Review
Cell Biology
Xinyue Wang, Xiao Tan, Jinping Zhang, Jiaping Wu, Hongjuan Shi
Summary: Ferroptosis, a newly discovered form of programmed cell death, is characterized by peroxidative damage to polyunsaturated-fatty-acid-containing phospholipids and is highly dependent on iron ions. It is closely associated with the pathogenesis of various diseases and is regulated by multiple signaling pathways, including the MAPK-AMPK pathway. This review summarizes the molecular mechanisms underlying the regulation of ferroptosis by the MAPK-AMPK pathway and discusses the potential therapeutic strategies targeting this pathway.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Engineering, Biomedical
Yu Peng, Junqin Yang, Zedong Li, Sheng Chen, Xianming Tang, Jun Zhou
Summary: In this study, we found that overexpression of SLC40A1 can inhibit the proliferation, migration, and invasion of hepatocellular carcinoma (HCC) cells by activating the autophagy pathway. SLC40A1 regulates the autophagy level of MHCC-97H through the AMPK/mTOR/ULK1 and AMPK/ULK1 signaling pathways.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2022)
Article
Pharmacology & Pharmacy
Wenxian Zhou, Yifeng Shi, Hui Wang, Caiyu Yu, Huanqing Zhu, Aimin Wu
Summary: The study demonstrated that Sin can protect against OA by promoting chondrocyte autophagy, suggesting its potential therapeutic value in OA treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Xiaomei Bao, Yiman Liu, Jiayan Huang, Shuangshuang Yin, Hua Sheng, Xiao Han, Qian Chen, Tao Wang, Sibao Chen, Yuling Qiu, Chunze Zhang, Haiyang Yu
Summary: This study is the first to report the inhibitory function of Stachydrine hydrochloride (SH) in hepatocellular carcinoma (HCC), which may be achieved through the induction of autophagy and cell senescence. This study provides novel insights and potential leads for the further development of drug candidates for HCC treatment.
Article
Biochemistry & Molecular Biology
Xunzhe Yin, Wenbo Li, Jiaxin Zhang, Wenjing Zhao, Huaxing Cai, Chi Zhang, Zuojia Liu, Yan Guo, Jin Wang
Summary: This study demonstrates that activating autophagy-mediated metabolic switching via AMPK could eliminate HepG2 cells, thus influencing the development of liver cancer.
Article
Plant Sciences
Elaine da Silva Siqueira, Virginia Marcia Concato, Fernanda Tomiotto-Pellissier, Taylon Felipe Silva, Bruna Taciane da Silva Bortoleti, Manoela Daiele Goncalves, Idessania Nazareth Costa, Waldiceu Aparecido Verri Junior, Wander Rogerio Pavanelli, Carolina Panis, Mario Sergio Mantovani, Milena Menegazzo Miranda-Sapla, Ivete Conchon-Costa
Summary: The study demonstrated that trans-chalcone exerts significant cytotoxic effects on human HCC HuH7.5 cells without toxicity to non-cancerous cells. It induces mitochondrial membrane damage, G0/G1 cell cycle arrest, decreases in beta-catenin levels, and promotes autophagic cell death, ultimately reducing the metastatic capacity of HuH7.5 cells.
Article
Oncology
Junhua Li, Wei Zhou, Qiang Mao, Dandan Gao, Lin Xiong, Xinyao Hu, Yongfa Zheng, Ximing Xu
Summary: The study revealed that HMGB1 enhances autophagy through the AMPK/mTOR pathway, promoting acquired drug resistance in HCC cells treated with doxorubicin (DOX). Inhibition of HMGB1 and autophagy increased sensitivity to DOX, suggesting HMGB1 inhibitors could be a promising targeted treatment strategy for HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yang Chen, Qian Li, Sisi Ren, Ting Chen, Bingtao Zhai, Jiangxue Cheng, Xiaoyan Shi, Liang Song, Yu Fan, Dongyan Guo
Summary: Curcuinin can treat hepatocellular carcinoma (HCC) through the p53 apoptotic pathway and the AMPK/Unc-51-like kinase 1 (ULK1) autophagy pathway, in which the mutual transformation of autophagy and apoptosis may occur through DRAM and p62.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Biochemistry & Molecular Biology
Feiling Feng, Tiehua Li, Yingchao Liang, Wei Gao, Liang Yang
Summary: This study evaluated the interaction between sinensetin and IFN γ both experimentally and theoretically, and found that sinensetin interacts with IFN γ through a static quenching mechanism. Cellular assays showed that sinensetin has a synergistic effect with IFN γ in inhibiting HepG2 cell proliferation, suggesting its potential as a therapeutic ligand-protein complex.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Thi Ha Nguyen, Tuan Minh Nguyen, Dinh Thi Minh Ngoc, Taesik You, Mi Kyung Park, Chang Hoon Lee
Summary: This review discusses the molecular mechanisms of autophagy and mitophagy in hepatocellular carcinoma (HCC) and highlights the dual role of autophagy in tumor initiation and progression. Additionally, a detailed analysis of autophagy- and mitophagy-related molecules reveals their specific functions during tumorigenesis and the progression of HCC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Khoa Nguyen, Katherine Hebert, Emily McConnell, Nicole Cullen, Thomas Cheng, Susanna Awoyode, Elizabeth Martin, Weina Chen, Tong Wu, Suresh K. Alahari, Reza Izadpanah, Bridgette M. Collins-Burow, Sean B. Lee, David H. Drewry, Matthew E. Burow
Summary: The liver is an important organ involved in biological functions such as digestion, nutrient storage, and detoxification. It plays an active role in regulating metabolism and is susceptible to hepatocellular carcinoma, which is often associated with chronic inflammation. LKB1 signaling has been found to regulate cellular metabolism and has a tumor suppressive role in many cancers. Using the KMPlotter database, this review correlates RNA levels of LKB1 signaling genes with hepatocellular carcinoma patient survival outcomes and identifies potential biomarkers for clinical use.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Juan Wang, Guoxiang Liu, Xiaojuan Li, Mengjie Huangfu, Yisa Liu, Xumei Li, Dan Yu, Luwei Zhou, Xu Chen
Summary: Curcumol induces autophagy through the AMPK/mTOR pathway in NPC cells, and inhibiting autophagy can increase proliferation while attenuating apoptosis and autophagy. Combining curcumol with the autophagy agonist rapamycin and apoptosis inducer MG132 synergizes the apoptotic and autophagic effect of curcumol, suggesting a potential new therapeutic strategy for NPC.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hongxia Liu, Wang Zheng, Qianping Chen, Yuchuan Zhou, Yan Pan, Jianghong Zhang, Yang Bai, Chunlin Shao
Summary: The study discovered that lncRNA CASC19 contributes to radioresistance in NPC by regulating autophagy. Suppressing autophagy through inhibition of the AMPK/mTOR pathway and promoting apoptosis through the PARP1 pathway enhanced the radiosensitivity of NPC cells. These findings suggest CASC19 as a potential molecular biomarker and therapeutic target in NPC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Mengmeng Chen, Yushan Fu, Xu Wang, Ruitong Wu, Dongmei Su, Nan Zhou, Yanhua Qi
Summary: The senescence of lens epithelial cells (LECs) is a major factor leading to age-related cataract (ARC). This study aimed to investigate the mechanism of ARC formation and explore the anti-aging effect of metformin (MET) on ARC. The results showed that MET effectively alleviated the senescence of LECs and the formation of ARC probably through inactivation of the AMPK pathway and augmentation of autophagy.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Lijun Qiao, Qiangnu Zhang, Zhe Sun, Quan Liu, Zongze Wu, Weibin Hu, Shiyun Bao, Qinhe Yang, Liping Liu
Summary: USP11 interacts with E2F1 to promote proliferation and metastasis of HCC cells while inhibiting autophagy. Combination treatment targeting USP11 and autophagy enhances apoptosis of HCC cells and inhibits tumor growth effectively. This suggests the potential of E2F1/USP11 as a therapeutic target in HCC.
