Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins

Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons

(2015) Vera Gielen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

(2014) Christopher J. Oldfield et al.   Annual Review of Biochemistry

Reconstruction of an active SOCS3-based E3 ubiquitin ligase complexin vitro: identification of the active components and JAK2 and gp130 as substrates

(2014) Nadia J. Kershaw et al.   GROWTH FACTORS

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection

(2014) Lukasz Kedzierski et al.   PLoS Pathogens

The complexity of recognition of ubiquitinated substrates by the 26S proteasome

(2013) Aaron Ciechanover et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms

(2013) Wojciech Stec et al.   MOLECULAR BIOLOGY OF THE CELL

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

(2013) Nadia J Kershaw et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

JAKs and STATs in Immunity, Immunodeficiency, and Cancer

(2013) John J. O'Shea et al.   NEW ENGLAND JOURNAL OF MEDICINE

Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1

(2013) Edmond M. Linossi et al.   PLoS One

The language of SH2 domain interactions defines phosphotyrosine-mediated signal transduction

(2012) Bernard A. Liu et al.   FEBS LETTERS

Potent antitumor activity of oncolytic adenovirus-mediated SOCS1 for hepatocellular carcinoma

(2012) L Liu et al.   GENE THERAPY

The biology and mechanism of action of suppressor of cytokine signaling 3

(2012) Jeffrey J. Babon et al.   GROWTH FACTORS

Biology and significance of the JAK/STAT signalling pathways

(2012) Hiu Kiu et al.   GROWTH FACTORS

Janus Kinase Deregulation in Leukemia and Lymphoma

(2012) Edwin Chen et al.   IMMUNITY

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

(2012) Jeffrey J. Babon et al.   IMMUNITY

The SOCS box-Adapting proteins for ubiquitination and proteasomal degradation

(2012) Edmond M. Linossi et al.   IUBMB LIFE

Suppressor of Cytokine Signaling 3 Inhibits Breast Tumor Kinase Activation of STAT3

(2012) Yiwei Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressor of Cytokine Signaling 6 (SOCS6) Negatively Regulates Flt3 Signal Transduction through Direct Binding to Phosphorylated Tyrosines 591 and 919 of Flt3

(2012) Julhash U. Kazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of JAK-STAT Pathway Components: Mechanisms and Role in Immune System Development

(2012) Clifford Liongue et al.   PLoS One

Interleukin-6 signalling: More than Jaks and STATs

(2011) René Eulenfeld et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon α Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2

(2011) Rebecca A. R. Piganis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-terminal domains of SOCS proteins: A conserved region in the disordered N-termini of SOCS4 and 5

(2011) Zhi-Ping Feng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Suppressor of cytokine signaling 1 (SOCS1) limits NFκB signaling by decreasing p65 stability within the cell nucleus

(2010) Julia Strebovsky et al.   FASEB JOURNAL

Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase

(2010) Fahad Zadjali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressor of Cytokine Signaling 2 Regulates IL-15-Primed Human NK Cell Function via Control of Phosphorylated Pyk2

(2010) S. H. Lee et al.   JOURNAL OF IMMUNOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

SOCS-6 Negatively Regulates T Cell Activation through Targeting p56lckto Proteasomal Degradation

(2009) Young Bong Choi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SOCS Box Encodes a Hierarchy of Affinities for Cullin5: Implications for Ubiquitin Ligase Formation and Cytokine Signalling Suppression

(2009) Jeffrey J. Babon et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and functional analysis of a nuclear localization signal in SOCS1

(2009) Christian Koelsche et al.   MOLECULAR IMMUNOLOGY

Intracellular Delivery of a Cell-Penetrating SOCS1 that Targets IFN-  Signaling

(2009) A. DiGiandomenico et al.   Science Signaling

Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation

(2008) Kristy Boyle et al.   CELLULAR SIGNALLING

Identification of a nuclear localization signal in suppressor of cytokine signaling 1

(2008) Andrea Baetz et al.   FASEB JOURNAL

The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase

(2008) Jeffrey J. Babon et al.   JOURNAL OF MOLECULAR BIOLOGY