A new therapeutic approach for type 1 diabetes: Rationale for GNbAC1, an anti-HERV-W-Env monoclonal antibody

Peptide Immunotherapy for Type 1 Diabetes—Clinical Advances

(2018) Emma L. Smith et al.   Frontiers in Immunology

Séquences provenant d’éléments génétiques mobiles, face cachée du génome humain

(2017) Julie Medina et al.   M S-MEDECINE SCIENCES

Mobile DNA in Health and Disease

(2017) Haig H. Kazazian et al.   NEW ENGLAND JOURNAL OF MEDICINE

The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis

(2017) Yong-chao Qiao et al.   PLoS One

T cells in type 1 diabetes: Instructors, regulators and effectors: A comprehensive review

(2016) Iria Gomez-Tourino et al.   JOURNAL OF AUTOIMMUNITY

MSRV envelope protein is a potent, endogenous and pathogenic agonist of human toll-like receptor 4: Relevance of GNbAC1 in multiple sclerosis treatment

(2016) Alexandra Madeira et al.   JOURNAL OF NEUROIMMUNOLOGY

Serum pharmacokinetics and cerebrospinal fluid concentration analysis of the new IgG4 monoclonal antibody GNbAC1 to treat multiple sclerosis: A Phase 1 study

(2016) François Curtin et al.   mAbs

Regulatory evolution of innate immunity through co-option of endogenous retroviruses

(2016) E. B. Chuong et al.   SCIENCE

A placebo randomized controlled study to test the efficacy and safety of GNbAC1, a monoclonal antibody for the treatment of multiple sclerosis – Rationale and design

(2016) Francois Curtin et al.   Multiple Sclerosis and Related Disorders

Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis

(2016) Jack van Horssen et al.   Multiple Sclerosis and Related Disorders

Human Endogenous Retrovirus and Neuroinflammation in Chronic Inflammatory Demyelinating Polyradiculoneuropathy

(2016) Raphaël Faucard et al.   EBioMedicine

Celiac Disease Increases Risk of Thyroid Disease in Patients With Type 1 Diabetes: A Nationwide Cohort Study

(2015) Matthew Kurien et al.   DIABETES CARE

Immunotherapies currently in development for the treatment of type 1 diabetes

(2015) Ian C Davis et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A phase IIa randomized clinical study testing GNbAC1, a humanized monoclonal antibody against the envelope protein of multiple sclerosis associated endogenous retrovirus in multiple sclerosis patients — A twelve month follow-up

(2015) Tobias Derfuss et al.   JOURNAL OF NEUROIMMUNOLOGY

The co-occurrence of multiple sclerosis and type 1 diabetes: Shared aetiologic features and clinical implication for MS aetiology

(2015) Prudence Tettey et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Treatment Against Human Endogenous Retrovirus: A Possible Personalized Medicine Approach for Multiple Sclerosis

(2015) François Curtin et al.   Molecular Diagnosis & Therapy

Disease modifying therapies in type 1 diabetes: Where have we been, and where are we going?

(2015) Sandra Lord et al.   PHARMACOLOGICAL RESEARCH

L1 Retrotransposons and Somatic Mosaicism in the Brain

(2014) Sandra R. Richardson et al.   Annual Review of Genetics

Blood and Islet Phenotypes Indicate Immunological Heterogeneity in Type 1 Diabetes

(2014) Sefina Arif et al.   DIABETES

Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?

(2014) P. N. Nelson et al.   JOURNAL OF RHEUMATOLOGY

Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein

(2014) François Curtin et al.   mAbs

A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients

(2014) Tobias Derfuss et al.   Multiple Sclerosis Journal

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

(2013) David Kremer et al.   ANNALS OF NEUROLOGY

Progress in immune-based therapies for type 1 diabetes

(2013) M. von Herrath et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Coxsackievirus B1 Is Associated With Induction of  -Cell Autoimmunity That Portends Type 1 Diabetes

(2013) O. H. Laitinen et al.   DIABETES

Thyroid autoimmunity in Type 1 diabetes: systematic review and meta-analysis

(2013) C. B. Shun et al.   DIABETIC MEDICINE

Natalizumab inhibits the expression of human endogenous retroviruses of the W family in multiple sclerosis patients: a longitudinal cohort study

(2013) Giannina Arru et al.   Multiple Sclerosis Journal

Human Endogenous Retrovirus Protein Activates Innate Immunity and Promotes Experimental Allergic Encephalomyelitis in Mice

(2013) Hervé Perron et al.   PLoS One

GNbAC1, a Humanized Monoclonal Antibody Against the Envelope Protein of Multiple Sclerosis—Associated Endogenous Retrovirus: A First-in-Humans Randomized Clinical Study

(2012) François Curtin et al.   CLINICAL THERAPEUTICS

Infection as a cause of type 1 diabetes?

(2012) Urs Christen et al.   CURRENT OPINION IN RHEUMATOLOGY

Immunological pathways to β-cell damage in Type 1 diabetes

(2012) M. Peakman   DIABETIC MEDICINE

Toll-like receptor 4 on islet β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes

(2012) Min Li et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

(2012) Hervé Perron et al.   Multiple Sclerosis Journal

Endogenous viruses: insights into viral evolution and impact on host biology

(2012) Cédric Feschotte et al.   NATURE REVIEWS GENETICS

Expression and Activation by Epstein Barr Virus of Human Endogenous Retroviruses-W in Blood Cells and Astrocytes: Inference for Multiple Sclerosis

(2012) Giuseppe Mameli et al.   PLoS One

Toll-like receptor 4 (TLR4) expression in human and murine pancreatic beta-cells affects cell viability and insulin homeostasis

(2011) Humberto M Garay-Malpartida et al.   BMC IMMUNOLOGY

T cell receptor recognition of self and foreign antigens in the induction of autoimmunity

(2011) Kai W. Wucherpfennig et al.   SEMINARS IN IMMUNOLOGY

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis

(2010) Renée Douville et al.   ANNALS OF NEUROLOGY

Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis

(2010) S. Sotgiu et al.   Multiple Sclerosis Journal

The enemy within: dormant retroviruses awaken

(2010) Michael E Engel et al.   NATURE MEDICINE

Enteroviruses in the pathogenesis of type 1 diabetes

(2010) Sisko Tauriainen et al.   Seminars in Immunopathology

The Human Endogenous Retrovirus Link between Genes and Environment in Multiple Sclerosis and in Multifactorial Diseases Associating Neuroinflammation

(2009) Hervé Perron et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Endogenous retroviral genes, Herpesviruses and gender in Multiple Sclerosis

(2009) Hervé Perron et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Incidence and prevalence of CIDP and the association of diabetes mellitus

(2009) R. S. Laughlin et al.   NEUROLOGY

Molecular mimicry and immunomodulation by the HRES-1 endogenous retrovirus in SLE

(2008) Andras Perl et al.   AUTOIMMUNITY

Endogenous Retrovirus Type W GAG and Envelope Protein Antigenemia in Serum of Schizophrenic Patients

(2008) Hervé Perron et al.   BIOLOGICAL PSYCHIATRY

Inhibition of multiple sclerosis–associated retrovirus as biomarker of interferon therapy

(2008) Giuseppe Mameli et al.   JOURNAL OF NEUROVIROLOGY