Inflammation and the neural diathesis-stress hypothesis of schizophrenia: a reconceptualization

Early life stress perturbs the maturation of microglia in the developing hippocampus

(2016) Jean-Christophe Delpech et al.   BRAIN BEHAVIOR AND IMMUNITY

Schizophrenia associated sensory gating deficits develop after adolescent microglia activation

(2016) Manuela Eßlinger et al.   BRAIN BEHAVIOR AND IMMUNITY

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review

(2016) M O Trépanier et al.   MOLECULAR PSYCHIATRY

In vivo imaging of brain microglial activity in antipsychotic-free and medicated schizophrenia: a [11C](R)-PK11195 positron emission tomography study

(2016) S E Holmes et al.   MOLECULAR PSYCHIATRY

A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression

(2016) D R Goldsmith et al.   MOLECULAR PSYCHIATRY

Schizophrenia risk from complex variation of complement component 4

(2016) Aswin Sekar et al.   NATURE

Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome

(2016) Kirstie J. Whitaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fetal exposure to maternal stress and risk for schizophrenia spectrum disorders among offspring: Differential influences of fetal sex

(2016) Anna M. Fineberg et al.   PSYCHIATRY RESEARCH

Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness

(2016) Marilia A. Calcia et al.   PSYCHOPHARMACOLOGY

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Refugee migration and risk of schizophrenia and other non-affective psychoses: cohort study of 1.3 million people in Sweden

(2016) Anna-Clara Hollander et al.   BMJ-British Medical Journal

Refugee migration and risk of schizophrenia and other non-affective psychoses: cohort study of 1.3 million people in Sweden

(2016) Anna-Clara Hollander et al.   BMJ-British Medical Journal

In vivo markers of inflammatory response in recent-onset schizophrenia: a combined study using [11C]DPA-713 PET and analysis of CSF and plasma

(2016) J M Coughlin et al.   Translational Psychiatry

The methodology of TSPO imaging with positron emission tomography

(2015) Federico E. Turkheimer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

In Search of Multimodal Neuroimaging Biomarkers of Cognitive Deficits in Schizophrenia

(2015) Jing Sui et al.   BIOLOGICAL PSYCHIATRY

Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

(2015) Tyrone D. Cannon et al.   BIOLOGICAL PSYCHIATRY

Roles of microglia in brain development, tissue maintenance and repair

(2015) Mackenzie A. Michell-Robinson et al.   BRAIN

Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses

(2015) Marie-Caroline Cotel et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Very Early Brain Damage Leads to Remodeling of the Working Memory System in Adulthood: A Combined fMRI/Tractography Study

(2015) S. Froudist-Walsh et al.   JOURNAL OF NEUROSCIENCE

Glutamate and dopamine in schizophrenia: An update for the 21st century

(2015) Oliver Howes et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α

(2015) D Baumeister et al.   MOLECULAR PSYCHIATRY

Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine

(2015) Il Hwan Kim et al.   NATURE NEUROSCIENCE

The role of inflammation in perinatal brain injury

(2015) Henrik Hagberg et al.   Nature Reviews Neurology

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

(2015) Christine M. Sandiego et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortisol and Inflammatory Biomarkers Predict Poor Treatment Response in First Episode Psychosis

(2015) Valeria Mondelli et al.   SCHIZOPHRENIA BULLETIN

Neuroinflammation and white matter pathology in schizophrenia: systematic review

(2015) Souhel Najjar et al.   SCHIZOPHRENIA RESEARCH

Therapeutic strategies in multiple sclerosis: A focus on neuroprotection and repair and relevance to schizophrenia

(2015) Matilde Inglese et al.   SCHIZOPHRENIA RESEARCH

The permissive role of glucocorticoids in neuroinflammatory priming

(2015) Matthew G. Frank et al.   Current Opinion in Endocrinology Diabetes and Obesity

Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset

(2015) M K Chan et al.   Translational Psychiatry

Serological Documentation of Maternal Influenza Exposure and Bipolar Disorder in Adult Offspring

(2014) Sarah E. Canetta et al.   AMERICAN JOURNAL OF PSYCHIATRY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder

(2014) Christa Hercher et al.   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Minocycline and Risperidone Prevent Microglia Activation and Rescue Behavioral Deficits Induced by Neonatal Intrahippocampal Injection of Lipopolysaccharide in Rats

(2014) Furong Zhu et al.   PLoS One

Inflamed moods: A review of the interactions between inflammation and mood disorders

(2014) Joshua D. Rosenblat et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Imaging Neuroinflammation in Gray and White Matter in Schizophrenia: An In-Vivo PET Study With [18F]-FEPPA

(2014) M. Kenk et al.   SCHIZOPHRENIA BULLETIN

Cytokine function in medication-naive first episode psychosis: A systematic review and meta-analysis

(2014) Rachel Upthegrove et al.   SCHIZOPHRENIA RESEARCH

From stress to psychosis: whom, how, when and why?

