Human Endogenous Retrovirus as Therapeutic Targets in Neurologic Disease

m6A RNA methylation regulates the fate of endogenous retroviruses

(2021) Tomasz Chelmicki et al.   NATURE

Activation of endogenous retroviruses during brain development causes an inflammatory response

(2021) Marie E Jönsson et al.   EMBO JOURNAL

Cytokine Imbalance in Schizophrenia. From Research to Clinic: Potential Implications for Treatment

(2021) Marcella Reale et al.   Frontiers in Psychiatry

Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3

(2021) Vidya Padmanabhan Nair et al.   Cell Stem Cell

Human Endogenous Retrovirus Type W Envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics

(2021) Benjamin Charvet et al.   VIROLOGICA SINICA

A Safety and Pharmacodynamics Study of Temelimab, an anti‐HERV‐W‐Env Monoclonal Antibody, in Type 1 Diabetes Patients

(2020) Francois Curtin et al.   DIABETES OBESITY & METABOLISM

Activation of Transposable Elements in Immune Cells of Fibromyalgia Patients

(2020) Tamara Ovejero et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglia in Multiple Sclerosis: Friend or Foe?

(2020) Brooke L. Guerrero et al.   Frontiers in Immunology

Endogenous Retrovirus-Derived lncRNA BANCR Promotes Cardiomyocyte Migration in Humans and Non-human Primates

(2020) Kitchener D. Wilson et al.   DEVELOPMENTAL CELL

Methylation-directed glycosylation of chromatin factors represses retrotransposon promoters

(2020) Mathieu Boulard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of stem cell function and neuronal differentiation by HERV-K via mTOR pathway

(2020) Tongguang Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Meeting report: “Human endogenous retroviruses: HERVs or transposable elements in autoimmune, chronic inflammatory and degenerative diseases or cancer”, Lyon, France, november 5th and 6th 2019 – an MS scientist's digest

(2020) David Kremer et al.   Multiple Sclerosis and Related Disorders

Human endogenous retroviral protein triggers deficit in glutamate synapse maturation and behaviors associated with psychosis

(2020) E. M. Johansson et al.   Science Advances

In amyotrophic lateral sclerosis blood cytokines are altered, but do not correlate with changes in brain topology

(2020) Arianna Polverino et al.   Brain Connectivity

Posttranscriptional regulation of human endogenous retroviruses by RNA-binding motif protein 4, RBM4

(2020) Amir K. Foroushani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons

(2020) Priscilla Turelli et al.   Science Advances

Origins and evolutionary consequences of ancient endogenous retroviruses

(2019) Welkin E. Johnson   NATURE REVIEWS MICROBIOLOGY

The clinical value of cytokines in chronic fatigue syndrome

(2019) Tiansong Yang et al.   Journal of Translational Medicine

Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing

(2019) Guido A. Stoll et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis

(2019) David Kremer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

(2019) Nora Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the origin of a pathogenic HERV-W envelope protein present in multiple sclerosis lesions

(2019) Klemens Ruprecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Children With Autism Spectrum Disorder and Their Mothers Share Abnormal Expression of Selected Endogenous Retroviruses Families and Cytokines

(2019) Emanuela Balestrieri et al.   Frontiers in Immunology

Transposable Elements, Inflammation, and Neurological Disease

(2019) Aurian Saleh et al.   Frontiers in Neurology

Environmental and genetic risk factors for MS: an integrated review

(2019) Emmanuelle Waubant et al.   Annals of Clinical and Translational Neurology

Monocytes and Monocyte-Derived Antigen-Presenting Cells Have Distinct Gene Signatures in Experimental Model of Multiple Sclerosis

(2019) Kelly L. Monaghan et al.   Frontiers in Immunology

Syncytin-1, an endogenous retroviral protein, triggers the activation of CRP via TLR3 signal cascade in glial cells

(2018) Xiuling Wang et al.   BRAIN BEHAVIOR AND IMMUNITY

TRIM28 and the control of transposable elements in the brain

(2018) Daniela A. Grassi et al.   BRAIN RESEARCH

Reactivation of endogenous retroviral elements via treatment with DNMT- and HDAC-inhibitors

(2018) Michael Daskalakis et al.   CELL CYCLE

A new therapeutic approach for type 1 diabetes: Rationale for GNbAC1, an anti-HERV-W-Env monoclonal antibody

(2018) Francois Curtin et al.   DIABETES OBESITY & METABOLISM

Pandemic influenza and subsequent risk of type 1 diabetes: a nationwide cohort study

(2018) Paz L. D. Ruiz et al.   DIABETOLOGIA

Switching roles for DNA and histone methylation depend on evolutionary ages of human endogenous retroviruses

(2018) Hitoshi Ohtani et al.   GENOME RESEARCH

Structural Basis of Heterochromatin Formation by Human HP1

(2018) Shinichi Machida et al.   MOLECULAR CELL

Long non-coding and endogenous retroviral RNA levels are associated with proinflammatory cytokine mRNA expression in peripheral blood cells: Implications for schizophrenia

(2018) Jennifer K. Melbourne et al.   PSYCHIATRY RESEARCH

Human Endogenous Retroviruses in Neurological Diseases

(2018) Patrick Küry et al.   TRENDS IN MOLECULAR MEDICINE

Detailed Characterization of T Cell Receptor Repertoires in Multiple Sclerosis Brain Lesions

(2018) Raquel Planas et al.   Frontiers in Immunology

The Properties of Cytokine in Multiple Sclerosis: Pros and Cons

(2018) Kexin Wang et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Proteomic analysis of the OGT interactome: novel links to epithelial–mesenchymal transition and metastasis of cervical cancer

(2018) Jie Gao et al.   CARCINOGENESIS

KAP1 regulates endogenous retroviruses in adult human cells and contributes to innate immune control

(2018) Christopher HC Tie et al.   EMBO REPORTS

Rescuing the negative impact of human endogenous retrovirus envelope protein on oligodendroglial differentiation and myelination

(2018) Peter Göttle et al.   GLIA

The Decrease in Human Endogenous Retrovirus-H Activity Runs in Parallel with Improvement in ADHD Symptoms in Patients Undergoing Methylphenidate Therapy

(2018) Cipriani Chiara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Treatment of multiple sclerosis — success from bench to bedside

(2018) Mar Tintore et al.   Nature Reviews Neurology

First-episode schizophrenia is associated with a reduction of HERV-K methylation in peripheral blood

(2018) Monika Mak et al.   PSYCHIATRY RESEARCH

Variation in proviral content among human genomes mediated by LTR recombination

(2018) Jainy Thomas et al.   Mobile DNA

Induction of Proinflammatory Multiple Sclerosis-Associated Retrovirus Envelope Protein by Human Herpesvirus-6A and CD46 Receptor Engagement

(2018) Benjamin Charvet et al.   Frontiers in Immunology

Revisiting inflammation in bipolar disorder

(2018) Gabriel R. Fries et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Long non-coding RNAs transcribed by ERV-9 LTR retrotransposon act in cis to modulate long-range LTR enhancer function

(2017) Tianxiang Hu et al.   NUCLEIC ACIDS RESEARCH

Epigenetic Control of Human Endogenous Retrovirus Expression: Focus on Regulation of Long-Terminal Repeats (LTRs)

(2017) Tara Hurst et al.   Viruses-Basel

H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1

(2017) Renata Z. Jurkowska et al.   Nature Communications

Systematic identification and characterization of regulatory elements derived from human endogenous retroviruses

(2017) Jumpei Ito et al.   PLoS Genetics

Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization

(2017) O D Howes et al.   Translational Psychiatry

Attention-Deficit/Hyperactivity Disorder And Inflammation: What Does Current Knowledge Tell Us? A Systematic Review

(2017) Deepa Anand et al.   Frontiers in Psychiatry

The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis

(2017) Yong-chao Qiao et al.   PLoS One

Cytokines and C-reactive protein alterations with respect to cognitive impairment in schizophrenia and bipolar disorder: A systematic review

(2017) Błażej Misiak et al.   SCHIZOPHRENIA RESEARCH

Dendritic cells in brain diseases

(2016) Peter Ludewig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of Endogenous Retroviruses in Dnmt1 −/− ESCs Involves Disruption of SETDB1-Mediated Repression by NP95 Binding to Hemimethylated DNA

(2016) Jafar Sharif et al.   Cell Stem Cell

O-GlcNAcylation of histone deacetylases 1 in hepatocellular carcinoma promotes cancer progression

(2016) Guizhou Zhu et al.   GLYCOBIOLOGY

MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: Relevance of GNbAC1 in multiple sclerosis treatment

(2016) Alexandra Madeira et al.   JOURNAL OF NEUROIMMUNOLOGY

NF-κB and IRF1 Induce Endogenous Retrovirus K Expression via Interferon-Stimulated Response Elements in Its 5′ Long Terminal Repeat

(2016) Mamneet Manghera et al.   JOURNAL OF VIROLOGY

Serum pharmacokinetics and cerebrospinal fluid concentration analysis of the new IgG4 monoclonal antibody GNbAC1 to treat multiple sclerosis: A Phase 1 study

