Inside the Insulin Secretory Granule

Loss of Znt8 function in diabetes mellitus: risk or benefit?

(2021) Carla P. Barragán-Álvarez et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Isolation and Proteomics of the Insulin Secretory Granule

(2021) Nicholas Norris et al.   Metabolites

Zinc and the Innovative Zinc-α2-Glycoprotein Adipokine Play an Important Role in Lipid Metabolism: A Critical Review

(2021) Michalina Banaszak et al.   Nutrients

Pancreatic β cell–selective zinc transporter 8 insufficiency accelerates diabetes associated with islet amyloidosis

(2021) Jie Xu et al.   JCI Insight

PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice

(2020) Yi-Chun Chen et al.   DIABETOLOGIA

Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 But Not PC2

(2020) Adam Ramzy et al.   DIABETES

Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells

(2020) Mototsugu Nagao et al.   DIABETES

Chromogranin A preferential interaction with Golgi phosphatidic acid induces membrane deformation and contributes to secretory granule biogenesis

(2020) Ophélie Carmon et al.   FASEB JOURNAL

The magnesium transporter NIPAL1 is a pancreatic islet-expressed protein that conditionally impacts insulin secretion

(2020) Yousef Manialawy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potential positive and negative consequences of ZnT8 inhibition

(2020) Kristen E Syring et al.   JOURNAL OF ENDOCRINOLOGY

Regulation of V-ATPase Activity and Organelle pH by Phosphatidylinositol Phosphate Lipids

(2020) Subhrajit Banerjee et al.   Frontiers in Cell and Developmental Biology

Paracrine and autocrine control of insulin secretion in human islets: evidence and pending questions

(2020) Jean-Claude Henquin   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Loss of Furin in β-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to β-Cell Dysfunction

(2020) Bas Brouwers et al.   DIABETES

Impaired glucose-stimulated proinsulin secretion is an early marker of β-cell impairment before prediabetes stage

(2019) Ying Yang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Lipid‐dependent coupling of secretory cargo sorting and trafficking at the trans‐Golgi network

(2019) Julia von Blume et al.   FEBS LETTERS

Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells

(2019) Shelby C. Bearrows et al.   JOURNAL OF CELL SCIENCE

Glutamate as intracellular and extracellular signals in pancreatic islet functions

(2019) Harumi TAKAHASHI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Atp6ap2 deletion causes extensive vacuolation that consumes the insulin content of pancreatic β cells

(2019) Katrina J. Binger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

(2019) Om Prakash Dwivedi et al.   NATURE GENETICS

Recent Insights into Beta-cell Exocytosis in Type 2 Diabetes

(2019) Debbie C. Thurmond et al.   JOURNAL OF MOLECULAR BIOLOGY

Differential sorting behavior for soluble and transmembrane cargoes at the trans-Golgi network in endocrine cells.

(2019) Blake H. Hummer et al.   MOLECULAR BIOLOGY OF THE CELL

Age-related changes of proinsulin processing in diabetic and non-diabetic Japanese individuals

(2018) Hiroshi Yoshino et al.   Geriatrics & Gerontology International

Control of insulin granule formation and function by the ABC transporters ABCG1 and ABCA1 and by oxysterol binding protein OSBP

(2018) Syed Saad Hussain et al.   MOLECULAR BIOLOGY OF THE CELL

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

(2018) Soren K. Thomsen et al.   NATURE GENETICS

Increased Beta Cell Workload Modulates Proinsulin/Insulin Ratio in Humans

(2018) Teresa Mezza et al.   DIABETES

Islet prohormone processing in health and disease

(2018) Yi-Chun Chen et al.   DIABETES OBESITY & METABOLISM

The β-cell assassin: IAPP cytotoxicity

(2017) Daniel Raleigh et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Zinc Supplementation Improves Glucose Homeostasis in High Fat-Fed Mice by Enhancing Pancreatic β-Cell Function

(2017) Vinícius Cooper-Capetini et al.   Nutrients

The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis

(2017) Samuel B. Stephens et al.   Cell Reports

The zinc transporter ZNT3 co-localizes with insulin in INS-1E pancreatic beta cells and influences cell survival, insulin secretion capacity, and ZNT8 expression

(2016) Kamille Smidt et al.   BIOMETALS

hZnT8 (Slc30a8) Transgenic Mice That Overexpress the R325W Polymorph Have Reduced Islet Zn 2+ and Proinsulin Levels, Increased Glucose Tolerance After a High-Fat Diet, and Altered Levels of Pancreatic Zinc Binding Proteins

(2016) Li Li et al.   DIABETES

Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide

(2016) Jaques A. Courtade et al.   DIABETOLOGIA

Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion

(2016) Kristen E. Syring et al.   ENDOCRINOLOGY

Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes

(2016) Chengfeng Merriman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIDT2 is involved in the NAADP-mediated release of calcium from insulin secretory granules

(2016) Guoying Chang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate

(2016) Ingrid C. Rulifson et al.   PLoS One

IP3receptors: Take four IP3to open

(2016) Colin W. Taylor et al.   Science Signaling

IP3receptors: Take four IP3to open

(2016) Colin W. Taylor et al.   Science Signaling

Pancreatic β-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function

(2015) Cristina Alarcon et al.   DIABETES

A Novel GLP1 Receptor Interacting Protein ATP6ap2 Regulates Insulin Secretion in Pancreatic Beta Cells

(2015) Feihan F. Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C

(2015) Dhivya Kumar et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Distribution Profile of Inositol 1,4,5-Trisphosphate Receptor/Ca2+ Channels in α and β Cells of Pancreas

(2015) Yong Suk Hur et al.   PANCREAS

Intracellular zinc in insulin secretion and action: a determinant of diabetes risk?

(2015) Guy A. Rutter et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Both Fasting and Glucose-Stimulated Proinsulin Levels Predict Hyperglycemia and Incident Type 2 Diabetes: A Population-Based Study of 9,396 Finnish Men

(2015) Jagadish Vangipurapu et al.   PLoS One

Inhibition of IAPP aggregation by insulin depends on the insulin oligomeric state regulated by zinc ion concentration

(2015) Praveen Nedumpully-Govindan et al.   Scientific Reports

The Ability of Insulin To Inhibit the Formation of Amyloid by Pro-Islet Amyloid Polypeptide Processing Intermediates Is Significantly Reduced in the Presence of Sulfated Glycosaminoglycans

(2014) Hui Wang et al.   BIOCHEMISTRY

SLC30A8 mutations in type 2 diabetes

(2014) Guy A. Rutter et al.   DIABETOLOGIA

The vacuolar-type H+-ATPase at a glance - more than a proton pump

(2014) M. E. Maxson et al.   JOURNAL OF CELL SCIENCE

Zinc transporter 8 (ZnT8) and β cell function

(2014) Howard W. Davidson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity

(2014) Shohei Sakamoto et al.   Scientific Reports

Inhibitory effect of zinc on glucose-stimulated zinc/insulin secretion in an insulin-secreting β-cell line

(2013) Kira G. Slepchenko et al.   EXPERIMENTAL PHYSIOLOGY

Zinc, insulin, and the liver: a ménage à trois

(2013) Thomas V. O’Halloran et al.   JOURNAL OF CLINICAL INVESTIGATION

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

(2013) Motoyuki Tamaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired Glucose Tolerance in a Mouse Model of Sidt2 Deficiency

(2013) Jialin Gao et al.   PLoS One

Saturated Fatty Acids Alter the Late Secretory Pathway by Modulating Membrane Properties

(2013) Laurie-Anne Payet et al.   TRAFFIC

Regulation of β-cell function by RNA-binding proteins

(2013) Maria Grazia Magro et al.   Molecular Metabolism

Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes

(2012) M. Liu et al.   DIABETES

Chromogranin A Induces the Biogenesis of Granules with Calcium- and Actin-Dependent Dynamics and Exocytosis in Constitutively Secreting Cells

(2012) Salah Elias et al.   ENDOCRINOLOGY

Vesicular Nucleotide Transporter-Mediated ATP Release Regulates Insulin Secretion

(2012) Jessica C. Geisler et al.   ENDOCRINOLOGY

Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptide

(2012) Michael Landreh et al.   FEBS Journal

Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability

(2012) S. Gharanei et al.   HUMAN MOLECULAR GENETICS

Proinsulin Intermolecular Interactions during Secretory Trafficking in Pancreatic β Cells

(2012) Leena Haataja et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi network

(2012) Julia von Blume et al.   JOURNAL OF CELL BIOLOGY

Multiple Sorting Systems for Secretory Granules Ensure the Regulated Secretion of Peptide Hormones

(2012) Meng Sun et al.   TRAFFIC

Cholesterol Accumulation Increases Insulin Granule Size and Impairs Membrane Trafficking

(2012) Jonathan S. Bogan et al.   TRAFFIC

Zinc transporters and their role in the pancreatic β-cell

(2012) Katleen Lemaire et al.   Journal of Diabetes Investigation

Membrane Disruption and Early Events in the Aggregation of the Diabetes Related Peptide IAPP from a Molecular Perspective

(2011) Jeffrey R. Brender et al.   ACCOUNTS OF CHEMICAL RESEARCH

ADF/Cofilin Regulates Secretory Cargo Sorting at the TGN via the Ca2+ ATPase SPCA1

(2011) Julia von Blume et al.   DEVELOPMENTAL CELL

Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model

(2011) A. B. Hardy et al.   DIABETES OBESITY & METABOLISM

The Extended Granin Family: Structure, Function, and Biomedical Implications

(2011) Alessandro Bartolomucci et al.   ENDOCRINE REVIEWS

Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic  -cells

(2011) M. Hatanaka et al.   HUMAN MOLECULAR GENETICS

Structural Analysis of Proinsulin Hexamer Assembly by Hydroxyl Radical Footprinting and Computational Modeling

(2011) Janna G. Kiselar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose Regulates Free Cytosolic Zn2+Concentration, Slc39 (ZiP), and Metallothionein Gene Expression in Primary Pancreatic Islet β-Cells

(2011) Elisa A. Bellomo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low pH Acts as Inhibitor of Membrane Damage Induced by Human Islet Amyloid Polypeptide

(2011) Lucie Khemtémourian et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Noninvasive MRI of  -cell function using a Zn2+-responsive contrast agent

(2011) A. J. M. Lubag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells

(2011) Kwan Yi Chu et al.   Islets

Serum levels of proamylin and amylin in normal subjects and patients with impaired glucose regulation and type 2 diabetes mellitus

(2010) Xiaoya Zheng et al.   ACTA DIABETOLOGICA

The role of amylin in the control of energy homeostasis

(2010) Thomas A. Lutz   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

ClC-3—A Granular Anion Transporter Involved in Insulin Secretion?

(2010) Thomas J. Jentsch et al.   Cell Metabolism

Cholesterol Biosynthesis Pathway Intermediates and Inhibitors Regulate Glucose-Stimulated Insulin Secretion and Secretory Granule Formation in Pancreatic β-Cells

(2010) Miho Tsuchiya et al.   ENDOCRINOLOGY

Pro-hormone Secretogranin II Regulates Dense Core Secretory Granule Biogenesis in Catecholaminergic Cells

(2010) Maïté Courel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptidylgycine α-amidating monooxygenase and copper: A gene-nutrient interaction critical to nervous system function

(2010) Danielle Bousquet-Moore et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Role of Zinc in Human Islet Amyloid Polypeptide Aggregation

(2010) Jeffrey R. Brender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion

(2010) I Kim et al.   PHARMACOGENOMICS JOURNAL

Defective Secretion of Islet Hormones in Chromogranin-B Deficient Mice

(2010) Stefanie Obermüller et al.   PLoS One

Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment

(2010) V. Lissandron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IP3 Receptors: Toward Understanding Their Activation

(2010) C. W. Taylor et al.   Cold Spring Harbor Perspectives in Biology

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Suppression of Sulfonylurea- and Glucose-Induced Insulin Secretion In Vitro and In Vivo in Mice Lacking the Chloride Transport Protein ClC-3

(2009) Dai-Qing Li et al.   Cell Metabolism

The Granular Chloride Channel ClC-3 Is Permissive for Insulin Secretion

(2009) Ludmila V. Deriy et al.   Cell Metabolism

Secretory granules in inositol 1,4,5-trisphosphate-dependent Ca2+ signaling in the cytoplasm of neuroendocrine cells

(2009) Seung Hyun Yoo   FASEB JOURNAL

Chromogranin A Promotes Peptide Hormone Sorting to Mobile Granules in Constitutively and Regulated Secreting Cells

(2009) Maité Montero-Hadjadje et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network

(2009) Robin W. Klemm et al.   JOURNAL OF CELL BIOLOGY

Secretogranin II binds to secretogranin III and forms secretory granules with orexin, neuropeptide Y, and POMC

(2009) Kikuko Hotta et al.   JOURNAL OF ENDOCRINOLOGY

Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

(2009) Jan L Vinkenborg et al.   NATURE METHODS

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amidation of Bioactive Peptides: The Structure of the Lyase Domain of the Amidating Enzyme

(2009) Eduardo E. Chufán et al.   STRUCTURE

Cellular fatty acid uptake: a pathway under construction

(2009) Xiong Su et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

BACE2 is Stored in Secretory Granules of Mouse and Rat Pancreatic β Cells

(2009) Giovanna Finzi et al.   ULTRASTRUCTURAL PATHOLOGY

Amylin Proprotein Processing Generates Progressively More Amyloidogenic Peptides that Initially Sample the Helical State†

(2008) Isaac T. Yonemoto et al.   BIOCHEMISTRY

The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies

(2008) Stéphane Cauchi et al.   BMC Medical Genetics

Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation

(2008) T. Giordano et al.   DIABETOLOGIA

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion

(2008) K. Kirchhoff et al.   DIABETOLOGIA

Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

(2008) Leena Haataja et al.   ENDOCRINE REVIEWS

7B2 Prevents Unfolding and Aggregation of Prohormone Convertase 2

(2008) Sang-Nam Lee et al.   ENDOCRINOLOGY

Sorting of the Neuroendocrine Secretory Protein Secretogranin II into the Regulated Secretory Pathway

(2008) Maïté Courel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the Vesicular Chloride Transporter ClC-3 in Neuroendocrine Tissue

(2008) T. Maritzen et al.   JOURNAL OF NEUROSCIENCE

Amyloid Fiber Formation and Membrane Disruption are Separate Processes Localized in Two Distinct Regions of IAPP, the Type-2-Diabetes-Related Peptide

(2008) Jeffrey R. Brender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Large Form of Secretogranin III Functions as a Sorting Receptor for Chromogranin A Aggregates in PC12 Cells

(2008) Lu Han et al.   MOLECULAR ENDOCRINOLOGY

Regulation of the V-ATPase along the Endocytic Pathway Occurs through Reversible Subunit Association and Membrane Localization

(2008) Céline Lafourcade et al.   PLoS One

Role of furin in granular acidification in the endocrine pancreas: Identification of the V-ATPase subunit Ac45 as a candidate substrate

(2008) E. Louagie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inactivation of the 7B2 inhibitory CT peptide depends on a functional furin cleavage site

(2003) J. R. Hwang et al.   JOURNAL OF NEUROCHEMISTRY