(2014) V. Mondelli   Epidemiology and Psychiatric Sciences

Urban social stress – Risk factor for mental disorders. The case of schizophrenia

(2013) Florian Lederbogen et al.   ENVIRONMENTAL POLLUTION

Microglial activation underlies cerebellar deficits produced by repeated cannabis exposure

(2013) Laura Cutando et al.   JOURNAL OF CLINICAL INVESTIGATION

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Layer V cortical neurons require microglial support for survival during postnatal development

(2013) Masaki Ueno et al.   NATURE NEUROSCIENCE

Microglia: New Roles for the Synaptic Stripper

(2013) Helmut Kettenmann et al.   NEURON

S100B and schizophrenia

(2013) Silvia Yelmo-Cruz et al.   PSYCHIATRY AND CLINICAL NEUROSCIENCES

A systematic review of the activity of the hypothalamic–pituitary–adrenal axis in first episode psychosis

(2013) Susana Borges et al.   PSYCHONEUROENDOCRINOLOGY

Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus

(2013) Matthew G. Frank et al.   PSYCHONEUROENDOCRINOLOGY

Evidences for a progressive microglial activation and increase in iNOS expression in rats submitted to a neurodevelopmental model of schizophrenia: Reversal by clozapine

(2013) Bruna Mara Machado Ribeiro et al.   SCHIZOPHRENIA RESEARCH

Perinatal maternal life events and psychotic experiences in children at twelve years in a birth cohort study

(2013) Sarah Dorrington et al.   SCHIZOPHRENIA RESEARCH

Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice

(2013) S. Giovanoli et al.   SCIENCE

Adolescent Stress-Induced Epigenetic Control of Dopaminergic Neurons via Glucocorticoids

(2013) M. Niwa et al.   SCIENCE

Urbanicity, social adversity and psychosis

(2013) Andreas Heinz et al.   World Psychiatry

Rethinking schizophrenia in the context of normal neurodevelopment

(2013) Vibeke S. Catts et al.   Frontiers in Cellular Neuroscience

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

(2012) Angela M. Kaindl et al.   ANNALS OF NEUROLOGY

The Nature of Dopamine Dysfunction in Schizophrenia and What This Means for Treatment

(2012) Oliver D. Howes et al.   ARCHIVES OF GENERAL PSYCHIATRY

Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: Further evidence for disease course-related immune alterations?

(2012) Stefan Busse et al.   BRAIN BEHAVIOR AND IMMUNITY

A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia

(2012) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

Prenatal stress increases the expression of proinflammatory cytokines and exacerbates the inflammatory response to LPS in the hippocampal formation of adult male mice

(2012) Yolanda Diz-Chaves et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuropsychological variability, symptoms, and brain imaging in chronic schizophrenia

(2012) Paul G. Nestor et al.   Brain Imaging and Behavior

DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience

(2012) Marta Peciña et al.   CORTEX

Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice

(2012) Yolanda Diz-Chaves et al.   Journal of Neuroinflammation

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

(2012) Jonathan Vinet et al.   Journal of Neuroinflammation

Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging

(2012) S. Lavisse et al.   JOURNAL OF NEUROSCIENCE

Abnormal synaptic pruning in schizophrenia: Urban myth or reality?

(2012) Patricia Boksa   JOURNAL OF PSYCHIATRY & NEUROSCIENCE

Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia

(2012) S G Fillman et al.   MOLECULAR PSYCHIATRY

Neuroinflammation and Synaptic Loss

(2012) Jagadeesh S. Rao et al.   NEUROCHEMICAL RESEARCH

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

(2012) Dorothy P. Schafer et al.   NEURON

Systematic meta-review and quality assessment of the structural brain alterations in schizophrenia

(2012) Alana M. Shepherd et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Microglia in the developing brain: A potential target with lifetime effects

(2012) G. Jean Harry et al.   NEUROTOXICOLOGY

Stress abnormalities in individuals at risk for psychosis: A review of studies in subjects with familial risk or with “at risk” mental state

(2012) Giuliano Aiello et al.   PSYCHONEUROENDOCRINOLOGY

Childhood infection and adult schizophrenia: A meta-analysis of population-based studies

(2012) Golam M. Khandaker et al.   SCHIZOPHRENIA RESEARCH

The role of microglia during life span in neuropsychiatric disease — an animal study

(2012) Marie Pierre Manitz et al.   SCHIZOPHRENIA RESEARCH

Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic

(2011) L. Sominsky et al.   BEHAVIOURAL BRAIN RESEARCH

Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses

(2011) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

(2011) M. Hinwood et al.   CEREBRAL CORTEX

Stress and Inflammation Reduce Brain-Derived Neurotrophic Factor Expression in First-Episode Psychosis

(2011) Valeria Mondelli et al.   JOURNAL OF CLINICAL PSYCHIATRY

A Lifespan Approach to Neuroinflammatory and Cognitive Disorders: A Critical Role for Glia

(2011) Staci D. Bilbo et al.   Journal of Neuroimmune Pharmacology

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

(2011) J. V. Faustino et al.   JOURNAL OF NEUROSCIENCE

Dopamine system dysregulation by the hippocampus: Implications for the pathophysiology and treatment of schizophrenia

