The Multifaceted Role of Flavonoids in Cancer Therapy: Leveraging Autophagy with a Double-Edged Sword

Mechanisms controlling pancreatic islet cell function in insulin secretion

(2021) Jonathan E. Campbell et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy: Mechanisms and Therapeutic Potential of Flavonoids in Cancer

(2021) Xuening Pang et al.   Biomolecules

Modulation of Autophagy in Cancer Cells by Dietary Polyphenols

(2021) Claudia Musial et al.   Antioxidants

Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways

(2021) Saleh A. Almatroodi et al.   MOLECULES

Natural products in drug discovery: advances and opportunities

(2021) Atanas G. Atanasov et al.   NATURE REVIEWS DRUG DISCOVERY

Hydroxysafflor yellow A promotes apoptosis via blocking autophagic flux in liver cancer

(2021) Na Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Proteomics, Personalized Medicine and Cancer

(2021) Miao Su et al.   Cancers

Flavonoids as Anticancer Agents

(2020) Dalia M. Kopustinskiene et al.   Nutrients

Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity Through Promoting Mitochondrial Autophagy

(2020) Haixia Xu et al.   Frontiers in Physiology

Cytoprotective Effects of Delphinidin for Human Chondrocytes against Oxidative Stress through Activation of Autophagy

(2020) Dong-Yeong Lee et al.   Antioxidants

Apigetrin induces extrinsic apoptosis, autophagy, and G2/M phase cell cycle arrest through PI3K/AKT/mTOR pathway in AGS human gastric cancer cell

(2020) Seong Min Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dietary modifications for enhanced cancer therapy

(2020) Naama Kanarek et al.   NATURE

Conservation and diversification of flavonoid metabolism in the plant kingdom

(2020) Weiwei Wen et al.   CURRENT OPINION IN PLANT BIOLOGY

Autophagy in kidney homeostasis and disease

(2020) Chengyuan Tang et al.   Nature Reviews Nephrology

Cellular senescence and cancer: Focusing on traditional Chinese medicine and natural products

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The anticancer potential of the dietary polyphenol rutin: Current status, challenges, and perspectives

(2020) Arakkaveettil Kabeer Farha et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Targeting Autophagy in Breast Cancer

(2020) Stefania Cocco et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Isoliquiritigenin Pretreatment Induces Endoplasmic Reticulum Stress-Mediated Hormesis and Attenuates Cisplatin-Induced Oxidative Stress and Damage in LLC-PK1 Cells

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ERF Gene Clusters: Working Together to Regulate Metabolism

(2020) Tsubasa Shoji et al.   TRENDS IN PLANT SCIENCE

Sinensetin Induces Autophagic Cell Death through p53-Related AMPK/mTOR Signaling in Hepatocellular Carcinoma HepG2 Cells

(2020) Seong Min Kim et al.   Nutrients

Liquiritin protects PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-κB pathway, activation Nrf2-Keap1 pathway, and inhibition mitochondrial apoptosis pathway

(2020) Xiao Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Natural compounds against cytotoxic drug‐induced cardiotoxicity: A review on the involvement of PI3K/Akt signaling pathway

(2020) Fatemeh Yarmohammadi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Cytotoxicity of apigenin toward multiple myeloma cell lines and suppression of iNOS and COX-2 expression in STAT1-transfected HEK293 cells

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Hydroxychloroquine can potentially interfere with immune function in COVID-19 patients: Mechanisms and insights

(2020) Asokan Devarajan et al.   Redox Biology

Effect of silibinin on ethanol- or acetaldehyde-induced damge of mouse primary hepatocytes in vitro

(2020) Xiao-Yu Song et al.   TOXICOLOGY IN VITRO

Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance

(2020) Hardeep Singh Tuli et al.   SEMINARS IN CANCER BIOLOGY

Silibinin ameliorates fructose-induced lipid accumulation and activates autophagy in HepG2 Cells

(2019) Yang Li et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

The Therapeutic Potential of Apigenin

(2019) Bahare Salehi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Collateral sensitivity of natural products in drug-resistant cancer cells

(2019) Thomas Efferth et al.   BIOTECHNOLOGY ADVANCES

Isoorientin alleviates UVB-induced skin injury by regulating mitochondrial ROS and cellular autophagy

(2019) Hongnan Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy-dependent mechanism of genistein-mediated elimination of behavioral and biochemical defects in the rat model of sporadic Alzheimer's disease

