Type I interferon: friend or foe?

Type I IFNs Enhance Susceptibility to Chlamydia muridarum Lung Infection by Enhancing Apoptosis of Local Macrophages

(2014) H. Qiu et al.   JOURNAL OF IMMUNOLOGY

A Critical Role for Type I IFN in Arthritis Development following Borrelia burgdorferi Infection of Mice

(2014) J. C. Miller et al.   JOURNAL OF IMMUNOLOGY

CCR2+ Monocyte-Derived Dendritic Cells and Exudate Macrophages Produce Influenza-Induced Pulmonary Immune Pathology and Mortality

(2014) K. L. Lin et al.   JOURNAL OF IMMUNOLOGY

A Genomic Approach to Human Autoimmune Diseases

(2010) Virginia Pascual et al.   Annual Review of Immunology

Recent advances on the immunomodulatory effects of IFN-α: Implications for cancer immunotherapy and autoimmunity

(2010) Paola Rizza et al.   AUTOIMMUNITY

Type I interferon therapy and its role in autoimmunity

(2010) Martina Biggioggero et al.   AUTOIMMUNITY

Oncogenic Ras Promotes Reovirus Spread by Suppressing IFN-β Production through Negative Regulation ofRIG-ISignaling

(2010) Maya Shmulevitz et al.   CANCER RESEARCH

Regulation of immune cell homeostasis by type I interferons

(2010) Fabrizio Mattei et al.   CYTOKINE & GROWTH FACTOR REVIEWS

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

(2010) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population

(2010) Lis R.V. Antonelli et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10

(2010) Kindra M. Kelly-Scumpia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of IFN-αβ enablesListeria monocytogenesto suppress macrophage activation by IFN-γ

(2010) Manira Rayamajhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Essential Role of Mitochondrial Antiviral Signaling, IFN Regulatory Factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-Mediated IFN-  Response and Control of Bacterial Replication in Human Endothelial Cells

(2010) C. Buss et al.   JOURNAL OF IMMUNOLOGY

Type I IFN Signaling Constrains IL-17A/F Secretion by    T Cells during Bacterial Infections

(2010) T. Henry et al.   JOURNAL OF IMMUNOLOGY

Interferon-Inducible p200-Family Proteins as Novel Sensors of Cytoplasmic DNA: Role in Inflammation and Autoimmunity

(2010) Divaker Choubey et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Autoimmunity, infection and adjuvants

(2010) NR Rose   LUPUS

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

(2010) Cristiana Guiducci et al.   NATURE

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis

(2010) Teresa Fernandes-Alnemri et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Genetics of SLE: evidence from mouse models

(2010) Laurence Morel   Nature Reviews Rheumatology

Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages

(2010) A. Triantafyllopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Crosstalk between Type I and II Interferon through the Regulated Expression of STAT1

(2010) Daniel J. Gough et al.   PLOS BIOLOGY

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Shifting the paradigm toward earlier treatment of multiple sclerosis with interferon beta

(2009) Giancarlo Comi   CLINICAL THERAPEUTICS

Type I interferon and lupus

(2009) Lars Rönnblom et al.   CURRENT OPINION IN RHEUMATOLOGY

Interferons Direct an Effective Innate Response toLegionella pneumophilaInfection

(2009) Courtney R. Plumlee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon–independent apoptosis in human melanoma cells

(2009) Robert Besch et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice

(2009) Arash Shahangian et al.   JOURNAL OF CLINICAL INVESTIGATION

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon drives tumor necrosis factor–induced lethal shock

(2009) Liesbeth Huys et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MyD88 and Type I Interferon Receptor-Mediated Chemokine Induction and Monocyte Recruitment during Listeria monocytogenes Infection

(2009) T. Jia et al.   JOURNAL OF IMMUNOLOGY

Deficiency of Type I IFN Receptor in Lupus-Prone New Zealand Mixed 2328 Mice Decreases Dendritic Cell Numbers and Activation and Protects from Disease

(2009) H. Agrawal et al.   JOURNAL OF IMMUNOLOGY

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

(2009) Giuseppe Mancuso et al.   NATURE IMMUNOLOGY

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

(2009) William O'Connor Jr et al.   NATURE IMMUNOLOGY

Double stranded RNA tricks melanoma cells into committing suicide

(2009) Romina S. Goldszmid et al.   Pigment Cell & Melanoma Research

Type I interferons as mediators of immune adjuvants for T- and B cell-dependent acquired immunity

(2009) Michaela Prchal et al.   VACCINE

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

(2009) Amit K. Pandey et al.   PLoS Pathogens

Type I IFN are host modulators of strain-specific Listeria monocytogenes virulence

(2008) Benjamin Reutterer et al.   CELLULAR MICROBIOLOGY

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

(2008) Marco Prinz et al.   IMMUNITY

Novel functions of type I interferons revealed by infection studies with Listeria monocytogenes

(2008) Silvia Stockinger et al.   IMMUNOBIOLOGY

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

(2008) Beichu Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Signalling pathways leading to IFN-α production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications

(2008) C. Guiducci et al.   JOURNAL OF INTERNAL MEDICINE

An IFN-Associated Cytotoxic Cellular Immune Response against Viral, Self-, or Tumor Antigens Is a Common Pathogenetic Feature in “Interface Dermatitis”

(2008) Joerg Wenzel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY

HIV-Induced Type I Interferon and Tryptophan Catabolism Drive T Cell Dysfunction Despite Phenotypic Activation

(2008) Adriano Boasso et al.   PLoS One