Oral Delivery of Biologics in Inflammatory Bowel Disease Treatment

JAK inhibitors safety in ulcerative colitis: practical implications

(2020) Manasi Agrawal et al.   Journal of Crohns & Colitis

Gut Microbiota in Ulcerative Colitis: Insights on Pathogenesis and Treatment

(2020) Xiao‐Yan Guo et al.   Journal of Digestive Diseases

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

(2020) Sang Hoon Lee et al.   Pharmaceutics

Gut-on-a-chip: Current progress and future opportunities

(2020) Nureddin Ashammakhi et al.   BIOMATERIALS

Site-specific targeted drug delivery systems for the treatment of inflammatory bowel disease

(2020) Xin Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Microbial therapeutics for acute colitis based on genetically modified Lactococcus lactis hypersecreting IL-1Ra in mice

(2020) Fu Namai et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Colonic delivery of vasoactive intestinal peptide nanomedicine alleviates colitis and shows promise as an oral capsule

(2020) Dulari Jayawardena et al.   Nanomedicine

Nanocomposites-based targeted oral drug delivery systems with infliximab in a murine colitis model

(2020) Jung Min Kim et al.   JOURNAL OF NANOBIOTECHNOLOGY

Antisense Oligonucleotide: Basic Concepts and Therapeutic Application in Inflammatory Bowel Disease

(2019) Davide Di Fusco et al.   Frontiers in Pharmacology

Orally Delivered Antisense Oligodeoxyribonucleotides of TNF-α via Polysaccharide-Based Nanocomposites Targeting Intestinal Inflammation

(2019) Bingchao Duan et al.   Advanced Healthcare Materials

Development of oral foams for topical treatment of inflammatory bowel disease

(2019) Dorota Haznar-Garbacz et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Self-organization and symmetry breaking in intestinal organoid development

(2019) Denise Serra et al.   NATURE

Oligonucleotides—A Novel Promising Therapeutic Option for IBD

(2019) Patrizio Scarozza et al.   Frontiers in Pharmacology

Mucosal delivery of Lactococcus lactis carrying an anti-TNF scFv expression vector ameliorates experimental colitis in mice

(2019) Maria José Chiabai et al.   BMC BIOTECHNOLOGY

Human-gut-microbiome on a chip

(2019) Roberta Poceviciute et al.   Nature Biomedical Engineering

Predictors of anti-TNF treatment failure in anti-TNF-naive patients with active luminal Crohn's disease: a prospective, multicentre, cohort study

(2019) Nicholas A Kennedy et al.   Lancet Gastroenterology & Hepatology

British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults

(2019) Christopher Andrew Lamb et al.   GUT

Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis

(2019) Yonghyun Lee et al.   NATURE MATERIALS

Phospholipid‐Free Small Unilamellar Vesicles for Drug Targeting to Cells in the Liver

(2019) Wunan Zhang et al.   Small

A Proresolving Peptide Nanotherapy for Site‐Specific Treatment of Inflammatory Bowel Disease by Regulating Proinflammatory Microenvironment and Gut Microbiota

(2019) Chenwen Li et al.   Advanced Science

Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome

(2019) Israr Khan et al.   Pathogens

Chitosan-modified lipid nanodrug delivery system for the targeted and responsive treatment of ulcerative colitis

(2019) Shao-qing Chen et al.   CARBOHYDRATE POLYMERS

Can naturally occurring nanoparticle-based targeted drug delivery effectively treat inflammatory bowel disease?

(2019) Chunhua Yang et al.   Expert Opinion on Drug Delivery

Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients with Ulcerative Colitis

(2019) William J. Sandborn et al.   GASTROENTEROLOGY

Nanoparticle-Mediated Drug Delivery Systems For The Treatment Of IBD: Current Perspectives

(2019) Chunhua Yang et al.   International Journal of Nanomedicine

ECCO Guidelines on Therapeutics in Crohn's Disease: Medical Treatment

(2019) Joana Torres et al.   Journal of Crohns & Colitis

Oral Anti-Tumour Necrosis Factor Domain Antibody V565 Provides High Intestinal Concentrations, and Reduces Markers of Inflammation in Ulcerative Colitis Patients

(2019) Suhail Nurbhai et al.   Scientific Reports

Mongersen (GED-0301) for Active Crohnʼs Disease

(2019) Bruce E. Sands et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Lycium barbarum lipid-based edible nanoparticles protect against experimental colitis

