCER RESEARCH

Suppression of SOCS3 increases susceptibility of renal cell carcinoma to interferon-α

(2010) Shintaro Tomita et al.   CANCER SCIENCE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Interferon-α targets JAK2V617F-positive hematopoietic progenitor cells and acts through the p38 MAPK pathway

(2010) Min Lu et al.   EXPERIMENTAL HEMATOLOGY

Sustained Molecular Response With Interferon Alfa Maintenance After Induction Therapy With Imatinib Plus Interferon Alfa in Patients With Chronic Myeloid Leukemia

(2010) Andreas Burchert et al.   JOURNAL OF CLINICAL ONCOLOGY

Type I IFN enhances follicular B cell contribution to the T cell–independent antibody response

(2010) Cristina L. Swanson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon: friend or foe?

(2010) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

APC Activation by IFN-  Decreases Regulatory T Cell and Enhances Th Cell Functions

(2010) L. Pace et al.   JOURNAL OF IMMUNOLOGY

Plasmacytoid Dendritic Cell Dichotomy: Identification of IFN-  Producing Cells as a Phenotypically and Functionally Distinct Subset

(2010) P. Bjorck et al.   JOURNAL OF IMMUNOLOGY

Resistance to IFN- -Induced Apoptosis Is Linked to a Loss of STAT2

(2010) A. L. Romero-Weaver et al.   MOLECULAR CANCER RESEARCH

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Imatinib plus Peginterferon Alfa-2a in Chronic Myeloid Leukemia

(2010) Claude Preudhomme et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

(2010) T. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling

(2009) Kanako Yuki et al.   CANCER LETTERS

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes

(2009) H. Cheon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant interferon-α2b improves immune response to hepatitis B vaccination in haemodialysis patients: Results of a randomised clinical trial

(2009) María E. Miquilena-Colina et al.   VACCINE

Ligand-independent pathway that controls stability of interferon alpha receptor

(2008) Jianghuai Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IFN-Induced Transmembrane Protein 1 Promotes Invasion at Early Stage of Head and Neck Cancer Progression

(2008) H. Hatano et al.   CLINICAL CANCER RESEARCH

Basal Ubiquitin-independent Internalization of Interferon α Receptor Is Prevented by Tyk2-mediated Masking of a Linear Endocytic Motif

(2008) K. G. Suresh Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY

An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer

(2008) R. R. Weichselbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

(2008) Z. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis

(2008) J. B. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA