Regulation of Notch signaling and endocytosis by the Lgl neoplastic tumor suppressor

Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent

(2014) Michael J Morgan et al.   Autophagy

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

STAT3-Mediated Autophagy Dependence Identifies Subtypes of Breast Cancer Where Autophagy Inhibition Can Be Efficacious

(2014) P. Maycotte et al.   CANCER RESEARCH

PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner

(2014) Marika Sjöqvist et al.   CELL RESEARCH

Lgl Regulates Notch Signaling via Endocytosis, Independently of the Apical aPKC-Par6-Baz Polarity Complex

(2014) Linda M. Parsons et al.   CURRENT BIOLOGY

The Scribble module regulates retromer-dependent endocytic trafficking during epithelial polarization

(2014) Geert de Vreede et al.   DEVELOPMENT

Sara endosomes and the asymmetric division of intestinal stem cells

(2014) C. Montagne et al.   DEVELOPMENT

Crumbs promotes expanded recognition and degradation by the SCFSlimb/ -TrCP ubiquitin ligase

(2014) P. Ribeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

lgl Regulates the Hippo Pathway Independently of Fat/Dachs, Kibra/Expanded/Merlin and dRASSF/dSTRIPAK

(2014) Linda Parsons et al.   Cancers

Chloroquine in Cancer Therapy: A Double-Edged Sword of Autophagy

(2013) T. Kimura et al.   CANCER RESEARCH

Autophagy-Mediated Tumor Promotion

(2013) Jessie Yanxiang Guo et al.   CELL

Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium

(2013) A. G. Petzoldt et al.   Disease Models & Mechanisms

The Par3/Par6/aPKC complex and epithelial cell polarity

(2013) Jia Chen et al.   EXPERIMENTAL CELL RESEARCH

Exploiting the bad eating habits of Ras-driven cancers

(2013) E. White   GENES & DEVELOPMENT

Chloroquine: Modes of action of an undervalued drug

(2013) Rodolfo Thomé et al.   IMMUNOLOGY LETTERS

Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling

(2013) Francis Kobia et al.   Molecular Oncology

Emerging regulation and functions of autophagy

(2013) Patricia Boya et al.   NATURE CELL BIOLOGY

The Hippo Signaling Pathway Interactome

(2013) Y. Kwon et al.   SCIENCE

Charcot-Marie-Tooth 2B mutations in rab7 cause dosage-dependent neurodegeneration due to partial loss of function

(2013) Smita Cherry et al.   eLife

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Positive Feedback and Mutual Antagonism Combine to Polarize Crumbs in the Drosophila Follicle Cell Epithelium

(2012) Georgina C. Fletcher et al.   CURRENT BIOLOGY

Endocytosis and control of Notch signaling

(2012) Vasundhara Kandachar et al.   CURRENT OPINION IN CELL BIOLOGY

Intracellular Proton Pumps as Targets in Chemotherapy: V-ATPases and Cancer

(2012) Agustin Hernandez et al.   CURRENT PHARMACEUTICAL DESIGN

Cell polarity: models and mechanisms from yeast, worms and flies

(2012) B. J. Thompson   DEVELOPMENT

Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis

(2012) B. S. Clark et al.   DEVELOPMENT

Cortical aPKC kinase activity distinguishes neural stem cells from progenitor cells by ensuring asymmetric segregation of Numb

(2012) Jill M. Haenfler et al.   DEVELOPMENTAL BIOLOGY

The Scribble–Dlg–Lgl polarity module in development and cancer: from flies to man

(2012) Imogen Elsum et al.   Essays in Biochemistry

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

The Scribble Polarity Protein Stabilizes E-Cadherin/p120-Catenin Binding and Blocks Retrieval of E-Cadherin to the Golgi

(2012) Madhura Lohia et al.   PLoS One

Notch and disease: A growing field

(2012) Angeliki Louvi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Notch ligand endocytosis: Mechanistic basis of signaling activity

(2012) Abdiwahab A. Musse et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Hippo pathway and apico–basal cell polarity

(2011) Alice Genevet et al.   BIOCHEMICAL JOURNAL

Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling

(2011) Karen Doggett et al.   BMC DEVELOPMENTAL BIOLOGY

Drosophila endocytic neoplastic tumor suppressor genes regulate Sav/Wts/Hpo signaling and the c-Jun N-terminal kinase pathway

(2011) Brian S. Robinson et al.   CELL CYCLE

Lgl1 Activation of Rab10 Promotes Axonal Membrane Trafficking Underlying Neuronal Polarization

(2011) Tong Wang et al.   DEVELOPMENTAL CELL

Drosophilacancer models

(2011) Vivek A. Rudrapatna et al.   DEVELOPMENTAL DYNAMICS

The a3 Isoform Vacuolar Type H+-ATPase Promotes Distant Metastasis in the Mouse B16 Melanoma Cells

(2011) T. Nishisho et al.   MOLECULAR CANCER RESEARCH

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

Lgl, the SWH pathway and tumorigenesis: It’s a matter of context and competition!

(2010) Nicola A Grzeschik et al.   CELL CYCLE

Regulation of Frizzled-Dependent Planar Polarity Signaling by a V-ATPase Subunit

(2010) Tobias Hermle et al.   CURRENT BIOLOGY

Wnt/Frizzled Signaling Requires dPRR, the Drosophila Homolog of the Prorenin Receptor

(2010) Tina Buechling et al.   CURRENT BIOLOGY

Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms

(2010) Nicola A. Grzeschik et al.   CURRENT BIOLOGY

Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded

(2010) Brian S. Robinson et al.   CURRENT BIOLOGY

Crumbs is required to achieve proper organ size control during Drosophila head development

(2010) E. C. N. Richardson et al.   DEVELOPMENT

The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor

(2010) T. Vaccari et al.   DEVELOPMENT

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway

(2010) Linda M Parsons et al.   FLY

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

(2010) C. Ling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

(2010) C.-L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs

(2009) Gregory R Leong et al.   BMC BIOLOGY

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

(2009) I. F. Robey et al.   CANCER RESEARCH

Endocytic regulation of Notch signaling

(2009) Mark E Fortini et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila

(2009) Yan Yan et al.   DEVELOPMENTAL CELL

Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants

(2009) T. Vaccari et al.   JOURNAL OF CELL SCIENCE

Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

(2009) F. Coumailleau et al.   NATURE

Endocytic Regulation of Notch Signalling During Development

(2009) Maximilian Fürthauer et al.   TRAFFIC

Linking Cell Cycle to Asymmetric Division: Aurora-A Phosphorylates the Par Complex to Regulate Numb Localization

(2008) Frederik Wirtz-Peitz et al.   CELL

Endosomal entry regulates Notch receptor activation inDrosophila melanogaster

(2008) Thomas Vaccari et al.   JOURNAL OF CELL BIOLOGY

Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila

(2007) A.-G. Tian et al.   DEVELOPMENT

Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene

(2007) Eva María Otero-Rey et al.   ORAL ONCOLOGY