(2019) Karolina Pierzynowska et al.   NEUROPHARMACOLOGY

Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells

(2019) Maria Saveria Gilardini Montani et al.   Cancers

Natural products: An upcoming therapeutic approach to cancer

(2019) Sayanta Dutta et al.   FOOD AND CHEMICAL TOXICOLOGY

Pelargonidin-3-O-glucoside Derived from Wild Raspberry Exerts Antihyperglycemic Effect by Inducing Autophagy and Modulating Gut Microbiota

(2019) Hongming Su et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Kaempferol: A Key Emphasis to Its Anticancer Potential

(2019) Muhammad Imran et al.   MOLECULES

Flavonoids nanoparticles in cancer: Treatment, prevention and clinical prospects

(2019) Haoon Khan et al.   SEMINARS IN CANCER BIOLOGY

The mechanism of anticancer action and potential clinical use of kaempferol in the treatment of breast cancer

(2019) Xueni Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Hallmarks of Endothelial Cell Metabolism in Health and Disease

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Dietary flavonoids: Nano delivery and nanoparticles for cancer therapy

(2019) Paola Aiello et al.   SEMINARS IN CANCER BIOLOGY

Enhancement of Quercetin-Induced Apoptosis by Cotreatment with Autophagy Inhibitor Is Associated with Augmentation of BAK-Dependent Mitochondrial Pathway in Jurkat T Cells

(2019) Eun Ji Ha et al.   Oxidative Medicine and Cellular Longevity

Flavonoid intake is associated with lower mortality in the Danish Diet Cancer and Health Cohort

(2019) Nicola P. Bondonno et al.   Nature Communications

New Frontiers in the Treatment of Type 1 Diabetes

(2019) Jeremy T. Warshauer et al.   Cell Metabolism

Cytotoxic effects of delphinidin in human osteosarcoma cells

(2018) Dong-Yeong Lee et al.   Acta Orthopaedica et Traumatologica Turcica

Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

(2018) Jiali Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

Involvement of estrogen receptors in silibinin protection of pancreatic β-cells from TNFα- or IL-1β-induced cytotoxicity

(2018) Jing Yang et al.   BIOMEDICINE & PHARMACOTHERAPY

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(2018) J.F. Buyel   BIOTECHNOLOGY ADVANCES

Apigenin: A dietary flavonoid with diverse anticancer properties

(2018) Josip Madunić et al.   CANCER LETTERS

Non-apoptotic cell death in malignant tumor cells and natural compounds

(2018) Jing Ye et al.   CANCER LETTERS

Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health

(2018) Dariush Mozaffarian et al.   CIRCULATION RESEARCH

Autophagy as a Molecular Target of Flavonoids Underlying their Protective Effects in Human Disease

(2018) Nestor Prieto-Domínguez et al.   CURRENT MEDICINAL CHEMISTRY

Apigenin promotes TRAIL-mediated apoptosis regardless of ROS generation

(2018) Chang-Hee Kang et al.   FOOD AND CHEMICAL TOXICOLOGY

The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation

(2018) Chang-Ju Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silibinin protects human endothelial cells from high glucose-induced injury by enhancing autophagic response

(2018) Aysa Rezabakhsh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Pathologic Angiogenesis of Malignant Vascular Sarcomas: Implications for Treatment

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The autophagic network and cancer

(2018) Marissa D. Rybstein et al.   NATURE CELL BIOLOGY

Kaempferol suppresses proliferation but increases apoptosis and autophagy by up-regulating microRNA-340 in human lung cancer cells

(2018) Xue Han et al.   BIOMEDICINE & PHARMACOTHERAPY

The role of flavonoids in autoimmune diseases: therapeutic updates

(2018) Kannan R.R. Rengasamy et al.   PHARMACOLOGY & THERAPEUTICS

Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells

(2018) Tae Woo Kim et al.   Cell Death & Disease

Curcumin attenuates doxorubicin-induced cardiotoxicity via suppressing oxidative stress and preventing mitochondrial dysfunction mediated by 14-3-3γ

(2018) Huan He et al.   Food & Function

Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

(2018) Muhammad Imran et al.   PHYTOTHERAPY RESEARCH

Redox signaling and unfolded protein response coordinate cell fate decisions under ER stress

(2018) Zhe Zhang et al.   Redox Biology

Liquiritin induces apoptosis and autophagy in cisplatin (DDP)-resistant gastric cancer cells in vitro and xenograft nude mice in vivo

(2017) Feng Wei et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibiting reactive oxygen species-dependent autophagy enhanced baicalein-induced apoptosis in oral squamous cell carcinoma

(2017) Bo Li et al.   Journal of Natural Medicines

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

(2017) Marisa Granato et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

(−)-Epigallocatechin-3-gallate alleviates doxorubicin-induced cardiotoxicity in sarcoma 180 tumor-bearing mice

