SLC30A8 mutations in type 2 diabetes

Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells

(2014) Philipp A. Gerber et al.   DIABETOLOGIA

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

(2014) Jason Flannick et al.   NATURE GENETICS

Zinc transporter 8 (ZnT8) and β cell function

(2014) Howard W. Davidson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance

(2013) Motoyuki Tamaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Of men, not mice

(2013)   NATURE MEDICINE

Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life

(2013) Wolfgang Maret   Advances in Nutrition

Animal Models of GWAS-Identified Type 2 Diabetes Genes

(2013) Gabriela da Silva Xavier et al.   Journal of Diabetes Research

Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8

(2012) A. B. Hardy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice

(2012) G. da Silva Xavier et al.   DIABETOLOGIA

The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background

(2012) Lynley D. Pound et al.   PLoS One

Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity

(2012) E. Hoch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

(2010) N. Wijesekara et al.   DIABETOLOGIA

Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets

(2010) Stéphane Cauchi et al.   MOLECULAR GENETICS AND METABOLISM

A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion

(2010) I Kim et al.   PHARMACOGENOMICS JOURNAL

Three-dimensional structure of β-cell-specific zinc transporter, ZnT-8, predicted from the type 2 diabetes-associated gene variant SLC30A8 R325W

(2010) Rob NM Weijers   Diabetology & Metabolic Syndrome

Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice

(2010) Motoyuki Tamaki et al.   Islets

Think zinc: New roles for zinc in the control of insulin secretion

(2010) Guy A. Rutter   Islets

SlC30A8 Is a Major Target of Humoral Autoimmunity in Type 1 Diabetes and a Predictive Marker in Prediabetes

(2009) Janet M. Wenzlau et al.   Annals of the New York Academy of Sciences

Mammalian Zinc Transporters: Nutritional and Physiologic Regulation

(2009) Louis A. Lichten et al.   Annual Review of Nutrition

Deletion of the mouseSlc30a8gene encoding zinc transporter-8 results in impaired insulin secretion

(2009) Lynley D. Pound et al.   BIOCHEMICAL JOURNAL

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet  -Cells

(2009) G. da Silva Xavier et al.   DIABETES

The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality

(2009) S. E. Kahn et al.   DIABETOLOGIA

Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis

(2009) Jan L Vinkenborg et al.   NATURE METHODS

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Predicting Type 2 Diabetes Based on Polymorphisms From Genome-Wide Association Studies: A Population-Based Study

(2008) M. van Hoek et al.   DIABETES

Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk

(2008) H. Lango et al.   DIABETES

Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion

(2008) K. Kirchhoff et al.   DIABETOLOGIA

The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients—the EUGENE2 study

(2008) T. W. Boesgaard et al.   DIABETOLOGIA