(2016) François Curtin et al.   mAbs

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

(2016) D R Goldsmith et al.   MOLECULAR PSYCHIATRY

TDP-43 regulates endogenous retrovirus-K viral protein accumulation

(2016) Mamneet Manghera et al.   NEUROBIOLOGY OF DISEASE

Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity

(2016) Kenji Ishimoto et al.   PLoS One

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

Immunology of Multiple Sclerosis

(2016) Mireia Sospedra et al.   SEMINARS IN NEUROLOGY

A placebo randomized controlled study to test the efficacy and safety of GNbAC1, a monoclonal antibody for the treatment of multiple sclerosis – Rationale and design

(2016) Francois Curtin et al.   Multiple Sclerosis and Related Disorders

Human Endogenous Retroviruses as Pathogenic Factors in the Development of Schizophrenia

(2016) Gorjan Slokar et al.   Frontiers in Psychiatry

Human Endogenous Retrovirus and Neuroinflammation in Chronic Inflammatory Demyelinating Polyradiculoneuropathy

(2016) Raphaël Faucard et al.   EBioMedicine

Molecular functions of human endogenous retroviruses in health and disease

(2015) Maria Suntsova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inflammatory response of endothelial cells to a human endogenous retrovirus associated with multiple sclerosis is mediated by TLR4

(2015) Alain Duperray et al.   INTERNATIONAL IMMUNOLOGY

A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patients — A twelve month follow-up

(2015) Tobias Derfuss et al.   JOURNAL OF NEUROIMMUNOLOGY

Treatment Against Human Endogenous Retrovirus: A Possible Personalized Medicine Approach for Multiple Sclerosis

(2015) François Curtin et al.   Molecular Diagnosis & Therapy

The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes

(2015) Patrick L. Collins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human endogenous retrovirus-K contributes to motor neuron disease

(2015) Wenxue Li et al.   Science Translational Medicine

TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells

(2015) Liana Fasching et al.   Cell Reports

Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements

(2014) Priscilla Turelli et al.   GENOME RESEARCH

Fibromyalgia and cytokines

(2014) Ignasi Rodriguez-Pintó et al.   IMMUNOLOGY LETTERS

HIV-1 Infection Leads to Increased Transcription of Human Endogenous Retrovirus HERV-K (HML-2) Proviruses In Vivo but Not to Increased Virion Production

(2014) N. Bhardwaj et al.   JOURNAL OF VIROLOGY

Unfixed Endogenous Retroviral Insertions in the Human Population

(2014) E. Marchi et al.   JOURNAL OF VIROLOGY

Transcriptional Derepression of the ERVWE1 Locus following Influenza A Virus Infection

(2014) F. Li et al.   JOURNAL OF VIROLOGY

Ectopic DNMT3L Triggers Assembly of a Repressive Complex for Retroviral Silencing in Somatic Cells

(2014) T.-H. Kao et al.   JOURNAL OF VIROLOGY

Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein

(2014) François Curtin et al.   mAbs

C9orf72 nucleotide repeat structures initiate molecular cascades of disease

(2014) Aaron R. Haeusler et al.   NATURE

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

(2013) David Kremer et al.   ANNALS OF NEUROLOGY

Role of Microglia in CNS Autoimmunity

(2013) Tobias Goldmann et al.   Clinical & Developmental Immunology

Multiple sclerosis

(2013) Matthew F. Cusick et al.   CURRENT OPINION IN RHEUMATOLOGY

Natalizumab inhibits the expression of human endogenous retroviruses of the W family in multiple sclerosis patients: a longitudinal cohort study

(2013) Giannina Arru et al.   Multiple Sclerosis Journal

The DNA Copy Number of Human Endogenous Retrovirus-W (MSRV-Type) Is Increased in Multiple Sclerosis Patients and Is Influenced by Gender and Disease Severity

(2013) Marta Garcia-Montojo et al.   PLoS One

Human-Specific HERV-K Insertion Causes Genomic Variations in the Human Genome

(2013) Wonseok Shin et al.   PLoS One

Human Endogenous Retrovirus Protein Activates Innate Immunity and Promotes Experimental Allergic Encephalomyelitis in Mice

(2013) Hervé Perron et al.   PLoS One

Activation of MSRV-Type Endogenous Retroviruses during Infectious Mononucleosis and Epstein-Barr Virus Latency: The Missing Link with Multiple Sclerosis?

