Metalloprotease ADAM10 Is Required for Notch1 Site 2 Cleavage

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

(2008) W. R. Gordon et al.   BLOOD

Kuz and TACE can activate Notch independent of ligand

(2008) A. Delwig et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ADAM10 is essential for proteolytic activation of Notch during thymocyte development

(2008) L. Tian et al.   INTERNATIONAL IMMUNOLOGY

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

(2008) Pedro J Real et al.   NATURE MEDICINE

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY