Preclinical and early clinical development of GNbAC1, a humanized IgG4 monoclonal antibody targeting endogenous retroviral MSRV-Env protein

Unfixed Endogenous Retroviral Insertions in the Human Population

(2014) E. Marchi et al.   JOURNAL OF VIROLOGY

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

(2013) David Kremer et al.   ANNALS OF NEUROLOGY

Natalizumab inhibits the expression of human endogenous retroviruses of the W family in multiple sclerosis patients: a longitudinal cohort study

(2013) Giannina Arru et al.   Multiple Sclerosis Journal

Human Endogenous Retrovirus Protein Activates Innate Immunity and Promotes Experimental Allergic Encephalomyelitis in Mice

(2013) Hervé Perron et al.   PLoS One

Novel therapeutic options for multiple sclerosis

(2013) François Curtin et al.   Expert Review of Clinical Pharmacology

GNbAC1, a Humanized Monoclonal Antibody Against the Envelope Protein of Multiple Sclerosis—Associated Endogenous Retrovirus: A First-in-Humans Randomized Clinical Study

(2012) François Curtin et al.   CLINICAL THERAPEUTICS

Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease

(2012) Hervé Perron et al.   Multiple Sclerosis Journal

Alemtuzumab Therapy for Multiple Sclerosis

(2012) Alasdair J. Coles   Neurotherapeutics

Expression and Activation by Epstein Barr Virus of Human Endogenous Retroviruses-W in Blood Cells and Astrocytes: Inference for Multiple Sclerosis

(2012) Giuseppe Mameli et al.   PLoS One

Managing the risks of immunosuppression

(2011) D Sean Riminton et al.   CURRENT OPINION IN NEUROLOGY

Epigenetic regulation of transcription and splicing of syncytins, fusogenic glycoproteins of retroviral origin

(2011) Kateřina Trejbalová et al.   NUCLEIC ACIDS RESEARCH

Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies

(2010) Diane R. Mould et al.   BIODRUGS

Monoclonal antibody therapy in multiple sclerosis

(2010) Paulo Fontoura   mAbs

Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies

(2010) Frank R. Brennan et al.   mAbs

Multiple sclerosis-associated retrovirus and progressive disability of multiple sclerosis

(2010) S. Sotgiu et al.   Multiple Sclerosis Journal

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Lack of immune responses against multiple sclerosis–associated retrovirus/human endogenous retrovirus W in patients with multiple sclerosis

(2008) Klemens Ruprecht et al.   JOURNAL OF NEUROVIROLOGY

Inhibition of multiple sclerosis–associated retrovirus as biomarker of interferon therapy

(2008) Giuseppe Mameli et al.   JOURNAL OF NEUROVIROLOGY

Rituximab levels in cerebrospinal fluid of patients with neurological autoimmune disorders

(2008) HF Petereit et al.   Multiple Sclerosis Journal