(2019) Menghang Zu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

ACG Clinical Guideline: Management of Crohn’s Disease in Adults

(2018) Gary R Lichtenstein et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Therapeutic peptides: Historical perspectives, current development trends, and future directions

(2018) Jolene L. Lau et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Redox-sensitive nanoparticles based on 4-aminothiophenol-carboxymethyl inulin conjugate for budesonide delivery in inflammatory bowel diseases

(2018) Qijuan Sun et al.   CARBOHYDRATE POLYMERS

Biological therapies in inflammatory bowel disease: Beyond anti-TNF therapies

(2018) Konstantinos H. Katsanos et al.   CLINICAL IMMUNOLOGY

Recent advances in oral delivery of biologics: nanomedicine and physical modes of delivery

(2018) Driton Vllasaliu et al.   Expert Opinion on Drug Delivery

pH-triggered surface charge-reversal nanoparticles alleviate experimental murine colitis via selective accumulation in inflamed colon regions

(2018) Muhammad Naeem et al.   Nanomedicine-Nanotechnology Biology and Medicine

Gene therapy comes of age

(2018) Cynthia E. Dunbar et al.   SCIENCE

Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH2) with anti-inflammatory activity in the mouse models of colitis

(2018) M Salaga et al.   PEPTIDES

Preparation and characterization of pH-sensitive nanoparticles of budesonide for the treatment of ulcerative colitis

(2018) Hong Zhou et al.   Drug Design Development and Therapy

Preclinical Development of a Novel, Orally-Administered Anti-Tumour Necrosis Factor Domain Antibody for the Treatment of Inflammatory Bowel Disease

(2018) J. Scott Crowe et al.   Scientific Reports

Therapeutic Oligonucleotides: State of the Art

(2018) C.I. Edvard Smith et al.   Annual Review of Pharmacology and Toxicology

Oral delivery of the anti-tumor necrosis factor α domain antibody, V565, results in high intestinal and fecal concentrations with minimal systemic exposure in cynomolgus monkeys

(2018) J. Scott Crowe et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

American Gastroenterological Association Institute Guideline on the Management of Mild-to-Moderate Ulcerative Colitis

(2018) Cynthia W. Ko et al.   GASTROENTEROLOGY

Non-invasive delivery strategies for biologics

(2018) Aaron C. Anselmo et al.   NATURE REVIEWS DRUG DISCOVERY

Alicaforsen for the treatment of inflammatory bowel disease

(2017) Vipul Jairath et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Recent Advances: The Imbalance of Cytokines in the Pathogenesis of Inflammatory Bowel Disease

(2017) Qingdong Guan et al.   MEDIATORS OF INFLAMMATION

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

(2017) Bo Xiao et al.   MOLECULAR THERAPY

Oral administration of ginger-derived nanolipids loaded with siRNA as a novel approach for efficient siRNA drug delivery to treat ulcerative colitis

(2017) Mingzhen Zhang et al.   Nanomedicine

Environmental triggers in IBD: a review of progress and evidence

(2017) Ashwin N. Ananthakrishnan et al.   Nature Reviews Gastroenterology & Hepatology

Anti-Adhesion Therapies in Inflammatory Bowel Disease—Molecular and Clinical Aspects

(2017) Sebastian Zundler et al.   Frontiers in Immunology

Bioengineered and biohybrid bacteria-based systems for drug delivery

(2016) Zeinab Hosseinidoust et al.   ADVANCED DRUG DELIVERY REVIEWS

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

(2016) Jung Soo Suk et al.   ADVANCED DRUG DELIVERY REVIEWS

Systematic review with meta-analysis: comparative efficacy of immunosuppressants and biologics for reducing hospitalisation and surgery in Crohn's disease and ulcerative colitis

(2016) E. J. Mao et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Enzyme- and pH-Responsive Microencapsulated Nanogels for Oral Delivery of siRNA to Induce TNF-α Knockdown in the Intestine

(2016) Jennifer M. Knipe et al.   BIOMACROMOLECULES

Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

(2016) Mingzhen Zhang et al.   BIOMATERIALS

Targeting Inflammatory Bowel Diseases by Nanocarriers Loaded with Small and Biopharmaceutical Anti-Inflammatory Drugs

(2016) Ana Beloqui et al.   CURRENT PHARMACEUTICAL DESIGN

Applications of lipid nanoparticles in gene therapy

(2016) Ana del Pozo-Rodríguez et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

