The Role of Intracellular Trafficking of Notch Receptors in Ligand-Independent Notch Activation

The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition

(2019) Judith Hounjet et al.   ONCOGENE

Fetal Dermal Mesenchymal Stem Cell-Derived Exosomes Accelerate Cutaneous Wound Healing by Activating Notch Signaling

(2019) Xiao Wang et al.   Stem Cells International

A randomized phase II trial of nab‐paclitaxel and gemcitabine with tarextumab or placebo in patients with untreated metastatic pancreatic cancer

(2019) Zishuo Ian Hu et al.   Cancer Medicine

RUMI is a novel negative prognostic marker and therapeutic target in non-small-cell lung cancer

(2018) May Chammaa et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

(2018) Marta Portela et al.   Science Signaling

Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex

(2018) Marta Portela et al.   Science Signaling

A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors

(2018) David C. Smith et al.   INVESTIGATIONAL NEW DRUGS

Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations

(2017) Brian J McMillan et al.   GLYCOBIOLOGY

Ligand-activated Notch undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing

(2017) Patricia Chastagner et al.   Science Signaling

Evidence of Extracellular Vesicles Biogenesis and Release in Mouse Embryonic Stem Cells

(2017) Lilian Cruz et al.   Stem Cell Reviews and Reports

Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling

(2017) Qiyu Wang et al.   Nature Communications

Ligand-activated Notch undergoes DTX4-mediated ubiquitylation and bilateral endocytosis before ADAM10 processing

(2017) Patricia Chastagner et al.   Science Signaling

Evidence of Extracellular Vesicles Biogenesis and Release in Mouse Embryonic Stem Cells

(2017) Lilian Cruz et al.   Stem Cell Reviews and Reports

Caveolin-1 Regulates γ-Secretase-Mediated AβPP Processing by Modulating Spatial Distribution of γ-Secretase in Membrane

(2017) Arun Kapoor et al.   JOURNAL OF ALZHEIMERS DISEASE

Notch1 endocytosis is induced by ligand and is required for signal transduction

(2016) G. Chapman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

DrosophilaCrumbs prevents ectopic Notch activation in developing wings by inhibiting ligand-independent endocytosis

(2016) Linda Nemetschke et al.   DEVELOPMENT

Numb regulates the balance between Notch recycling and late-endosome targeting in Drosophila neural progenitor cells

(2016) Seth A. Johnson et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor

(2015) Marta Portela et al.   CELL CYCLE

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

(2015) Wendy R. Gordon et al.   DEVELOPMENTAL CELL

Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17

(2015) Roger A. J. Habets et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling

(2015) Haiying Li et al.   JOURNAL OF CELL BIOLOGY

Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling

(2015) Maria J. Gomez-Lamarca et al.   JOURNAL OF CELL BIOLOGY

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region

(2015) Xiang Xu et al.   STRUCTURE

A Voltage-Gated Calcium Channel Regulates Lysosomal Fusion with Endosomes and Autophagosomes and Is Required for Neuronal Homeostasis

(2015) Xuejun Tian et al.   PLOS BIOLOGY

The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling

(2015) Nadja Drusenheimer et al.   PLoS Genetics

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Compensatory Flux Changes within an Endocytic Trafficking Network Maintain Thermal Robustness of Notch Signaling

(2014) Hideyuki Shimizu et al.   CELL

PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner

(2014) Marika Sjöqvist et al.   CELL RESEARCH

Lgl Regulates Notch Signaling via Endocytosis, Independently of the Apical aPKC-Par6-Baz Polarity Complex

(2014) Linda M. Parsons et al.   CURRENT BIOLOGY

Sara endosomes and the asymmetric division of intestinal stem cells

(2014) C. Montagne et al.   DEVELOPMENT

Basal body proteins regulate Notch signaling through endosomal trafficking

(2014) C. C. Leitch et al.   JOURNAL OF CELL SCIENCE

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

(2014) A. J. Groot et al.   MOLECULAR AND CELLULAR BIOLOGY

Coordinate Hyperactivation of Notch1 and Ras/MAPK Pathways Correlates with Poor Patient Survival: Novel Therapeutic Strategy for Aggressive Breast Cancers

(2014) S. Mittal et al.   MOLECULAR CANCER THERAPEUTICS

Endocytic Accessory Factors and Regulation of Clathrin-Mediated Endocytosis

(2014) C. J. Merrifield et al.   Cold Spring Harbor Perspectives in Biology

Dynamin triple knockout cells reveal off target effects of commonly used dynamin inhibitors

(2013) R. J. Park et al.   JOURNAL OF CELL SCIENCE

Insights into Notch3 Activation and Inhibition Mediated by Antibodies Directed against Its Negative Regulatory Region

(2013) Kittichoat Tiyanont et al.   JOURNAL OF MOLECULAR BIOLOGY

Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling

(2013) Francis Kobia et al.   Molecular Oncology

The Drosophila Importin-α3 Is Required for Nuclear Import of Notch In Vivo and It Displays Synergistic Effects with Notch Receptor on Cell Proliferation