(2011) Anthony A. Grace   NEUROPHARMACOLOGY

Inflammatory processes in schizophrenia: A promising neuroimmunological target for the treatment of negative/cognitive symptoms and beyond

(2011) Urs Meyer et al.   PHARMACOLOGY & THERAPEUTICS

Adverse childhood experiences, allostasis, allostatic load, and age-related disease

(2011) Andrea Danese et al.   PHYSIOLOGY & BEHAVIOR

Microglial glucocorticoid receptors play a pivotal role in regulating dopaminergic neurodegeneration in parkinsonism

(2011) F. Ros-Bernal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extraordinary neoteny of synaptic spines in the human prefrontal cortex

(2011) Zdravko Petanjek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroanatomical Maps of Psychosis Onset: Voxel-wise Meta-Analysis of Antipsychotic-Naive VBM Studies

(2011) P. Fusar-Poli et al.   SCHIZOPHRENIA BULLETIN

Age of Onset of Schizophrenia: Perspectives From Structural Neuroimaging Studies

(2011) N. Gogtay et al.   SCHIZOPHRENIA BULLETIN

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Prenatal Infection and Schizophrenia: A Review of Epidemiologic and Translational Studies

(2010) Alan S. Brown et al.   AMERICAN JOURNAL OF PSYCHIATRY

Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions

(2010) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

Effects of prenatal infection on brain development and behavior: A review of findings from animal models

(2010) Patricia Boksa   BRAIN BEHAVIOR AND IMMUNITY

Peripheral benzodiazepine receptors in patients with chronic schizophrenia: a PET study with [11C]DAA1106

(2010) Akihiro Takano et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The role of p38 MAPK in valproic acid induced microglia apoptosis

(2010) Nanchang Xie et al.   NEUROSCIENCE LETTERS

The environment and susceptibility to schizophrenia

(2010) Alan S. Brown   PROGRESS IN NEUROBIOLOGY

Prenatal stress alters microglial development and distribution in postnatal rat brain

(2009) Beatriz Gómez-González et al.   ACTA NEUROPATHOLOGICA

Actions of estrogens on glial cells: Implications for neuroprotection

(2009) María-Angeles Arevalo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cingulate White Matter Neurons in Schizophrenia and Bipolar Disorder

(2009) Caroline M. Connor et al.   BIOLOGICAL PSYCHIATRY

Gene expression in the prefrontal cortex during adolescence: implications for the onset of schizophrenia

(2009) Laura W Harris et al.   BMC Medical Genomics

Glial cells in schizophrenia: pathophysiological significance and possible consequences for therapy

(2009) Hans-Gert Bernstein et al.   Expert Review of Neurotherapeutics

Anti-inflammatory and anti-oxidant activity of anionic dendrimer–N-acetyl cysteine conjugates in activated microglial cells

(2009) Bing Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Neuroinflammation in Schizophrenia-Related Psychosis: A PET Study

(2009) J. Doorduin et al.   JOURNAL OF NUCLEAR MEDICINE

Microglia Activation in Recent-Onset Schizophrenia: A Quantitative (R)-[11C]PK11195 Positron Emission Tomography Study

(2008) Bart N. van Berckel et al.   BIOLOGICAL PSYCHIATRY

Prenatal lipopolysaccharide does not accelerate progressive dopamine neuron loss in the rat as a result of normal aging

(2008) Zaodung Ling et al.   EXPERIMENTAL NEUROLOGY

Steroid hormone receptor expression and function in microglia

(2008) Amanda Sierra et al.   GLIA

Inhibitory effects of aripiprazole on interferon--induced microglial activation via intracellular Ca2+regulationin vitro

(2008) Takahiro Kato et al.   JOURNAL OF NEUROCHEMISTRY

Imaging of Peripheral Benzodiazepine Receptor Expression as Biomarkers of Detrimental versus Beneficial Glial Responses in Mouse Models of Alzheimer's and Other CNS Pathologies

(2008) B. Ji et al.   JOURNAL OF NEUROSCIENCE

Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain

(2008) M. Cosenza-Nashat et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Cumulative social disadvantage, ethnicity and first-episode psychosis: a case-control study

(2008) C. Morgan et al.   PSYCHOLOGICAL MEDICINE

Bacterial infection early in life protects against stressor-induced depressive-like symptoms in adult rats

(2008) Staci D. Bilbo et al.   PSYCHONEUROENDOCRINOLOGY

Psychosocial Stress and Psychosis. A Review of the Neurobiological Mechanisms and the Evidence for Gene-Stress Interaction

(2008) R. van Winkel et al.   SCHIZOPHRENIA BULLETIN

Selected Infectious Agents and Risk of Schizophrenia Among U.S. Military Personnel

(2007) David W. Niebuhr et al.   AMERICAN JOURNAL OF PSYCHIATRY

S100B-immunopositive glia is elevated in paranoid as compared to residual schizophrenia: A morphometric study

(2007) Johann Steiner et al.   JOURNAL OF PSYCHIATRIC RESEARCH