(2013) Giuseppe Mameli et al.   PLoS One

GNbAC1, a Humanized Monoclonal Antibody Against the Envelope Protein of Multiple Sclerosis—Associated Endogenous Retrovirus: A First-in-Humans Randomized Clinical Study

(2012) François Curtin et al.   CLINICAL THERAPEUTICS

Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development

(2012) S.-L. Tan et al.   DEVELOPMENT

Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

(2012) Hervé Perron et al.   Multiple Sclerosis Journal

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Expression and Activation by Epstein Barr Virus of Human Endogenous Retroviruses-W in Blood Cells and Astrocytes: Inference for Multiple Sclerosis

(2012) Giuseppe Mameli et al.   PLoS One

Impaired monocyte activation in schizophrenia

(2012) Norbert Müller et al.   PSYCHIATRY RESEARCH

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

The KRAB-ZFP/KAP1 System Contributes to the Early Embryonic Establishment of Site-Specific DNA Methylation Patterns Maintained during Development

(2012) Simon Quenneville et al.   Cell Reports

Citrullination of Histone H3 Interferes with HP1-Mediated Transcriptional Repression

(2012) Priyanka Sharma et al.   PLoS Genetics

Molecular characteristics of Human Endogenous Retrovirus type-W in schizophrenia and bipolar disorder

(2012) H Perron et al.   Translational Psychiatry

Pathology of Demyelinating Diseases

(2011) Bogdan F.Gh. Popescu et al.   Annual Review of Pathology-Mechanisms of Disease

Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis

(2011) Humberto M Garay-Malpartida et al.   BMC IMMUNOLOGY

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in mESCs

(2011) Mohammad M. Karimi et al.   Cell Stem Cell

Coevolution of retroelements and tandem zinc finger genes

(2011) J. H. Thomas et al.   GENOME RESEARCH

KAP1 Protein: An Enigmatic Master Regulator of the Genome

(2011) Sushma Iyengar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses

(2011) Ravi P Subramanian et al.   Retrovirology

Human endogenous retrovirus type W (HERV-W) in schizophrenia: A new avenue of research at the gene–environment interface

(2011) Marion Leboyer et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

(2010) Alan S. Brown et al.   AMERICAN JOURNAL OF PSYCHIATRY

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

(2010) Renée Douville et al.   ANNALS OF NEUROLOGY

HERVs in Neuropathogenesis

(2010) Tove Christensen   Journal of Neuroimmune Pharmacology

Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis

(2010) S. Sotgiu et al.   Multiple Sclerosis Journal

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

(2010) Yingying Zhang et al.   NUCLEIC ACIDS RESEARCH

The environment and susceptibility to schizophrenia

(2010) Alan S. Brown   PROGRESS IN NEUROBIOLOGY

An N-terminally truncated envelope protein encoded by a human endogenous retrovirus W locus on chromosome Xq22.3

(2010) Christina Roebke et al.   Retrovirology

Implication of the env Gene of the Human Endogenous Retrovirus W Family in the Expression of BDNF and DRD3 and Development of Recent-Onset Schizophrenia

(2010) W. Huang et al.   SCHIZOPHRENIA BULLETIN

Enteroviruses in the pathogenesis of type 1 diabetes

(2010) Sisko Tauriainen et al.   Seminars in Immunopathology

KRAB–Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading

(2010) Anna C. Groner et al.   PLoS Genetics

The Human Endogenous Retrovirus Link between Genes and Environment in Multiple Sclerosis and in Multifactorial Diseases Associating Neuroinflammation

(2009) Hervé Perron et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Human herpesvirus-6B induces expression of the human endogenous retrovirus K18-encoded superantigen

(2009) Vanda Lauridsen Turcanova et al.   JOURNAL OF CLINICAL VIROLOGY

HHV-6A infection induces expression of HERV-K18-encoded superantigen

(2009) Albert K. Tai et al.   JOURNAL OF CLINICAL VIROLOGY

B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity

(2009) Tomasz Brudek et al.   Retrovirology

Effects of Retroviruses on Host Genome Function

(2008) Patric Jern et al.   Annual Review of Genetics

Endogenous Retrovirus Type W GAG and Envelope Protein Antigenemia in Serum of Schizophrenic Patients

(2008) Hervé Perron et al.   BIOLOGICAL PSYCHIATRY

Human endogenous retrovirus HERV-K113 is capable of producing intact viral particles

(2008) K. Boller et al.   JOURNAL OF GENERAL VIROLOGY

Inhibition of multiple sclerosis–associated retrovirus as biomarker of interferon therapy

(2008) Giuseppe Mameli et al.   JOURNAL OF NEUROVIROLOGY

Inflammatory Cytokine Alterations in Schizophrenia: A Systematic Quantitative Review

(2007) Stéphane Potvin et al.   BIOLOGICAL PSYCHIATRY