RUMI is a novel negative prognostic marker and therapeutic target in non-small-cell lung cancer

Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA

(2016) J. C. Thompson et al.   CLINICAL CANCER RESEARCH

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

(2016) Joshua D Campbell et al.   NATURE GENETICS

Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity

(2016) Po-Nien Tsao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study

(2016) Yinghui Xu et al.   Oncotarget

JAG1 Is Associated with Poor Survival through Inducing Metastasis in Lung Cancer

(2016) Wen-Hsin Chang et al.   PLoS One

Squamousness: Next-generation sequencing reveals shared molecular features across squamous tumor types

(2015) Maria Schwaederle et al.   CELL CYCLE

Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma

(2015) Arun M Unni et al.   eLife

Meta-analysis reveals the correlation of Notch signaling with non-small cell lung cancer progression and prognosis

(2015) Xun Yuan et al.   Scientific Reports

Mutations in POGLUT1, Encoding Protein O-Glucosyltransferase 1, Cause Autosomal-Dominant Dowling-Degos Disease

(2014) F. Buket Basmanav et al.   AMERICAN JOURNAL OF HUMAN GENETICS

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2

(2014) Xia Xu et al.   GENES & DEVELOPMENT

Multiple cells-of-origin of mutant K-Ras–induced mouse lung adenocarcinoma

(2014) Kate D. Sutherland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Rare Population of CD24+ITGB4+Notchhi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal

(2013) Yanyan Zheng et al.   CANCER CELL

Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53

(2013) S. Licciulli et al.   CANCER RESEARCH

Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors

(2013) A. F. Schott et al.   CLINICAL CANCER RESEARCH

Jagged1 is the major regulator of notch-dependent cell fate in proximal airways

(2013) Shubing Zhang et al.   DEVELOPMENTAL DYNAMICS

Frequency of EGFR and KRAS mutations in patients with non small cell lung cancer by racial background: Do disparities exist?

(2013) Joshua Bauml et al.   LUNG CANCER

Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma

(2013) S. Mainardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Aurora A Kinase Regulates Mammary Epithelial Cell Fate by Determining Mitotic Spindle Orientation in a Notch-Dependent Manner

(2013) Joseph L. Regan et al.   Cell Reports

Therapeutic Effect of γ-Secretase Inhibition in KrasG12V-Driven Non-Small Cell Lung Carcinoma by Derepression of DUSP1 and Inhibition of ERK

(2012) Antonio Maraver et al.   CANCER CELL

Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells

(2012) M. Morimoto et al.   DEVELOPMENT

Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors

(2012) Ian Krop et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Study of RO4929097, a Gamma Secretase Inhibitor of Notch Signaling, in Patients With Refractory Metastatic or Locally Advanced Solid Tumors

(2012) Anthony W. Tolcher et al.   JOURNAL OF CLINICAL ONCOLOGY

Dll4-Fc, an Inhibitor of Dll4-Notch Signaling, Suppresses Liver Metastasis of Small Cell Lung Cancer Cells through the Downregulation of the NF- B Activity

(2012) T. Kuramoto et al.   MOLECULAR CANCER THERAPEUTICS

The Notch signalling system: recent insights into the complexity of a conserved pathway

(2012) K. G. Guruharsha et al.   NATURE REVIEWS GENETICS

Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma

(2012) X. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the expression of the Notch3 receptor protein in adult lung cancer

(2012) MIN ZHOU et al.   Oncology Letters

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Combining Notch inhibition with current therapies for breast cancer treatment

(2012) Keith Brennan et al.   Therapeutic Advances in Medical Oncology

Identification of Tumorigenic Cells in KrasG12D-Induced Lung Adenocarcinoma

(2011) H.-C. Cho et al.   CANCER RESEARCH

Activated Notch1 Induces Lung Adenomas in Mice and Cooperates with Myc in the Generation of Lung Adenocarcinoma

(2011) T. D. Allen et al.   CANCER RESEARCH

Multiple O -glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling

(2011) Jessica Leonardi et al.   DEVELOPMENT

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi

(2011) R. Fernandez-Valdivia et al.   DEVELOPMENT

The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200–dependent pathway in mice

(2011) Yanan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch Signaling Contributes to Lung Cancer Clonogenic Capacity In Vitro but May Be Circumvented in Tumorigenesis In Vivo

(2011) J. Osanyingbemi-Obidi et al.   MOLECULAR CANCER RESEARCH

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase

(2011) H. Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer

(2010) Tom Donnem et al.   CANCER

Targeting Specific Regions of the Notch3 Ligand-Binding Domain Induces Apoptosis and Inhibits Tumor Growth in Lung Cancer

(2010) L. Lin et al.   CANCER RESEARCH

Role of glycans and glycosyltransferases in the regulation of Notch signaling

(2010) H. Jafar-Nejad et al.   GLYCOBIOLOGY

Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate

(2010) M. Morimoto et al.   JOURNAL OF CELL SCIENCE

Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis

(2009) Keli Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch signaling controls the balance of ciliated and secretory cell fates in developing airways

(2009) P.-N. Tsao et al.   DEVELOPMENT

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development

(2009) J. S. Guseh et al.   DEVELOPMENT

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

A Notch updated

(2009) An-Chi Tien et al.   JOURNAL OF CELL BIOLOGY

Notch3 cooperates with the EGFR pathway to modulate apoptosis through the induction of bim

(2009) J Konishi et al.   ONCOGENE

Alterations of the Notch pathway in lung cancer

(2009) Britta Westhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging role of Notch in stem cells and cancer

(2008) Zhiwei Wang et al.   CANCER LETTERS

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

(2008) Melih Acar et al.   CELL

Activity of γ -Secretase on Substrates Other than APP

(2008) Alberto D.   CURRENT TOPICS IN MEDICINAL CHEMISTRY