Differential Surface Expression of ADAM10 and ADAM17 on Human T Lymphocytes and Tumor Cells

ADAM17, shedding, TACE as therapeutic targets

(2013) Stefan Rose-John   PHARMACOLOGICAL RESEARCH

The TspanC8 Subgroup of Tetraspanins Interacts with A Disintegrin and Metalloprotease 10 (ADAM10) and Regulates Its Maturation and Cell Surface Expression

(2012) Elizabeth J. Haining et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammals

(2012) Emmanuel Dornier et al.   JOURNAL OF CELL BIOLOGY

Tumor Necrosis Factor Signaling Requires iRhom2 to Promote Trafficking and Activation of TACE

(2012) C. Adrain et al.   SCIENCE

iRhom2 Regulation of TACE Controls TNF-Mediated Protection Against Listeria and Responses to LPS

(2012) D. R. McIlwain et al.   SCIENCE

Pro- and anti-apoptotic CD95 signaling in T cells

(2011) Maren Paulsen et al.   Cell Communication and Signaling

Effector granules in human T lymphocytes: the luminal proteome of secretory lysosomes from human T cells

(2011) Hendrik Schmidt et al.   Cell Communication and Signaling

The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9

(2011) Maria Dolores Gutiérrez-López et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

(2011) S. Weber et al.   DEVELOPMENT

ADAM9 Inhibition Increases Membrane Activity of ADAM10 and Controls α-Secretase Processing of Amyloid Precursor Protein

(2011) Marcia L. Moss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of sandwich ELISA for detection and quantification of human and murine a disintegrin and metalloproteinase17

(2011) Ahmad Trad et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Effector Granules in Human T Lymphocytes: Proteomic Evidence for Two Distinct Species of Cytotoxic Effector Vesicles

(2011) Hendrik Schmidt et al.   JOURNAL OF PROTEOME RESEARCH

PKCα and PKCδ Regulate ADAM17-Mediated Ectodomain Shedding of Heparin Binding-EGF through Separate Pathways

(2011) Marie Kveiborg et al.   PLoS One

TACE/ADAM-17 Phosphorylation by PKC-Epsilon Mediates Premalignant Changes in Tobacco Smoke-Exposed Lung Cells

(2011) Hassan Lemjabbar-Alaoui et al.   PLoS One

ADAM17: a molecular switch to control inflammation and tissue regeneration

(2011) Jürgen Scheller et al.   TRENDS IN IMMUNOLOGY

ADAM-17 Is Activated by the Mitogenic Protein Kinase ERK in a Model of Kidney Fibrosis

(2010) L. Gabriel Navar et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Ectodomain shedding of the Notch ligand Jagged1 is mediated by ADAM17, but is not a lipid-raft-associated event

(2010) Catherine A. Parr-Sturgess et al.   BIOCHEMICAL JOURNAL

Adam10 is essential for early embryonic cardiovascular development

(2010) Chi Zhang et al.   DEVELOPMENTAL DYNAMICS

Insights into the molecular regulation of FasL (CD178) biology

(2010) Marcus Lettau et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

(2010) David R. Gibb et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enrichment and analysis of secretory lysosomes from lymphocyte populations

(2009) Hendrik Schmidt et al.   BMC IMMUNOLOGY

Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein

(2009) Daosong Xu et al.   FASEB JOURNAL

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

(2009) Geert van Tetering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling

(2009) E. C. Bozkulak et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial Reactive Oxygen Species Mediate GPCR–induced TACE/ADAM17-dependent Transforming Growth Factor-α Shedding

(2009) Timothy J. Myers et al.   MOLECULAR BIOLOGY OF THE CELL

Regulated intramembrane proteolysis—A story about sheddases and I-CliPs

(2009) Willem G. Annaert et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Posttranslational regulation of Fas ligand function

(2008) Matthias Voss et al.   Cell Communication and Signaling

ADAM10 is essential for proteolytic activation of Notch during thymocyte development

(2008) L. Tian et al.   INTERNATIONAL IMMUNOLOGY

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

2-D DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cells

(2008) Hendrik Schmidt et al.   PROTEOMICS

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PI3-K- and PKC-dependent up-regulation of APP processing enzymes by retinoic acid

(2007) Sofia Holback et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS