PAM haploinsufficiency does not accelerate the development of diet- and human IAPP-induced diabetes in mice

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

(2018) Anubha Mahajan et al.   NATURE GENETICS

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

(2018) Soren K. Thomsen et al.   NATURE GENETICS

Microvillar and ciliary defects in zebrafish lacking an actin-binding bioactive peptide amidating enzyme

(2018) Dhivya Kumar et al.   Scientific Reports

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis

(2018) Diane C. Saunders et al.   Cell Metabolism

Islet inflammation in type 2 diabetes and physiology

(2017) Kosei Eguchi et al.   JOURNAL OF CLINICAL INVESTIGATION

A bioactive peptide amidating enzyme is required for ciliogenesis

(2017) Dhivya Kumar et al.   eLife

Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes

(2016) Åsa Segerstolpe et al.   Cell Metabolism

Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide

(2016) Jaques A. Courtade et al.   DIABETOLOGIA

Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCore

(2016) James Lyon et al.   ENDOCRINOLOGY

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

(2016) Andisheh Abedini et al.   eLife

Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology

(2016) Rehana Akter et al.   Journal of Diabetes Research

High-fat diet induced obesity primes inflammation in adipose tissue prior to liver in C57BL/6j mice

(2015) Roel A van der Heijden et al.   Aging-US

Striking Oxygen Sensitivity of the Peptidylglycine α-Amidating Monooxygenase (PAM) in Neuroendocrine Cells

(2015) Peter D. Simpson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

60 YEARS OF POMC: From POMC and α-MSH to PAM, molecular oxygen, copper, and vitamin C

(2015) Dhivya Kumar et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Long-Term Over-Expression of Neuropeptide Y in Hypothalamic Paraventricular Nucleus Contributes to Adipose Tissue Insulin Resistance Partly via the Y5 Receptor

(2015) Min Long et al.   PLoS One

Pamheterozygous mice reveal essential role for Cu in amygdalar behavioral and synaptic function

(2014) Eric D. Gaier et al.   Annals of the New York Academy of Sciences

GSDS 2.0: an upgraded gene feature visualization server

(2014) Bo Hu et al.   BIOINFORMATICS

Mutational Analysis of Preamyloid Intermediates: The Role of His-Tyr Interactions in Islet Amyloid Formation

(2014) Ling-Hsien Tu et al.   BIOPHYSICAL JOURNAL

Mig6 haploinsufficiency protects mice against streptozotocin-induced diabetes

(2014) Yi-Chun Chen et al.   DIABETOLOGIA

A Histidine-rich Linker Region in Peptidylglycine α-Amidating Monooxygenase Has the Properties of a pH Sensor

(2014) Kurutihalli Vishwanatha et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human IAPP–induced pancreatic β cell toxicity and its regulation by autophagy

(2014) Nayumi Shigihara et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes

(2014) Valgerdur Steinthorsdottir et al.   NATURE GENETICS

Resident Macrophages Mediate Islet Amyloid Polypeptide–Induced Islet IL-1β Production and β-Cell Dysfunction

(2013) Clara Y. Westwell-Roper et al.   DIABETES

Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes

(2012) Martha Campbell-Thompson et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion

(2012) Jeroen R Huyghe et al.   NATURE GENETICS

Impaired Insulin Secretion and Enhanced Insulin Sensitivity in Cholecystokinin-Deficient Mice

(2011) C.-M. Lo et al.   DIABETES

IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction

(2011) C. Westwell-Roper et al.   JOURNAL OF IMMUNOLOGY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Peptidylgycine α-amidating monooxygenase and copper: A gene-nutrient interaction critical to nervous system function

(2010) Danielle Bousquet-Moore et al.   JOURNAL OF NEUROSCIENCE RESEARCH

A Novel Pathway of Insulin Sensitivity in Chromogranin A Null Mice

(2009) Jiaur R. Gayen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amidation of Bioactive Peptides: The Structure of the Lyase Domain of the Amidating Enzyme

(2009) Eduardo E. Chufán et al.   STRUCTURE

Intracerebroventricular Administration of Neuropeptide Y Induces Hepatic Insulin Resistance via Sympathetic Innervation

(2008) A. M. van den Hoek et al.   DIABETES

Reversal of Physiological Deficits Caused by Diminished Levels of Peptidylglycine α-Amidating Monooxygenase by Dietary Copper

(2008) D. Bousquet-Moore et al.   ENDOCRINOLOGY