(2013) Nalani Sachan et al.   PLoS One

Differential Surface Expression of ADAM10 and ADAM17 on Human T Lymphocytes and Tumor Cells

(2013) Henriette Ebsen et al.   PLoS One

Notch Ligand Endocytosis Generates Mechanical Pulling Force Dependent on Dynamin, Epsins, and Actin

(2012) Laurence Meloty-Kapella et al.   DEVELOPMENTAL CELL

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

(2012) Emmanuel Dornier et al.   JOURNAL OF CELL BIOLOGY

Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome

(2012) M. Schneider et al.   JOURNAL OF CELL SCIENCE

Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors

(2012) Ian Krop et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors

(2012) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

Notch signaling from the endosome requires a conserved dileucine motif

(2012) Li Zheng et al.   MOLECULAR BIOLOGY OF THE CELL

Multiple O -glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling

(2011) Jessica Leonardi et al.   DEVELOPMENT

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Roles of Drosophila Deltex in Notch receptor endocytic trafficking and activation

(2011) Kenta Yamada et al.   GENES TO CELLS

Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal

(2011) Kazuya Hori et al.   JOURNAL OF CELL BIOLOGY

Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL

(2011) M L Sulis et al.   LEUKEMIA

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

(2011) Dan R Robinson et al.   NATURE MEDICINE

Endocytic control of growth factor signalling: multivesicular bodies as signalling organelles

(2011) Radek Dobrowolski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dual Roles of Notch in Regulation of Apically Restricted Mitosis and Apicobasal Polarity of Neuroepithelial Cells

(2011) Shinya Ohata et al.   NEURON

Interaction Between Notch and Hif-  in Development and Survival of Drosophila Blood Cells

(2011) T. Mukherjee et al.   SCIENCE

Ion flux and the function of endosomes and lysosomes: pH is just the start

(2010) Cameron C. Scott et al.   BIOESSAYS

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

(2010) H. Sheldon et al.   BLOOD

Notch1 signaling is mediated by importins alpha 3, 4, and 7

(2010) Kerstin Huenniger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor

(2010) T. Vaccari et al.   DEVELOPMENT

Alternative Promoter Usage at the Notch1 Locus Supports Ligand-Independent Signaling in T Cell Development and Leukemogenesis

(2010) Pablo Gómez-del Arco et al.   IMMUNITY

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

γ-Secretase-Dependent Cleavage Initiates Notch Signaling from the Plasma Membrane

(2010) Erika B. Sorensen et al.   TRAFFIC

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer

(2009) Karin Rennstam et al.   BREAST CANCER RESEARCH AND TREATMENT

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Endocytic regulation of Notch signaling

(2009) Mark E Fortini et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila

(2009) Yan Yan et al.   DEVELOPMENTAL CELL

Regulation of endosomal clathrin and retromer-mediated endosome to Golgi retrograde transport by the J-domain protein RME-8

(2009) Anbing Shi et al.   EMBO JOURNAL

Multiple routes of protein transport from endosomes to the trans Golgi network

(2009) Suzanne R. Pfeffer   FEBS LETTERS

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

(2009) Geert van Tetering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Secretase: Successive Tripeptide and Tetrapeptide Release from the Transmembrane Domain of  -Carboxyl Terminal Fragment

(2009) M. Takami et al.   JOURNAL OF NEUROSCIENCE

Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

(2009) E. C. Bozkulak et al.   MOLECULAR AND CELLULAR BIOLOGY

Pathways and mechanisms of endocytic recycling

(2009) Barth D. Grant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

(2009) Wendy R. Gordon et al.   PLoS One

Alterations of the Notch pathway in lung cancer

(2009) Britta Westhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

(2008) W. R. Gordon et al.   BLOOD

Human RME-8 Is Involved in Membrane Trafficking through Early Endosomes

(2008) Akemi Fujibayashi et al.   CELL STRUCTURE AND FUNCTION

The V-type H+-ATPase in vesicular trafficking: targeting, regulation and function

(2008) Vladimir Marshansky et al.   CURRENT OPINION IN CELL BIOLOGY

Drosophila HOPS and AP-3 Complex Genes Are Required for a Deltex-Regulated Activation of Notch in the Endosomal Trafficking Pathway

(2008) Marian Wilkin et al.   DEVELOPMENTAL CELL

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal entry regulates Notch receptor activation inDrosophila melanogaster

(2008) Thomas Vaccari et al.   JOURNAL OF CELL BIOLOGY

Pofut1 is required for the proper localization of the Notch receptor during mouse development

(2008) Yoshiaki Okamura et al.   MECHANISMS OF DEVELOPMENT

NUMB controls p53 tumour suppressor activity

(2008) Ivan N. Colaluca et al.   NATURE

AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand

(2008) Patricia Chastagner et al.   PLoS One