Review
Dentistry, Oral Surgery & Medicine
Rafael Paschoal Esteves Lima, Andressa Rafaela Silva Atanazio, Fernando Oliveira Costa, Fabiano Araujo Cunha, Lucas Guimaraes Abreu
Summary: This study found that non-surgical periodontal therapy has a significant impact on serum TNF-alpha levels in individuals with type 2 diabetes mellitus six months after treatment. Included studies showed low risk of bias.
JOURNAL OF EVIDENCE-BASED DENTAL PRACTICE
(2021)
Review
Biochemistry & Molecular Biology
Mitra Hariri, Bahareh Amirkalali, Hamid Reza Baradaran, Ali Gholami
Summary: This study conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effect of parenteral selenium on inflammatory markers. The results revealed that parenteral selenium supplementation significantly reduced serum IL-6 levels but did not have a significant effect on CRP levels.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Chemistry, Medicinal
Mitra Hariri, Hamid Reza Baradaran, Ali Gholami
Summary: The study found that soy isoflavones or the combination of soy isoflavones and soy protein do not significantly reduce serum concentration of TNF-alpha, based on a systematic review and meta-analysis of randomized clinical trials.
PHYTOTHERAPY RESEARCH
(2021)
Review
Clinical Neurology
Baotian Wang, Fan Wang, De Wu, Xiaoyan Xu, Li Yang, Jing Zhu, Jinjing Yuan, Jiulai Tang
Summary: The meta-analysis found an association between blood TNF-alpha levels and the risk of cerebral palsy in children, confirming the correlation between the two. Further investigation is needed to explore the exact relationship between TNF-alpha and cerebral palsy.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jesselina Francisco dos Santos Haber, Sandra Maria Barbalho, Jose Augusto Sgarbi, Rafael Santos de Argollo Haber, Roger William de Labio, Lucas Fornari Laurindo, Eduardo Federighi Baisi Chagas, Spencer Luiz Marques Payao
Summary: This study aimed to investigate the expression of interleukin-10 (IL-10) and tumor necrosis factor-alpha (TNF-α) in type 1 diabetes mellitus (T1DM). The study found that cytokine gene expression was higher in T1DM patients, with IL-10 gene expression significantly increased in patients with ketoacidosis and positively correlated with HbA1c levels. IL-10 expression was negatively correlated with the age of diabetes patients and the time of diagnosis. TNF-α expression showed a positive correlation with age. The expression of IL-10 and TNF-α genes significantly increased in T1DM patients.
Review
Environmental Sciences
Zhouyang Xu, Wanzhou Wang, Qisijing Liu, Zichuan Li, Lei Lei, Lihua Ren, Furong Deng, Xinbiao Guo, Shaowei Wu
Summary: Short-term exposure to gaseous air pollutants is significantly associated with increased levels of inflammatory biomarkers, while the associations with long-term exposure are weaker and require further verification. Studies with better design and higher quality show more apparent associations.
ENVIRONMENTAL POLLUTION
(2022)
Review
Biochemistry & Molecular Biology
Cristina Maria Sabo, Mohamed Ismaiel, Abdulrahman Ismaiel, Daniel-Corneliu Leucuta, Stefan-Lucian Popa, Simona Grad, Dan L. L. Dumitrascu
Summary: In this study, the levels of tumor necrosis factor-alpha (TNF-a) in the colon were evaluated in patients with diverticular disease (DD). The results showed no significant difference in mucosal TNF-a levels between symptomatic uncomplicated DD and asymptomatic DD patients. However, TNF-a levels were significantly higher in DD patients compared to irritable bowel syndrome (IBS) patients. These findings suggest that TNF-a may play a key role in the pathogenesis of DD and could be a potential target for future therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Aleksandar Jakovljevic, Nadja Nikolic, Jelena Jacimovic, Maja Miletic, Miroslav Andric, Jelena Milasin, Anita Aminoshariae, Amir Azarpazhooh
Summary: This study found no significant association between TNF-alpha 2308 G/A SNP and the risk of development of apical periodontitis (AP). Genetic factors did not show significant correlation with the clinical manifestations of AP (acute vs chronic). Further well-designed multicentric studies are needed to explore the relationship between TNF-alpha SNP and the development of AP due to the very low certainty of evidence.