Article
Environmental Sciences
Ho Jeong Lee, Ju Hong Lee, Seon Min Lee, Na Hyun Kim, Yeon Gyu Moon, Tae Kil Tak, Moonjung Hyun, Jeong Doo Heo
Summary: The toxicity of cadmium occurs through accumulation in the environment, but the exact mechanism remains unclear. This study found that cadmium can induce cell apoptosis, loss of mitochondrial membrane potential, and caspase-dependent cell death. In addition, cadmium also increases ROS and ER stress, and down-regulates the AKT pathway, leading to apoptotic cell death.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shailima Rampogu, Seong Min Kim, Minky Son, Ayoung Baek, Chanin Park, Gihwan Lee, Yumi Kim, Gon Sup Kim, Ju Hyun Kim, Keun Woo Lee
Article
Biochemistry & Molecular Biology
Preethi Vetrivel, Seong Min Kim, Sang Eun Ha, Hun Hwan Kim, Pritam Bhagwan Bhosale, Kalaiselvi Senthil, Gon Sup Kim
Article
Nutrition & Dietetics
Seong Min Kim, Sang Eun Ha, Preethi Vetrivel, Hun Hwan Kim, Pritam Bhagwan Bhosale, Jung Eun Park, Jeong Doo Heo, Young Sil Kim, Gon Sup Kim
Article
Biochemistry & Molecular Biology
Anjugam Paramanantham, Eun Joo Jung, Se-IL Go, Bae Kwon Jeong, Jin-Myung Jung, Soon Chan Hong, Gon Sup Kim, Won Sup Lee
Summary: This study suggests that activated ERK signaling is one of the major hub signals related to the radio-resistance of MDA-MB-231 breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Preethi Vetrivel, Rajeswari Murugesan, Pritam Bhagwan Bhosale, Sang Eun Ha, Hun Hwan Kim, Jeong Doo Heo, Gon Sup Kim
Summary: This study utilized a network pharmacology approach to identify that the core targets of PG against gastric cancer are HSP90AA1, CDK2, and MMP1. Functional enrichment and pathway analysis revealed significant biological mechanisms associated with these targets.
Review
Integrative & Complementary Medicine
Pritam Bhagwan Bhosale, Hun Hwan Kim, Abuyaseer Abusaliya, Preethi Vetrivel, Sang Eun Ha, Min Yeong Park, Ho Jeong Lee, Gon Sup Kim
Summary: The transcriptional machinery and the role of AP-1, a transcription factor, in different diseases and cancer have been extensively researched. Dysfunctional AP-1 activity is associated with various diseases, particularly cancer and inflammatory disorders. Targeting AP-1 with natural compounds is an effective option for cancer prevention and treatment.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Min Yeong Park, Yoonjung Kim, Sang Eun Ha, Hun Hwan Kim, Pritam Bhangwan Bhosale, Abuyaseer Abusaliya, Se Hyo Jeong, Gon Sup Kim
Summary: Breast cancer is a leading cause of death, especially among women, and can be caused by various factors, including genetic alterations. Radiation is commonly used for detection and treatment of breast cancer, but the development of radiation resistance calls for new treatment strategies. Researchers have discovered a flavonoid that is being investigated as a potentially safer alternative to the approved medicine currently used in the field for treating radiation-resistant breast cancer. This study focuses on the role of flavonoids in suppressing breast cancer, genetic anomalies related to breast cancer, and the resulting mechanism of cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Se Hyo Jeong, Hun Hwan Kim, Sang Eun Ha, Min Young Park, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Kwang Il Park, Jeong Doo Heo, Hyun Wook Kim, Gon Sup Kim
Summary: This article discusses the important role of flavones in inducing apoptosis in cancer cells, focusing on key flavones such as apigenin, acacetin, baicalein, luteolin, tangeretin, and wogonin. The main aim of the study is to investigate the effects of selected flavones on apoptosis and cell signaling pathways that contribute to death from various types of cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yeon-Seop Jung, Ho Jeong Lee, Moonjung Hyun, Hye-Jin Kim, Je-Hein Kim, Kwang-Hyun Hwang, Woong-Soo Kim, Jungil Choi, Jeong Doo Heo
Summary: The study found that 3,3'-diindolylmethane (DIM) effectively suppressed cadmium (Cd)-induced lung fibroblast cell death by upregulating antioxidant systems and reducing oxidative stress levels, providing a potential drug strategy for preventing diseases related to cadmium exposure.
Article
Nutrition & Dietetics
Hun Hwan Kim, Sang Eun Ha, Min Yeong Park, Se Hyo Jeong, Pritam Bhagwan Bhosale, Abuyaseer Abusaliya, Chung Kil Won, Jeong Doo Heo, Meejung Ahn, Je Kyung Seong, Hyun Wook Kim, Gon Sup Kim
Summary: Using RNA sequencing, this study identified KYNA as a potential therapeutic target for gastric cancer. KYNA treatment inhibited cancer cell growth and proliferation, while inducing cell death. This research can provide valuable insights for the development of drugs targeting gastric cancer.