AVX-470, an Orally Delivered Anti-Tumour Necrosis Factor Antibody for Treatment of Active Ulcerative Colitis: Results of a First-in-Human Trial

(2016) M. Scott Harris et al.   Journal of Crohns & Colitis

Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease

(2016) Alon D. Levin et al.   Journal of Crohns & Colitis

Ozanimod Induction and Maintenance Treatment for Ulcerative Colitis

(2016) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mongersen, an oral Smad7 antisense oligonucleotide, in patients with active Crohn’s disease

(2016) Sandro Ardizzone et al.   Therapeutic Advances in Gastroenterology

Inflammatory Bowel Disease: Pathogenesis, Causative Factors, Issues, Drug Treatment Strategies, and Delivery Approaches

(2015) Deependra Singh et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Loss of Infliximab Into Feces Is Associated With Lack of Response to Therapy in Patients With Severe Ulcerative Colitis

(2015) Johannan F. Brandse et al.   GASTROENTEROLOGY

Adeno-associated viral vectors for the treatment of hemophilia

(2015) Katherine A. High et al.   HUMAN MOLECULAR GENETICS

Systematic Review

(2015) Russell D. Cohen et al.   INFLAMMATORY BOWEL DISEASES

Microneedles for Drug Delivery via the Gastrointestinal Tract

(2015) Giovanni Traverso et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: Selective targeting to diseased versus healthy tissue

(2015) Susan Hua et al.   Nanomedicine-Nanotechnology Biology and Medicine

Cloning and variation of ground state intestinal stem cells

(2015) Xia Wang et al.   NATURE

Biologic agents for IBD: practical insights

(2015) Silvio Danese et al.   Nature Reviews Gastroenterology & Hepatology

Immunopathogenesis of IBD: current state of the art

(2015) Heitor S. P. de Souza et al.   Nature Reviews Gastroenterology & Hepatology

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

(2015) Hyun Jung Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and Cancer

(2015) Suniti Misra et al.   Frontiers in Immunology

Treatment of IBD: Where We Are and Where We Are Going

(2014) Charles N Bernstein   AMERICAN JOURNAL OF GASTROENTEROLOGY

Mucosal gene therapy using a pseudotyped lentivirus vector encoding murine interleukin-10 (mIL-10) suppresses the development and relapse of experimental murine colitis

(2014) Hiroshi Matsumoto et al.   BMC GASTROENTEROLOGY

pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease

(2014) Ana Beloqui et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Lectin-decorated nanoparticles enhance binding to the inflamed tissue in experimental colitis

(2014) Brice Moulari et al.   JOURNAL OF CONTROLLED RELEASE

Oral Delivery of Glucagon Like Peptide-1 by a Recombinant Lactococcus lactis

(2014) Payal Agarwal et al.   PHARMACEUTICAL RESEARCH

Inflammatory bowel disease: Pathogenesis

(2014) Yi-Zhen Zhang   WORLD JOURNAL OF GASTROENTEROLOGY

Current, new and future biological agents on the horizon for the treatment of inflammatory bowel diseases

(2014) Aurelien Amiot et al.   Therapeutic Advances in Gastroenterology

Galactosylated trimethyl chitosan–cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages

(2013) Jing Zhang et al.   BIOMATERIALS

Histologic Remission: The Ultimate Therapeutic Goal in Ulcerative Colitis?

(2013) Laurent Peyrin–Biroulet et al.   Clinical Gastroenterology and Hepatology

Adrenomedullin as a Potential Therapeutic Agent for Inflammatory Bowel Disease

(2013) Shinya Ashizuka et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

History of gene therapy

(2013) Thomas Wirth et al.   GENE

AVX-470

(2013) Kailash C. Bhol et al.   INFLAMMATORY BOWEL DISEASES

Mucoadhesive intestinal devices for oral delivery of salmon calcitonin

(2013) Vivek Gupta et al.   JOURNAL OF CONTROLLED RELEASE

Grape Exosome-like Nanoparticles Induce Intestinal Stem Cells and Protect Mice From DSS-Induced Colitis

(2013) Songwen Ju et al.   MOLECULAR THERAPY

Targeting Intestinal Inflammation With CD98 siRNA/PEI–loaded Nanoparticles

(2013) Hamed Laroui et al.   MOLECULAR THERAPY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease

(2013) Ole Haagen Nielsen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liposome: classification, preparation, and applications

(2013) Abolfazl Akbarzadeh et al.   Nanoscale Research Letters

Nanoparticles for oral delivery: Targeted nanoparticles with peptidic ligands for oral protein delivery

(2012) Yeonhee Yun et al.   ADVANCED DRUG DELIVERY REVIEWS

An Orally Administered Redox Nanoparticle That Accumulates in the Colonic Mucosa and Reduces Colitis in Mice

(2012) Long Binh Vong et al.   GASTROENTEROLOGY

Differential MicroRNA expression tracks neoplastic progression in inflammatory bowel disease-associated colorectal cancer

(2012) Ziad Kanaan et al.   HUMAN MUTATION

A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting

(2012) GuangXi Zhai et al.   International Journal of Nanomedicine

Inflammatory bowel disease in Asia: A systematic review

(2012) Lani Prideaux et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

RNA therapeutics: beyond RNA interference and antisense oligonucleotides

(2012) Ryszard Kole et al.   NATURE REVIEWS DRUG DISCOVERY

VIP in Inflammatory Bowel Disease: State of the Art

(2012) Catalina Abad et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Review article: loss of response to anti-TNF treatments in Crohn’s disease

(2011) S. Ben-Horin et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Salmonella-mediated gene therapy in experimental colitis in mice

(2011) Roland Palffy et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Cathelicidin Signaling via the Toll-like Receptor Protects Against Colitis in Mice

(2011) Hon Wai Koon et al.   GASTROENTEROLOGY

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Polymers for colon targeted drug delivery

(2011) H Rajpurohit et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Regulatory macrophages induced by infliximab are involved in healing in vivo and in vitro

(2011) Anne Christine W. Vos et al.   INFLAMMATORY BOWEL DISEASES

Polymersomes for drug delivery: Design, formation and characterization

(2011) Jung Seok Lee et al.   JOURNAL OF CONTROLLED RELEASE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

Dual TNF-α/Cyclin D1 Gene Silencing With an Oral Polymeric Microparticle System as a Novel Strategy for the Treatment of Inflammatory Bowel Disease

(2011) Christina Kriegel et al.   Clinical and Translational Gastroenterology

Delivery of siRNA Therapeutics: Barriers and Carriers

(2010) Jie Wang et al.   AAPS Journal

Drug targeting strategies for the treatment of inflammatory bowel disease: a mechanistic update

(2010) Arik Dahan et al.   Expert Review of Clinical Immunology

Anti–Tumor Necrosis Factor-α Antibodies Induce Regulatory Macrophages in an Fc Region-Dependent Manner

(2010) Anne Christine W. Vos et al.   GASTROENTEROLOGY

Genetics of ulcerative colitis

(2010) Alexandra I. Thompson et al.   INFLAMMATORY BOWEL DISEASES

Oral TNF-α gene silencing using a polymeric microsphere-based delivery system for the treatment of inflammatory bowel disease

(2010) Christina Kriegel et al.   JOURNAL OF CONTROLLED RELEASE

Neuroinflammation in inflammatory bowel disease

(2010) Shaheen E Lakhan et al.   Journal of Neuroinflammation

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

Review: Anti-adhesion molecule therapy for inflammatory bowel disease

(2010) Subrata Ghosh et al.   Therapeutic Advances in Gastroenterology

Lipid-based systemic delivery of siRNA

(2009) Yu-Cheng Tseng et al.   ADVANCED DRUG DELIVERY REVIEWS

Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAi-based gene therapy

(2009) Yuki Takahashi et al.   ADVANCED DRUG DELIVERY REVIEWS

Biological Therapies for Inflammatory Bowel Diseases

(2009) Paul Rutgeerts et al.   GASTROENTEROLOGY

Drug-Loaded Nanoparticles Targeted to the Colon With Polysaccharide Hydrogel Reduce Colitis in a Mouse Model

(2009) Hamed Laroui et al.   GASTROENTEROLOGY

Orally administered L. lactis secreting an anti-TNF Nanobody demonstrate efficacy in chronic colitis

(2009) K Vandenbroucke et al.   Mucosal Immunology

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

Interleukin-10-independent anti-inflammatory actions of glucagon-like peptide 2

(2008) Catherine P. A. Ivory et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Oral IL-10 gene delivery in a microsphere-based formulation for local transfection and therapeutic efficacy in inflammatory bowel disease

(2008) M D Bhavsar et al.   GENE THERAPY

PepT1-Mediated Tripeptide KPV Uptake Reduces Intestinal Inflammation

(2007) Guillaume Dalmasso et al.   GASTROENTEROLOGY