JOURNAL OF ENDODONTICS
(2021)
Article
Endocrinology & Metabolism
Jing Liu, Guang Song, Ge Zhao, Tao Meng
Summary: The meta-analysis found a significant association between TNF-alpha rs1800629 and GDM risk in the Asian population, while no association was observed for rs361525 and rs1799724. Further multi-ethnic and larger sample size studies are needed to confirm these findings.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Review
Psychiatry
Hisashi Eguchi, Kazuhiro Watanabe, Norito Kawakami, Emiko Ando, Kotaro Imamura, Asuka Sakuraya, Natsu Sasaki, Akiomi Inoue, Kanami Tsuno, Yasumasa Otsuka, Reiko Inoue, Norimitsu Nishida, Mai Iwanaga, Ayako Hino, Akihito Shimazu, Akizumi Tsutsumi
Summary: This study conducted a systematic review and meta-analysis to evaluate the prospective effect of adverse work-related psychosocial factors on increases in inflammatory markers. The results showed a weak positive association between adverse work-related psychosocial factors and increases in inflammatory markers.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Ji Won Han, Da In Kim, Hee Chul Nam, U. Im Chang, Jin Mo Yang, Do Seon Song
Summary: This study investigates the association between systemic inflammation and sarcopenia in liver cirrhosis. The results demonstrate that serum tumor necrosis factor-alpha (TNF-alpha) levels are elevated in liver cirrhosis rats and correlated with muscle weight and myofiber diameter. Furthermore, treatment with rifaximin reduces TNF-alpha levels and improves sarcopenia in liver cirrhosis. These findings suggest a potential therapeutic target for managing sarcopenia in liver cirrhosis patients.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Review
Immunology
Zeynab Kavyani, Vali Musazadeh, Sahar Golpour-hamedani, Amir Hossein Moridpour, Mahdi Vajdi, Gholamreza Askari
Summary: This study aimed to evaluate the effect of Nigella sativa supplementation on inflammatory and oxidative markers among adults. The results of 20 randomized controlled trials showed that N. sativa supplementation significantly reduced serum CRP, TNF-a, and MDA levels, and significantly improved TAC, GPx, and SOD levels. However, there was no significant reduction in IL-6 levels. Therefore, Nigella sativa can be recommended as an adjuvant anti-oxidant agent and anti-inflammatory.
INFLAMMOPHARMACOLOGY
(2023)
Review
Food Science & Technology
Shanshan Hou, Zezhong Tian, Dan Zhao, Ying Liang, Suming Dai, Qiuhua Ji, Zhiying Fan, Zhihao Liu, Meitong Liu, Yan Yang
Summary: This meta-analysis examines the efficacy and optimal dose of CoQ10 supplementation on inflammatory indicators. The results show that CoQ10 can significantly reduce the levels of circulating CRP, IL-6, and TNF-a, and increase the concentration of circulating CoQ10. Daily supplementation of 300-400 mg CoQ10 is recommended for superior inhibition of inflammatory factors.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Medicine, General & Internal
Chul-Hyun Cho, Du-Hwan Kim, Eun-Hee Baek, Du-Han Kim
Summary: The study aimed to determine serum levels of sleep-related cytokines in patients with rotator cuff tear experiencing pain-related sleep disturbance. The results showed that TNF-alpha levels were significantly higher in the sleep disturbance group compared to the non-sleep disturbance group and control group. Additionally, levels of IL-8 and IL-10 were also significantly higher in the sleep disturbance group. There were no associations found between serum levels of sleep-related cytokines and clinical scores.
Article
Environmental Sciences
Tao Zhang, Shuo Wang, Ludi Li, An Zhu, Qi Wang
Summary: This study used computational methods and the adverse outcome pathway (AOP) framework to investigate the mechanism between DEHP and GDM. By constructing a DEHP-Gene-Phenotype-GDM network and assessing computational AOPs, it was found that the effects of DEHP on GDM may be achieved through increased TNF-alpha and regulation of glucose uptake.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)