(2017) Yu-Fei Yao et al.   LIFE SCIENCES

Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling

(2017) Rabia Johnson et al.   MOLECULES

Autophagy in UV Damage Response

(2017) Ashley Sample et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Kaempferol induces autophagic cell death of hepatocellular carcinoma cells via activating AMPK signaling

(2017) Bing Han et al.   Oncotarget

Paclitaxel and the dietary flavonoid fisetin: a synergistic combination that induces mitotic catastrophe and autophagic cell death in A549 non-small cell lung cancer cells

(2016) Anna Klimaszewska-Wisniewska et al.   Cancer Cell International

Pharmacokinetic properties and drug interactions of apigenin, a natural flavone

(2016) Ding Tang et al.   Expert Opinion on Drug Metabolism & Toxicology

Delicaflavone induces autophagic cell death in lung cancer via Akt/mTOR/p70S6K signaling pathway

(2016) Yuxia Sui et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses

(2016) Meixin Chen et al.   MOLECULAR CELL

Counting on natural products for drug design

(2016) Tiago Rodrigues et al.   Nature Chemistry

Cardioprotective Potentials of Plant-Derived Small Molecules against Doxorubicin Associated Cardiotoxicity

(2016) Shreesh Ojha et al.   Oxidative Medicine and Cellular Longevity

Exploring Cancer Therapeutics with Natural Products from African Medicinal Plants, Part I: Xanthones, Quinones, Steroids, Coumarins, Phenolics and other Classes of Compounds

(2015) Conrad Simoben et al.   Anti-Cancer Agents in Medicinal Chemistry

Exploring Cancer Therapeutics with Natural Products from African Medicinal Plants, Part II: Alkaloids, Terpenoids and Flavonoids

(2015) Justina N. Nwodo et al.   Anti-Cancer Agents in Medicinal Chemistry

Autophagy in malignant transformation and cancer progression

(2015) L. Galluzzi et al.   EMBO JOURNAL

Diabetes Associated With Short Survival in Pancreatic Cancer

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Apigenin induces autophagic cell death in human papillary thyroid carcinoma BCPAP cells

(2015) Li Zhang et al.   Food & Function

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Delphinidin-3-glucoside protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury by autophagy upregulation via the AMPK/SIRT1 signaling pathway

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Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer

(2014) N Hasima et al.   Cell Death & Disease

Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells

(2014) Betty Yuen Kwan Law et al.   Scientific Reports

Green tea polyphenol epigallocatechin-3-gallate (EGCG) as adjuvant in cancer therapy

(2013) Elena Lecumberri et al.   CLINICAL NUTRITION

Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells

(2013) WEN-WEN HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Autophagy induced by silibinin protects human epidermoid carcinoma A431 cells from UVB-induced apoptosis

(2013) Weiwei Liu et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Quercetin Induces Mitochondrial Mediated Apoptosis and Protective Autophagy in Human Glioblastoma U373MG Cells

(2013) Hyeonji Kim et al.   Oxidative Medicine and Cellular Longevity

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

(2013) L. M. Coussens et al.   SCIENCE

Chemistry and Biological Activities of Flavonoids: An Overview

(2013) Shashank Kumar et al.   TheScientificWorldJOURNAL

Is Diabetes Mellitus an Independent Risk Factor for Colon Cancer and Rectal Cancer?

(2011) Hiroki Yuhara et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Tea polyphenols protect against irradiation-induced injury in submandibular glands’ cells: A preliminary study

(2011) Zhe Peng et al.   ARCHIVES OF ORAL BIOLOGY

Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling

(2011) Kui Wang et al.   Autophagy

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

A Review on the Dietary Flavonoid Kaempferol

(2011) J. M. Calderon-Montano et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A Major Green Tea Component, (−)-Epigallocatechin-3-gallate, Ameliorates Doxorubicin-Mediated Cardiotoxicity in Cardiomyocytes of Neonatal Rats

(2010) Wenjuan Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats

(2010) Kazim Sahin et al.   LIFE SCIENCES

Impact of Natural Products on Developing New Anti-Cancer Agents†

(2009) Gordon M. Cragg et al.   CHEMICAL REVIEWS

Studies on the protective effect of green tea against cisplatin induced nephrotoxicity

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Luteolin, a Flavonoid with Potential for Cancer Prevention and Therapy

(2008) Yong Lin et al.   CURRENT CANCER DRUG TARGETS

Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: Relationship with silibinin levels

(2008) Richard D. Verschoyle et al.   EUROPEAN JOURNAL OF CANCER

Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways

(2008) Sonia Ramos   MOLECULAR NUTRITION & FOOD RESEARCH